Ana G. Cristancho, MD, PhD, is a pediatric neurologist with the Division of Neurology at Children's Hospital of Philadelphia, with special interest in fetal and neonatal neurology. Dr. Cristancho's research focus includes developing experimental models of prenatal hypoxic injury. Her goal is to understand the effect of acute and chronic low oxygen states on the developing brain throughout pregnancy to better understand new opportunities for intervention, management and prognosis.
MD - University of Pennsylvania School of Medicine, Philadelphia, PA
Child Neurology - Children’s Hospital of Philadelphia, Philadelphia, PA (Chief Resident)
General Pediatrics - Children’s Hospital of Philadelphia, Philadelphia, PA
Fetal Neurology and Research Fellow - Children's Hospital of Philadelphia, Philadelphia, PA
PhD in Cancer Biology - University of Pennsylvania School of Medicine, Philadelphia, PA
Instructor of Neurology, Perelman School of Medicine at the University of Pennsylvania
Mignot C, McMahon AC, Bar C, Campeau PM, … Cristancho AG, … Moller RS, Lesca G, Helbig KL, Nabbout R, Verbeek NE, Depienne C (86 authors). IQSEC2-related encephalopathy in males and females: a comparative study including 37 novel patients. Genetics in Medicine. 2018 Sep 12. [Epub ahead of print]
Gray IN, Cristancho AG, Licht DJ, Liu GT. Ocular Dipping in a Patient With Hemiplegic Migraine. Journal of Pediatric Ophthalmology and Strabismus. 2018 Jan 31;55:e4-e6.
Tian G*, Cristancho AG*, Dubbs HA, Liu GT, Cowan NJ, Goldberg EM. A patient with lissencephaly, developmental delay, and infantile spasms, due to de novo heterozygous mutation of KIF2A. Molecular Genetics and Genomic Medicine. 2016 Nov; 4(6): 599–603. * co-first authors
Cristancho AG, Lazar MA. Double SET point: G9a makes its mark in adipogenesis. EMBO Journal. 2013 Jan 9; 32(1): 4-6.
Cristancho AG, Lazar MA. Forming functional fat: a growing understanding of adipocyte differentiation. Nature Reviews Molecular Cell Biology. 2011 Sep 28;12(11):722-34.
Cristancho AG, Schupp M, Lefterova MI, Cao S, Cohen DM, Chen CS, Steger DJ, Lazar MA. Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells. Proceedings of the National Academy of Sciences. 2011 Sep 27;108(39):16271-6.
Schupp M, Cristancho AG, Lefterova MI, Hanniman EA, Briggs ER, Steger DJ, Qatanani M, Curtin JC, Schug J, Ochsner SA, McKenna NJ, Lazar MA. Re-expression of GATA2 cooperates with peroxisome proliferator-activated receptor-gamma depletion to revert the adipocyte phenotype. Journal of Biological Chemistry. 2009 Apr 3;284(14):9458-64.
Schupp M, Lefterova M, Janke J, Leitner K, Cristancho AG, Mullican SE, Szwergold N, Steger DJ, Curtin JC, Kim RJ, Suh M, Albert MR, Engeli S, Gudas LJ, and Lazar MA. Retinol Saturase Promotes Adipogenesis and Is Down-Regulated in Obesity. Proceedings of the National Academy of Sciences. 2009 Jan 27;106(4):1105-10.
Lefterova MI, Zhang Y, Steger DJ, Schupp M, Schug J, Cristancho A, Feng D, Zhuo D, Stoeckert, Jr CJ, Liu XS, and Lazar MA. PPARgamma and C/EBP Factors Orchestrate Adipocyte Biology Via Adjacent Binding on a Genome-Wide Scale. Genes and Development. 2008 Nov 1;22(21):2941-52.
Moise AR, Domínguez M, Alvarez S, Alvarez R, Schupp M, Cristancho AG, Kiser PD, de Lera AR, Lazar MA, Palczewski K. Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids. Journal of the American Chemical Society. 2008 Jan 30;130(4):1154-5.
Cristancho, AG, Streicher, D, Vossough A, Treat JR, Licht DJ, Streicher, JL. Characterization of Features of PHACE Syndrome on Fetal MRI and Natural History of Postnatal Management. Presented at American Academy of Neurology. April 24, 2018.
Cristancho, AG, Vossough A, Treat JR, Licht DJ, Streicher, JL. Characterization of Features of PHACE Syndrome on Fetal MRI and Natural History of Postnatal Management. Presented at American Neurological Association. October 16, 2017.
Cristancho, AG, Vossough A, Treat JR, Licht DJ, Streicher, JL. Characterization of Features of PHACE Syndrome on Fetal MRI and Natural History of Postnatal Management. Presented at International Symposium for Fetal Brain. August 24, 2017.
Cristancho AG, Wedin T. Clinical Conundrums: When a fever gets cross-eyed. Society for Hospitalist Medicine Annual Meeting. March 31, 2015. (Winner of Pediatric Vignette Competition)
Cristancho AG, Foerster DL, Shinnick JE, França Jr. M, Lynch DR. Body Habitus is Inversely Related to Neurological Disease Severity in Children with Friedreich Ataxia. International Ataxia Research Conference. March 27, 2015.
2016-present, Neurocritical Care Advisory Committee
2017-present, Child Neurology Society
2015-present, American Academy of Neurology
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