New Study Shows AML Ages Immune Cells, Leading to Poor Treatment Response
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A new study has found that acute myeloid leukemia (AML) ages and exhausts immune cells, impairing their ability to fight off cancer.
Relapsed Leukemia and Lymphoma Program News and Updates
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CHOP Researchers Develop Allogeneic CART for Relapsed or Refractory T-ALL Using Base Editing
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CHOP researchers have tested and developed an “off-the-shelf” chimeric antigen receptor T-cell (CART) using base editing.
CHOP Brings Together Experts to Discuss Precision Medicine in Pediatric Cancer Care
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More than 250 experts gathered in Philadelphia and virtually to discuss the latest scientific advancements and breakthroughs in pediatric precision medicine oncology.
CHOP-Led Study Finds Bortezomib Improves Survival in Children with Newly Diagnosed T-Cell Lymphoblastic Lymphoma
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In a COG trial, CHOP researchers found adding bortezomib to chemotherapy significantly improved overall survival in children and young adults with newly diagnosed T-cell lymphoblastic lymphoma (T-LL).
CHOP Researchers Develop Humanized CAR T-Cell Therapy that Shows Potential for Patients with Relapsed B-ALL
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The treatment modifies a domain in the CAR that targets CD19, making it look more human and therefore less likely to be rejected by patients.
AML Immunotherapy Trial Opens
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CHOP has opened a phase 1 trial using CAR T for tough acute myeloid leukemia, hoping to replicate the therapy’s success for acute lymphoblastic leukemia.
Immunotherapy: What’s Next for CAR-T Therapy
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Trials of more game-changing cell therapies for pediatric cancer and other diseases are underway or on the horizon at Children's Hospital of Philadelphia.
Humanized CD19: CAR-T Immunotherapy for First Relapse of ALL in Down Syndrome Patient
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An alternative, humanized CD19 CAR T product for first relapse of pediatric ALL is being evaluated in a clinical trial at Children's Hospital of Philadelphia.
CHOP Scientists Report How Some Cancer Cells Develop Resistance to CAR T-cell Therapy
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CHOP researchers analyze how some cancer cells resist a groundbreaking cellular therapy, and have found clues to overcoming that resistance.
Parents Magazine Names Children’s Hospital of Philadelphia Among 20 Most Innovative Children’s Hospitals
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Children’s Hospital of Philadelphia was recognized specifically for significant contributions to the development of a new treatment for a certain pediatric leukemia.