Jennifer Heimall, MD

Jennifer Heimall, MD

Jennifer Heimall, MD, is an attending physician in the Division of Allergy and Immunology Service at Children's Hospital of Philadelphia.

Areas of Expertise: Hyper IgE syndromes, Post-transplant immune reconstitution, Recurrent staphylococcal infections and atopic dermatitis, Appropriate transition of care from pediatric to adult physicians, Atopic dermatitis, IgE mediated food allergy, Asthma
Locations: Buerger Center for Advanced Pediatric Care
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - UMDNJ-New Jersey Medical School, Newark, NJ

Internship

Medicine and Pediatrics - UMDNJ-New Jersey Medical School, Newark, NJ

Residency

Medicine and Pediatrics - UMDNJ-New Jersey Medical School, Newark, NJ

Fellowship

Clinical Fellow in Allergy and Immunology - National Institutes of Health-NIAID, Bethesda, MD

Research Fellow in Allergy and Immunology - National Institutes of Health-NIAID, Bethesda, MD

Board Certification

Allergy and Immunology
Internal Medicine
Pediatrics

Titles and Academic Titles

Attending Physician

Departments and Services

Publications

Papers

2019

Heimall J. Genetic Testing to Diagnose Primary Immunodeficiency Disorders and to Identify Targeted Therapy. Immunol Allergy Clin North Am. 2019 Feb;39(1):129-140. doi: 10.1016/j.iac.2018.08.009. Review. PMID: 30466769

2018

Arnold DE, Seif AE, Jyonouchi S, Sullivan KE, Bunin NJ, Heimall JR. Allogeneic Hematopoietic Stem Cell Transplantation in Adolescent Patients with Chronic Granulomatous Disease. J Allergy Clin Immunol Pract. 2018 Nov 1. pii: S2213-2198(18)30705-0. doi: 10.1016/j.jaip.2018.10.034. [Epub ahead of print] PMID: 30391552

Kennedy K, Heimall J, Spergel JM. Advances in Atopic Dermatitis in 2017. J Allergy Clin Immunol. 2018 Oct 22. pii: S0091-6749(18)31480-5. doi: 10.1016/j.jaci.2018.10.012. [Epub ahead of print] PMID: 30359683

Bird JA, Spergel JM, Jones SM, Rachid R, Assa'ad AH, Wang J, et al. Efficacy and Safety of AR101 in Oral Immunotherapy for Peanut Allergy: Results of ARC001, a Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial. J Allergy Clin Immunol Pract. 2018 Mar - Apr;6(2):476-485.e3. doi: 10.1016/j.jaip.2017.09.016. Epub 2017 Oct 31. PMID: 29092786

Wang KY, Lee J, Cianferoni A, Ruffner MA, Dean A, Heimall J, et al. Food Protein-Induced Enterocolitis Syndrome Food Challenges: Experience from a Large Referral Center. J Allergy Clin Immunol Pract. 2018 Sep 20. pii: S2213-2198(18)30585-3. doi: 10.1016/j.jaip.2018.09.009. [Epub ahead of print] PMID: 30243880

Dvorak CC, Haddad E, Buckley RH, Cowan MJ, Logan B, Heimall J, et al. The genetic landscape of severe combined immunodeficiency in the United States and Canada in the current era (2010-2018). J Allergy Clin Immunol. 2018 Sep 5. pii: S0091-6749(18)31271-5. doi: 10.1016/j.jaci.2018.08.027. [Epub ahead of print] PMID: 30193840

Haddad E, Logan BR, Griffith LM, Buckley RH, Parrott RE, Heimall J, et al. SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery. Blood. 2018 Oct 25;132(17):1737-1749. doi: 10.1182/blood-2018-03-840702. Epub 2018 Aug 28. PMID: 30154114

Capucilli P, Cianferoni A, Fiedler J, Gober L, Pawlowski N, Heimall J, et al. Differences in egg and milk food challenge outcomes based on tolerance to the baked form. Ann Allergy Asthma Immunol. 2018 Nov;121(5):580-587. doi: 10.1016/j.anai.2018.07.018. Epub 2018 Jul 21. PMID: 30036581

Romberg N, Le Coz C, Glauzy S, Schickel JN, Trofa M, Heimall J, et al. Patients with common variable immunodeficiency with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses. J Allergy Clin Immunol. 2018 Jun 20. pii: S0091-6749(18)30897-2. doi: 10.1016/j.jaci.2018.06.012. [Epub ahead of print] PMID: 29935219

Heimall JR, Hagin D, Hajjar J, Henrickson SE, Hernandez-Trujillo HS, Tan Y, et al. Use of Genetic Testing for Primary Immunodeficiency Patients. J Clin Immunol. 2018 Apr;38(3):320-329. doi: 10.1007/s10875-018-0489-8. Epub 2018 Apr 19. Erratum in: J Clin Immunol. 2018 May 21. PMID: 29675737

2017

Arnold DE, Heimall JR. A Review of Chronic Granulomatous Disease. Adv Ther. 2017 Dec;34(12):2543-2557. doi: 10.1007/s12325-017-0636-2. Epub 2017 Nov 22. Review. PMID: 29168144

Heimall J, Logan BR, Cowan MJ, Notarangelo LD, Griffith LM, Puck JM, et al. Immune reconstitution and survival of 100 SCID patients post-hematopoietic cell transplant: a PIDTC natural history study. Blood. 2017 Dec 21;130(25):2718-2727. doi: 10.1182/blood-2017-05-781849. Epub 2017 Oct 11. PMID: 29021228

Heimall J, Cowan MJ. Long term outcomes of severe combined immunodeficiency: therapy implications. Expert Rev Clin Immunol. 2017 Nov;13(11):1029-1040. doi: 10.1080/1744666X.2017.1381558. Epub 2017 Sep 23. Review. PMID: 28918671

Arora M, Bagi P, Strongin A, Heimall J, Zhao X, Lawrence MG, et al. Gastrointestinal Manifestations of STAT3-Deficient Hyper-IgE Syndrome. J Clin Immunol. 2017 Oct;37(7):695-700. doi: 10.1007/s10875-017-0429-z. Epub 2017 Aug 13. PMID: 28803389

Heimall J, Spergel JM. New pathways for itching in patients with atopic dermatitis? J Allergy Clin Immunol. 2017 Aug;140(2):393-394. doi: 10.1016/j.jaci.2017.06.004. Epub 2017 Jun 23. PMID: 28652154

Barry JC, Crowley TB, Jyonouchi S, Heimall J, Zackai EH, Sullivan KE, McDonald-McGinn DM. Identification of 22q11.2 Deletion Syndrome via Newborn Screening for Severe Combined Immunodeficiency. J Clin Immunol. 2017 Jul;37(5):476-485. doi: 10.1007/s10875-017-0403-9. Epub 2017 May 24. PMID: 28540525

2016

MacGinnitie AJ, Rachid R, Gragg H, Little SV, Lakin P, Cianferoni A, et al. Omalizumab facilitates rapid oral desensitization for peanut allergy. J Allergy Clin Immunol. 2017 Mar;139(3):873-881.e8. doi: 10.1016/j.jaci.2016.08.010. Epub 2016 Sep 5. PMID: 27609658

Kamoun C, Morsheimer M, Sullivan KE, Holland SM, Rundles CC, Bunin N, Heimall JR. Successful unrelated cord blood transplant for complete IFN-γ receptor 2 deficiency. J Allergy Clin Immunol. 2016 Nov;138(5):1489-1491. doi: 10.1016/j.jaci.2016.06.017. Epub 2016 Jul 14. PMID: 27522156

Heimall J, Chen J, Church JA, Griffin R, Melamed I, Kleiner GI. Pharmacokinetics, Safety, and Tolerability of Subcutaneous Immune Globulin Injection (Human), 10 % Caprylate/Chromatography Purified (GAMUNEX®-C) in Pediatric Patients with Primary Immunodeficiency Disease. J Clin Immunol. 2016 Aug;36(6):600-9. doi: 10.1007/s10875-016-0311-4. Epub 2016 Jun 25. PMID: 27342758

Keller MD, Pandey R, Li D, Glessner J, Tian L, Heimall J, et al. Mutation in IRF2BP2 is responsible for a familial form of common variable immunodeficiency disorder. J Allergy Clin Immunol. 2016 Aug;138(2):544-550.e4. doi: 10.1016/j.jaci.2016.01.018. Epub 2016 Mar 23. PMID: 27016798

Naik S, Nicholas SK, Martinez CA, Leen AM, Hanley PJ, Heimall J, et al. Adoptive immunotherapy for primary immunodeficiency disorders with virus-specific T lymphocytes. J Allergy Clin Immunol. 2016 May;137(5):1498-1505.e1. doi: 10.1016/j.jaci.2015.12.1311. Epub 2016 Feb 24. PMID: 26920464

Morsheimer MM, Rychik J, Forbes L, Dodds K, Goldberg DJ, Sullivan K, Heimall JR. Risk Factors and Clinical Significance of Lymphopenia in Survivors of the Fontan Procedure for Single-Ventricle Congenital Cardiac Disease. J Allergy Clin Immunol Pract. 2016 May-Jun;4(3):491-6. doi: 10.1016/j.jaip.2015.11.034. Epub 2016 Feb 18. PMID: 26897303

2015

Patel NC, Gallagher JL, Ochs HD, Prescott Atkinson T, Wahlstrom J, Heimall J, et al. Subcutaneous Immunoglobulin Replacement Therapy with Hizentra® is Safe and Effective in Children Less Than 5 Years of Age. J Clin Immunol. 2015 Aug;35(6):558-65. doi: 10.1007/s10875-015-0190-0. Epub 2015 Sep 4. PMID: 26336818

Oshrine B, Morsheimer M, Heimall J, Bunin N. Reduced-intensity conditioning for hematopoietic cell transplantation of chronic granulomatous disease. Pediatr Blood Cancer. 2015 Feb;62(2):359-361. doi: 10.1002/pbc.25225. Epub 2014 Aug 30. PMID: 25175046

Gupta M, Sindher S, Saltzman R, Heimall J. Evaluation and subsequent safe administration of rabies vaccine to a child presumably allergic to the gelatin content of PCECV Rabavert. J Allergy Clin Immunol Pract. 2015 Mar-Apr;3(2):281-2. doi: 10.1016/j.jaip.2014.10.005. Epub 2014 Nov 18. PMID: 25609331

2014

Privette ED, Ram G, Treat JR, Yan AC, Heimall JR. Healing of granulomatous skin changes in ataxia-telangiectasia after treatment with intravenous immunoglobulin and topical mometasone 0.1% ointment. Pediatr Dermatol. 2014 Nov-Dec;31(6):703-7. doi: 10.1111/pde.12411. Epub 2014 Sep 18. PMID: 25236668

Griffith LM, Cowan MJ, Notarangelo LD, Kohn DB, Puck JM, Heimall JR, et al. Primary Immune Deficiency Treatment Consortium (PIDTC) report. J Allergy Clin Immunol. 2014 Feb;133(2):335-47. doi: 10.1016/j.jaci.2013.07.052. Epub 2013 Oct 15. PMID: 24139498

2011

Sekhsaria V, Dodd LE, Hsu AP, Hemall JR, Freeman AF, Ding L, et al. Plasma metalloproteinase levels are dysregulated in signal transducer and activator of transcription 3 mutated hyper-IgE syndrome. J Allergy Clin Immunol. 2011 Nov;128(5);1124-7. Epub 2011 Aug 27. Cited in PubMed; PMID 21872914. No abstract available.

Heimall J, Davis J, Shaw P, Hsu A, Gu W, Welch P, et al. Paucity of genotype-phenotype correlations in STAT3 mutated hyper IgE syndrome (HIES) patients. Clin Immunol. 2011 Apr;139(1):75-84. Epub 2011 Jan 14. Cited in PubMed; PMID 21288777. Read the abstract

Hemall J, Freeman A, Holland SM. Pathogenesis of hyper IgE syndrome. Clin Rev Allergy Immunol. 2010 Feb;38(1):32-8. Review. Cited in PubMed; PMID 19452285. Read the abstract

Books

Chapters

Heimall J, Bielory L. Complementary and alternative medicine in the treatment of allergic and asthmatic disease. In: Mahmoudi M, editor. Allergy and asthma practical diagnosis and management. New York: McGraw Hill Medical; 2008.

Posters and Presentations

2011

Heimall J, Siegel AM, Shaw PA, Hsu A, Holland SM, Freeman AF, et al. Early onset of varicella zoser virus reactivation (VZV, shingles) in patients with autosomal dominant hyper IgE syndrome (AD-HIES) [abstract presentation]. American Academy of Allergy, Asthma & Immunology; 2011 Mar 28-22; San Francisco, CA.

Leiding JW, Heimall J, Song YJ, Holland SM, Siegel RM, Freeman AF. Idiopathic CD4+ lymphocytopenia: clinical and autoimmune phenotype [abstract presentation]. American Academy of Allergy, Asthma & Immunology; 2011 Mar 28-22; San Francisco, CA.

2010

Heimall JR, Collins KR, Milner JD, Holland SM, Freeman AF, Siegel R. Autoimmune phenotypes in patients with autosomal dominant hyper-IgE/Job's syndrome [abstract presentation]. American Academy of Allergy, Asthma & Immunology; 2010 Feb 26-Mar 2; New Orleans, LA.

2009

Heimall J, Fessler M, Jain A. Eosinophilic esophagitis and atopic dermatitis treated with omalizumab in a patient with NEMO defect [abstract presentation]. FOCIS (Federation of Clinical Immunology Societies) Annual Meeting; Je 11-14; San Francisco, CA.

Mannino E, Gharib AM, Hsu A, Heimall J, Holland S, Freeman AF. Coronary artery abnormalities in HIES [abstract presentation]. FOCIS (Federation of Clinical Immunology Societies) Annual Meeting; Je 11-14; San Francisco, CA.

Milner J, Hsu A, Freeman AF, Heimall J, Brenchley J, Pittaluga S, et al. Somatic mosaicism for STAT3 mutation unveils critical role in human T-cell memory development and B-cell help [abstract presentation]. FOCIS (Federation of Clinical Immunology Societies) Annual Meeting; Je 11-14; San Francisco, CA.

Heimall J, Freeman AF, Davis J, Hsu A, Shaw P, Holland S. Genotype-phenotype correlations in STAT3 mutated hyper IgE syndrome (HIES patients [abstract presentation]. FOCIS (Federation of Clinical Immunology Societies) Annual Meeting; Je 11-14; San Francisco, CA.

Editorial and Academic Positions

Academic committees

2009-2010, Fellow Liaison, Graduate Medical Education Committee
2009, Chief Judge, FARE (Fellows Award for Research Excellence)
2008-2009, Chair, Distinguished Clinical Teachers Award Committee
2008-2009, NIAID Clinical Representative, NIH Fellows Committee