Julie C. Fitzgerald, MD, PhD

Julie C. Fitzgerald, MD, PhD

Julie Fitzgerald, MD, PhD, is a pediatric intensivist in the Department of Anesthesiology and Critical Care Medicine, and the Pediatric Intensive Care Unit at CHOP.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Dr. Fitzgerald is a graduate of the University of Pennsylvania College of Arts and Sciences and the University of Pennsylvania Perelman School of Medicine, where she obtained both an MD and a PhD in Cell and Molecular Biology. Dr. Fitzgerald completed pediatrics residency and pediatric critical care medicine fellowship training at Children’s Hospital of Philadelphia (CHOP). In 2011, she joined the faculty at the University of Pennsylvania Perelman School of Medicine and is currently an Assistant Professor of Critical Care and Pediatrics, as well as an attending physician in the CHOP pediatric intensive care unit.

In collaboration with a multidisciplinary team in the CHOP PICU, she developed and implemented the CHOP PICU severe sepsis pathway in 2012, a set of recommendations for severe sepsis management in the PICU. In 2016, Dr. Fitzgerald took on the role of physician lead for Hospital-wide sepsis quality improvement/sepsis governance committee at CHOP.  She is a member of the task force that recently updated the American College of Critical Care Medicine Pediatric Shock Practice Parameters, and was a member of a committee convened by the Commonwealth of Pennsylvania Secretary of Health in 2016 to provide recommendations on state-wide hospital regulations for sepsis recognition and response.

In parallel with these quality improvement and regulatory efforts, Dr. Fitzgerald has been collaborating in sepsis-related clinical research at CHOP, with a focus on sepsis epidemiology. She and Dr. Scott Weiss led an international pediatric severe sepsis epidemiologic study that studied pediatric severe sepsis in 128 pediatric intensive care units (PICUs) in 26 countries and described the prevalence, current etiologies and therapies, and outcomes of pediatric severe sepsis. Together with Dr. Fran Balamuth and Dr. Weiss, she has studied the impact of timely sepsis therapies on outcome in children with sepsis locally at CHOP.

In 2017, Dr. Fitzgerald completed her Master of Science in Clinical Epidemiology at the University of Pennsylvania. Currently, she is further focusing on the impact of pediatric sepsis on renal dysfunction, examining biomarkers that may be helpful in predicting renal dysfunction in septic acute kidney injury, and the impact of resuscitative therapies in sepsis on the development of sepsis-related renal dysfunction.

Education and Training

Medical School

MD - University of Pennsylvania School of Medicine, Philadelphia, PA

Residency

Pediatrics - Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

Critical Care Medicine - Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Critical Care Medicine
Pediatrics

Graduate Degree

PhD in Cell and Molecular Biology - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Pediatric Intensivist

Assistant Professor in Anesthesiology and Critical Care Medicine, Perelman School of Medicine at the University of Pennsylvania

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Sepsis
Acute kidney injury
Oncology patients in the ICU

Publications

Papers

2019

Weiss SL, Balamuth F, Thurm CW, Downes KJ, Fitzgerald JC, Laskin BL: Major adverse kidney events in pediatric sepsis. Clinical Journal of American Society of Nephrology Epub ahead of print 2019.

Pais GM, Avedissian SN, O'Donnell JN, Rhodes NJ, Lodise TP, Prozialeck WC, Lamar PC, Cluff C, Gulati A, Fitzgerald JC, Downes KJ, Zuppa AF, Scheetz MH: Comparative performance of urinary biomarkers for vancomycin induced kidney injury according to timeline of injury. Antimicrob Agents Chemotherapy Epub ahead of print 2019.

Fitzgerald JC, Zane NR, Himebauch AS, Reedy MD, Downes KJ, Topjian AA, Furth SL, Thomas NJ, Scheetz MH, Zuppa AF: Vancomycin prescribing and therapeutic drug monitoring in children with and without acute kidney injury after cardiac arrest. Pediatric Drugs Epub ahead of print 2019.

Lindell RB, Nishisaki A, Weiss SL, Balamuth F, Traynor DM, Chilutti MR, Grudmeier RW, Fitzgerald JC: Comparison of methods for identification of pediatric severe sepsis and septic shock in the virtual pediatric systems database. Critical Care Medicine 47(2): e129-e135, February 2019.

Mahadeo K, Khazal S, Abdel-Azim H, Fitzgerald JC, Taraseviciute A, Bollard C, Tewari P, Duncan C, Traube C, McCall D, Steiner M, Cheifetz I, Lehmann L, Mejia R, Slopis J, Bajwa R, Kebriaei P, Martin P, Moffet J, McArthur J, Petropoulos D, Curry JO, Featherston S, Foglesong J, Shoberu B, Glubis A, Mireles M, Hafemeister L, Nguyen C, Kapoor N, Rezvani K, Neelapu SS, Shpall E, PALISI Network: Guidelines for Chimeric Antigen Recepter T-Cell (CAR-T) therapy management of pediatric patients. Nat Rev Clin Oncol 16(1): 45-63, January 2019.

2018

Downes, KJ, Fitzgerald JC, Schriver E, Boge C, Russo M, Weiss SL, Balamuth F, Kubis SE, Tolomeo P, Bilker W, Han JH, Lautenbach E, Coffin SE, Gerber JS, for the CDC Prevention Epicenters Program: Implementation of a pragmatic biomarker-driven algorithm to guide antibiotic use in the pediatric intensive care unit: the Optimizing Antibiotic Strategies in Sepsis (OASIS) II study. Journal of the Pediatric Infectious Diseases Society Epub ahead of press 2018.

Stenson EK, Cvijanovich NZ, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Jain PN, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Lutfi R, Gertz S, Grunwell JR, Wong HR, Anas N: Hyperchloremia is associated with acute kidney injury in pediatric patients with septic shock. Intensive Care Medicine 44(11): 2004-2005, November 2018.

Irving SY, Daly B, Verger J, Typpo KV, Brown AM, Hanlon A, Weiss SL, Fitzgerald JC, Nadkarni VM, Thomas NJ, Srinivasan V: The association of nutrition status expressed as body mass index z-score with outcomes in children with severe sepsis: a secondary analysis from the Sepsis Prevalence, Outcomes and Therapies (SPROUT) study. Critical Care Medicine 46(11): e1029-e1039, November 2018.

Rowan CM, McArthur J, Hsing DD, Gertz SJ, Smith LS, Loomis A, Fitzgerald JC, Nitu ME, Moser EAS, Duncan CN, Mahadeo KM, Moffet J, Hall MW, Pinos EL, Tamburro RF, Cheifetz IM; Investigators of the Pediatric Acute Lung Injury and Sepsis Network: Acute respiratory failure in pediatric hematopoietic cell transplantation - A Multicenter Study. Critical Care Medicine 46(10): e967-e974, October 2018.

Rowan CM, McArthur J, Hsing DD, Gertz SJ, Smith LS, Loomis A, Fitzgerald JC, Nitu ME, Moser EAS, Duncan CN, Mahadeo KM, Moffet J, Hall MW, Pinos EL, Tamburro RF, Cheifetz IM; Investigators of the Pediatric Acute Lung Injury and Sepsis Network: Acute respiratory failure in pediatric hematopoietic cell transplantation - A Multicenter Study. Critical Care Medicine 46(10): e967-e974, October 2018.

Fitzgerald JC, Ross ME, Thomas NJ, Weiss SL, Balamuth F, Anderson AH: Risk factors and inpatient outcomes associated with acute kidney injury at Pediatric Severe Sepsis Presentation. Pediatric Nephrology 33(10): 1781-1790, October 2018.

Cornell TT, Selewski DT, Alten JA, Askenazi D, Fitzgerald JC, Topjian AA, Holubkov R, Page K, Slomine BS, Christensen JR, Dean JM, Moler FW: Acute kidney injury after out of hospital pediatric cardiac arrest. Resuscitation 131: 63-38, October 2018.

Fitzgerald JC, Li Y, Fisher BT, Huang YS, Miller TP, Bagatell R, Seif AE, Aplenc R, Thomas NJ: Hospital variation in intensive care resource utilization and mortality in newly diagnosed pediatric leukemia. Pediatric Critical Care 19(6): e312-e320, June 2018.Signoff JK, Fitzgerald JC, Teachey DT, Balamuth F, Weiss SL: Hypofibrinogenemia is associated with poor outcome and secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome in pediatric severe sepsis. Pediatric Critical Care Medicine 19(5): 397-405, May 2018.

Rowan CM, Loomis A, McArthur J, Smith LS, Gertz SJ, Fitzgerald JC, Nitu ME, Moser EA, Hsing DD, Duncan CN, Mahadeo KM, Moffet J, Hall MW, Pinos EL, Tamburro RF, Cheifetz IM: High-frequency oscillatory ventilation use and severe pediatric ARDS in the pediatric hematopoietic cell transplant recipient. Respiratory Care 63(4): 404-411, April 2018.

Michelson KN, Reubenson G, Weiss SL, Fitzgerald JC, Ackerman K, Christie L, Bush JL, Nadkarni VM, Thomas NJ, Schreiner MJ: Site variability in regulatory oversight for an international study of pediatric sepsis. Pediatric Critical Care Medicine 19(4): e180-e188, April 2018.

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Grunwell JR, Lindsell CJ: Endotype transitions during the acute phase of pediatric septic shock reflect changing risk and treatment response. Critical Care Medicine 46(3): e242-e249, March 2018.

Stenson EK, Cvijanovich NZ, Anas N, Allen GL, MD5, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak N, Raj SS, Gertz S, Grunwell JR, Wong HR: Hyperchloremia is associated with complicated course and mortality in pediatric patients with septic shock. Pediatric Critical Care Medicine 19(2): 155-160, February 2018.

2017

Lindell RB, Gertz SJ, Rowan CM, McArthur J, Beske F, Plunkett A, Weiss SL, Thomas NJ, Nadkarni VM, Fitzgerald JC for the SPROUT Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network: High levels of morbidity and mortality among pediatric hematopoietic cell transplant recipients with severe sepsis: insights from the SPROUT international point prevalence study. Pediatric Critical Care Medicine 18(12): 1114-1125, December 2017Lindell RB, Gertz SJ, Rowan CM, McArthur J, Beske F, Plunkett A, Weiss SL, Thomas NJ, Nadkarni VM, Fitzgerald JC for the SPROUT Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network: High levels of morbidity and mortality among pediatric hematopoietic cell transplant recipients with severe sepsis: insights from the SPROUT international point prevalence study. Pediatric Critical Care Medicine 18(12): 1114-1125, December 2017

Lin JC, Spinella PC, Fitzgerald JC, Tucci M, Bush JL, Nadkarni VM, Thomas NJ, Weiss SL for the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. New or progressive multiple organ dysfunction syndrome (NPMODS) in pediatric severe sepsis: a sepsis phenotype with higher morbidity and mortality. Pediatric Critical Care Medicine 2017;18(1):8-16.

Weiss SL, Keele L, Balamuth F, Vendetti N, Ross R, Fitzgerald JC, Gerber JS. Crystalloid fluid choice and clinical outcomes in pediatric sepsis: a match retrospective cohort study. Journal of Pediatrics 2017;182:304-310.

Davis AL, Carcillo JA, Aneja RK, Deymann AJ, Lin JC, Nguyen C, Okhuysen-Cawley R, Relvas MS, Rozenfeld RA, Skippen PW, Stojadinovic BJ, Williams EA, Yeh TS, Balamuth F, Brierley J, deCaen AR, Cheifetz IM, Choong K, Conway E, Cornell T, Doctor A, Dugas MA, Feldman JD, Fitzgerald JC, Flori HR, Fortenbery JD, Graciano AL, Greenwald BM, Hall MW, Han YY, Hernan LJ, Irazuzta JE, Iselin E, van der Jagt, EW, Jeffries HE, Kache S, Katyal C, Kissoon N, Kon AA, Kutko MC, MacLaren G, Maul T, Mehta R, Odetola F, Parbuoni K, Paul R, Peters MJ, Ranjit S, Reuter-Rice KE, Schnitzler EJ, Scott HF, Torres A, Weingarten-Abrams, J, Weiss SL, Zimmerman JJ, Zuckerberg AL: The American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: Executive Summary. Pediatric Critical Care Medicine 18(9): 884-890, September 2017.

Morgan RW, Fitzgerald JC, Weiss SL, Nadkarni VM, Sutton RM, Berg RA: Sepsis-associated in-hospital cardiac arrest: Epidemiology, pathophysiology, and potential therapies. Journal of Critical Care 40: 128-135, August 2017.

Downes KJ, Weiss SL, Klieger SB, Fitzgerald JC, Balamuth F, Kubis S, Tolomeo P, Bilker W, Han X, Nachamkin I, Garrigan C, Han J, Lautenbach E. Gerber JS, Coffin S for The CDC Prevention Epicenters Program. A Pragmatic Biomarker-Driven Algorithm to Guide Antibiotic Use in the Pediatric Intensive Care Unit: the Optimizing Antibiotic Strategies in Sepsis (OASIS) Study. Journal of the Pediatric Infectious Diseases Society 2017;6:134-141.

Han M, Fitzgerald JC, Balamuth F, Keele L, Alpern ER, Lavelle J, Chilutti M, Grundmeier RW, Nadkarni VM, Thomas NJ, Weiss SL.  Association of delayed antimicrobial therapy with one-year mortality in pediatric sepsis. Shock 2017 Jan 20 [Epub ahead of print].

Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald J, Checchia PA, Meyer K, Quasney M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Grunwell JR, Opoka A, Wong HR. Glucocorticoid receptor polymorphisms and outcomes in pediatric septic shock. Pediatric Critical Care Medicine 2017;18(4):299-303.

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Grunwell JR, Lindsell CJ.  Improved risk stratification in pediatric septic shock using both protein and mRNA biomarkers: PERSEVERE-XP. American Journal of Respiratory and Critical Care Medicine 2017 Mar 21 [Epub ahead of print].

Balamuth F, Alpern ER, Funari MK, Hayes K, Schast A, Lavelle J, Fitzgerald JC, Weiss SL, Zorc JJ. Improving recognition of pediatric severe sepsis in the emergency department: contributions of a vital sign based electronic alert and bedside clinician identification. Annals of Emergency Medicine Annals of Emerg Med. 2017 (17)30315-3.

Weiss SL, Balamuth F, Hensley J, Fitzgerald JC, Bush J, Nadkarni VM, Thomas NJ, Hall M, Muszynski J. The epidemiology of hospital death following pediatric severe sepsis: when, why, and how children with sepsis die. Pediatr Crit Care Med. 2017 May 25. doi: 10.1097/PCC.0000000000001222. [Epub ahead of print]

Rowan CM, Smith LS, Loomis A, McArthur J, Gertz SJ, Fitzgerald JC, Nitu ME, Moser EA, Hsing DD, Duncan CN, Mahadeo KM, Moffet J, Hall MW, Pinos EL, Tamburro RF, Cheifetz IM on behalf of the Investigators of the Pediatric Acute Lung Injury and Sepsis Network. Pediatric acute respiratory distress syndrome in pediatric allogeneic hematopoietic stem cell transplants: A multicenter study. Pediatric Critical Care Medicine 2017 April;1(4):304-309.

Davis AL, Carcillo JA, Aneja RK, Deymann AJ, Lin JC, Nguyen TC, Okhuysen-Cawley RS, Relvas MS, Rozenfeld RA, Skippen PW, Stojadinovic BJ, Williams EA, Yeh TS, Balamuth F, Brierley J, de Caen AR, Cheifetz IM, Choong K, Conway E, Cornell T, Doctor A, Dugas M, Feldman JD, Fitzgerald JC, Flori HR, Fortenberry JD, Braciano AL, Greenwald BM, Hall MW, Han YY, Hernan LK, Irazuzta JE, Iselin E, van der Jagt WE, Jeffries HE, Kache S, Katyal C, Kissoon N, Kon AA, Jutko MC, MacLaren G, Maul T, Mehta R, Odetola F, Parbuoni K, Paul R, Peters MJ, Ranjit S, Reuter-Rice KE, Schnitzler EJ, cott H, Torees A, Weingarten-Abrams J, Weiss SL, Zimmerman JJ, Zuckerberg AL.  American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal shock. Critical Care Medicine 2017 June; 45(6):1061-1093.

Neumayr TM, Gill J, Fitzgerald JC, Gazit A, Pineda JA, Berg RA, Dean M, Moler FW, Doctor A. Identifying risk for acute kidney injury in infants and children following cardiac arrest. Pediatr Crit Care Med. 2017 Jul 21. doi: 10.1097/PCC.0000000000001280. [Epub ahead of print]

Fitzgerald JC, Weiss SL, Maude SL, Barrett DM, Lacey SF, Melenhorst JJ, Shaw P, Berg RA, June CH, Porter DL, Frey NV, Grupp SA, Teachey DT.: Cytokine release syndrome after chimeric antigen receptor T cell therapy for Acute Lymphoblastic Leukemia. Critical Care Medicine 45(2), February 2017.

2016

Klieger SB, Fitzgerald JC, Weiss SL, Balamuth F, Teszner E, Sammons JS, Coffin SE. Pediatric Severe Sepsis/Septic Shock Associated with Healthcare-Associated Infections. Infect Control Hosp Epidemiol 2016;37(4):483-5.

Giuliano JS, Jr, Markovitz BP, Brierley J, Levin R, Williams G,  Lum LC, Dorofaeff T, Cruces P, Bush JL, Keele L, Nadkarni VM, Thomas NJ, Fitzgerald JC, Weiss SL for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Variability in pediatric severe sepsis managed in USA and European intensive care units. Pediatric Critical Care Medicine 2016;17(6):522-30.

Balamuth F, Weiss SL, Fitzgerald JC, Hayes K, Centkowski S, Chilutti M, Grundmeier R, Lavelle J, Alpern ER. Protocolized treatment is associated with decreased organ dysfunction in pediatric severe sepsis. Pediatric Critical Care Medicine 2016; 17(9):817-822.

Teachey DT, Lacey SF, Shaw PA, Melenhorst JJ, Maude SL, Frey N, Pequignot E, Gonzalez VE, Chen F, Finklestein J, Barrett DM, Weiss SL, Fitzgerald JC, Berg RA, Aplenc R, Callahan C, Rheingold SR, Zheng Z, Rose-John S, Nazimuddin F, Wertheim G, Levine BL,  June CH, Porter DL, Grupp SA. Identification of predictive biomarkers for cytokine release syndrome after chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Cancer Discovery 2016;6(6):664-679.

Wong HR, Atkinson SJ, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Lindsell CJ. Combining prognostic and predictive enrichment strategies to identify children with septic shock responsive to corticosteroids. Critical Care Medicine 2016;44(10)e1000-10003.

Fitzgerald JC, Basu R, Akcan-Arikan A, Izquierdo LM, Pineres Olave BE, Hassinger AB, Szczepanski M, Deep A, Williams D, Sapru A, Roy JA, Nadkarni VM, Thomas NJ, Weiss SL, Furth S for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Acute kidney injury in pediatric severe sepsis: an independent risk for death and new disability. Critical Care Medicine 2016;44(12):2241-2250.

Randolph AG, Flanagan RF, Meece JK, Fitzgerald JC, Loftis LL, Truemper EJ, Li S,Ferdinands JM, Pediatric Acute Lung Injury and Sepsis Investigators  PICFlu Study Group. Optimizing virus identification in critically ill children suspected of having an acute severe viral infection. Pediatric Critical Care Medicine 2016 April;17(4):279-286.

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald J, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Howard K, Harmon K, Lahni P, Frank E, Hart KW, Nguyen TC, Lindsell CJ. Pediatric sepsis biomarker risk model-II:  Redefining the pediatric sepsis biomarker risk model with septic shock phenotype. Crit Care Med 2016;44(11):2010-2017.

Fitzgerald JC, Weiss SL, Maude S, Barrett D, Lacey S, Melenhorst J, Shaw P, Berg R, June C, Porter D, Frey N, Grupp S, Teachey D. Cytokine release syndrome after chimeric antigen receptor T-cell therapy for leukemia. Critical Care Medicine 2016 Sept 14 [Epub ahead of print].

2015

Weiss SL*, Fitzgerald JC*, Pappachan J, Wheeler D, Jaramillo-Bustamante JC, Salloo A,  Singhi SC, Erickson S, Roy JA, Bush JL, Nadkarni VM, Thomas NJ for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Global epidemiology of pediatric severe sepsis: the Sepsis PRevalence, OUtcomes, and Therapies (SPROUT) study. Am J Respir Crit Care Med 2015;191(10):1147-57.  (*contributed equally)

Balamuth F, Alpern ER, Weiss SL, Grundmeier R, Chilutti M, Fitzgerald JC, Hayes K, Bilker W, Lautenbach E. Comparison of Two Sepsis Recognition Methods in a Pediatric Emergency Department.  Academic Emergency Medicine 2015;22(11):1298-306.

Grunwell JR, Weiss SL, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Cecchia PA, Shanley TP, Bigham MT, Fitzgerald JC, Howard K, Frank E, Harmon K, Wong HR. Differential expression of the Nrf2-linked genes in pediatric septic shock. Critical Care 2015;19:327.

Weiss SL, Fitzgerald JC, Maffei F, Kane JM, Rodriguez-Nunez A, Hsing DD, Franzon D, Ying Kee S, Bush JL, Roy JA, Thomas, NJ, Nadkarnin VM for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Discordant Identification of Pediatric Severe Sepsis by Research and Clinical Definitions in the SPROUT International Point Prevalence Study.  Critical Care 2015;19:325.

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishstat RJ, Nowak J, Shekhar RS, Gertz S, Howard K, Harmon K, Lahni P, Frank E, Hart KW, Lindsell CJ.  Prospective testing and redesign of a temporal biomarker based risk model for patients with septic shock: implications for septic shock biology. EBioMedcine 2015:2(12);2087-93.

2014

Wong HR, Weiss SL, Giuliano JS, Wainwright M, Cvijanovich NZ, MD, Thomas NJ, Allen GL, Anas N, Bigham MT, Hall M, Freishtat RJ, Sen A, Meyer K, Checchia PA, Shanley TP,  Nowak J, Quasney M, Chopra A, Fitzgerald JC, Gedeit R, Banschbach S, Beckman E, Lahni P, Hart K, Lindsell CJ. Testing the Prognostic Accuracy of the Pediatric Sepsis Biomarker Risk Model. PLoS One. 2014; 2014;9(1):e86242.

Wong HR, Weiss SL, Giuliano JS, Wainwright M, Cvijanovich NZ, MD, Thomas NJ, Allen GL, Anas N, Bigham MT, Hall M, Freishtat RJ, Sen A, Meyer K, Checchia PA, Shanley TP,  Nowak J, Quasney M, Chopra A, Fitzgerald JC, Gedeit R, Banschbach S, Beckman E, Lahni P, Hart K, Lindsell CJ. The temporal version of the pediatric sepsis biomarker risk model. PLoS One. 2014;9(3):e92121.

Weiss SL, Fitzgerald JC, Faustino EV, Festa MS, Fink EL, Jouvet P, Bush JL, Kissoon N, Marshall J, Nadkarni VM, Thomas NJ.  Understanding the global epidemiology of pediatric critical illness:  the power, pitfalls, and practicalities of point prevalence studies. Pediatric Critical Care Medicine. 2014;15(7):660-6.

Weiss SL, Fitzgerald JC, Balamuth F, Alpern ER, Lavelle J, Chilutti M, Grundmeier R, Nadkarni VM, Thomas NJ. Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis. Critical Care Medicine 2014;42(11):2409-2417.

Weiss SL, Cvijanovich NZ, Allen GA, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Shanley TP, Bigham MT, Fitzgerald J, Banschbach S, Beckman E, Howard K, Frank E, Harmon K, Wong HR. Differential expression of the nuclear-encoded mitochondrial transcriptome based on genome-wide expression profiling in pediatric septic shock. Critical Care. 2014;18(6):623.

2013

Teachey DT, Rheingold SR, Maude SL, Zugmaier G, Barrett DM, Seif AE, Nichols LE. Suppa EK,  Kalos M, Berg RA, Fitzgerald JC, Aplenc R, Gore L, Grupp SA. Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine directed therapy. Blood 2013 June;121(26):5154-7.

2011

Fitzgerald JC, Topjian AA, McInnes AD, Mattei P, McCloskey JJ, Friess SH, Kilbaugh TJ. Bi-caval dual lumen venovenous extracorporeal membrane oxygenation and high frequency percussive ventilatory support for postintubation tracheal injury and acute respiratory distress syndrome. Journal of Pediatric Surgery 2011 December;46(12):e11-5.

2009

Santra S, Sun Y, Korioth-Schmitz B, Fitzgerald J, Charbonneau C, Santos G, Seaman MS, Ratcliffe SJ, Montefiori DC, Nabel GJ, Ertl HC, Letvin NL. Heterologous prime/boost immunizations of rhesus monkeys using chimpanzee adenovirus vectors. Vaccine. 27(42):5837-45, 2009 Sept 25.

2007

Tatsis N, Fitzgerald JC, Reyes-Sandoval A, Harris-McCoy KC, Hensley S, Zhou D, Lin SW, Bian A, Xiang ZQ, Iparraguirre A, Lopez-Camacho C, Wherry EJ, Ertl HC. Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines. Blood. September 2007;110(6):1916-23.

2006

Dobrzynski E, Fitzgerald JC, Cao O, Mingozzi F, Wang L, Herzog RW. Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells. PNAS. 2006 March;103(12):4592-4597.

2004

*Reyes-Sandoval A, *Fitzgerald JC, Grant R, Roy S, Xiang ZQ, Li Y, Gao GP,  Wilson JM, Ertl HC. Human Immunodeficiency Virus Type 1-Specific Immune Responses in Primates upon Sequential Immunization with Adenoviral Vaccine Carriers of Human and Simian Serotypes. J Virol. 2004 July;78(14):7392-9. *These two authors contributed equally to the manuscript

Sabatino DE, Armstrong E, Edmonson S, Liu YL, Pleimes M, Schuettrumpf J, Fitzgerald J, Herzog RW, Arruda VR, High KA. Novel Hemophilia B Mouse Models Exhibiting a Range of Mutations in the Factor IX Gene. Blood 2004 November;104(9):2767-74.

Pinto AR, Fitzgerald JC, Gao GP, Wilson JM, Ertl HC. Induction of CD8+ T cells to an HIV-1 antigen upon oral immunization of mice with a simian E1-deleted adenoviral vector. Vaccine 2004 January; 22(5-6):697-703.

2003

Pinto AR, Fitzgerald JC, Giles-Davis W, Gao GP, Wilson JM, Ertl HC. Induction of CD8+ T cells to an HIV-1 antigen through a prime boost regimen with heterologous E1-deleted adenoviral vaccine carriers. J Immunol. 2003 December;171(12):6774-9.

Fitzgerald JC, Gao GP, Reyes-Sandoval A, Pavlakis GN, Xiang ZQ, Wlazlo AP, Giles-Davis W, Wilson JM, Ertl HCJ. A simian replication-defective adenoviral recombinant vaccine to HIV-1 Gag. J. Immunol. 2003 February;170(3):1416-22.

2002

Konig S, Burkman J, Fitzgerald J, Mitchell M, Su L, Stedman H. Modular organization of phylogenetically conserved domains controlling developmental regulation of the human skeletal myosin heavy chain gene family. J. Biol. Chem 2002 August; 277(31): 27593-605.

2000

Fitzgerald JC, Scherr AM, Barr FG. Structural analysis of PAX7 rearrangements in alveolar rhabdomyosarcoma. Cancer Genetics & Cytogenetics 2000 February;117(1):37-40.

1999

Barr FG, Fitzgerald JC, Ginsberg JP, Vanella ML, Davis RJ, Bennicelli  JL. Predominant expression of alternative PAX3 and PAX7 forms in myogenic and neural tumor cell lines. Cancer Research 1999 November; 59(21):5443-8.

1998

Barr FG, Nauta LE, Hollows (Fitzgerald) JC. Structural analysis of PAX3 genomic rearrangements in alveolar rhabdomyosarcoma. Cancer Genetics & Cytogenetics 1998 April; 102(1):32-9.

Books

Chapters

2017

Kakajiwala AK, Ferguson MA, Fitzgerald JC. Chapter: Acute Kidney Injury, Fundamentals of Pediatric Surgery, P Mattei, Editor. Springer International Publishing AG, Switzerland, 2017 p. 75-85.

2016

Balamuth F, Fitzgerald JC, Weiss SL. Chapter 5: Shock In Leisher and Ludwig’s Textbook of Emergency Medicine. 7th Edition, Shaw K, Chamberlain J, Lavelle J, Nagler J, and Shook J. (Editors). 2016, Pg. 55-68.

2015

Thomas NJ, Tamburro RF, Rajasekaran S, Fitzgerald JC, Weiss SL, Hall MW. Chapter 87: Bacterial Sepsis. In Rogers’ Textbook of Pediatric Intensive Care. 5th Edition,  David G. Nichols, MD and Donald H. Shaffner, MD, Editors Wolters Kluwer, 2015, Pg. 1377-1396.

2003

Fitzgerald JC and H.C.J. Ertl. Activation of the Innate Immune System by DNA Vaccines. In DNA Vaccines. H.C.J. Ertl, ed. Kluwer Academic/Plenum Publishers, New York, NY, p. 60, 2003.

Posters and Presentations

2019

Becker A, Fitzgerald JC, Kubis S, Traynor D, Vossough A, Weiss SL, Topjian A, Kirschen M: MRI abnormalities in pediatric sepsis. Critical Care Medicine 47(1 Suppl 1), January 2019 Notes: Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Chiotos K, Biedron L, Fitzgerald JC, Robbins-Tighe S, Weiss SL, Woods-Hill C: Sepsis huddles in the PICU: Understanding the impact on timely antibiotics, perceptions, and barriers. Critical Care Medicine 47(1 Suppl 1), January 2019 Notes: Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Lindell R, Fitzgerald JC, Nishisaki A, Traynor D, Weiss SL: Predictive validity of mortality prediction scores in pediatric severe sepsis and septic shock. Critical Care Medicine 47(1 Suppl 1), January 2019 Notes: Research snapshot Presentation at 48th Critical Care Congress, February 2019, San Diego, CA.

Lindell R, Nishisaki A, Weiss SL, Traynor D, Fitzgerald JC: Risk of mortality in immunocompromised children with severe sepsis and septic shock. Critical Care Medicine 47(1 Suppl 1), January 2019 Notes: Research snapshot Presentation at 48th Critical Care Congress, February 2019, San Diego, CA

Walker SB, Conlon TW, Zhang B, Mensinger J, Fitzgerald JC, Himebauch AS, Glau CL, Nishisaki A, Ranjit S, Nadkarni VM, Weiss SL: Targeting vasoactive therapies to warm versus cold pediatric septic shock. Critical Care Medicine 47(1 Suppl 1), January 2019 Notes: Research Snapshot Presentation at 48th Critical Care Congress, February 2019, San Diego, CA.

2018

Fitzgerald JC, Zane NR, Himebauch AS, Reedy MD, Downes KJ, Topjian AA, Furth SL, Thomas NJ, Scheetz MH, Zuppa AF: Vancomycin therapeutic drug monitoring in children with and without acute kidney injury after cardiac arrest. Pediatric Critical Care Medicine 20(2): e106, February 2019 Notes: Poster Presentation at the Pediatric Critical Care Colloquium October 5-7, 2018, Baltimore, MD.

Shelov E, Woods-Hill C, Kaminski S, Bruhn R, Biedron L, Hadley S, Weiss S, Fitzgerald J: Using order and administration patterns to improve time to antimicrobial administration in a pediatric ICU. CHOP Quality and Safety Day 2018 Notes: Poster presentation at CHOP Quality and Safety Day, May 2018, Philadelphia, PA.

Cahen VC, Li Y, Burrows E, Elgarten CW, DiNofia AM, Wilkes JJ, Winestone LE, Huang YSV, Fitzgerald JC, Gramatges MM, Rabin KR, Fisher BT, Getz KD, Aplenc R: A novel approach to identifying septic shock (SS) in children with acute lymphoblastic leukemia (ALL) using pediatric health information system (PHIS) Data: Methods validation and incidence estimation in a national cohort. Transfusion December 2018 Notes: Poster Presentation at the 60th American Society of Hematology Annual Meeting and Exposition, December 1-4, 2018, San Diego, CA.

Walker S, Conlon TW, Zhang B, Mensinger J, Fitzgerald JC, Himebauch A, Glau C, Nishisaki A, Ranjit S, Nadkarni VM, Weiss SL: Application of clinical signs to differentiate warm versus cold pediatric septic shock. Pediatric Academic Societies Meeting May 2018 Notes: Poster Presentation at PAS Meeting, May 2018, Toronto, Canada.

Dziorny A, Fitzgerald JC, Weiss SL: A data-driven improvement initiative to reduce unnecessary laboratory testing in the PICU. Critical Care Medicine January 2018 Notes: Research snapshot Presentation at 47th Critical Care Congress, February 2018, San Antonio, TX.

2017

Woods-Hill CZ, Biedron LM, Rigby VA, Kaminiski S, Papili KE, Fitzgerald JC, Weiss SL: Electronically augmented huddle improved antibiotic delivery for sepsis in the pediatric intensive care unit. Pediatric Quality & Safety 2018 Notes: Children's Hospital Association Improving Pediatric Sepsis Outcomes Workshop, December, 2017, Dallas, TX.

Downes KJ, Schriver E, Russo M, Weiss SL, Fitzgerald JC, Balamuth F, Tolomeo P, Bilker WB, Han JH, Lautenbach E, Coffin SE, Gerber JS for the CDC Prevention Epicenter Program. Implementation of a pragmatic biomarker-driven algorithm to guide antibiotic use in the pediatric intensive care unit: the optimizing antibiotic strategies in sepsis (OASIS) II study. Poster Presentation at the ID Week 2017 Conference, October 4-8, 2017, San Diego, CA

Gu H, Keele L, Hayes K, Fitzgerald JC, Weiss SL, Balamuth F. Machine learning predictive modeling for organ dysfunction in children with suspected sepsis in the emergency department. Oral Presentation at the American Academy of Pediatric Annual Meeting, September 2017, Chicago, IL

Fitzgerald JC, Ditaranto S. Hospital-wide sepsis quality improvement program improves and sustains rapid pediatric sepsis care. 2017 Quality and Safety Day Poster Presentation at The Children’s Hospital of Philadelphia, May 2017.

Dziorny A, Fitzgerald JC, Weiss SL. A data-driven approach to reduce unnecessary oximetry testing in the PICU.  2017 Quality and Safety Day Poster Presentation at The Children’s Hospital of Philadelphia, Philadelphia, May 2017.

Weiss SL, Balamuth F, Fitzgerald JC, Hensley J, Bush J, Thomas N, Hall M, Muszynski J. Epidemiology of death following pediatric sepsis: When why, and how septic kids die. Critical Care Medicine 2016 December. Research Presentation at 46th Critical Care Congress, January 2017, Honolulu, Hawaii

2016

Ballantine A, DiTaranto S, Roberts K, Balamuth F, Weiss SL, Fitzgerald JC, Hadley S, Minich C, Rigby V, Keren R. Improving response to suspected sepsis: Results of a hospital-wide quality improvement initiative. Poster Presentation, American Academy of Pediatrics National Conference & Exhibition, October 22-25, 2016, San Francisco, CA

Abaya R, Weiss SL, Fitzgerald JC, Balamuth F. Utility of procalcitonin to predict intensive care unit admission and identify bacterial illness in the ED resuscitation of pediatric sepsis. Poster presentation, Pediatric Academic Societies’ Annual Meeting, April 3-May 3, 2016, Baltimore, MD.

Fitzgerald JC, Pinos E, Tamburro R, Hsing D, Cheifetz I, Nitu M, Rowan C, PALISI Subsection on HSCT: Fluid overload is not associated with mortality in pediatric hematopoietic cell transplant patients. Critical Care Medicine 43(12 Suppl), December 2015 Notes: Poster Presentation at 45th Critical Care Congress, February 2016, Orlando FL.

Han M, Fitzgerald JC, Balamuth F, Chilutti M, Grundmier R, Nadkarni VM, Thomas N, Weiss SL. Hourly delays to antimicrobial therapy do not increase one-year mortality in pediatric severe sepsis. Critical Care Medicine 2015 December; Poster Presentation at 45th Critical Care Congress, February 2016, Orlando, FL.

Signoff J, Fitzgerald JC, Teachey D, Balamuth F, Weiss SL. Hypofibrinogenemia is associated with poor outcome and secondary HLH in pediatric severe sepsis. Critical Care Medicine 2015 December; Poster Presentation at 45th Critical Care Congress, February 2016, Orlando, FL.

2015

Downes KJ, Weiss SL, Klieger SB, Fitzgerald JC, Balamuth F, Kubis S, Tolomeo P, Bilker W, Han X, Nachamkin I, Garrigan C, Han J, Lautenbach E, Gerber JS, Coffin S for The CDC Prevention Epicenters Program. Developing a biomarker-driven algorithm to improve antibiotic use in the pediatric intensive care unit: The optimizing Antibiotic strategies in sepsis (OASIS) Study. Oral Presentation at the Infectious Disease Conference, San Diego, CA, October 2015.

Balamuth F, Funari MK, Hayes K, Schast A, Lavelle J, Fitzgerald JC, Weiss SL, Alpern ER, Zorc JJ. Improved emergency department recognition of pediatric severe sepsis/septic shock with an electronic alert. Platform Presentation Pediatric Academic Societies Annual Meeting, San Diego, CA April 2015.

Balamuth F, Hayes K, Centkowski S, Gagel A, Fitzgerald JC, Weiss SL, Chilutti M, Grundmieier R, Lavelle J, Alpern ER. Decreased organ failure in pediatric sepsis treated according to a bundled treatment guideline. Poster Presentation at the Pediatric Academic Societies’ Annual Meeting, April 2015 San Diego, CA

Invited Lectures

2019

Fitzgerald JC. "Critical Complications of Chimeric Antigen Receptor T Cell Therapy", lecture at the Pediatric Onco-Critical Care Symposium, St. Jude Children's Research Hospital, Memphis, TN, Apr, 2019.

Fitzgerald JC. "Chimeric Antigen Receptor T Cell-Associated Cytokline Storm", lecture at the 48th Critical Care Congress Meeting, February 19, 2019. San Diego, CA, Feb, 2019.

Fitzgerald JC. "How Do We Measure Adherence to Protocols" lecture at the 48th Critical Care Congress Meeting, February 17, 2019, San Diego, CA, Feb, 2019.

2018

Fitzgerald JC. "How Can Collaborative Research Help My Career?", Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Clinical Research Course, September 5, 2018, Boston, MA, Spe, 2018.

Fitzgerald JC. "Top articles on sepsis that will change your practice", Children's Hospital Association Improving Pediatric Sepsis Outcomes Workshop, June 13, 2018, Chicago, IL., June, 2018.

2017

Fitzgerald JC. "Cytokine Release Syndrome After CAR-T Cell Therapy: Expected Course and Experience with ICU Management, Johns Hopkins All Children's Hospital, November 15, 2017, Baltimore, MD, Nov, 2017.

Fitzgerald JC. "Cytokine Release Syndrome after CAR-T Cell Therapy: Expected Course and Experience with ICU Management", St. Jude Children's Research Hospital, October 17, 2017, Memphis, TN, Oct, 2017.

2016

Fitzgerald JC. "Early fluid overload is not associated with mortality in pediatric hematopoietic cell transplant patients: Subanalysis of the SIRCH study", Pediatric Acute Lung Injury and Sepsis Investigators Hematopoietic Stem Cell Transplant Subgroup Meeting, San Diego, CA, Mar, 2016

Fitzgerald JC. "Winter 2016 PALISI Update: Sepsis PRevalence OUtcomes and Therapies", Pediatric Acute Lung Injury and Sepsis Investigators Network Meeting, San Diego, CA, Mar, 2016.

2014

Fitzgerald JC. "Fall 2014 PALISI Update: Sepsis PRevalence OUtcomes and Therapies", Pediatric Acute Lung Injury and Sepsis Investigators Network Meeting, Montreal, Canada, Oct, 2014.

Fitzgerald JC. "Pediatric Sepsis: A Growing Problem with Potential Solutions", Pediatric Infectious Disease Consortium Webinar, September 5, 2014., Sep, 2014.

Fitzgerald JC. "BNP Ancillary Study: AKI & Inflammatory Biomarkers Update", Pediatric Acute Lung Injury and Sepsis Investigators Hematopoietic Stem Cell Transplant Subgroup Meeting, Park City, UT, Mar, 2014.

Fitzgerald JC. "Winter 2014 PALISI Update: Sepsis PRevalence OUtcomes and Therapies", Pediatric Acute Lung Injury and Sepsis Investigators Network Meeting, Park City, UT, Mar, 2014.

Awards and Honors

2005, Henrietta and Jacob Lowenburg Prize in Pediatrics

2002-2003, Graduate work supported by NCI training grant

1997, Completed Bachelor of Arts summa cum laude

1994-1997, Benjamin Franklin Scholar

1997, Phi Beta Kappa

1997, Gold Key National Honor Society

Editorial and Academic Positions

Editorial Positions

2016-present, Reviewer, Pediatric Critical Care Medicine

2015-present, Reviewer, Bone Marrow Transplantation

2014-present, Reviewer, JAMA Pediatrics

2014-present, Reviewer, Respiratory Care

2013-present, Reviewer, Pediatric Emergency Care

2013-present, Reviewer, Clinical Journal of the American Society of Nephrology

2010-present, Ad hoc reviewer, Pediatric Critical Care Medicine

2008-present, Ad hoc reviewer, Critical Care Medicine

Academic and Institutional Committees

2016-present, Physician Lead for Hospital-Wide Sepsis Quality Improvement

2013-present,Critical Care Medicine Clinical Documentation Workgroup

2011-2016, PICU Severe Sepsis Quality Improvement Committee, Co-chair

2010-present, CHOP Preventing Codes Outside of the ICU Steering Committee

Leadership and Memberships

Memberships in Professional Organizations

2010-present, Pediatric Acute Lung Injury and Sepsis Investigators

2007-present, Society of Critical Care Medicine

2005-present, American Academy of Pediatrics