Julie C. Fitzgerald, MD, PhD

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Julie Fitzgerald, MD, PhD, is a pediatric intensivist in the Department of Anesthesiology and Critical Care Medicine, and the Pediatric Intensive Care Unit at CHOP.

Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Dr. Fitzgerald is a graduate of the University of Pennsylvania College of Arts and Sciences and the University of Pennsylvania Perelman School of Medicine, where she obtained both an MD and a PhD in Cell and Molecular Biology. Dr. Fitzgerald completed pediatrics residency and pediatric critical care medicine fellowship training at Children’s Hospital of Philadelphia (CHOP). In 2011, she joined the faculty at the University of Pennsylvania Perelman School of Medicine and is currently an Assistant Professor of Critical Care and Pediatrics, as well as an attending physician in the CHOP pediatric intensive care unit.

In collaboration with a multidisciplinary team in the CHOP PICU, she developed and implemented the CHOP PICU severe sepsis pathway in 2012, a set of recommendations for severe sepsis management in the PICU. In 2016, Dr. Fitzgerald took on the role of physician lead for Hospital-wide sepsis quality improvement/sepsis governance committee at CHOP.  She is a member of the task force that recently updated the American College of Critical Care Medicine Pediatric Shock Practice Parameters, and was a member of a committee convened by the Commonwealth of Pennsylvania Secretary of Health in 2016 to provide recommendations on state-wide hospital regulations for sepsis recognition and response.

In parallel with these quality improvement and regulatory efforts, Dr. Fitzgerald has been collaborating in sepsis-related clinical research at CHOP, with a focus on sepsis epidemiology. She and Dr. Scott Weiss led an international pediatric severe sepsis epidemiologic study that studied pediatric severe sepsis in 128 pediatric intensive care units (PICUs) in 26 countries and described the prevalence, current etiologies and therapies, and outcomes of pediatric severe sepsis. Together with Dr. Fran Balamuth and Dr. Weiss, she has studied the impact of timely sepsis therapies on outcome in children with sepsis locally at CHOP.

In 2017, Dr. Fitzgerald completed her Master of Science in Clinical Epidemiology at the University of Pennsylvania. Currently, she is further focusing on the impact of pediatric sepsis on renal dysfunction, examining biomarkers that may be helpful in predicting renal dysfunction in septic acute kidney injury, and the impact of resuscitative therapies in sepsis on the development of sepsis-related renal dysfunction.

Education and Training

Medical School

MD - University of Pennsylvania School of Medicine, Philadelphia, PA

Residency

Pediatrics - Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

Critical Care Medicine - Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Critical Care Medicine
Pediatrics – American Board of Pediatrics

Graduate Degree

PhD in Cell and Molecular Biology - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Pediatric Intensivist

Assistant Professor in Anesthesiology and Critical Care Medicine, Perelman School of Medicine at the University of Pennsylvania

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Sepsis
Acute kidney injury
Oncology patients in the ICU

Publications

Papers

2022

Chiotos K, Fitzgerald JC, Hayes M, et al. Improving Vancomycin Stewardship in Critically Ill Children. Pediatrics 149 (4), April 2022.

Becker AE, Teixeira SR, Lunig NA, Mondal A, Fitzgerald JC, Topjian AA, Weiss SL, Griffis H, Schramm SE, Traynor DM, Vossough A, Kirschen MP: Sepsis-Related Brain MRI Abnormalities Are Associated With Mortality and Poor Neurological Outcome in Pediatric Sepsis. Pediatric Neurology 128: 1-8, March 2022.

Alcamo AM, Weiss SL, Fitzgerald JC, Kirschen MP, Loftis LL, Tang Sf, Thomas NJ, Nadkarni VM, Nett ST: Outcomes Associated with Timing of Neurologic Dysfunction Onset Relative to Pediatric Sepsis Recognition. Pediatric Critical Care Medicine 2022.

Hobbs CV, Woodworth K, Young CC, Jackson AM, Newhams MM, Dapul H, Maamari M, Hall MW, Maddux AB, Singh AR, Schuster JE, Rowan CM, Fitzgerald JC, Irby K, Kong M, Mack EH, Staat MA, Cvijanovich NZ, Bembea MM, Coates BM, Halasa NB, Walker TC, McLaughlin GE, Babbitt CJ, Nofziger RA, Loftis LL, Bradford TT, Campbell AP, Patel MM, Randolph AG; Overcoming COVID-19 Investigators: Frequency, Characteristics and Complications of COVID-19 in Hospitalized Infants. Pediatr Infect Dis Journal Epub ahead of print 2022.

2021

Traube C, Tucci M, Nellis ME, Avery KL, McQuillen PS, Fitzgerald JC, Muszynski JA, Cholette JM, Schwarz AJ, Stalets EL, Quaid MA, Hanson SJ, Lacroix J, Reeder RW, Spinella PC: Transfusion Associated Delirium in Children: No Difference between Short-storage versus Standard-issue Red Blood Cells. Critical Care Medicine In Press, In Press 2021.

Periasamy U, Chilutti M, Kaplan SL, Hickey CP, Hayes K, Pennington JW, Balamuth F, Fitzgerald JC, Weiss SL: Prevalence of and associations with for avascular necrosis after pediatric sepsis:  a single-center retrospective study. Pediatric Critical Care Medicine In Press 2021.

Chiotos K, Fitzgerald JC, Hayes M, Dashefsky H, Metjian T, Woods-Hill C, Biedron L, Stinson H, Ku B, Tighe SR, Weiss SL, Balamuth F, Schriver E, Gerber JS: Improving vancomycin stewardship in critically ill children. Pediatrics In Press 2021.

Leonard JC, Josephson CD, Luther JF, Wisniewski SR, Allen C, Chiusolo F, Davis AL, Finkelstein RA, Fitzgerald JC, Gaines BA, Gooble SM, Hanson SJ, Hewes HA, Johnson LH, McCollum MO, Muszynski JA, Nair AB, Rosenberg RB, Rouse TM, Sikavitsas A, Singleton MN, Steiner ME, Upperman JS, Vogel AM, Wills H, Winkler MK, Spinella PC: Life-threatening bleeding in children: A prospective observational study. Crit Care Med 49(11): 1943-1954, November 2021.

Geva A, Patel MM, Newhams MM, Young CC, Son MBF, Kong M, Maddux AB, Hall MW, Riggs BJ, Singh AR, Giuliano JS, Hobbs CV, Loftis LL, McLaughlin GE, Schwartz SP, Schuster JE, Babbitt CJ, Halasa NB, Gertz SJ, Doymaz S, Hume JR, Bradford TT, Irby K, Carroll CL, McGuire JK, Tarquinio KM, Rowan CM, Mack EH, Cvijanovich NZ, Fitzgerald JC, Spinella PC, Staat MA, Clouser KN, Soma VL, Dapul H, Maamari M, Bowens C, Havlin KM, Mourani PM, Heidemann SM, Horwitz SM, Feldstein LR, Tenforde MW, Newburger JW, Mandl KD, Randolph AG; Overcoming COVID-19 Investigators: Data-driven clustering identifies features distinguishing multisystem inflammatory syndrome from acute COVID-19 in children and adolescents. E Clinical Medicine 40: 101112, October 2021.

Son MBF, Murray N, Friedman K, Young CC, Newhams MW, Feldstein LR, Loftis LL, Tarquinio KM, Singh AR, Heidemann SB, Fitzgerald JC, Kong M, Doymaz S, Giuliano Jr JS, Keenaghan MA, Hume JR, Hobbs CV, Schuster JE, Clouser KN, Hall MW, Bradford TT, Maddux AB, Babbitt CJ, Rowan CM, McLaughlin GE, Carroll RW, Mack EH, Carroll CL, Halasa NB, Cvijanovich NZ, Rose CE, Newburger JW, Patel MM, Randolph AG, on behalf of the Overcoming COVID-19 Investigators: Multisystem Inflammatory Syndrome in Children- Initial Therapy and Outcomes. N Engl J Med 385(1): 23-34, July 2021.

Sallee CJ, Smith LS, Rowan CM, Heckbert SR, Angelo JR, Daniel MC, Gertz SJ, Hsing DD, Mahadeo KM, McArthur MA, Fitzgerald JC, on behalf of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network: Early cumulative fluid balance and outcomes in pediatric allogeneic hematopoietic cell transplant recipients with acute respiratory failure: a multicenter study. Front Oncol July 2021 Notes: eCollection 2021.

Payne AB, Gilani Z, Godfred-Cato S, Belay ED, Feldstein LR, Patel MM, Randolph AG, Newhams M, Thomas D, Magleby R, Hsu K, Burns M, Dufort E, Maxted A, Pietrowski M, Longenberger A, Bidol S, Henderson J, Sosa L, Edmundson A, Tobin-D'Angelo M, Edison L, Heidemann S, Singh AR, Giuliano JS Jr, Kleinman LC, Tarquinio KM, Walsh RF, Fitzgerald JC, Clouser KN, Gertz SJ, Carroll RW, Carroll CL, Hoots BE, Reed C, Dahlgren FS, Oster ME, Pierce TJ, Curns AT, Langley GE, Campbell AP; MIS-C Incidence Authorship Group, Balachandran N, Murray TS, Burkholder C, Brancard T, Lifshitz J, Leach D, Charpie I, Tice C, Coffin SE, Perella D, Jones K, Marohn KL, Yager PH, Fernandes ND, Flori HR, Koncicki ML, Walker KS, Di Pentima MC, Li S, Horwitz SM, Gaur S, Coffey DC, Harwayne-Gidansky I, Hymes SR, Thomas NJ, Ackerman KG, Cholette JM: Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2. JAMA Network Open 4(6): e2116420, June 2021.

Fitzgerald JC, Kelly N, Hickey CP, Balamuth F, Thomas NH, Hogan A, Stack NJ, Trimarchi T, Weiss SL: Implementation of a follow-up system for pediatric sepsis survivors in a large academic PICU. Frontiers in Pediatrics 9: 691692, June 2021.

Stanski NL, Wong HR, Basu RK, Cvijanovich NZ, Weiss SL, Fitzgerald JC, Bigham MT, Jain PN, Schwarz A, Lutfi R, Nowak J, Allen GL, Thomas NJ, Grunwell JR. Baines T, Quasney M, Haileselassie B, Chawla LS, Goldstein SL: Recalibration of the renal angina index for pediatric septic shock. Kidney International Reports 6(7): 1858-1867, May 2021.

Rowan CM, Fitzgerald JC, Agulnik A, Zinter MS, Sharron MP, Slaven JE, Kreml EM, Bajwa RPS, Mahadeo KM, Moffet JR, Tarquinio KM, Steiner ME: Risk factors for noninvasive ventilation failure in children post-hematopoietic cell transplant. Front Oncol 11: 653607, May 2021.

Traube C, Gerber LM, Mauer EA, Small K, Broglie L, Chopra YR, Duncan CN, Ebens CL, Fitzgerald J, Freedman JL, Hudspeth MP, Hurley C, Mahadeo KM, McArthur JA, Shapiro MC, Sharron MP, Wall D, Zinter MS, Greenwald BM, Silver G, Boulad F: Delirium in children undergoing hematopoietic cell transplantation: a multi-institutional point prevalence study. Frontiers in Oncology In Press 2021.

Kadauke S, Myers RM, Li Y, Aplenc R, Baniewicz D, Barrett DM, Leahy AB, Callahan C, Dolan JG, Fitzgerald JC, Gladney W, Lacey SF, Liu H, Maude SL, McGuire R, Motley LS, Teachey DT, Wertheim GB, Wray L, DiNofia AM, Grupp SA: Risk-adapted preemptive tocilizumab to prevent severe cytokine release syndrome after CTL019 for pediatric B-Cell Acute Lymphoblastic Leukemia: A prospective clinical trial. J Clin Oncol Epub ahead of print 2021.

Feldstein LR, Tenforde MW, Friedman KG, Newhams M, Rose EB, Dapul H, Soma VL, Maddux AB, Mourani PM, Bowens C, Maamari M, Hall MW, Riggs BJ, Giuliano JS, Singh AR, Li S, Kong M, Schuster JE, McLaughlin GE, Schwartz SP, Walker TC, Loftis LL, Hobbs CV, Halasa NB, Doymaz S, Babbitt CJ, Hume JR, Gertz SJ, Irby K, Clouser KN, Cvijanovich NZ, Bradford TT, Smith LS, Heidemann SM, Zackai SP, Wellnitz K, Nofziger RA, Horwitz SM, Carroll RW, Rowan CM, Tarquinio KM, Mack EH, Fitzgerald JC, Coates BM, Jackson AM, Young CC, Son MBF, Patel MM, Newburger JW, Randolph AG, for the Overcoming COVID-19 Investigators: Characteristics and outcomes of US children and adolescents with multisystem inflammatory syndrome in children (MIS-C) compared with severe acute COVID-19. JAMA Epub ahead of print 2021.

Arnoldi S, Glau CL, Walker S, Himebauch AS, Parikh DS, Udeh SC, Weiss SL, Fitzgerald JC, Nishisaki A, Conlon TW: Integrating focused cardiac ultrasound into pediatric septic shock assessment. Pediatric Critical Care Medicine Epub ahead of print 2021.

Weiss SL, Fitzgerald JC, Balamuth F: Let Us Not Forget Early Mortality in Pediatric Sepsis. Pediatr Crit Care Med, 22(4):434-436, April 2021.

Ragoonanan D, Khazal SJ, Abdel-Azim H, McCall D, Cuglievan B, Tambaro FP, Ahmad AH, Rowan CM, Gutierrez C, Schadler K et al: Diagnosis, grading and management of toxicities from immunotherapies in children, adolescents and young adults with cancer. Nat Rev Clin Oncol Epub ahead of print 2021.

LaRovere KL, Riggs BJ, Poussaint TY, Young CC, Newhams MM, Maamari M, Walker TC, Singh AR, Dapul H, Hobbs CV et al: Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome. JAMA Neurol Epub ahead of print 2021.

Bjornstad EC, Krallman KA, Askenazi D, Zappitelli M, Goldstein SL, Basu RK, Investigators S: Preliminary Assessment of Acute Kidney Injury in Critically Ill Children Associated with SARS-CoV-2 Infection: A Multicenter Cross-Sectional Analysis. Clin J Am Soc Nephrol, 16(3):446-448, March 2021

Mah KE, Alten JA, Cornell TT, Selewski DT, Askenazi D, Fitzgerald JC, Topjian AA, Page K, Holubkov R, Slomine BS, Christensen JR, Dean M, Moler FW: Acute kidney injury after in-hospital cardiac arrest. Resuscitation 160: 49-58, March 2021.

Fitzgerald JC, Ross ME, Thomas NJ, Weiss SL, Balamuth F, Chilutti M, Grundmeier RW, Anderson AH: Association of early hypotension in pediatric sepsis with development of new or persistent acute kidney injury. Pediatric Nephrology 36(2), February 2021.

Larsen GY, Brilli R, Macias CG, Niedner M, Auletta JJ, Balamuth F, Campbell D, Depinet H, Frizzola M, Hueschen L, Lowerre T, Mack E, Paul R, Razzaqi F, Schafer , Scott HF, Silver P, Wathen B, Lukasiewicz G, Stuart J, Richardson T, Ward L, Huskins WC, on behalf of the Improving Pediatric Sepsis Outcomes Collaborative Investigators (Ahrens Alqahtani Barnett Booker Braun Bundy Cappon Conlon Custer Dawson DiGerolamo Duffy Dykstra-Nykanen Fitzgerald Gelvez Haines Hakim Hess Horvat Kandil Kelly Khoury Kirkpatrick Lane Laurich Loberger Murphy Panisello Park Patankar Priebe Redfern Rojas Rutman Schwartz Sharron Silverman Spack Stalets Thukaram Timmons Weddington Wilkes Wilson): Development of a quality improvement learning collaborative to improve pediatric sepsis outcomes. Pediatrics 147(1): e20201434, January 2021

2020

Walker SB, Conlon TW, Zhang B, Mensinger JL, Fitzgerald JC, Himebauch AS, Glau C, Nishisaki A, Ranjit S, Nadkarni VM, Weiss SL: Clinical signs to categorize shock and target vasoactive medications in warm versus cold pediatric septic shock. Pediatric Critical Care Medicine 21(12): 1051-1058, December 2020.

Diorio C, McNerney KO, Lambert M, Paessler M, Anderson EM, Henrickson SE, Chase J, Liebling EJ, Burudpakdee C, Lee JH, Balamuth FB, Blatz AM, Chiotos K, Fitzgerald JC, Giglia TM, Gollomp K, Odom John AR, Jasen C, Leng T, Petrosa W, Vella LA, Witmer C, Sullivan KE, Laskin BL, Hensley SE, Bassiri H, Behrens EM, Teachey DT: Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations. Blood Adv. 4(23): 6051-6063, December 2020.

Diorio C, Henrickson SE, Vella LA, McNerney KO, Chase JM, Burudpakdee C, Lee JH, Jasen C, Balamuth F, Barrett DM, Banwell B, Bernt KM, Blatz AM, Chiotos K, Fisher BT, Fitzgerald JC, Gerber JS, Gollomp K, Gray C, Grupp SA, Harris RM, Kilbaugh TJ, Odom John AR, Lambert MP, Liebling EJ, Paessler M, Petrosa W, Phillips CA, Reilly AF, Romberg N, Seif AE, Sesok-Pizzini D, Sullivan K, Vardaro J, Behrens EM, Teachey DT, Bassiri H: Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2  Journal of Clinical Investigation 130(11): 5967-5975, November 2020.

Diorio C, Anderson E, McNerney K, Goodwin E, Chase J, Bolton M, Arevalo C, Weirick M, Gouma S, Vella L, Henrickson S, Chiotos K, Fitzgerald J, Kilbaugh TJ, John A, Blatz A, Lambert M, Sullivan K, Tartaglione M, Zambrano D, Martin M, Lee J, Young P, Friedman D, Sesok-Pizzini D, Hensley S, Behrens E, Bassiri H, Teachey D: Convalescent plasma for pediatric patients with COVID-19 associated acute respiratory distress syndrome. Pediatric Blood & Cancer 67(11): e28693, November 2020.

Scott HF, Brilli RJ, Paul R, Macias CG; Niedner M, Depinet H, Richardson T, Riggs R, Gruhler H, Larsen GY, Huskins WC, Balamuth F for the Improving Pediatric Sepsis Outcomes (IPSO) Collaborative Investigators (Auletta, Barnett, Bhattarai, Bundy, Campbell, Conlon, Custer, Dawson, Duffy, Dykstra-Nykanen, Egbelakin, Emerson, Fitzgerald, Frizzola, Horvat, Hueschen, Kandil, Khoury, Laurich, Lavin, Loberger, Lockwood, Mack, Mathur, McFadden, Michiels, Murphy, Patankar, Perron, Pino, Priebe, Ramachandran, Razzaqi, Rilinger, Rutman, Schafer, Schwartz, Sebring, Shah, Sheehan, Silver, Silverman, Spack, Stalets, Stephen, Stinson, Timmons, Wathen, Wilson, Workman): Evaluating Pediatric Sepsis Definitions Designed for Electronic Health Record Extraction and Multicenter Quality Improvement. Critical Care Medicine 48(10): e916-e926, October 2020.

Nickel AJ, Jiang S, Napolitano N, Yehya N, Fitzgerald JC, Bruins, BB, Lockman JL, Nadkarni VM, Nishisaki A: Full finger reperfusion time measured by pulse oximeter waveform analysis in children. Critical Care Medicine 48(10): e927-e933, October 2020.

Atreya MR, Whitacre BE, Cvijanovich NZ, Bigham MT, Thomas NJ, Schwarz AJ, Weiss SL, Fitzgerald JC, Allen GL, Lutfi R, Nowak JE, Quasney MW, Shah AS, Wong HR: Proprotein convertase Subtilisin/Kexin Type 9 loss-of-function is detrimental to the juvenile host with septic shock. Critical Care Medicine 48(10): 1513-1520, October 2020.

Starr MC, Banks R, Reeder RW, Fitzgerald JC, Pollack MM, Meert KL, McQuillen PS, Mourani PM, Chima RS, Sorenson S, Varni JW, Hingorani S, Zimmerman JJ; Life After Pediatric Sepsis Evaluation (LAPSE) Investigators: Severe acute kidney injury is associated with increased risk of death and new morbidity after pediatric septic shock. Pediatric Critical Care Medicine 21(9): e686-e695, September 2020.

Gordon SM, Srinivasan L, Taylor DM, Master SR, Tremoglie MA, Hankeova A, Flannery DD, Abbasi S, Fitzgerald JC, Harris MC: Derivation of a metabolic signature associated with bacterial meningitis in infants. Pediatric Research 88(2): 184-191, August 2020.

Gertz SJ, McArthur J, Hsing DD, Nitu ME, Smith LS, Loomis A, Fitzgerald JC, Duncan CN, Mahadeo KM, Moffet J, Hall MW, Pinos EL, Cheifetz IM, Rowan CM; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network: Respiratory Pathogens Associated with Intubated Pediatric Patients following Hematopoietic Cell Transplant. Transplant Infectious Disease 22(4): e13297, August 2020.

Lindell RB, Nishisaki A, Weiss SL, Traynor D, Fitzgerald JC: Risk of mortality in immunocompromised children with severe sepsis and septic shock. Critical Care Medicine 48(7): 1026-1033, July 2020.

Feldstein LR, Rose EB, Horwitz SM, Collins JP, Newhams MM, Son MBF, Newburger JW, Kleinman LC, Heidemann SM, Martin AA, Singh AR, Li S, Tarquinio KM, Jaggi P, Oster ME, Zackai S, Gillen J, Ratner AJ, Walsh RF, Fitzgerald JC, Keenaghan MA, Alharash H, Doymaz S, Clouser KN, Giuliano JS, Gupta A, Parker RM, Maddux AB, Havalad V, Ramsingh S, Bukulmez H, Bradford TT, Smith LS, Tenforde MW, Carroll CL, Riggs BJ, Gertz SJ, Daube A, Lansell A, Coronado Munoz A, Hobbs CV, Marohn KL, Halasa NB, Patel MM, Randolph AG. Overcoming COVID-19 Investigators and the CDC COVID-19 Response Team: Multisystem Inflammatory Syndrome in U.S. children and adolescents. NEJM 383(4): 334-346, July 2020.

Chiotos K, Bassiri H, Behrens EM, Blatz AM, Chang J, Diorio C, Fitzgerald JC, Topjian AA, Odom John AR: Multisystem inflammatory syndrome in children during the COVID-19 pandemic: a case series. Journal of the Pediatric Infectious Diseases Society 9(3): 393-398, July 2020.

Stanski NL, Cvijanovich NZ, Fitzgerald JC, Bigham MT, Wong HR: Genomics of Pediatric Septic Shock Investigators: Severe acute kidney injury is independently associated with mortality in children with septic shock. Intensive Care Medicine 46(5): 1050-1051, May 2020.

Pais G, Liu J, Avedissian S, Hiner D, Xanthos T, Chalkias A, d'Aloja E, Locci E, Gilchrist A, Prozialeck W, Rhodes N, Lodise T, Fitzgerald JC, Downes K, Zuppa AF, Scheetz M: Lack of synergistic nephrotoxicity between vancomycin and piperacillin-tazobactam nephrotoxicity in a rat model and a confirmatory cellular model. Journal of Antimicrobial Chemotherapy 75(5): 1228-1236, May 2020.

Stanski NL, Stenson EK, Cvijanovich NZ, Weiss SL, Fitzgerald JC, Bigham MT, Jain PN, Schwarz A, Lutfi R, Nowak J, Allen GL, Thomas NJ, Grunwell JR, Baines T, Quasney M, Haileselassie B, Wong HR: PERSEVERE biomarkers predict severe acute kidney injury and renal recovery in pediatric septic shock. American Journal of Respiratory Critical Care Medicine 20(7): 848-855, April 2020.

Weiss SL, Balamuth F, Chilutti M, Ramos MJ, McBride P, Kelly N, Payton KJ, Fitzgerald JC, Pennington JW: Identification of pediatric sepsis for epidemiologic surveillance using electronic clinical data. Pediatric Critical Care Medicine 21(2): 113-121, February 2020.

Moffet JR, Mahadeo KM, McArthur J, Hsing DD, Gertz SJ, Smith LS, Loomis A, Fitzgerald JC, Nitu ME, Duncan CN, Hall MW, Pinos EL, Tamburro RF, Simmons R, Troy J, Cheifetz IM, Rowan CM; Investigators of the Pediatric Acute Lung Injury and Sepsis Network: Acute respiratory failure and the kinetics of neutrophil recovery in pediatric hematopoietic cell transplantation: A multicenter study. Bone Marrow Transplantation 55(2): 341-348, February 2020.

Downes KJ, Fitzgerald JC, Schriver E, Boge C, Russo M, Weiss SL, Balamuth F, Kubis SE, Tolomeo P, Bilker W, Han JH, Lautenbach E, Coffin SE, Gerber JS, for the CDC Prevention Epicenters Program: Implementation of a pragmatic biomarker-driven algorithm to guide antibiotic use in the pediatric intensive care unit: the Optimizing Antibiotic Strategies in Sepsis (OASIS) II study. Journal of the Pediatric Infectious Diseases Society 9(1): 36-43, February 2020.

2019

Weiss SL, Balamuth F, Thurm CW, Downes KJ, Fitzgerald JC, Laskin BL: Major adverse kidney events in pediatric sepsis. Clinical Journal of American Society of Nephrology 14(5): 664-672, May 2019.

Weiss SL, Balamuth F, Thurm CW, Downes KJ, Fitzgerald JC, Laskin BL: Major adverse kidney events in pediatric sepsis. Clinical Journal of American Society of Nephrology Epub ahead of print 2019.

Pais GM, Avedissian SN, O'Donnell JN, Rhodes NJ, Lodise TP, Prozialeck WC, Lamar PC, Cluff C, Gulati A, Fitzgerald JC, Downes KJ, Zuppa AF, Scheetz MH: Comparative performance of urinary biomarkers for vancomycin induced kidney injury according to timeline of injury. Antimicrob Agents Chemotherapy Epub ahead of print 2019.

Fitzgerald JC, Zane NR, Himebauch AS, Reedy MD, Downes KJ, Topjian AA, Furth SL, Thomas NJ, Scheetz MH, Zuppa AF: Vancomycin prescribing and therapeutic drug monitoring in children with and without acute kidney injury after cardiac arrest. Pediatric Drugs Epub ahead of print 2019.

Lindell RB, Nishisaki A, Weiss SL, Balamuth F, Traynor DM, Chilutti MR, Grudmeier RW, Fitzgerald JC: Comparison of methods for identification of pediatric severe sepsis and septic shock in the virtual pediatric systems database. Critical Care Medicine 47(2): e129-e135, February 2019.

Mahadeo K, Khazal S, Abdel-Azim H, Fitzgerald JC, Taraseviciute A, Bollard C, Tewari P, Duncan C, Traube C, McCall D, Steiner M, Cheifetz I, Lehmann L, Mejia R, Slopis J, Bajwa R, Kebriaei P, Martin P, Moffet J, McArthur J, Petropoulos D, Curry JO, Featherston S, Foglesong J, Shoberu B, Glubis A, Mireles M, Hafemeister L, Nguyen C, Kapoor N, Rezvani K, Neelapu SS, Shpall E, PALISI Network: Guidelines for Chimeric Antigen Recepter T-Cell (CAR-T) therapy management of pediatric patients. Nat Rev Clin Oncol 16(1): 45-63, January 2019.

Weiss SL, Blowey B, Keele L, Ganetskey R, Murali CN, Fitzgerald JC, Sutton RM, Berg RA: Matched retrospective cohort study of thiamine to treat persistent hyperlactatemia in pediatric septic shock. Pediatric Critical Care Medicine 20(9): e452-e456, September 2019.

Le S, Hoffman J, Barton C, Fitzgerald JC, Allen A, Pellegrini E, Calvert J, Das R: Pediatric severe sepsis prediction using machine learning. Frontiers in Pediatrics 4(413): 1-8, October 2019.

Thakkar RK, Weiss SL, Fitzgerald JC, Thomas NJ, Nadkarni VM, Muszynski JA. Hall MW for the SPROUT Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network: Risk factors for mortality in pediatric post-surgical versus medical severe sepsis. Journal of Surgical Research 242: 100-110, October 2019.

Wong HR, Cvijanovich NZ, Weiss SL, Fitzgerald JC, Bigham MT, Jain PN, Schwartz A, Lutfi R, Nowak J, Allen GL, Thomas NJ, Grunwell JR, Baines T, Quasney M, Haileselassie B, Lindsell CJ: Prospective clinical testing and experimental validation of the pediatric sepsis biomarker risk model. Science Translational Medicine 11(519): eaax9000, November 2019.

2018

Downes, KJ, Fitzgerald JC, Schriver E, Boge C, Russo M, Weiss SL, Balamuth F, Kubis SE, Tolomeo P, Bilker W, Han JH, Lautenbach E, Coffin SE, Gerber JS, for the CDC Prevention Epicenters Program: Implementation of a pragmatic biomarker-driven algorithm to guide antibiotic use in the pediatric intensive care unit: the Optimizing Antibiotic Strategies in Sepsis (OASIS) II study. Journal of the Pediatric Infectious Diseases Society Epub ahead of press 2018.

Stenson EK, Cvijanovich NZ, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Jain PN, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Lutfi R, Gertz S, Grunwell JR, Wong HR, Anas N: Hyperchloremia is associated with acute kidney injury in pediatric patients with septic shock. Intensive Care Medicine 44(11): 2004-2005, November 2018.

Irving SY, Daly B, Verger J, Typpo KV, Brown AM, Hanlon A, Weiss SL, Fitzgerald JC, Nadkarni VM, Thomas NJ, Srinivasan V: The association of nutrition status expressed as body mass index z-score with outcomes in children with severe sepsis: a secondary analysis from the Sepsis Prevalence, Outcomes and Therapies (SPROUT) study. Critical Care Medicine 46(11): e1029-e1039, November 2018.

Rowan CM, McArthur J, Hsing DD, Gertz SJ, Smith LS, Loomis A, Fitzgerald JC, Nitu ME, Moser EAS, Duncan CN, Mahadeo KM, Moffet J, Hall MW, Pinos EL, Tamburro RF, Cheifetz IM; Investigators of the Pediatric Acute Lung Injury and Sepsis Network: Acute respiratory failure in pediatric hematopoietic cell transplantation - A Multicenter Study. Critical Care Medicine 46(10): e967-e974, October 2018.

Rowan CM, McArthur J, Hsing DD, Gertz SJ, Smith LS, Loomis A, Fitzgerald JC, Nitu ME, Moser EAS, Duncan CN, Mahadeo KM, Moffet J, Hall MW, Pinos EL, Tamburro RF, Cheifetz IM; Investigators of the Pediatric Acute Lung Injury and Sepsis Network: Acute respiratory failure in pediatric hematopoietic cell transplantation - A Multicenter Study. Critical Care Medicine 46(10): e967-e974, October 2018.

Fitzgerald JC, Ross ME, Thomas NJ, Weiss SL, Balamuth F, Anderson AH: Risk factors and inpatient outcomes associated with acute kidney injury at Pediatric Severe Sepsis Presentation. Pediatric Nephrology 33(10): 1781-1790, October 2018.

Cornell TT, Selewski DT, Alten JA, Askenazi D, Fitzgerald JC, Topjian AA, Holubkov R, Page K, Slomine BS, Christensen JR, Dean JM, Moler FW: Acute kidney injury after out of hospital pediatric cardiac arrest. Resuscitation 131: 63-38, October 2018.

Fitzgerald JC, Li Y, Fisher BT, Huang YS, Miller TP, Bagatell R, Seif AE, Aplenc R, Thomas NJ: Hospital variation in intensive care resource utilization and mortality in newly diagnosed pediatric leukemia. Pediatric Critical Care 19(6): e312-e320, June 2018.Signoff JK, Fitzgerald JC, Teachey DT, Balamuth F, Weiss SL: Hypofibrinogenemia is associated with poor outcome and secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome in pediatric severe sepsis. Pediatric Critical Care Medicine 19(5): 397-405, May 2018.

Rowan CM, Loomis A, McArthur J, Smith LS, Gertz SJ, Fitzgerald JC, Nitu ME, Moser EA, Hsing DD, Duncan CN, Mahadeo KM, Moffet J, Hall MW, Pinos EL, Tamburro RF, Cheifetz IM: High-frequency oscillatory ventilation use and severe pediatric ARDS in the pediatric hematopoietic cell transplant recipient. Respiratory Care 63(4): 404-411, April 2018.

Michelson KN, Reubenson G, Weiss SL, Fitzgerald JC, Ackerman K, Christie L, Bush JL, Nadkarni VM, Thomas NJ, Schreiner MJ: Site variability in regulatory oversight for an international study of pediatric sepsis. Pediatric Critical Care Medicine 19(4): e180-e188, April 2018.

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Grunwell JR, Lindsell CJ: Endotype transitions during the acute phase of pediatric septic shock reflect changing risk and treatment response. Critical Care Medicine 46(3): e242-e249, March 2018.

Stenson EK, Cvijanovich NZ, Anas N, Allen GL, MD5, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak N, Raj SS, Gertz S, Grunwell JR, Wong HR: Hyperchloremia is associated with complicated course and mortality in pediatric patients with septic shock. Pediatric Critical Care Medicine 19(2): 155-160, February 2018.

2017

Lindell RB, Gertz SJ, Rowan CM, McArthur J, Beske F, Plunkett A, Weiss SL, Thomas NJ, Nadkarni VM, Fitzgerald JC for the SPROUT Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network: High levels of morbidity and mortality among pediatric hematopoietic cell transplant recipients with severe sepsis: insights from the SPROUT international point prevalence study. Pediatric Critical Care Medicine 18(12): 1114-1125, December 2017Lindell RB, Gertz SJ, Rowan CM, McArthur J, Beske F, Plunkett A, Weiss SL, Thomas NJ, Nadkarni VM, Fitzgerald JC for the SPROUT Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network: High levels of morbidity and mortality among pediatric hematopoietic cell transplant recipients with severe sepsis: insights from the SPROUT international point prevalence study. Pediatric Critical Care Medicine 18(12): 1114-1125, December 2017

Lin JC, Spinella PC, Fitzgerald JC, Tucci M, Bush JL, Nadkarni VM, Thomas NJ, Weiss SL for the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. New or progressive multiple organ dysfunction syndrome (NPMODS) in pediatric severe sepsis: a sepsis phenotype with higher morbidity and mortality. Pediatric Critical Care Medicine 2017;18(1):8-16.

Weiss SL, Keele L, Balamuth F, Vendetti N, Ross R, Fitzgerald JC, Gerber JS. Crystalloid fluid choice and clinical outcomes in pediatric sepsis: a match retrospective cohort study. Journal of Pediatrics 2017;182:304-310.

Davis AL, Carcillo JA, Aneja RK, Deymann AJ, Lin JC, Nguyen C, Okhuysen-Cawley R, Relvas MS, Rozenfeld RA, Skippen PW, Stojadinovic BJ, Williams EA, Yeh TS, Balamuth F, Brierley J, deCaen AR, Cheifetz IM, Choong K, Conway E, Cornell T, Doctor A, Dugas MA, Feldman JD, Fitzgerald JC, Flori HR, Fortenbery JD, Graciano AL, Greenwald BM, Hall MW, Han YY, Hernan LJ, Irazuzta JE, Iselin E, van der Jagt, EW, Jeffries HE, Kache S, Katyal C, Kissoon N, Kon AA, Kutko MC, MacLaren G, Maul T, Mehta R, Odetola F, Parbuoni K, Paul R, Peters MJ, Ranjit S, Reuter-Rice KE, Schnitzler EJ, Scott HF, Torres A, Weingarten-Abrams, J, Weiss SL, Zimmerman JJ, Zuckerberg AL: The American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: Executive Summary. Pediatric Critical Care Medicine 18(9): 884-890, September 2017.

Morgan RW, Fitzgerald JC, Weiss SL, Nadkarni VM, Sutton RM, Berg RA: Sepsis-associated in-hospital cardiac arrest: Epidemiology, pathophysiology, and potential therapies. Journal of Critical Care 40: 128-135, August 2017.

Downes KJ, Weiss SL, Klieger SB, Fitzgerald JC, Balamuth F, Kubis S, Tolomeo P, Bilker W, Han X, Nachamkin I, Garrigan C, Han J, Lautenbach E. Gerber JS, Coffin S for The CDC Prevention Epicenters Program. A Pragmatic Biomarker-Driven Algorithm to Guide Antibiotic Use in the Pediatric Intensive Care Unit: the Optimizing Antibiotic Strategies in Sepsis (OASIS) Study. Journal of the Pediatric Infectious Diseases Society 2017;6:134-141.

Han M, Fitzgerald JC, Balamuth F, Keele L, Alpern ER, Lavelle J, Chilutti M, Grundmeier RW, Nadkarni VM, Thomas NJ, Weiss SL.  Association of delayed antimicrobial therapy with one-year mortality in pediatric sepsis. Shock 2017 Jan 20 [Epub ahead of print].

Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald J, Checchia PA, Meyer K, Quasney M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Grunwell JR, Opoka A, Wong HR. Glucocorticoid receptor polymorphisms and outcomes in pediatric septic shock. Pediatric Critical Care Medicine 2017;18(4):299-303.

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Grunwell JR, Lindsell CJ.  Improved risk stratification in pediatric septic shock using both protein and mRNA biomarkers: PERSEVERE-XP. American Journal of Respiratory and Critical Care Medicine 2017 Mar 21 [Epub ahead of print].

Balamuth F, Alpern ER, Funari MK, Hayes K, Schast A, Lavelle J, Fitzgerald JC, Weiss SL, Zorc JJ. Improving recognition of pediatric severe sepsis in the emergency department: contributions of a vital sign based electronic alert and bedside clinician identification. Annals of Emergency Medicine Annals of Emerg Med. 2017 (17)30315-3.

Weiss SL, Balamuth F, Hensley J, Fitzgerald JC, Bush J, Nadkarni VM, Thomas NJ, Hall M, Muszynski J. The epidemiology of hospital death following pediatric severe sepsis: when, why, and how children with sepsis die. Pediatr Crit Care Med. 2017 May 25. doi: 10.1097/PCC.0000000000001222. [Epub ahead of print]

Rowan CM, Smith LS, Loomis A, McArthur J, Gertz SJ, Fitzgerald JC, Nitu ME, Moser EA, Hsing DD, Duncan CN, Mahadeo KM, Moffet J, Hall MW, Pinos EL, Tamburro RF, Cheifetz IM on behalf of the Investigators of the Pediatric Acute Lung Injury and Sepsis Network. Pediatric acute respiratory distress syndrome in pediatric allogeneic hematopoietic stem cell transplants: A multicenter study. Pediatric Critical Care Medicine 2017 April;1(4):304-309.

Davis AL, Carcillo JA, Aneja RK, Deymann AJ, Lin JC, Nguyen TC, Okhuysen-Cawley RS, Relvas MS, Rozenfeld RA, Skippen PW, Stojadinovic BJ, Williams EA, Yeh TS, Balamuth F, Brierley J, de Caen AR, Cheifetz IM, Choong K, Conway E, Cornell T, Doctor A, Dugas M, Feldman JD, Fitzgerald JC, Flori HR, Fortenberry JD, Braciano AL, Greenwald BM, Hall MW, Han YY, Hernan LK, Irazuzta JE, Iselin E, van der Jagt WE, Jeffries HE, Kache S, Katyal C, Kissoon N, Kon AA, Jutko MC, MacLaren G, Maul T, Mehta R, Odetola F, Parbuoni K, Paul R, Peters MJ, Ranjit S, Reuter-Rice KE, Schnitzler EJ, Scott H, Torees A, Weingarten-Abrams J, Weiss SL, Zimmerman JJ, Zuckerberg AL.  American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal shock. Critical Care Medicine 2017 June; 45(6):1061-1093.

Neumayr TM, Gill J, Fitzgerald JC, Gazit A, Pineda JA, Berg RA, Dean M, Moler FW, Doctor A. Identifying risk for acute kidney injury in infants and children following cardiac arrest. Pediatr Crit Care Med. 2017 Jul 21. doi: 10.1097/PCC.0000000000001280. [Epub ahead of print]

Fitzgerald JC, Weiss SL, Maude SL, Barrett DM, Lacey SF, Melenhorst JJ, Shaw P, Berg RA, June CH, Porter DL, Frey NV, Grupp SA, Teachey DT.: Cytokine release syndrome after chimeric antigen receptor T cell therapy for Acute Lymphoblastic Leukemia. Critical Care Medicine 45(2), February 2017.

2016

Klieger SB, Fitzgerald JC, Weiss SL, Balamuth F, Teszner E, Sammons JS, Coffin SE. Pediatric Severe Sepsis/Septic Shock Associated with Healthcare-Associated Infections. Infect Control Hosp Epidemiol 2016;37(4):483-5.

Giuliano JS, Jr, Markovitz BP, Brierley J, Levin R, Williams G,  Lum LC, Dorofaeff T, Cruces P, Bush JL, Keele L, Nadkarni VM, Thomas NJ, Fitzgerald JC, Weiss SL for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Variability in pediatric severe sepsis managed in USA and European intensive care units. Pediatric Critical Care Medicine 2016;17(6):522-30.

Balamuth F, Weiss SL, Fitzgerald JC, Hayes K, Centkowski S, Chilutti M, Grundmeier R, Lavelle J, Alpern ER. Protocolized treatment is associated with decreased organ dysfunction in pediatric severe sepsis. Pediatric Critical Care Medicine 2016; 17(9):817-822.

Teachey DT, Lacey SF, Shaw PA, Melenhorst JJ, Maude SL, Frey N, Pequignot E, Gonzalez VE, Chen F, Finklestein J, Barrett DM, Weiss SL, Fitzgerald JC, Berg RA, Aplenc R, Callahan C, Rheingold SR, Zheng Z, Rose-John S, Nazimuddin F, Wertheim G, Levine BL,  June CH, Porter DL, Grupp SA. Identification of predictive biomarkers for cytokine release syndrome after chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Cancer Discovery 2016;6(6):664-679.

Wong HR, Atkinson SJ, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Lindsell CJ. Combining prognostic and predictive enrichment strategies to identify children with septic shock responsive to corticosteroids. Critical Care Medicine 2016;44(10)e1000-10003.

Fitzgerald JC, Basu R, Akcan-Arikan A, Izquierdo LM, Pineres Olave BE, Hassinger AB, Szczepanski M, Deep A, Williams D, Sapru A, Roy JA, Nadkarni VM, Thomas NJ, Weiss SL, Furth S for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Acute kidney injury in pediatric severe sepsis: an independent risk for death and new disability. Critical Care Medicine 2016;44(12):2241-2250.

Randolph AG, Flanagan RF, Meece JK, Fitzgerald JC, Loftis LL, Truemper EJ, Li S,Ferdinands JM, Pediatric Acute Lung Injury and Sepsis Investigators  PICFlu Study Group. Optimizing virus identification in critically ill children suspected of having an acute severe viral infection. Pediatric Critical Care Medicine 2016 April;17(4):279-286.

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald J, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Howard K, Harmon K, Lahni P, Frank E, Hart KW, Nguyen TC, Lindsell CJ. Pediatric sepsis biomarker risk model-II:  Redefining the pediatric sepsis biomarker risk model with septic shock phenotype. Crit Care Med 2016;44(11):2010-2017.

Fitzgerald JC, Weiss SL, Maude S, Barrett D, Lacey S, Melenhorst J, Shaw P, Berg R, June C, Porter D, Frey N, Grupp S, Teachey D. Cytokine release syndrome after chimeric antigen receptor T-cell therapy for leukemia. Critical Care Medicine 2016 Sept 14 [Epub ahead of print].

2015

Weiss SL*, Fitzgerald JC*, Pappachan J, Wheeler D, Jaramillo-Bustamante JC, Salloo A,  Singhi SC, Erickson S, Roy JA, Bush JL, Nadkarni VM, Thomas NJ for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Global epidemiology of pediatric severe sepsis: the Sepsis PRevalence, OUtcomes, and Therapies (SPROUT) study. Am J Respir Crit Care Med 2015;191(10):1147-57.  (*contributed equally)

Balamuth F, Alpern ER, Weiss SL, Grundmeier R, Chilutti M, Fitzgerald JC, Hayes K, Bilker W, Lautenbach E. Comparison of Two Sepsis Recognition Methods in a Pediatric Emergency Department.  Academic Emergency Medicine 2015;22(11):1298-306.

Grunwell JR, Weiss SL, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Cecchia PA, Shanley TP, Bigham MT, Fitzgerald JC, Howard K, Frank E, Harmon K, Wong HR. Differential expression of the Nrf2-linked genes in pediatric septic shock. Critical Care 2015;19:327.

Weiss SL, Fitzgerald JC, Maffei F, Kane JM, Rodriguez-Nunez A, Hsing DD, Franzon D, Ying Kee S, Bush JL, Roy JA, Thomas, NJ, Nadkarnin VM for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Discordant Identification of Pediatric Severe Sepsis by Research and Clinical Definitions in the SPROUT International Point Prevalence Study.  Critical Care 2015;19:325.

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishstat RJ, Nowak J, Shekhar RS, Gertz S, Howard K, Harmon K, Lahni P, Frank E, Hart KW, Lindsell CJ.  Prospective testing and redesign of a temporal biomarker based risk model for patients with septic shock: implications for septic shock biology. EBioMedcine 2015:2(12);2087-93.

2014

Wong HR, Weiss SL, Giuliano JS, Wainwright M, Cvijanovich NZ, MD, Thomas NJ, Allen GL, Anas N, Bigham MT, Hall M, Freishtat RJ, Sen A, Meyer K, Checchia PA, Shanley TP,  Nowak J, Quasney M, Chopra A, Fitzgerald JC, Gedeit R, Banschbach S, Beckman E, Lahni P, Hart K, Lindsell CJ. Testing the Prognostic Accuracy of the Pediatric Sepsis Biomarker Risk Model. PLoS One. 2014; 2014;9(1):e86242.

Wong HR, Weiss SL, Giuliano JS, Wainwright M, Cvijanovich NZ, MD, Thomas NJ, Allen GL, Anas N, Bigham MT, Hall M, Freishtat RJ, Sen A, Meyer K, Checchia PA, Shanley TP,  Nowak J, Quasney M, Chopra A, Fitzgerald JC, Gedeit R, Banschbach S, Beckman E, Lahni P, Hart K, Lindsell CJ. The temporal version of the pediatric sepsis biomarker risk model. PLoS One. 2014;9(3):e92121.

Weiss SL, Fitzgerald JC, Faustino EV, Festa MS, Fink EL, Jouvet P, Bush JL, Kissoon N, Marshall J, Nadkarni VM, Thomas NJ.  Understanding the global epidemiology of pediatric critical illness:  the power, pitfalls, and practicalities of point prevalence studies. Pediatric Critical Care Medicine. 2014;15(7):660-6.

Weiss SL, Fitzgerald JC, Balamuth F, Alpern ER, Lavelle J, Chilutti M, Grundmeier R, Nadkarni VM, Thomas NJ. Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis. Critical Care Medicine 2014;42(11):2409-2417.

Weiss SL, Cvijanovich NZ, Allen GA, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Shanley TP, Bigham MT, Fitzgerald J, Banschbach S, Beckman E, Howard K, Frank E, Harmon K, Wong HR. Differential expression of the nuclear-encoded mitochondrial transcriptome based on genome-wide expression profiling in pediatric septic shock. Critical Care. 2014;18(6):623.

2013

Teachey DT, Rheingold SR, Maude SL, Zugmaier G, Barrett DM, Seif AE, Nichols LE. Suppa EK,  Kalos M, Berg RA, Fitzgerald JC, Aplenc R, Gore L, Grupp SA. Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine directed therapy. Blood 2013 June;121(26):5154-7.

2011

Fitzgerald JC, Topjian AA, McInnes AD, Mattei P, McCloskey JJ, Friess SH, Kilbaugh TJ. Bi-caval dual lumen venovenous extracorporeal membrane oxygenation and high frequency percussive ventilatory support for postintubation tracheal injury and acute respiratory distress syndrome. Journal of Pediatric Surgery 2011 December;46(12):e11-5.

2009

Santra S, Sun Y, Korioth-Schmitz B, Fitzgerald J, Charbonneau C, Santos G, Seaman MS, Ratcliffe SJ, Montefiori DC, Nabel GJ, Ertl HC, Letvin NL. Heterologous prime/boost immunizations of rhesus monkeys using chimpanzee adenovirus vectors. Vaccine. 27(42):5837-45, 2009 Sept 25.

2007

Tatsis N, Fitzgerald JC, Reyes-Sandoval A, Harris-McCoy KC, Hensley S, Zhou D, Lin SW, Bian A, Xiang ZQ, Iparraguirre A, Lopez-Camacho C, Wherry EJ, Ertl HC. Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines. Blood. September 2007;110(6):1916-23.

2006

Dobrzynski E, Fitzgerald JC, Cao O, Mingozzi F, Wang L, Herzog RW. Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells. PNAS. 2006 March;103(12):4592-4597.

2004

*Reyes-Sandoval A, *Fitzgerald JC, Grant R, Roy S, Xiang ZQ, Li Y, Gao GP,  Wilson JM, Ertl HC. Human Immunodeficiency Virus Type 1-Specific Immune Responses in Primates upon Sequential Immunization with Adenoviral Vaccine Carriers of Human and Simian Serotypes. J Virol. 2004 July;78(14):7392-9. *These two authors contributed equally to the manuscript

Sabatino DE, Armstrong E, Edmonson S, Liu YL, Pleimes M, Schuettrumpf J, Fitzgerald J, Herzog RW, Arruda VR, High KA. Novel Hemophilia B Mouse Models Exhibiting a Range of Mutations in the Factor IX Gene. Blood 2004 November;104(9):2767-74.

Pinto AR, Fitzgerald JC, Gao GP, Wilson JM, Ertl HC. Induction of CD8+ T cells to an HIV-1 antigen upon oral immunization of mice with a simian E1-deleted adenoviral vector. Vaccine 2004 January; 22(5-6):697-703.

2003

Pinto AR, Fitzgerald JC, Giles-Davis W, Gao GP, Wilson JM, Ertl HC. Induction of CD8+ T cells to an HIV-1 antigen through a prime boost regimen with heterologous E1-deleted adenoviral vaccine carriers. J Immunol. 2003 December;171(12):6774-9.

Fitzgerald JC, Gao GP, Reyes-Sandoval A, Pavlakis GN, Xiang ZQ, Wlazlo AP, Giles-Davis W, Wilson JM, Ertl HCJ. A simian replication-defective adenoviral recombinant vaccine to HIV-1 Gag. J. Immunol. 2003 February;170(3):1416-22.

2002

Konig S, Burkman J, Fitzgerald J, Mitchell M, Su L, Stedman H. Modular organization of phylogenetically conserved domains controlling developmental regulation of the human skeletal myosin heavy chain gene family. J. Biol. Chem 2002 August; 277(31): 27593-605.

2000

Fitzgerald JC, Scherr AM, Barr FG. Structural analysis of PAX7 rearrangements in alveolar rhabdomyosarcoma. Cancer Genetics & Cytogenetics 2000 February;117(1):37-40.

1999

Barr FG, Fitzgerald JC, Ginsberg JP, Vanella ML, Davis RJ, Bennicelli  JL. Predominant expression of alternative PAX3 and PAX7 forms in myogenic and neural tumor cell lines. Cancer Research 1999 November; 59(21):5443-8.

1998

Barr FG, Nauta LE, Hollows (Fitzgerald) JC. Structural analysis of PAX3 genomic rearrangements in alveolar rhabdomyosarcoma. Cancer Genetics & Cytogenetics 1998 April; 102(1):32-9.

Books

Chapters

2017

Kakajiwala AK, Ferguson MA, Fitzgerald JC. Chapter: Acute Kidney Injury, Fundamentals of Pediatric Surgery, P Mattei, Editor. Springer International Publishing AG, Switzerland, 2017 p. 75-85.

2016

Balamuth F, Fitzgerald JC, Weiss SL. Chapter 5: Shock In Leisher and Ludwig’s Textbook of Emergency Medicine. 7th Edition, Shaw K, Chamberlain J, Lavelle J, Nagler J, and Shook J. (Editors). 2016, Pg. 55-68.

2015

Thomas NJ, Tamburro RF, Rajasekaran S, Fitzgerald JC, Weiss SL, Hall MW. Chapter 87: Bacterial Sepsis. In Rogers’ Textbook of Pediatric Intensive Care. 5th Edition,  David G. Nichols, MD and Donald H. Shaffner, MD, Editors Wolters Kluwer, 2015, Pg. 1377-1396.

2003

Fitzgerald JC and H.C.J. Ertl. Activation of the Innate Immune System by DNA Vaccines. In DNA Vaccines. H.C.J. Ertl, ed. Kluwer Academic/Plenum Publishers, New York, NY, p. 60, 2003.

Posters and Presentations

2022

Yehya N, Fitzgerald J, Hayes K, Zhang D, Bush J, Koterba N, Chen F, Tuluc F, Teachey D, Balamuth F, Lacey S, Melenhorst J, Weiss S: Temperature Trajectory Subphenotypes and the Immunoinflammatory Response in Pediatric Sepsis. Critical Care Medicine 50(1): 722, January 2022 Notes: Research Snapshot Presentation at the 51st Critical Care Congress, February 2022, San Juan, Puerto Rico.

Lindell RB, Fitzgerald JC, Rowan CW, Flori HR, Di Nardo M, Napolitano N, Traynor DM, Lenz KB, Emeriaud G, Jeyapalan A, Nishisaki A: Duration of pre-intubation respiratory support is associated with increased mortality in immunocompromised children with respiratory failure. Critical Care Medicine January 2022 Notes: Research Snapshot Presentation at 51st Critical Care Congress, February 2022, San Juan, Puerto Rico (Virtual).

Fitzgerald JC, Zuppa AF: Population Pharmacokinetic Evaluation of Vancomycin in Critically Ill Children With Sepsis. Critical Care Medicine 50(1): 504, January 2022 Notes: Research Snapshot Presentation at the 51st Critical Care Congress, February 22, San Juan, Puerto Rico.

Fitzgerald JC, Zuppa AF: Nephrotoxic Medication Exposures in Critically Ill Children With Sepsis. Critical Care Medicine 50(1): 732, January 2022 Notes: Research Snapshot Presentation at the 51st Critical Care Congress, February 2022, San Juan, Puerto Rico.

Downes KJ, Sharova A, Gianchetti L, Fitzgerald JC, Zuppa AF: Attainment of Cefepime Therapeutic Targets in Critically Ill Children. Critical Care Medicine 50(1): 698, January 2022 Notes: Research Snapshot Presentation at the 51st Critical Care Congress, February 2022, San Juan, Puerto Rico.

Brennan MM, Lindell RB, Nishisaki A, Fitzgerald JC, Dziorny AC: Application of Machine Learning in a Linked Multicenter Dataset: Classifying MODS in Septic Shock. Critical Care Medicine 50(1): 721, January 2022 Notes: Research Snapshot Presentation at the 51st Critical Care Congress, February 2022, San Juan, Puerto Rico.

2021

Banigan M, Zhang B, Fitzgerald JC: Association of continuous renal replacement therapy (CRRT) timing and mortality in critically ill children. Pediatric Academic Societies May 2021 Notes: Highlighted e-Poster at the Pediatric Academic Societies Virtual Conference.

Sallee CJ, Smith LS, Rowan CM, Fitzgerald JC: Increasing fluid balance is associated with impaired oxygenation in pediatric hematopoietic cell transplant recipients with pediatric acute respiratory distress syndrome. Pediatric Onco-Critical Care Symposium April 2021 Notes: Presented at the Pediatric Onco-Critical Care Symposium, St. Jude Children's Research Hospital, Memphis, TN (virtual).

Stinson H, Dashefsky H, Chiotos K, Woods-Hill C, Weiss SL, Fitzgerald JC: Care delivery related to sepsis in a SARS-CoV-2 Pediatric Intensive Care Unit. Critical Care Medicine 49(1), January 2021 Notes: Research Snapshot Presentation at the 50th Critical Care Congress, February, 2021 (Virtual).

Sallee CJ, Smith LS, Rowan CM, Fitzgerald JC: Positive fluid balance is associated with worse oxygenation in pediatric HCT recipients with PARDS. Critical Care Medicine 49(1), January 2021 Notes: Research Snapshot Presentation at 50th Critical Care Congress, February 2021, (Virtual).

Sallee CJ, Smith LS, Rowan CM, Fitzgerald JC: Renal replacement modifies effect of fluid balance on PICU mortality in pediatric HCT recipients. Critical Care Medicine 49(1), January 2021 Notes: Research Snapshot Presentation at 50th Critical Care Congress, February 2021, (Virtual).

Periasamy U, Fitzgerald JC, Balamuth F, Chiliutti M, Hickey C, Weiss SL: Avascular necrosis diagnosed after pediatric sepsis Critical Care Medicine 49(1), January 2021 Notes: Research Snapshot Presentation at the 50th Critical Care Congress, February, 2021, (Virtual).

Lenz K, Nishisaki A, Lindell RB, Yehya N, Laverriere EK, Bruins BB, Napolitano N, Craig D, Traynor D, Fitzgerald JC: Stem cell transplant status is not associated with adverse events during tracheal intubation. Critical Care Medicine 49(1): 462, January 2021 Notes: Research Snapshot Presentation at 50th Critical Care Congress, February 2021, (Virtual).

Dashefsky H, Hayes K, Liu H, Stinson H, Balamuth F, Fitzgerald J, Chilutti M, Weiss SL: Incidence and risk factors for hospital readmission after treatment for sepsis in children. Critical Care Medicine 49(1), January 2021 Notes: Research Snapshot Presentation at the 50th Critical Care Congress, February, 2021 (Virtual).

Banigan M, Traynor D, Fitzgerald JC: Association of continuous renal replacement therapy timing and mortality in critically ill children. Critical Care Medicine 49(1), January 2021 Notes: Research Snapshot Presentation at the 50th Critical Care Congress, February, 2021, (Virtual).

Alcamo A, Fitzgerald JC, Weiss SL, Kirschen MP, Lofis L, Tang S, Thomas N, Nadkarni VM, Nett S: Impact of timing of acute neurologic dysfunction on outcomes in pediatric sepsis Critical Care Medicine 49(1), January 2021 Notes: Research Snapshot Presentation at 50th Critical Care Congress, SCCM Star Research Achievement Award winning abstract, February, 2021 (Virtual).

2020

Arnoldi S, Glau C, Walker S, Himebauch A, Parikh D, Udeh S, Weiss SL, Fitzgerald JC, Nishisaki A, Conlon TW: Integrating focused cardiac ultrasound into pediatric septic shock assessment. Critical Care Medicine 48(1): 760, January 2020 Notes: Research Snapshot Presentation, 49th Critical Care Congress, February 2020, Orlando, FL

Becker A, Teixeira S, Fitzgerald JC, Lunig N, Schramm S, Murphy M, Traynor D, Kubis S, Weiss SL, Topjian AA, Vossough A, Kirschen MP: Prevalence of brain MRI abnormalities in pediatric sepsis patients. Critical Care Medicine 48(1): 324, January 2020 Notes: Research Snapshot Presentation at 49th Critical Care Congress, February 2020, Orlando, FL.

Dziorny A, Lindell R, Moore J, Nishisaki A, Fitzgerald JC: Classification of MODS beyond Day 1 of illness in pediatric severe sepsis and septic shock. Critical Care Medicine 48(1): 754, January 2020 Notes: Research Snapshot Presentation, 49th Critical Care Congress, February 2020, Orlando, FL.

Rowan C, Fitzgerald JC, Agulnik A, Sharron M, Mahadeo K, Moffet J, Tarquinio K, Zinter M, Bajwa R, Slaven J, Steiner M: Factors Associated With Failure of Noninvasive Ventilation in Children After Stem Cell Transplant. Critical Care Medicine 48(1): 6, January 2020 Notes: Star Research Presentations: Pediatric Pulmonology, 49th Critical Care Congress, February 2020, Orlando, FL.

Banigan M, Lindell RB, Fitzgerald JC: Timing Of renal replacement therapy in critically ill oncology and hematopoietic stem cell transplant patients. Frontiers in Oncology April 2020 Notes: Poster at Pediatric Onco-Critical Care Symposium at St. Jude Children's Research Hospital, Winner of "POCCS Best Abstract Award", April 2020 (conference cancelled due to COVID-19), Memphis, TN.

2019

Becker A, Fitzgerald JC, Kubis S, Traynor D, Vossough A, Weiss SL, Topjian A, Kirschen M: MRI abnormalities in pediatric sepsis. Critical Care Medicine 47(1 Suppl 1), January 2019 Notes: Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Chiotos K, Biedron L, Fitzgerald JC, Robbins-Tighe S, Weiss SL, Woods-Hill C: Sepsis huddles in the PICU: Understanding the impact on timely antibiotics, perceptions, and barriers. Critical Care Medicine 47(1 Suppl 1), January 2019 Notes: Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Lindell R, Fitzgerald JC, Nishisaki A, Traynor D, Weiss SL: Predictive validity of mortality prediction scores in pediatric severe sepsis and septic shock. Critical Care Medicine 47(1 Suppl 1), January 2019 Notes: Research snapshot Presentation at 48th Critical Care Congress, February 2019, San Diego, CA.

Lindell R, Nishisaki A, Weiss SL, Traynor D, Fitzgerald JC: Risk of mortality in immunocompromised children with severe sepsis and septic shock. Critical Care Medicine 47(1 Suppl 1), January 2019 Notes: Research snapshot Presentation at 48th Critical Care Congress, February 2019, San Diego, CA

Walker SB, Conlon TW, Zhang B, Mensinger J, Fitzgerald JC, Himebauch AS, Glau CL, Nishisaki A, Ranjit S, Nadkarni VM, Weiss SL: Targeting vasoactive therapies to warm versus cold pediatric septic shock. Critical Care Medicine 47(1 Suppl 1), January 2019 Notes: Research Snapshot Presentation at 48th Critical Care Congress, February 2019, San Diego, CA.

Invited Lectures

2020

Fitzgerald JC. "Acute Kidney Injury in Pediatric Sepsis: Epidemiology and Prevention", lecture for Pediatric Departmental Research Series at Penn State University College of Medicine/Penn State Hershey Children's Hospital, October 28, 2020, Hershey, PA.

Fitzgerald JC. "Cytokine release syndrome and other complications of cancer immunotherapy: a new reason for PICU admission", lecture at the 1st European Pediatric Onco-Critical Care Hot Topics Symposium, September 17, 2020, UMC Utrecht Wilhelmina Children's Hospital, Utrecht, The Netherlands. Cancelled due to COVID-19.

Fitzgerald JC. "COVID-19 and Pediatric Patients", invited webinar for the Pennsylvania Society for Respiratory Care Neonatal-Pediatric Webinar, September 9, 2020.

Fitzgerald JC. "Immunomodulatory therapy for COVID-19", invited talk at the International PICU-COVID 19 Collaboration webinar, August 1, 2020, hosted by Harvard University/Boston Children's Hospital, Boston, MA

Fitzgerald JC. "IPSO Pediatric Sepsis Annual Literature Review", invited webinar for the Children's Hospital Association Improving Pediatric Sepsis Outcomes Collaborative, June 29, 2020.

Fitzgerald JC. "Cytokine Directed Therapies for COVID-19", invited talk at the International PICU-COVID 19 Collaboration webinar, April 18, 2020, hosted by Harvard University/Boston Children's Hospital, Boston, MA

Fitzgerald JC. "Is there a cytokine storm in COVID-19?", invited talk at the International PICU-COVID 19 Collaboration webinar, March 25, 2020, hosted by Harvard University/Boston Children's Hospital, Boston, MA

2019

Fitzgerald JC. "Pediatric Sepsis: Epidemiology, Outcomes, and Challenges of Caring for the Child with Sepsis", lecture at the Solving the Puzzle of Sepsis - Putting the Pieces Together in Pennsylvania conference, hosted by the Hospital and Healthsystem Association of Pennsylvania (HAP), September 23, 2019, Lancaster, PA

Fitzgerald JC. "Association of Hypotension Early in Pediatric Severe Sepsis with Development of New or Persistent Acute Kidney Injury and with Renal Recovery", lecture at the 3rd World Nephrology and Therapeutics Congress, June 24, 2019, Philadelphia, PA

Fitzgerald JC. "How Do We Measure Adherence to Sepsis Protocols", webinar for the Sepsis Steering Committee at Lucile Packard Children's Hospital/Stanford School of Medicine, June 19, 2019, Palo Alta, CA

Fitzgerald JC. "Critical Complications of Chimeric Antigen Receptor T Cell Therapy", lecture at the Pediatric Onco-Critical Care Symposium, St. Jude Children's Research Hospital, Memphis, TN, Apr, 2019.

Fitzgerald JC. "Chimeric Antigen Receptor T Cell-Associated Cytokine Storm", lecture at the 48th Critical Care Congress Meeting, February 19, 2019. San Diego, CA, Feb, 2019.

Fitzgerald JC. "How Do We Measure Adherence to Protocols" lecture at the 48th Critical Care Congress Meeting, February 17, 2019, San Diego, CA, Feb, 2019.

Awards and Honors

2020, Presidential Citation, Society of Critical Care Medicine Fellow of the American, College of Critical Care Medicine
2019, Pediatric Critical Care Medicine "Editor's Top Picks of Original Reports 2016, 2017, 2018"
2019, Pediatric Critical Care Medicine “Editors Top Picks of Original Reports 2015’” for Conlon et al, PCCM 16(3):219-226.
2019, Presidential Citation, Society of Critical Care Medicine
2017-2019, CHOP Department of Pediatrics Chair’s Initiative Awardee to develop CHOP Pediatric Sepsis Program, Children’s Hospital of Philadelphia
2002-2003, Graduate work supported by NCI training grant
2005, Henrietta and Jacob Lowenburg Prize in Pediatrics
2002-2003, Graduate work supported by NCI training grant
1997, Completed Bachelor of Arts summa cum laude
1994-1997, Benjamin Franklin Scholar
1997, Phi Beta Kappa
1997, Gold Key National Honor Society

Editorial and Academic Positions

Editorial Positions

2021-present, Reviewer, Critical Care Medicine
2020-present, Associate Editor in Pediatric Critical Care, Frontiers in Pediatrics
2020-present, Reviewer, The Lancet Child & Adolescent Health
2020-present, Reviewer, BMC Pediatrics
2019-present, Reviewer, Inflammation
2019-present, Reviewer, JAMA Network Open
2019-present, Reviewer, Hospital Pediatrics
2019-present, Reviewer, Resuscitation
2019-present, Reviewer, Pediatrics
2019-present, Reviewer, Pediatric Quality & Safety
2019-present, Reviewer, The Lancet Infectious Diseases
2018-present, Reviewer, Critical Care
2018-present, Reviewer, Journal of Critical Care
2017-present, Reviewer, Journal of Intensive Care Medicine
2017-present, Reviewer, American Journal of Respiratory and Critical Care Medicine
2016-present, Reviewer, Pediatric Critical Care Medicine
2015-present, Reviewer, Bone Marrow Transplantation
2014-present, Reviewer, JAMA Pediatrics
2014-present, Reviewer, Respiratory Care
2013-present, Reviewer, Pediatric Emergency Care
2013-present, Reviewer, Clinical Journal of the American Society of Nephrology
2010-present, Ad hoc reviewer, Pediatric Critical Care Medicine
2008-present, Ad hoc reviewer, Critical Care Medicine

Academic and Institutional Committees

2021-present, Member, Pediatric Critical Care Medicine Program Evaluation Committee
2021-present, Member, Nephrology Division Chief Search Committee
2020-present, Member, Anesthesia and Critical Care Medicine Research Council
2020-present, Member, Critical Care Medicine Research Operations Committee
2018-2021, Member, Scholarship Oversight Committee, Pediatric Critical Care Medicine Fellowship Class 2018-2021
2017-present, Member, ICU Acute Kidney Injury Quality Improvement Project
2016-present, Physician Lead for Hospital-Wide Sepsis Quality Improvement
2013-present,Critical Care Medicine Clinical Documentation Workgroup
2011-2016, PICU Severe Sepsis Quality Improvement Committee, Co-chair
2010-present, CHOP Preventing Codes Outside of the ICU Steering Committee

Leadership and Memberships

Memberships in Professional Organizations

2020, Swiss National Science Foundation (External grant reviewer)
2018-present, Children's Hospital Association Improving Pediatric Sepsis Outcomes Research Working Group
2017-present, Pediatric Organ Dysfunction Information Update Mandate
 - 2017-present, Chair, Renal Organ Dysfunction Workgroup
2010-present, Pediatric Acute Lung Injury and Sepsis Investigators
2007-present, Society of Critical Care Medicine
2005-present, American Academy of Pediatrics