Sarah E. Henrickson, MD, PhD

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Sarah E. Henrickson, MD, PhD, is an attending physician with the Division of Allergy and Immunology at Children's Hospital of Philadelphia.

Areas of Expertise: Asthma
Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Harvard Medical School, Cambridge, MA


Pediatrics - Boston Combined Residency, Boston, MA


Pediatrics - Children’s Hospital of Philadelphia, Philadelphia, PA
Pediatrics - Boston Combined Residency, Boston, MA


Allergy Immunology - Children’s Hospital of Philadelphia, Philadelphia, PA

Board Certification

Allergy and Immunology

Graduate Degree

PhD - Harvard Medical School, Cambridge, MA

Titles and Academic Titles

Attending Physician

Instructor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services




Henrickson SE, Walter JE, Quinn C, Kanakry JA, Bardakjian T, Dimitrova D, et al. Adult-Onset Myopathy in a Patient with Hypomorphic RAG2 Mutations and Combined Immune Deficiency. J Clin Immunol. 2018 Aug 30.

Ruffner MA, Henrickson SE,Chilutti M, Grundmeier R, Spergel JM, Brown-Whitehorn TF. Improving allergy office scheduling increases patient follow up and reduces asthma readmission after pediatric asthma hospitalization. Ann Allergy Asthma Immunol. 2018 Aug 28. pii: S1081-1206(18)30705-1. [Epub ahead of print]

Heimall JR, Hagin D, Hajjar J, Henrickson SE, Hernandez-Trujillo, Tan Y, Kobrynski L, Paris K, Torgerson TR, Verbsky JW, Wasserman RL, Hsieh EW, Blessing JJ, Chou JS, Lawrence MG, Marsh RA, Rosenzweig SD, Orange JS, Abraham RS. Use of Genetic Testing for Primary Immunodeficiency Patients. J Clin Immunol (2018) 38 (3): 320-329.

Henrickson SE, Jongco AM, Thomsen KF, Garabedian EK, Thomsen IP.  Noninfectious Manifestations and Complications of Chronic Granulomatous Disease.  Pediatric Infect Dis Soc. (2018). 7 (suppl_1):S18-S24.

Lawless D, Geier CB, Farmer JR, Lango HA, Thwaites D, Henrickson SE, et al.  Prevalence and clinical challenges among adult primary immunodeficiency patients with RAG deficiency. J Allergy Clin Immunol. 2018.

Henrickson SE*, Manne S*, Dolfi DV, Mansfield KD, Parkhouse K, Mistry RD, Alpern ER, Hensley SE, Sullivan KE, Coffin SE, Wherry EJ. “Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection. Cell Reports (2018). 22: 411-426.  * = co-first authors.


M Ruffner, KE Sullivan and SE Henrickson. “Recurrent and Sustained Viral Infections in Primary Immunodeficiencies.” Frontiers in Immunology. (2017) 19 (8): 665.

Langan SM, Abuabara K, Henrickson SE, Hoffstad O, Margolis DJ. Increased risk of cutaneous and systemic infections in atopic dermatitis – A cohort study. J Invest Dermatol. (2017) 137 (6): 1375-1377.


Henrickson SE and Treat JR. Topical cidofovir for recalcitrant verrucae in SCID patients post hematopoetic stem cell transplant. Pediatric Dermatology. 2016. Oct 4 (e-pub).

Tuttle KL, Schneider TR, Henrickson SE, Morris D, Abonia JP, Spergel JM, Laidlaw TM. Aspirin-exacerbated respiratory disease: not always “adult-onset.” JACI: In Practice. 2016 4(4): 756-8.

Keller MD, Pandey R, Li D, Glessner J, Tian L, Henrickson SE, Chinn IK, Monaco-Shawver, Heimall J, Hou C, Otieno FG, Jyonouchi S, Calabrese L, van Montfrans J, Orange JS, Hakonarson H. Mutation in IRF2BP2 is responsible for a familial form of common variable immunodeficiency disorder. JACI. 2016 138 (2): 544-550. Epub 2016 March 23.


Textor J, Henrickson SE, Mandl JN, von Andrian UH, Westermann J, de Boer RJ, Beltman JB. Random migration and signal integration promote rapid and robust T cells recruitment. PLoS Comput Biol. 2014 Aug 7;10(8).


Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN, von Andrian UH. Antigen Availability Determines CD8+ T Cell-Dendritic Cell Interaction Kinetics and Memory Fate Decisions.  Immunity (2013) 39: 496-507.


Sung JH, Zhang H, Moseman EA, Alvarez D, Iannacone M, Henrickson SE, de la Torre JC, Groom JR, Luster AD, von Andrian UH.  Chemokine guidance of central memory T cells is critical for antiviral l recall responses in lymph nodes. PNAS (2012) 14:  1249-63.

Kasianowicz JJ, Reiner JE, Robertson JW, Henrickson SE, Rodrigues C and Krasilnikov OV.  Detecting and characterizing individual molecules with single nanopores. Methods in Molecular Biology. Ed Maria E. Gracheva. (2012) 870: 3-20.

Henrickson S and Altshuler D. Risk and Return for the Clinician Scientist. Science Translational Medicine (2012) 4: 135cm6.  DOI: 10.1126/scitranslmed.3004110


Textor J, Peixoto A, Henrickson SE, Sinn M, von Andrian UH, Westermann J. Defining the quantitative limits of intravital two-photon lymphocyte tracking. PNAS (2011) 108: 12401-6.

Henrickson SE, Agyemang AF, Garg S and Hafler J.  Integrating clinical perspectives into graduate education. Clinical Immunology.  2011 141: 228-230.


Iannaconne M, Moseman EA, Tonti E, Bosurgi L, Junt T, Henrickson SE, Whelan S, Guidotti LG and UH von Andrian. Subcapsular Sinus Macrophages Prevent CNS Invasion Upon Peripheral Infection With a Neurotropic Virus. Nature  (2010). 465: 1079-83

Henrickson SE, DiMarzio EA, Wang Q, Stanford VM and JJ Kasianowicz.  “Probing Single Nanometer-Scale Pores with Polymeric Molecular Rulers.” J. Chem. Phys. (2010) 132: 135101.

Boscacci RT, Pfeiffer F, Gollmer K, Sevilla AI, Martin AM, Soriano SF, Natale D, Henrickson S, von Andrian UH, Fukui Y, Mellado M, Deutsch U, Engelhardt B and JV Stein. Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and non-redundant roles of ICAM-1, ICAM-2 and VCAM-1 in lymphocyte homing. Blood (2010) 116(6): 915-25.


Beltman JB, Henrickson SE, von Andrian UH, de Boer RJ and AFM Maree. Towards estimating the true duration of dendritic cell contacts with T cells. Journal of Immunological Methods. (2009) 347: 54-69.


Zheng H, Jin B, Henrickson SE, Perelson AS, von Andrian UH and AK Chakraborty.  How antigen quantity and quality determine T cell decisions in lymphoid tissue.  Mol Cell Biol. (2008) 28: 4040-51.

Henrickson SE, Mempel TR, Mazo IB, Artyomov MN, Zheng H, Liu B, Flynn M, Senman B, Junt T, Wong HC, Chakraborty AK, UH von Andrian.  T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation.  Nat. Immunol. (2008) 9: 282-291.

Henrickson SE, Mempel TR, Mazo IB, Artyomov MN, Zheng H, Liu B, Flynn M, Senman B, Junt T, Wong HC, Chakraborty AK, UH von Andrian.  In vivo imaging of T cell priming.  Sci. Signal. (2008) 1, pt2.


Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Henrickson SE, Shayakhmetov DM, van Rooijen N, Mempel TR, Whelan SP and UH von Andrian.  Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature.  (2007) 450: 110-114.

Hauser AE, Junt T, Mempel TR, Sneddon MW, Leinstein SH, Henrickson SE, von Andrian UH, Shlomchik MJ and AM Haberman. Definition of Germinal-Center B cell Migration In Vivo Reveals Predominant Intrazonal Circulation Patterns. Immunity (2007) 26: 1-13.


Thompson MA, Stumph J, Henrickson SE, Rosenwald A, Wang Q, Olson S, Brandt SJ, Roberts J, Zhang X, Shyr Y, and MC Kinney. Differential gene expression in anaplastic lymphoma kinase–positive and anaplastic lymphoma kinase–negative anaplastic large cell lymphomas. Human Pathology (2005) 36: 494-504.


Mempel T, Henrickson SE and UH von Andrian. T-cell priming by Dendritic cells in Lymph Nodes Occurs in Three Distinct Phases. Nature. (2004) 427: 154-159. [Highlighted by Thomson ISI as New Hot Paper in Immunology, March and November 2005.

Cahir-McFarland ED, Carter K, Rosenwald A, Giltnane JM, Henrickson SE, Staudt LM, Kieff E. Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells. J Virol. Apr. 2004 78: 4108-19.


Wiestner A, Rosenwald A, Barry TS, Wright G, Davis RE, Henrickson SE, Zhao H, Ibbotson RE, Orchard JA, Davis Z, Stetler-Stevenson M, Raffeld M, Arthur DC, Marti GE, Wilson WH, Hamblin TJ, Oscier DG and LM Staudt. ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. Blood. 15 June 2003 101: 4944-4951.

Rosenwald A, Wright G, Wiestner A, Chan WC, Connors JM, Campo E, Gascoyne RD, Grogan TM, Muller-Hermelink HK, Smeland EB, Chiorazzi M, Giltnane JM, Hurt EM, Zhao H, Averett L, Henrickson SE, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Montserrat E, Bosch F, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Fisher RI, Miller TP, LeBlanc M, Ott G, Kvaloy S, Holte H, Delabie J and LM Staudt. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell. Feb 2003 3: 185-97.


Kasianowicz JJ, Henrickson SE, Weetall HH and B Robertson.  Simultaneous multianalyte detection with a nanometer-scale pore. Anal Chem. May 15 2001 73: 2268-72.

Henrickson SE, Wong T, Allen P, Ford T and PR Epstein. Marine swimming-related illness: implications for monitoring and environmental policy. Environ. Health Perspect. July 2001 109: 645-50.


Henrickson SE, Misakian M, Robertson B and JJ Kasianowicz. Asymmetric Driven DNA transport into a Nanometer-scale Pore. Phys. Rev. Letters. 2000 85: 3057-3060. 



SE Henrickson, S Manne, RS Herati, LA Vella, B Bengsch, SE Hensley, JD Rabinowitz, S Coffin, E.J. Wherry.  Metabolic and Deep Immune Profiling Reveal Coordinate Effects on Immune Function in Asthma and Obesity. JACI.  2017. 139 (2) Supplement: AB197.




Kasianowicz JJ, Lerman JC, Henrickson SE, Misakian M, Panchal RG, Nguyen T, Gussio R, Halverson KM, Bavari M, Shenoy DK and VM Stanford. “The Detection and characterization of ions, DNA and proteins using nanometer-scale pores.” Handbook of Biosensors and Biochips. Eds. Marks, R.S.; Lowe, C.R.; Cullen, D.C., Weetall, H.H.; Karube, I. 2007.  J. Wiley & Sons.  811-830.


Kasianowicz, JJ, Henrickson SE, Misakian M, Weetall HH, Robertson B and V. Stanford. 2002. Physics of DNA threading through a nanometer pore and applications to simultaneous multianalyte sensing. NATO Advanced Research Workshop. Structure and Dynamics of Confined Polymers. Kluwer Press. Eds. J.J. Kasianowicz, M. Kellermayer and D.W. Deamer. p. 141-163.

Posters and Presentations

Invited Lectures


Henrickson SE. “Deep Immunoprofiling in Immune Dysregulation”. Washington University School of Medicine, Department of Pediatrics.  (St. Louis, MO). June 2018.

Henrickson SE. “PTCRA mutations yield novel T cell immune deficiency.” Primary Immune Deficiency Treatment Consortium (Philadelphia, PA). May 2018.

Henrickson SE. “PTCRA mutations yield novel T cell immune deficiency.” Clinical Immunology Society (Toronto, Ontario). April 2018.

Henrickson SE. “Chronic Allergen Stimulation Yields T cell Dysfunction in Obese Asthmatics.”  AAAAI Annual Meeting (Orlando, FL). March 2018.

Awards and Honors

2018-2023, Burroughs-Wellcome Fund CAMS grant recipient

2018-2021, AAAAI Foundation Faculty Development Grant

2017, CHOP Children’s Health Research Center (CHRC) K12 grant

2017, Annual Research Day Poster Prize, CHOP

2016-2018, CIS/Horizon Fellow Award

2015,  Selected for CIS Primary Immunodeficiency Summer School

2015-2017, CHOP Institutional Training Grant in Pediatric Research (T32 HD43021)

2014, CHOP Foerderer Grant for Excellence

2012, American Association of Immunology Annual Meeting Trainee Travel Award and Oral Presentation

2011-2012, Fred Lovejoy Resident Research Fund Awards

2011, James Tolbert Shipley Prize for Research and Scholarship (HMS Commencement Prize)

2011, Elected to the Aesculapian Club of Harvard Medical School

2010-2011, Oral Presentation and Travel Awards for Keystone Symposia (on Vaccines, Seattle, 2010 and Immunological Memory, Banff, 2011)

2009, Jeffrey Modell Prize for excellence in graduate work and PhD dissertation in Immunology

2009, HMS Soma Weiss Student Research Day, chosen as one of four oral presenters

2008, MD/PhD -- Leader Program Grand Rounds, selected as inaugural speaker

2008-2009, Osaka University Immunology Frontier Research Center Postdoctoral Fellowship

2008, Martha Gray Prize for Excellence in Research, Imaging and Optics category

2008, Federation Of Clinical Immunology Societies (FOCiS) Travel Award for 2008 Annual Conference

2006, Teaching Award: Promoted to “Instructor-G” status as a TA for teaching achievement

2005, Selected to present a plenary lecture at HMS Medical Education Day

2001, summa cum laude, Harvard University, Cambridge, MA

1998, US Patent # 5,845,746. S. Henrickson, R. Goel and B. Conaway.  Wheelchair Dynamic Braking System (1998)

1997, Westinghouse Semifinalist; National Merit Scholarship Finalist; National Junior Sciences and Humanities Symposium Winner; International Science and Engineering Fair, Second Place, Physics

Editorial and Academic Positions

Editorial Positions

2012-present, Translational Immunology Update, contributor

Leadership and Memberships

Memberships in Professional Organizations

2015-present, Clinical Immunology Society
 - 2018-present, Women’s Committee
 - 2018-present, Programming Committee
 - 2016-present, Advocacy Committee
2014-present, American Association of Allergy, Asthma and Immunology
 - 2018-present, Primary Immunodeficiency Committee
 - 2018-present, Genetics, Molecular Biology & Epidemiology Committee
2014-present, American College of Allergy, Asthma and Immunology
2011-present, Society for Pediatric Dermatology
 - 2011-present, Research Committee
2010-present, American Pediatric Association
2008-present, Federation of Clinical Immunology Societies
2006-present, American Association of Immunologists