Alan W. Flake, MD, FACS, FAAP

Alan Flake, MD, is an attending pediatric and fetal surgeon in the Division of Pediatric General, Thoracic and Fetal Surgery and holds the Ruth M. and Tristram C. Colket, Jr. Endowed Chair in Pediatric Surgery at Children’s Hospital of Philadelphia.

Areas of Expertise: Fetal surgery, Clinical applications of fetal diagnosis and therapy, In utero stem cell transplantation, Minimally invasive surgery, Neonatal Surgery
Locations: Main Hospital

Appointments and Referrals (800-IN UTERO): 800-468-8376

Dr. Flake is an attending surgeon in the Division of Pediatric General, Thoracic and Fetal Surgery and holds the Ruth M. and Tristram C. Colket, Jr. Endowed Chair in Pediatric Surgery at Children’s Hospital of Philadelphia. He serves as Director of CHOP’s Center for Fetal Research and is a professor of Surgery and Obstetrics and Gynecology at the Perelman School of Medicine at the University of Pennsylvania.

Tackling Extreme Prematurity

CHOP researchers design a unique womb-like, fluid-filled environment to bridge critical time from mother’s womb to outside world.

Dr. Flake was the Director of Fetal Surgery at the Children’s Hospital of Michigan before joining the Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment at CHOP in 1996. Today, he spearheads an active research laboratory focused on fetal stem cell and gene therapy. He has been at the forefront of cutting-edge studies aimed at treating genetic disorders before birth. Dr. Flake is committed to discovering ways to help children live disease-free, and is currently moving toward a human clinical trial for sickle cell disease, utilizing in utero transplantation of maternal cells to the fetus. The goal is to increase the newborn’s tolerance for a successful bone marrow transplant.

“We’ve made significant progress in the lab,” he says. “The dream is to prevent these diseases before the children are born so they can live healthy lives.” Dr. Flake’s work in sickle cell disease has the potential to offer new hope for many other immunodeficiency disorders.

Dr. Flake’s clinical specialties include fetal diagnosis and therapy and neonatal surgery.

“I have been fortunate to be a part of developing the fetal treatment program here and we have the best in the world,” he says.

Dr. Flake is a leader in performing minimally invasive surgery, mostly on neonates, including thoracoscopic and laparoscopic procedures. He continues to refine and develop these delicate surgical techniques for the unique requirements of pediatric patients.

Dr. Flake earned his bachelor’s degree from the University of Arkansas and his medical degree from University of Arkansas for Medical Sciences. He completed his general surgery residency and fellowship in fetal biology and therapy research at the University of California, San Francisco, and served as a pediatric surgery fellow at Children’s Medical Center in Cincinnati. He is board certified in general and pediatric surgery.

To contact the Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment, call 1-800-468-8376 (1-800-IN-UTERO).

Medical School

MD - University of Arkansas for Medical Sciences, Little Rock, AK

Internship

Children's Hospital Medical Center, Cincinnati, OH

Residency

University of California, San Francisco, CA

Fellowship

Fellow, Fetal Biology and Therapy Research - University of California, San Francisco, CA
Fellow, Pediatric Surgery - Children's Hospital Medical Center, Cincinnati, OH

Board Certification

General Surgery – American Board of Surgery
Pediatric Surgery – American Board of Surgery

Undergraduate Degree

BS - University of Arkansas, Fayetteville, AK

Attending Surgeon

Director, Center for Fetal Research

Ruth M. and Tristram C. Colket Jr. Endowed Chair, Pediatric Surgery

Professor of Surgery, Obstetrics and Gynecology, Perelman School of Medicine at the University of Pennsylvania

Papers

2019

Ozawa K, Davey MG, Tian Z, Hornick MA, Mejaddam AY, McGovern PE, Flake AW, Rychik J. Fetal echocardiographic assessment of the cardiovascular impact of prolonged support in the EXTrauterine Environment for Neonatal Development (EXTEND) system. [Published online ahead of print April 15, 2019] Ultrasound Obstet Gynecol.

Lawrence KM, McGovern PE, Mejaddam A, Rossidis AC, Baumgarten H, Kim A, Grinspan JB, Licht DJ, Didier RA, Vossough A, Radaelli E, Rychik J, Song L, Peranteau WH, Davey MG, Flake AW, Gaynor JW. Chronic intrauterine hypoxia alters neurodevelopment in fetal sheep. J Thorac Cardiovasc Surg. 2019;157(5):1982–1991.

Moldenhauer JS, Flake AW. Open fetal surgery for neural tube defects. Best Pract Res Clin Obstet Gynaecol. 2019 Mar 18;. [Epub ahead of print] PMID: 31078425

Rossidis AC, Angelin A, Lawrence KM, Baumgarten HD, Kim AG, Mejaddam AY, Coons BE, Hartman HA, Hwang G, Monos S, Peranteau WH, Davey MG, Murdock D, Wallace DC, Flake AW. Premature Lambs Exhibit Normal Mitochondrial Respiration after Long-Term Extrauterine Support. Fetal Diagn Ther. 2019 Mar 12;:1-7. PMID: 30861524

Gebb JS, Khalek N, Qamar H, Ozcan T, Johnson MP, Oliver ER, Coleman BG, Peranteau WH, Hedrick HL, Flake AW, Adzick NS, Moldenhauer JS: High tumor volume to fetal weight ratio is associated with worse fetal outcomes and increased maternal risks in fetuses with sacrococcygeal teratoma. Fetal Diagn Ther. 2019;45(2):94-101. doi: 10.1159/000486782. Epub 2018 Mar 1.

Mejaddam AY, Hornick MA, McGovern PE, Baumgarten HD, Lawrence KM, Rossidis AC, Hwang G, Young K, Abdulmalik O, Partridge EA, Peranteau WH, Davey MG, Flake AW. Erythropoietin Prevents Anemia and Transfusions in Extremely Premature Lambs Supported by an EXTrauterine Environment for Neonatal Development (EXTEND). Fetal Diagn Ther. 2019 Jan 31;:1-7. PMID: 30703769

Mattar CNZ, Tan YW, Johana N, Biswas A, Tan LG, Choolani M, Bakkour S, Johnson M, Chan JKY, Flake AW. Fetoscopic versus Ultrasound-Guided Intravascular Delivery of Maternal Bone Marrow Cells in Fetal Macaques: A Technical Model for Intrauterine Haemopoietic Cell Transplantation. Fetal Diagn Ther. 2019 Jan 18;:1-12. PMID: 30661073

2018

Lawrence KM, Hennessy-Strahs S, McGovern PE, Mejaddam AY, Rossidis AC, Baumgarten HD, Bansal E, Villeda M, Han J, Gou Z, Zhao S, Rychik J, Peranteau WH, Davey MG, Flake AW, Gaynor JW, Bartoli CR. Fetal hypoxemia causes abnormal myocardial development in a preterm ex utero fetal ovine model. JCI Insight. 2018;3(24).

Danzer E, Hoffman C, D'Agostino J, Connelly JT, Waqar LN, Gerdes M, Bernbaum J, Rintoul NE, Herkert LM, Peranteau WH, Flake AW, Adzick NS, Hedrick HL: Short-term neurodevelopmental outcome in congenital diaphragmatic hernia: The impact of extracorporeal membrane oxygenation and timing of repair. Pediatric Critical Care Medicine 19:64-74, 2018.

Danzer E, Hoffman C, D’Agostino JA, Boelig MM, Gerdes M, Bernbaum J, Rosenthal H, Waqar LN, Rintoul NE, Herkert LM, Kallan MJ, Peranteau WH, Flake AW, Adzick NS, Hedrick HL: Short-term neurodevelopmental outcome in children born with high-risk congenital lung lesions. Annals of Thoracic Surgery 105:1827-1834, 2018.

Danzer E, Hoffman C, D'Agostino J, Ryan M, Gerdes M, Bernbaum J, Rintoul NE, Herkert LM, Peranteau WH, Flake AW, Adzick NS, Hedrick HL: Rate and risk factors associated with autism spectrum disorder in congenital diaphragmatic hernia. Journal of Autism and Developmental Disorders48:2112-2121, 2018.

Fraga MV, Laje P, Peranteau WH, Hedrick HL, Khalek N, Gebb JS, Moldenhauer JS, Johnson MP, Flake AW, Adzick NS: The influence of gestational age, delivery mode, and abdominal wall closure method in neonates with uncomplicated gastroschisis. Pediatr Surg Int 34:415-9, 2018.

Didier RA, Sridharan A, Lawrence K, Coleman BG, Davey MG, Flake AW. Contrast-Enhanced Ultrasound in Extracorporeal Support: In Vitro Studies and Initial Experience and Safety Data in the Extreme Premature Fetal Lamb Maintained by the Extrauterine Environment for Neonatal Development. J Ultrasound Med. 2018 Dec 17;. PMID: 30560564

Ahn NJ, Stratigis JD, Coons BE, Flake AW, Nah-Cederquist HD, Peranteau WH. Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model. J Vis Exp. 2018 Oct 9;(140).

Joyeux L, Danzer E, Flake AW, Deprest J. Fetal surgery for spina bifida aperta. Arch Dis Child Fetal Neonatal Ed. 2018 Jul 13. pii: fetalneonatal-2018-315143. doi: 10.1136/archdischild-2018-315143. [Epub ahead of print]

Rossidis AC, Baumgarten HD, Lawrence KM, McGovern PE, Mejaddam AY, Li H, Hwang G, Young K, Peranteau WH, Davey MG, Gaynor JW, Flake AW. Chronically Hypoxic Fetal Lambs Supported by an Extra-Uterine Device Exhibit Mitochondrial Dysfunction and Elevations of Hypoxia Inducible Factor 1-Alpha. Fetal Diagn Ther. 2018 Jun 28; 1-8. [Epub ahead of print]

Riley JS, Antiel RM, Rintoul NE, Ades AM, Waqar LN, Lin N, Herkert LM, D'Agostino JA, Hoffman C, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Reduced oxygen concentration for the resuscitation of infants with congenital diaphragmatic hernia. J Perinatol. 2018 Jun 11. [Epub ahead of print]

Vrecenak JD, Pearson EG, Todorow CA, Li H, Johnson MP, Flake AW. A Preclinical Canine Model of Graft Versus Host Disease Following in Utero Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2018 May 23. [Epub ahead of print] PMID: 29802901

Baumgarten HD, Gebb JS, Khalek N, Moldenhauer JS, Johnson MP, Peranteau WH, Hedrick HL, Adzick NS, Flake AW. Preemptive Delivery and Immediate Resection for Fetuses with High-Risk Sacrococcygeal Teratomas. Fetal Diagn Ther. 2018 May 7; 1-8. [Epub ahead of print] PMID: 29734172

Wong KKY, Flake AW, Tibboel D, Rottier RJ, Tam PKH. Congenital pulmonary airway malformation: advances and controversies. Lancet Child Adolesc Health. 2018 Apr;2(4):290-297. PMID: 30169300

Partridge EA, Davey MG, Hornick M, Dysart KC, Olive A, Caskey R, Connelly JT, Hedrick HL, Peranteau WH, Flake AW. Pumpless arteriovenous extracorporeal membrane oxygenation: A novel mode of respiratory support in a lamb model of congenital diaphragmatic hernia. J Pediatr Surg. 2018 Mar 9;. [Epub ahead of print] PMID: 29605270

Laje P, Fraga MV, Peranteau WH, Hedrick HL, Khalek N, Gebb JS, Moldenhauer JS, Johnson MP, Flake AW, Adzick NS. Complex gastroschisis: Clinical spectrum and neonatal outcomes at a referral center. J Pediatr Surg. 2018 Mar 14;. [Epub ahead of print] PMID: 29628208

Victoria T, Danzer E, Oliver ER, Edgar JC, Iyoob S, Partridge EA, Johnson AM, Peranteau WH, Coleman BG, Flake AW, Johnson MP, Hedrick HL, Adzick NS: Right congenital diaphragmatic hernias: Is there a correlation between prenatal lung volume and postnatal survival, as in isolated left diaphragmatic hernias? Fetal Diagnosis and Therapy 2018; 43: 12-18, January 2018.

2017

Peranteau WH, Iyoob SD, Boelig MM, Khalek N, Moldenhauer JS, Johnson MP, Hedrick HL, Flake AW, Coleman BG, Adzick NS. Prenatal growth characteristics of lymphatic malformations. J Pediatr Surg. 2017 Jan;52(1):65-68.

Antiel RM, Flake AW, Johnson MP, Khalek N, Rintoul NE, Lantos JD, Curlin FA, Tilburt JC, Feudtner C. Specialty-Based Variation in Applying Maternal-Fetal Surgery Trial Evidence. Fetal Diagn Ther. 2017 Mar 17. Doi:10.1159/000455024 [Epub ahead of print]

Emily A. Partridge, Marcus G. Davey, Matthew A. Hornick, Patrick E. McGovern, Ali Y. Mejaddam, Jesse D. Vrecenak, Carmen Mesas-Burgos, Aliza Olive, Robert C. Caskey, Theodore R. Weiland III, Jiancheng Han, James T. Connelly, Kevin C. Dysart, Alexander J. Schupper, Jack Rychik, Holly L. Hedrick, William H. Peranteau, and Alan W. Flake. “An extra-uterine physiologic support system for the extreme premature lamb.” Nature Communications. Published online April 25, 2017.

Partridge EA, Davey MG, Hornick MA, McGovern PE, Mejaddam AY, Vrecenak JD, Mesas-Burgos C, Olive A, Caskey RC, Weiland TR, Han J, Schupper AJ, Connelly JT, Dysart KC, Rychik J, Hedrick HL, Peranteau WH, Flake AW. Corrigendum: An extra-uterine system to physiologically support the extreme premature lamb. Nat Commun. 2017 May 23;8:15794. Doi: 10.1038/ncomms15794.

Antiel RM, Halpem SD, Stevens EM, Vrecenak JD, Patterson CA, Tchume-Johnson T, Smith-Whitley K, Peranteau WH, Flake AW, Baraket LP. Acceptability of In Utero Hematopoietic Cell Transplantation for Sickle Cell Disease. Med Decis Making. 2017 May 1:272989X17707214. Doi: 10.1177/0272989x17707214. [Epub ahead of print].

Kim AG, Danzer E, Moldenhauer JS, Khalek N, McClain LE, Waqar LN, Hedrick HL, Johnson MP, Adzick NS, Peranteau WH, Flake AW. Amniotic Fluid Concentrations of Glial Fibrillary Acidic Protein Do Not Correlate with Prenatal Metrics in Fetuses with Myelomeningocele. Fetal Diagn Ther. 2017 Jul 29. Doi: 10.1159/000478258. [Epub ahead of print].

Burgos CM, Davey MG, Riley JS, Jia H, Flake AW, Peranteau WH. Lung function and pulmonary artery blood flow following prenatal maternal retinoic acid and imatinib in the nitrofen model of congenital diaphragmatic hernia. J Pediatr Surg. 2018 Sep;53(9):1681-1687. Epub 2017 Dec 19.

2016

Burgos CM, Pearson EG, Davey M, Riley J, Jia H, Laje P, Flake AW, Peranteau WH. Improved pulmonary function in the nitrofen model of congenital diaphragmatic hernia following prenatal maternal dexamethasone and/or sildenafil. Pediatr Res. 2016 Oct;80(4):577-85.

Danzer E, Hoffman C, D'Agostino JA, Gerdes M, Bernbaum J, Antiel RM, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcomes at 5 years of age in congenital diaphragmatic hernia. J Pediatr Surg. 2016 Aug 30. pii: S0022-3468(16)30284-6. doi: 10.1016/j.jpedsurg.2016.08.008.

Rychik J, Khalek N, Gaynor JW, Johnson MP, Adzick NS, Flake AW, Hedrick HL. Fetal Intrapericardial Teratoma: Natural History and Management Including Successful In Utero Surgery. Am J Obstet Gynecol. 2016 Aug 13. pii: S0002-9378(16)30575-0. doi: 10.1016/j.ajog.2016.08.010.

Partridge EA, Peranteau WH, Herkert L, Rendon N, Smith H, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Right- versus left-sided congenital diaphragmatic hernia: a comparative outcomes analysis. J Pediatr Surg. 2016 Jun;51(6):900-2.

Partridge EA, Peranteau WH, Herkert L, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Rate of increase of lung-to-head ratio over the course of gestation is predictive of survival in left-sided congenital diaphragmatic hernia. J Pediatr Surg. 2016 May;51(5):703-5.

Laje P, Hedrick HL, Flake AW, Adzick NS, Peranteau WH. Delayed abdominal closure after congenital diaphragmatic hernia repair. J Pediatr Surg. 2016 Feb;51(2):240-3.

Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Herkert LM, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Younger gestational age is associated with increased risk of adverse neurodevelopmental outcome during infancy in congenital diaphragmatic hernia. J Pediatr Surg. 2016 Jan 5.

Antiel RM, Riley JS, Cahill PJ, Campbell RM, Waqar L, Herkert LM, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Management and outcomes of scoliosis in children with congenital diaphragmatic hernia. J Pediatr Surg. 2016;51(12):1921-1925.

2015

Laje P, Pearson EG, Simpao AF, Rehman MA, Sinclair T, Hedrick HL, Adzick NS, Flake AW. The first 100 infant thoracoscopic lobectomies: Observations through the learning curve and comparison to open lobectomy. J Pediatr Surg. 2015 Nov;50(11):1811-6.

Laje P, Peranteau WH, Hedrick HL, Flake AW, Johnson MP, Moldenhauer JS, Adzick NS. Ex utero intrapartum treatment (EXIT) in the management of cervical lymphatic malformation. J Pediatr Surg. 2015 Feb;50(2):311-4. doi: 10.1016/j.jpedsurg.2014.11.024. Epub 2014 Nov 10.

Peranteau WH, Boelig MM, Khalek N, Moldenhauer JS, Martinez-Poyer J, Hedrick HL, Flake AW, Johnson MP, Adzick NS. Effect of single and multiple courses of maternal betamethasone on prenatal congenital lung lesion growth and fetal survival. J Pediatr Surg. 2015 Oct 23.

Olive A, Moldenhauer JS, Laje P, Johnson MP, Coleman BG, Victoria T, Flake AW, Adzick NS. Axillary lymphatic malformations: Prenatal evaluation and postnatal outcomes. J Pediatr Surg. 2015 Oct;50(10):1711-5.

Peranteau WH, Tharakan SJ, Partridge E, Herkert L, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Systemic hypertension in giant omphalocele: An underappreciated association. J Pediatr Surg. 2015 Sep;50(9):1477-80

Moldenhauer JS, Soni S, Rintoul NE, Spinner SS, Khalek N, Martinez-Poyer J, Flake AW, Hedrick HL, Peranteau WH, Rendon N, Koh J, Howell LJ, Heuer GG, Sutton LN, Johnson MP, Adzick NS. Fetal Myelomeningocele Repair: The Post-MOMS Experience at the Children's Hospital of Philadelphia. Fetal Diagn Ther. 2015;37(3):235-40. Epub 2014 Aug 15.

Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Herkert L, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcome at one year of age in congenital diaphragmatic hernia infants not treated with extracorporeal membrane oxygenation. J Pediatr Surg. 2015 Jun;50(6):898-903. doi: 10.1016.

Partridge EA, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Frequency and complications of inguinal hernia repair in giant omphalocele. J Pediatr Surg. 2015 May 29. pii: S0022-3468(15)00353- PMID: 26078212.

Danzer E, Gerdes M, D’Agostino JA, Bernbaum J, Hoffman C, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Patient characteristics are important determinants of neurodevelopmental outcome during infancy in giant omphalocele. Early Hum Dev. 2015 Mar;91(3):187-93.

Partridge EA, Peranteau WH, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Timing of repair of congenital diaphragmatic hernia in patients supported by extracorporeal membrane oxygenation (ECMO). J Pediatr Surg. 2015 Feb;50(2):260-2.

Partridge EA, Hanna BD, Rintoul NE, Herkert L, Flake AW, Adzick NS, Hedrick HL, Peranteau WH. Brain-type natriuretic peptide levels correlate with pulmonary hypertension and requirement for extracorporeal membrane oxygenation in congenital diaphragmatic hernia. J Pediatr Surg. 2015 Feb;50(2):263-6.

Peranteau WH, Scott Adzick N, Boelig MM, Alan W F, Hedrick HL, Howell LJ, Moldenhauer JS, Khalek N, Martinez-Poyer J, Johnson MP. Thoracoamniotic shunts for the management of fetal lung lesions and pleural effusions: a single-institution review and predictors of survival in 75 cases. J Pediatr Surg. 2015 Feb;50(2):301-5.

Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Patient characteristics are important determinants of neurodevelopmental outcome during infancy in giant omphalocele. Early Hum Dev. 2015 Feb 9;91(3):187-193.

Partridge EA, Victoria T, Coleman BG, Martinez-Poyer J, Laje P, Hedrick HL, Flake AW, Adzick NS. Prenatal diagnosis of esophageal bronchus: first report of a rare foregut malformation in utero. J Pediatr Surg. 2015 Feb;50(2):306-10.

Rychik J, Cohen D, Tran KM, Szwast A, Natarajan SS, Johnson MP, Moldenhauer JS, Khalek N, Martinez-Poyer J, Flake AW, Hedrick HL, Adzick NS. The role of echocardiography in the intraoperative management of the fetus undergoing myelomeningocele repair. Fetal Diagn Ther. 2015;37(3):172-8.

2014

Vrecenak JD, Howell LJ, Khalek N, Moldenhauer JS, Johnson MP, Coleman BG, Victoria T, Hedrick HL, Peranteau WH, Flake AW, Adzick NS. Outcomes of prenatally diagnosed lung lesions in multigestational pregnancies. Fetal Diagn Ther. 2014 Dec;36(4):312-9.

Partridge EA, Hanna BD, Panitch HB, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Pulmonary hypertension in giant omphalocele infants. J Pediatr Surg. 2014 Dec;49(12):1767-70.

Partridge EA, Bridge C, Donaher JG, Herkert LM, Grill E, Danzer E, Gerdes M, Hoffman CH, D’Agostino JA, Bernbaum JC, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Incidence and factors associated with sensorineural and conductive hearing loss among survivors of congenital diaphragmatic hernia. J Pediatr Surg. 2014 Jun;49(6):890-4.

Tsai J, Blinman TA, Collins JL, Laje P, Hedrick HL, Adzick NS, Flake AW. The contribution of hiatal hernia to severe gastroesophageal reflux disease in patients with gastroschisis. J Pediatr Surg. 2014 Mar;49(3):395-8.

Partridge EA, Canning D, Long C, Peranteau WH, Hedrick HL, Adzick NS, Flake AW. Urologic and anorectal complications of sacrococcygeal teratomas: prenatal and postnatal predictors. J Pediatr Surg. 2014 Jan;49(1):139-43.

Peranteau WH, Moldenhauer JS, Khalek N, Martinez-Poyer JL, Howell LJ, Johnson MP, Flake AW, Adzick NS, Hedrick HL. Open fetal surgery for central bronchial atresia. Fetal Diagn Ther. 2014;35(2):141-7.

2013

Laje P, Howell LJ, Johnson MP, Hedrick HL, Flake AW, Adzick NS. Perinatal management of congenital oropharyngeal tumors: the ex utero intrapartum treatment (EXIT) approach. J Pediatr Surg. 2013 Oct;48(10):2005-10.

Danzer E, Gerdes M, D’Agostino JA, Hoffman C, Bernbaum J, Bebbington MW, Siegle J, Sulkowski J, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Longitudinal neurodevelopmental and neuromotor outcome in congenital diaphragmatic hernia patients in the first 3 years of life. J Perinatol. 2013 Nov;33(11):893-8.

2012

Danzer E, Zarnow D, Gerdes M, D'Agostino JA, Siegle J, Bebbington MW, et al. Abnormal brain development and maturation on magnetic resonance imaging in survivors of severe congenital diaphragmatic hernia. J Pediatr Surg. 2012 Mar;47(3):453-61. Cited in PubMed; PMID:22424337.

Roybal JL, Laje P, Vrecenak JD, Flake AW. Use of manipulated stem cells for prenatal therapy. Methods Mol Biol. 2012;891:169-81. Cited in PubMed; PMID:22648772.

Nijagal A, Flake AW, MacKenzie TC. In utero hematopoietic cell transplantation for the treatment of congenital anomalies. Clin Perinatol. 2012 Jun;39(2):301-10. Epub 2012 May 8. Cited in PubMed; PMID:22682381.

Abi-Nader KN, Boyd M, Flake AW, Mehta V, Peebles D, David AL. Animal models for prenatal gene therapy: the sheep model. Methods Mol Biol. 2012;891:219-48. Cited in PubMed; PMID:22648775.

Roybal JL, Endo M, Buckley SM, Herbert BR, Waddington SN, Flake AW. Animal models for prenatal gene therapy: rodent models for prenatal gene therapy. Methods Mol Biol. 2012;891:201-18. Cited in PubMed; PMID:22648774.

Laje P, Johnson MP, Howell LJ, Bebbington MW, Hedrick HL, Flake AW, Adzick NS. Ex utero intrapartum treatment in the management of giant cervical teratomas. J Pediatr Surg. 2012 Jun;47(6):1208-16. Cited in PubMed; PMID:22703795.

Prior Select Publications

Crombleholme TM, Coleman BG, Howell LJ, Liechty KW, Johnson MP, Flake AW, Hedrick HL, Adzick NS: Elevated cystic adenomatoid malformation volume ratio (CVR) predicts outcome in prenatal diagnosis of cystic adenomatoid malformation of the lung. J Pediatr Surg 37:331-338, 2002.

Books

Chapters

2022

Flake, A.W. (2022). Choledochal Cysts. In: Mattei, P. (eds) Fundamentals of Pediatric Surgery. Springer, Cham. https://doi.org/10.1007/978-3-031-07524-7_91

Flake, A.W. (2022). Biliary Atresia. In: Mattei, P. (eds) Fundamentals of Pediatric Surgery. Springer, Cham. https://doi.org/10.1007/978-3-031-07524-7_88

2022, Philadelphia Magazine's Top Doctors in Pediatric Surgery

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Alan W. Flake, MD, FACS, FAAP

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