Sarah E. Henrickson, MD, PhD
Locations: Buerger Center for Advanced Pediatric Care
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MD - Harvard Medical School, Cambridge, MA
Pediatrics - Boston Combined Residency, Boston, MA
Pediatrics - Children’s Hospital of Philadelphia, Philadelphia, PA
Pediatrics - Boston Combined Residency, Boston, MA
Allergy Immunology - Children’s Hospital of Philadelphia, Philadelphia, PA
Allergy and Immunology – American Board of Allergy and ImmunologyPediatrics – American Board of Pediatrics
PhD - Harvard Medical School, Cambridge, MA
Assistant Professor of Pediatrics, University of Pennsylvania School of Medicine
Assistant Professor of Microbiology, University of Pennsylvania School of Medicine (Secondary)
Primary immune deficiency
Asthma and obesity
Samir Sayed, Avantika R Diwadkar, Jesse W Dudley, Janielle O'Brien, Donald Dvorin, Chén C Kenyon, Blanca E Himes, David A Hill, Sarah E Henrickson: COVID-19 Pandemic-Related Reductions in Pediatric Asthma Exacerbations Corresponded with an Overall Decrease in Respiratory Viral Infections. JACI in Practice 10(1): 91-99.e12, Jan 2022 Notes: doi: 10.1016/j.jaip.2021.10.067.
Victoria R Dimitriades, Alexandra F Freeman, Sarah E Henrickson, Roshini S Abraham: Supporting Careers of Women in Clinical Immunology: From Conceptualization to Implementation. Frontiers in Pediatrics 10(864734), March 2022.
Brodin P, Casari G, Townsend L, O'Farrelly C, Tancevski I, Löffler-Ragg J, Mogensen TH, Casanova JL; COVID Human Genetic Effort. (SEH as member of COVID HGE): Studying severe long COVID to understand post-infectious disorders beyond COVID-19. Nat Med 28(5): 879-882, May 2022.
Scott L Weiss, Sarah E Henrickson, Robert B Lindell, Laura F Sartori, Donglan Zhang, Jenny Bush, Sumera Farooqi, Jonathan Starr, Clifford S Deutschman, Francis X McGowan Jr, Lance Becker, Florin Tuluc, E John Wherry, Martin Picard, Douglas C Wallace: Influence of Immune Cell Subtypes on Mitochondrial Measurements in Peripheral Blood Mononuclear Cells From Children With Sepsis. Shock 57(5): 630-638, May 2022 Notes: doi: 10.1097/SHK.0000000000001903.
Lindell RB, Zhang D, Bush J, Wallace DC, Rabinowitz JD, Lu W, Wherry EJ, Weiss SL, Henrickson SE: Impaired Lymphocyte Responses in Pediatric Sepsis Vary by Pathogen Type and are Associated with Features of Immunometabolic Dysregulation. Shock 57(6): 191-199, Jun 2022.
Campbell TM, Liu Z, Zhang Q, Moncada-Velez M, Covill LE, Zhang P, Alavi Darazam I, Bastard P, Bizien L, Bucciol G, Lind Enoksson S, Jouanguy E, Karabela ÅžN, Khan T, Kendir-Demirkol Y, Arias AA, Mansouri D, Marits P, Marr N, Migeotte I, Moens L, Ozcelik T, Pellier I, Sendel A, Shahrooei M, Smith CIE, Vandernoot I, Willekens K; *COVID Human Genetic Effort, Bergman P, Abel L, Cobat A, Casanova JL, Meyts I, Bryceson YT. (*S. Henrickson as member of COVID human genetic effort, authorship listed in Pubmed).: Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency. J Exp Med 219(7): e20220202, Jul 2022.
Csomos K, Ujhazi B, Blazso P, Herrera JL, Tipton CM, Kawai T, Gordon S, Ellison M, Wu K, Stowell M, Haynes L, Cruz R, Zakota B, Nguyen J, Altrich M, Geier CB, Sharapova S, Dasso JF, Leiding JW, Smith G, Al-Herz W, de Barros Dorna M, Fadugba O, Fronkova E, Kanderova V, Svaton M, Henrickson SE, Hernandez JD, Kuijpers T, Kandilarova SM, Naumova E, Milota T, Sediva A, Moshous D, Neven B, Saco T, Sargur R, Savic S, Sleasman J, Sunkersett G, Ward BR, Komatsu M, Pittaluga S, Kumanovics A, Butte MJ, Cancro MP, Pillai S, Meffre E, Notarangelo LD, Walter JE.: Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B cells. Nat Immunol Jul 2022.
Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, Bohlen J, Liu Z, Moncada-Velez M, Kendir-Demirkol Y, Jing H, Bizien L, Marchal A, Abolhassani H, Delafontaine S, Bucciol G; COVID Human Genetic Effort, Bayhan GI, Keles S, Kiykim A, Hancerli S, Haerynck F, Florkin B, Hatipoglu N, Ozcelik T, Morelle G, Zatz M, Ng LFP, Lye DC, Young BE, Leo YS, Dalgard CL, Lifton RP, Renia L, Meyts I, Jouanguy E, Hammarström L, Pan-Hammarström Q, Boisson B, Bastard P, Su HC, Boisson-Dupuis S, Abel L, Rice CM, Zhang SY, Cobat A, Casanova JL. (*S. Henrickson as member of COVID human genetic effort, authorship listed in Pubmed).: Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia. J Exp Med 219(8): e20220131, Aug 2022.
G Chandler Floyd, Jesse W Dudley, Rui Xiao, Chris Feudtner, Kiara Taquechel, Kristen Miller, Sarah E Henrickson, David A Hill, Chén C Kenyon: Prevalence of asthma in hospitalized and non-hospitalized children with COVID-19. J Allergy Clin Immunol Pract. S2213-2198(21): 00243-9, Mar 2021.
Laura A Vella, Josephine R Giles, Amy E Baxter, Derek A Oldridge, Caroline Diorio, Leticia Kuri-Cervantes, Cécile Alanio, M Betina Pampena, Jennifer E Wu, Zeyu Chen, Yinghui Jane Huang, Elizabeth M Anderson, Sigrid Gouma, Kevin O McNerney, Julie Chase, Chakkapong Burudpakdee, Jessica H Lee, Sokratis A Apostolidis, Alexander C Huang, Divij Mathew, Oliva Kuthuru, Eileen C Goodwin, Madison E Weirick, Marcus J Bolton, Claudia P Arevalo, Andre Ramos, C J Jasen, Peyton E Conrey, Samir Sayed, Heather M Giannini, Kurt D'Andrea, UPenn COVID Processing Unit; Nuala J Meyer, Edward M Behrens, Hamid Bassiri, Scott E Hensley, Sarah E Henrickson, David T Teachey, Michael R Betts, E John Wherry : Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19. Science Immunology 6(57): eabf7570, Mar 2021.
Patel T, Henrickson SE, Moser EK, Field NS, Maurer K, Dawany N, Conrad M, Bunin N, Freedman JL, Heimall J, Arnold DE, Wang J, Markowitz JE, Payne-Poff SB, Williams KW, Russo PA, Wherry EJ, Devoto M, Oliver P, Sullivan KE, Kelsen JR.: Immune dysregulation in human ITCH deficiency successfully treated with hematopoietic cell transplantation. J Allergy Clin Immunol Pract S2213-2198(21): 00450-5, Mar 2021.
Sancho-Shimizu V, Brodin P, Cobat A, Biggs CM, Toubiana J, Lucas CL, Henrickson SE, Belot A; MIS-C@CHGE, Tangye SG, Milner JD, Levin M, Abel L, Bogunovic D, Casanova JL, Zhang SY.: SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease? J Exp Med 218(6): e20210446, Jun 2021.
Gabryszewski SJ, England RN, Sun D, Gentile TL, Hochgertel W, Jyonouchi S, Silverman M, Zaoutis T, Sullivan KE, Henrickson SE.: Self-Limited COVID-19 in a Patient with Artemis Hypomorphic SCID. J Clin Immunol August 2021 Notes: doi: 10.1007/s10875-021-01093-5.
Paul Bastard, Adrian Gervais , Tom Le Voyer, Jérémie Rosain, Quentin Philippot, ... Sarah E Henrickson, et al (SEH is listed in Pubmed under "COVID Human Genetic Effort"). : Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths. Science Immunology 6(62): eabl4340, August 2021.
Takaki Asano, Bertrand Boisson , Fanny Onodi , Daniela Matuozzo , Marcela Moncada-Velez , ... Sarah E Henrickson, et al: X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19. Science Immunology 6(62): eabl4348, August 2021.
Caroline Diorio, Rawan Shraim, Laura A Vella, Josephine R Giles, Amy E Baxter, Derek A Oldridge, Scott W Canna, Sarah E Henrickson, Kevin O McNerney, Frances Balamuth, Chakkapong Burudpakdee, Jessica Lee, Tomas Leng, Alvin Farrel, Michele P Lambert, Kathleen E Sullivan, E John Wherry, David T Teachey #, Hamid Bassiri #, Edward M Behrens #: Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction. Nat Commun 12(1): 7222. Dec 2021 Notes: doi: 10.1038/s41467-021-27544-6.
De Roos AJ, Kenyon CC, Zhao Y, Moore K, Melly S, Hubbard RA, Henrickson SE, Forrest CB, Diez Roux AV, Maltenfort M, Schinasi LH.: Ambient daily pollen levels in association with asthma exacerbation among children in Philadelphia, Pennsylvania. Environ Int. 145: 106138, Dec 2020.
Schneider WM, Razooky BS, Hoffmann HH, Michailidis E, Moens L, Han JE, Lorenzo L, Bizien L, Meade P, Neehus AL, Ugurbil AC, Corneau A, Kerner G, Zhang P, Rapaport F, Seeleuthner Y, Manry J, Masson C, Schmitt Y, Schlüter A, Le Voyer T, Khan T, Li J, Fellay J, Roussel L, Shahrooei M, Alosaimi MF, Mansouri D, Al-Saud H, Al-Mulla F, Almourfi F, Al-Muhsen SZ, Alsohime F, Al Turki S, Hasanato R, van de Beek D, Biondi A, Bettini LR, D'Angio' M, Bonfanti P, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Oler AJ, Tompkins MF, Alba C, Vandernoot I, Goffard JC, Smits G, Migeotte I, Haerynck F, Soler-Palacin P, Martin-Nalda A, Colobran R, Morange PE, Keles S, Ã‡ölkesen F, Ozcelik T, Yasar KK, Senoglu S, Karabela ÅžN, Rodríguez-Gallego C, Novelli G, Hraiech S, Tandjaoui-Lambiotte Y, Duval X, Laouénan C; COVID-STORM Clinicians; COVID Clinicians; Imagine COVID Group; French COVID Cohort Study Group; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort; NIAID-USUHS/TAGC COVID Immunity Group, Snow AL, Dalgard CL, Milner JD, Vinh DC, Mogensen TH, Marr N, Spaan AN, Boisson B, Boisson-Dupuis S, Bustamante J, Puel A, Ciancanelli MJ, Meyts I, Maniatis T, Soumelis V, Amara A, Nussenzweig M, García-Sastre A, Krammer F, Pujol A, Duffy D, Lifton RP, Zhang SY, Gorochov G, Béziat V, Jouanguy E, Sancho-Shimizu V, Rice CM, Abel L, Notarangelo LD, Cobat A, Su HC, Casanova JL.: Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science 370(6515): eabd4570, Oct 2020.
Corwin DJ, Sartori LF, Chiotos K, Odom John AR, Cohn K, Bassiri H, Behrens EM, Teachey DT, Henrickson SE, Diorio CJ, Zorc JJ, Balamuth F.: Distinguishing Multisystem Inflammatory Syndrome in Children From Kawasaki Disease and Benign Inflammatory Illnesses in the SARS-CoV-2 Pandemic. Pediatr Emerg Care 36(11): 554-558, Nov 2020.
Diorio C, Anderson EM, McNerney KO, Goodwin EC, Chase JC, Bolton MJ, Arevalo CP, Weirick ME, Gouma S, Vella LA, Henrickson SE, Chiotos K, Fitzgerald JC, Kilbaugh TJ, John ARO, Blatz AM, Lambert MP, Sullivan KE, Tartaglione MR, Zambrano D, Martin M, Lee JH, Young P, Friedman D, Sesok-Pizzini DA, Hensley SE, Behrens EM, Bassiri H, Teachey DT.: Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome. Pediatr Blood Cancer 67(11): e28693, Nov 2020.
Diorio C, Henrickson SE, Vella LA, McNerney KO, Chase JM, Burudpakdee C, Lee JH, Jasen C, Balamuth F, Barrett DM, Banwell B, Bernt KM, Blatz AM, Chiotos K, Fisher BT, Fitzgerald JC, Gerber JS, Gollomp K, Gray C, Grupp SA, Harris RM, Kilbaugh TJ, Odom John AR, Lambert MP, Liebling EJ, Paessler M, Petrosa W, Phillips CA, Reilly AF, Romber N, Seif AE, Sesok-Pizzini D, Sullivan K, Vardaro J, Behrens EM, Teachey DT and Bassiri H: Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2. J Clin Invest 11(130): 5967-5975, Nov 2020.
Anderson EM, Diorio C, Goodwin EC, McNerney KO, Weirick ME, Gouma S, Bolton MJ, Arevalo CP, Chase J, Hicks P, Manzoni TB, Baxter AE, Andrea KP, Burudpakdee C, Lee JH, Vella LA, Henrickson SE, Harris RM, Wherry EJ, Bates P, Bassiri H, Behrens EM, Teachey DT, Hensley SE.: SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19. J Pediatric Infect Dis Soc Page: piaa161, Dec 2020.
Caroline Diorio, Kevin O McNerney, Michele Lambert, Michele Paessler, Elizabeth M Anderson, Sarah E Henrickson, Julie Chase, Emily J Liebling, Chakkapong Burudpakdee, Jessica H Lee, Frances B Balamuth, Allison M Blatz, Kathleen Chiotos, Julie C Fitzgerald, Therese M Giglia, Kandace Gollomp, Audrey R Odom John, Cristina Jasen, Tomas Leng, Whitney Petrosa, Laura A Vella, Char Witmer, Kathleen E Sullivan, Benjamin L Laskin, Scott E Hensley, Hamid Bassiri, Edward M Behrens, David T Teachey: Evidence of thombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations. Blood Adv 4(23): 6051-6063, Dec 2020.
Hajaj E, Eisenberg G, Klein S, Frankenburg S, Merims S, Ben David I, Eisenhaure T, Henrickson SE, Villani AC, Hacohen N, Abudi N, Abramovich R, Cohen JE, Peretz T, Veillette A, Lotem M.: SLAMF6 deficiency augments tumor killing and skews towards an effector phenotype revealing it as a novel T cell checkpoint. Elife 3(9): e52539, Mar 2020.
Taquechel K*, Diwadkar AR*, Sayed S*, Dudley JW, Grundmeier RW, Kenyon CC, Henrickson SE**, Blanca Himes**, Hill DA**. * and ** contributed equally: Pediatric Asthma Healthcare Utilization, Viral Testing and Air Pollution Changes During the COVID-19 Pandemic. JACI in Practice Aug 2020.
Kenyon CC, Hill DA, Henrickson SE, Bryant-Stephens TC and Zorc JJ: Initial effects of the COVID-19 pandemic on pediatric asthma emergency department utilization. JACI in Practice Sept 2020.
Kenyon CC, Maltenfort MG, Hubbard RA, Schinasi LH, De Roos AJ, Henrickson SE, Bryant-Stephens TC, Forrest CB. : Variability in Diagnosed Asthma in Young Children in a Large Pediatric Primary Care Network. Acad Pediatr S1876-2859(20): 30057, Sept-Oct 2020.
Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Shaw E, Haljasmägi L, Peterson P, Lorenzo L, Bizien L, Trouillet-Assant S, Dobbs K, de Jesus AA, Belot A, Kallaste A, Catherinot E, Tandjaoui-Lambiotte Y, Le Pen J, Kerner G, Bigio B, Seeleuthner Y, Yang R, Bolze A, Spaan AN, Delmonte OM, Abers MS, Aiuti A, Casari G, Lampasona V, Piemonti L, Ciceri F, Bilguvar K, Lifton RP, Vasse M, Smadja DM, Migaud M, Hadjadj J, Terrier B, Duffy D, Quintana-Murci L, van de Beek D, Roussel L, Vinh DC, Tangye SG, Haerynck F, Dalmau D, Martinez-Picado J, Brodin P, Nussenzweig MC, Boisson-Dupuis S, Rodríguez-Gallego C, Vogt G, Mogensen TH, Oler AJ, Gu J, Burbelo PD, Cohen JI, Biondi A, Bettini LR, D'Angio M, Bonfanti P, Rossignol P, Mayaux J, Rieux-Laucat F, Husebye ES, Fusco F, Ursini MV, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Castagnoli R, Montagna D, Licari A, Marseglia GL, Duval X, Ghosn J; HGID Lab; NIAID-USUHS Immune Response to COVID Group; COVID Clinicians; COVID-STORM Clinicians; Imagine COVID Group; French COVID Cohort Study Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort, Tsang JS, Goldbach-Mansky R, Kisand K, Lionakis MS, Puel A, Zhang SY, Holland SM, Gorochov G, Jouanguy E, Rice CM, Cobat A, Notarangelo LD, Abel L, Su HC, Casanova JL.: Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science 370(6515): eabd4585, Oct 2020.
Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi F, Korniotis S, Karpf L, Philippot Q, Chbihi M, Bonnet-Madin L, Dorgham K, Smith N,
Greenblatt Rebecca E, Zhao Edward J, Henrickson Sarah E, Apter Andrea J, Hubbard Rebecca A, Himes Blanca E: Factors associated with exacerbations among adults with asthma according to electronic health record data. Asthma research and practice 18(5): 1, January 2019.
Farmer JR, Foldvari Z, Ujhazi B, De Ravin SS, Chen K, Bleesing JJH, Schuetz C, Al-Herz W, Abraham RS, Joshi AY, Costa-Carvalho BT, Buchbinder D, Booth C, Reiff A, Ferguson PJ, Aghamohammadi A, Abolhassani H, Puck JM, Adeli M, Cancrini C, Palma P, Bertaina A, Locatelli F, Di Matteo G, Geha RS, Kanariou MG, Lycopoulou E, Tzanoudaki M, Sleasman JW, Parikh S, Pinero G, Fischer BM, Dbaibo G, Unal E, Patiroglu T, Karakukcu M, Al-Saad KK, Dilley MA, Pai SY, Dutmer CM, Gelfand EW, Geier CB, Eibl MM, Wolf HM, Henderson LA, Hazen MM, Bonfim C, Wolska-KuÅ›nierz B, Butte MJ, Hernandez JD, Nicholas SK, Stepensky P, Chandrakasan S, Miano M, Westermann-Clark E, Goda V, Kriván G, Holland SM, Fadugba O, Henrickson SE, Ozen A, Karakoc-Aydiner E, Baris S, Kiykim A, Bredius R, Hoeger B, Boztug K, Pashchenko O, Neven B, Moshous D, Villartay JP, Bousfiha AA, Hill HR, Notarangelo LD, Walter JE.: Outcomes and treatment strategies for autoimmunity and
hyperinflammation in patients with RAG deficiency. J Allergy Clin Immunol Pract. S2213-2198(19): 30260, March 2019.
Henrickson SE, Andre-Schmutz I, Lagresle-Peyrou C, Deardorff MA, Jyonouchi H, Neven B, Bunin Nand Heimall JR.Hematopoetic : Stem Cell Transplant for the Treatment of X-MAID. Front Pediatr. 7: 160, May 2019.
Henrickson SE, Dolan JG, Forbes LR, Vargas-Hernandez A, Nishimura S, Okada S, Kersun L, Brodeur GM and Heimall JR. : Gain-of-Function STAT1 Mutation with Familial Lymphadenopathy and Hodgkin Lymphoma. Front Pediatr. 7: 160, May 2019.
Virtue AT, McCright SJ, Wright JM, Jimenez MT, Mowel WK, Kotzin JJ, Joannas L, Basavappa MG, Spencer SP, Clark ML, Eisennagel SH, Williams A, Levy M, Manne S, Henrickson SE, Wherry EJ, Thaiss CA, Elinav E, Henao-Mejia J. : The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs. Sci Transl Med 12(11): 496, Jun 2019.
Kawai AT, Martin D, Henrickson SE, Goff A, Reidy M, Santiago D, Selvam N, Selvan M, McMahill-Walraven C, Lee GM. : Validation of febrile seizures identified in the Sentinel Post-Licensure Rapid Immunization Safety Monitoring Program. Vaccine 37(30): 4172, Jul 2019.
Le Coz C, Bengsch B, Khanna C, Trofa M, Ohtani T, Nolan BE, Henrickson SE, Lambert MP, Kim TO, Despotovic JM, Feldman S, Fadugba OO, Takach P, Ruffner M, Jyonouchi S, Heimall J, Sullivan KE, Wherry EJ, Romberg N. : Common variable immunodeficiency-associated
endotoxemia promotes early commitment to the T follicular lineage. J Allergy Clin Immunol 144(6): 1660, Dec 2019.
Henrickson SE, Walter JE, Quinn C, Kanakry JA, Bardakjian T, Dimitrova D, et al. Adult-Onset Myopathy in a Patient with Hypomorphic RAG2 Mutations and Combined Immune Deficiency. J Clin Immunol. 2018 Aug 30.
Ruffner MA, Henrickson SE,Chilutti M, Grundmeier R, Spergel JM, Brown-Whitehorn TF. Improving allergy office scheduling increases patient follow up and reduces asthma readmission after pediatric asthma hospitalization. Ann Allergy Asthma Immunol. 2018 Aug 28. pii: S1081-1206(18)30705-1. [Epub ahead of print]
Heimall JR, Hagin D, Hajjar J, Henrickson SE, Hernandez-Trujillo, Tan Y, Kobrynski L, Paris K, Torgerson TR, Verbsky JW, Wasserman RL, Hsieh EW, Blessing JJ, Chou JS, Lawrence MG, Marsh RA, Rosenzweig SD, Orange JS, Abraham RS. Use of Genetic Testing for Primary Immunodeficiency Patients. J Clin Immunol (2018) 38 (3): 320-329.
Henrickson SE, Jongco AM, Thomsen KF, Garabedian EK, Thomsen IP. Noninfectious Manifestations and Complications of Chronic Granulomatous Disease. Pediatric Infect Dis Soc. (2018). 7 (suppl_1):S18-S24.
Lawless D, Geier CB, Farmer JR, Lango HA, Thwaites D, Henrickson SE, et al. Prevalence and clinical challenges among adult primary immunodeficiency patients with RAG deficiency. J Allergy Clin Immunol. 2018.
Henrickson SE*, Manne S*, Dolfi DV, Mansfield KD, Parkhouse K, Mistry RD, Alpern ER, Hensley SE, Sullivan KE, Coffin SE, Wherry EJ. “Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection. Cell Reports (2018). 22: 411-426. * = co-first authors.
M Ruffner, KE Sullivan and SE Henrickson. “Recurrent and Sustained Viral Infections in Primary Immunodeficiencies.” Frontiers in Immunology. (2017) 19 (8): 665.
Langan SM, Abuabara K, Henrickson SE, Hoffstad O, Margolis DJ. Increased risk of cutaneous and systemic infections in atopic dermatitis – A cohort study. J Invest Dermatol. (2017) 137 (6): 1375-1377.
Henrickson SE and Treat JR. Topical cidofovir for recalcitrant verrucae in SCID patients post hematopoetic stem cell transplant. Pediatric Dermatology. 2016. Oct 4 (e-pub).
Tuttle KL, Schneider TR, Henrickson SE, Morris D, Abonia JP, Spergel JM, Laidlaw TM. Aspirin-exacerbated respiratory disease: not always “adult-onset.” JACI: In Practice. 2016 4(4): 756-8.
Keller MD, Pandey R, Li D, Glessner J, Tian L, Henrickson SE, Chinn IK, Monaco-Shawver, Heimall J, Hou C, Otieno FG, Jyonouchi S, Calabrese L, van Montfrans J, Orange JS, Hakonarson H. Mutation in IRF2BP2 is responsible for a familial form of common variable immunodeficiency disorder. JACI. 2016 138 (2): 544-550. Epub 2016 March 23.
Textor J, Henrickson SE, Mandl JN, von Andrian UH, Westermann J, de Boer RJ, Beltman JB. Random migration and signal integration promote rapid and robust T cells recruitment. PLoS Comput Biol. 2014 Aug 7;10(8).
Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN, von Andrian UH. Antigen Availability Determines CD8+ T Cell-Dendritic Cell Interaction Kinetics and Memory Fate Decisions. Immunity (2013) 39: 496-507.
Sung JH, Zhang H, Moseman EA, Alvarez D, Iannacone M, Henrickson SE, de la Torre JC, Groom JR, Luster AD, von Andrian UH. Chemokine guidance of central memory T cells is critical for antiviral l recall responses in lymph nodes. PNAS (2012) 14: 1249-63.
Kasianowicz JJ, Reiner JE, Robertson JW, Henrickson SE, Rodrigues C and Krasilnikov OV. Detecting and characterizing individual molecules with single nanopores. Methods in Molecular Biology. Ed Maria E. Gracheva. (2012) 870: 3-20.
Henrickson S and Altshuler D. Risk and Return for the Clinician Scientist. Science Translational Medicine (2012) 4: 135cm6. DOI: 10.1126/scitranslmed.3004110
Textor J, Peixoto A, Henrickson SE, Sinn M, von Andrian UH, Westermann J. Defining the quantitative limits of intravital two-photon lymphocyte tracking. PNAS (2011) 108: 12401-6.
Henrickson SE, Agyemang AF, Garg S and Hafler J. Integrating clinical perspectives into graduate education. Clinical Immunology. 2011 141: 228-230.
Iannaconne M, Moseman EA, Tonti E, Bosurgi L, Junt T, Henrickson SE, Whelan S, Guidotti LG and UH von Andrian. Subcapsular Sinus Macrophages Prevent CNS Invasion Upon Peripheral Infection With a Neurotropic Virus. Nature (2010). 465: 1079-83
Henrickson SE, DiMarzio EA, Wang Q, Stanford VM and JJ Kasianowicz. “Probing Single Nanometer-Scale Pores with Polymeric Molecular Rulers.” J. Chem. Phys. (2010) 132: 135101.
Boscacci RT, Pfeiffer F, Gollmer K, Sevilla AI, Martin AM, Soriano SF, Natale D, Henrickson S, von Andrian UH, Fukui Y, Mellado M, Deutsch U, Engelhardt B and JV Stein. Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and non-redundant roles of ICAM-1, ICAM-2 and VCAM-1 in lymphocyte homing. Blood (2010) 116(6): 915-25.
Beltman JB, Henrickson SE, von Andrian UH, de Boer RJ and AFM Maree. Towards estimating the true duration of dendritic cell contacts with T cells. Journal of Immunological Methods. (2009) 347: 54-69.
Zheng H, Jin B, Henrickson SE, Perelson AS, von Andrian UH and AK Chakraborty. How antigen quantity and quality determine T cell decisions in lymphoid tissue. Mol Cell Biol. (2008) 28: 4040-51.
Henrickson SE, Mempel TR, Mazo IB, Artyomov MN, Zheng H, Liu B, Flynn M, Senman B, Junt T, Wong HC, Chakraborty AK, UH von Andrian. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat. Immunol. (2008) 9: 282-291.
Henrickson SE, Mempel TR, Mazo IB, Artyomov MN, Zheng H, Liu B, Flynn M, Senman B, Junt T, Wong HC, Chakraborty AK, UH von Andrian. In vivo imaging of T cell priming. Sci. Signal. (2008) 1, pt2.
Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Henrickson SE, Shayakhmetov DM, van Rooijen N, Mempel TR, Whelan SP and UH von Andrian. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature. (2007) 450: 110-114.
Hauser AE, Junt T, Mempel TR, Sneddon MW, Leinstein SH, Henrickson SE, von Andrian UH, Shlomchik MJ and AM Haberman. Definition of Germinal-Center B cell Migration In Vivo Reveals Predominant Intrazonal Circulation Patterns. Immunity (2007) 26: 1-13.
Thompson MA, Stumph J, Henrickson SE, Rosenwald A, Wang Q, Olson S, Brandt SJ, Roberts J, Zhang X, Shyr Y, and MC Kinney. Differential gene expression in anaplastic lymphoma kinase–positive and anaplastic lymphoma kinase–negative anaplastic large cell lymphomas. Human Pathology (2005) 36: 494-504.
Mempel T, Henrickson SE and UH von Andrian. T-cell priming by Dendritic cells in Lymph Nodes Occurs in Three Distinct Phases. Nature. (2004) 427: 154-159. [Highlighted by Thomson ISI as New Hot Paper in Immunology, March and November 2005.
Cahir-McFarland ED, Carter K, Rosenwald A, Giltnane JM, Henrickson SE, Staudt LM, Kieff E. Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells. J Virol. Apr. 2004 78: 4108-19.
Wiestner A, Rosenwald A, Barry TS, Wright G, Davis RE, Henrickson SE, Zhao H, Ibbotson RE, Orchard JA, Davis Z, Stetler-Stevenson M, Raffeld M, Arthur DC, Marti GE, Wilson WH, Hamblin TJ, Oscier DG and LM Staudt. ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. Blood. 15 June 2003 101: 4944-4951.
Rosenwald A, Wright G, Wiestner A, Chan WC, Connors JM, Campo E, Gascoyne RD, Grogan TM, Muller-Hermelink HK, Smeland EB, Chiorazzi M, Giltnane JM, Hurt EM, Zhao H, Averett L, Henrickson SE, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Montserrat E, Bosch F, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Fisher RI, Miller TP, LeBlanc M, Ott G, Kvaloy S, Holte H, Delabie J and LM Staudt. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell. Feb 2003 3: 185-97.
Kasianowicz JJ, Henrickson SE, Weetall HH and B Robertson. Simultaneous multianalyte detection with a nanometer-scale pore. Anal Chem. May 15 2001 73: 2268-72.
Henrickson SE, Wong T, Allen P, Ford T and PR Epstein. Marine swimming-related illness: implications for monitoring and environmental policy. Environ. Health Perspect. July 2001 109: 645-50.
Henrickson SE, Misakian M, Robertson B and JJ Kasianowicz. Asymmetric Driven DNA transport into a Nanometer-scale Pore. Phys. Rev. Letters. 2000 85: 3057-3060.
SE Henrickson, S Manne, RS Herati, LA Vella, B Bengsch, SE Hensley, JD Rabinowitz, S Coffin, E.J. Wherry. Metabolic and Deep Immune Profiling Reveal Coordinate Effects on Immune Function in Asthma and Obesity. JACI. 2017. 139 (2) Supplement: AB197.
SE Henrickson: Basophils getting on your nerves? Itching for clarity on flares in atopic dermatitis. Science Immunology 6(56): eabg8047, Feb 2021.
Sarah E Henrickson: Learning from our Immunological History: What can SARS-CoV teach us about SARS-CoV-2? Science Immunology 5(46), Apr 2020.
Sarah E. Henrickson: Susceptibility to Human Papillomavirus. Stiehm's Immune Deficiencies. Kathleen Sullivan (eds.). Elsevier, May 2020.
Campos JS, Henrickson SE, Abraham RS.: Expanding mechanistic insights into the pathogenesis of idiopathic CD4+ T cell lymphocytopenia. J Clin Invest. 130(10), Oct 2020.
Henrickson SE. "Obese Asthma", Mexican College of Pediatricians Specialized in Allergy and Clinical Immunology (COMPEDIA) XXIX Annual Conference. Invited Virtual Plenary talk at conference located in Acapulco, Mexico 7-13-22. Technical issues prevented the AV team from playing the taped talk so rescheduled as a webinar for that national association on 08-08-22. July 2022
Henrickson SE. "Immunometabolic Dysregulation in Primary Immune Regulation Disorders", Yale Human and Translational Immunology Seminar Series (New Haven, CT). May 2022
Henrickson SE. "Diagnosis and Treatment of MIS-C in Children", workshop co-run with Eve Wu, AAAAI, Phoenix, AZ (02-27-2022). Feb 2022.
Henrickson SE. "The Impact of Obesity on Immune Function in Pediatric Asthma", AAAAI Annual Meeting, Phoenix, AZ (02-25-2022). Invited talk. Feb 2022
Henrickson SE. "Obesity dysregulates immune and metabolic status in asthma and alters infection susceptibility", Canadian Nutrition Society. Planned for Toronto, Ontario but moved to virtual for COVID. Jan 2022
Henrickson SE. "Immunometabolic Dysfunction in Primary Immune Regulatory Disorders", University of Colorado School of Medicine HI3 Seminar Series, Virtual Colloquium. Dec 2021.
Henrickson SE. "Altered STAT landscape and _T cell dysfunction", Primary Immune Deficiency Treatment Consortium (PIDTC), Asilomar, CA. Nov 2021.
Henrickson SE. "Patient/Community Engagement" panel member. CZI Single Cell Biology Annual Meeting. Oct 2021.
Henrickson SE. "Clinical genetics - use of development and pediatric single-cell atlas data to identify disease causing variants in patients". Co-lead workshop/breakout session with Dr. Helen Firth. HCA Developmental and Pediatric Cell Atlas Meeting, Virtual. Aug 2021.
Henrickson SE. "Single-cell in rare disease" Keynote at Advancing Diagnosis in Rare Disease Through Patient-Researcher Collaborations Using Single-Cell Methods workshop, Chan Zuckerberg Initiative, virtual. 06.08.21. June 2021.
Henrickson SE. "Finding the Zebra in Your Practice"; Immune Deficiency Foundation Clinician Education Webinar. May 2021.
Henrickson SE. "Obesity dysregulates immunometabolic status in pediatric asthma", PAS Virtual Annual Meeting; Highlighted e-Poster with Live Q&A. May 2021.
Henrickson SE. "Selective IgA deficiency alters systemic immune response to commensal gut microbiome", PAS Virtual Annual Meeting. Given by my technician Peyton Conrey. May 2021.
Henrickson SE. "Selective IgA deficiency alters systemic immune response to commensal gut microbiome", PAS Virtual Annual Meeting. Given by my technician Peyton Conrey. Apr 2021.
Henrickson SE. Advanced Single Cell Analysis Methods Including CyTOF and Spectral Cytometry. Virtual Clinical Immunology Society Annual Meeting. Given with Elena Hsieh. Apr 2021.
Henrickson SE. Obesity dysregulates immunometabolic status in pediatric asthma and impacts vaccine responses. Cold Spring Harbor Laboratory, Virtual Systems Immunology Symposium (oral abstract). 04-20-21. Apr 2021.
Henrickson SE. Decoding the inflammatory landscape of childhood obesity. CZIl Inflammation Monthly Webinar. 04-14-21. Given with Jorge Henao-Mejia. Apr 2021.
Henrickson SE. "Selective IgA deficiency alters systemic immune response to commensal gut microbiome", AAAAI Virtual Annual Meeting. Given by my technician Peyton Conrey. Feb 2021.
Henrickson SE. "Defining Exhaustion and Immunometabolic Alterations in Primary Immunodeficiency", AAAAI Virtual Annual Meeting. Feb 2021.
Henrickson SE. "Activated PI3 kinase delta syndrome alters CD4 and CD8 T cell activation and is only partially corrected by targeted therapy", AAAAI Virtual Annual Meeting. Feb 2021.
Henrickson SE. "Alterations in STAT Signaling Dysregulate CD8 T Cell Activation", AAAAI virtual annual meeting. Given by graduate student Jose Campos. Feb 2021.
Henrickson SE. "Preferential Loss of Peripheral Non-Naïve CD4+ Lymphocytes in Pediatric Sepsis", AAAAI Virtual Annual Meeting. Given by Assistant Professor Brad Lindell, in my lab. Feb 2021.
Henrickson SE. "Finding Unicorns Among Zebras: When and How to Test CVID Patients for Underlying Immune Dysregulatory Conditions" workshop co-run with Millie Kwan at AAAAI Virtual Annual Meeting. Feb 2021.
Henrickson SE. "Pediatric immune health and its dysregulation in inflammation, inborn errors of immunity and COVID-19". Becton Dickinson Annual Meeting (Virtual). Nov 2020.
Henrickson SE. "Repeated life threatening respiratory viral infections in novel AD STAT1 LOF" JAK-STAT Virtual Cold Spring Harbor Laboratory Symposium. Nov 2020.
Henrickson SE. "Alterations in STAT3 signaling dysregulate CD8 T cell activation". Cold Spring Harbor JAK-STAT meeting (virtual). Given by graduate student Jose Campos. Nov 2020.
Henrickson SE. "Pediatric immune health and its dysregulation in inborn errors of immunity and COVID-19". Becton Dickinson annual meeting (virtual). Nov 2020.
Henrickson SE. "Selective IgA deficiency alters systemic immune response to commensal gut microbiome". Virtual European Society for Immune Deficiency. Selected for live discussion of e-poster and won best e-poster in session. Oct 2020.
Henrickson SE. "Immune dysregulation in pediatric COVID-19 and MIS-C", Human Cell Atlas COVID Virtual Symposium. Oct 2020.
Henrickson SE. "Immunopathogenesis of MIS-C". Children's National - NIAID 3rd Annual Virtual Symposium. Sept 2020.
Henrickson SE. "Immune Dysregulation in pediatric COVID-19 in Philadelphia". COVID Human Genetic Effort (virtual, international consortium). June 2020.
Henrickson SE. "Decoding the Inflammatory Landscape in Childhood Obesity", Chan Zuckerberg Initiative: Virtual New Investigators Meeting. June 2020.
Henrickson SE. Invited but meeting cancelled; Pediatric Academic Societies (May 2020; Philadelphia): "Obesity Dysregulates Immunometabolic Function in Pediatric Asthma". Apr 2020.
Henrickson SE. Invited but meeting cancelled: American Association of Asthma, Allergy and Immunology (March 2020; Philadelphia) "The Role of Biologics in the Treatment of Patients with Asthma". Mar 2020.
Henrickson SE. Invited but meeting cancelled: American Association of Asthma, Allergy and Immunology (March 2020; Philadelphia) "Next Steps when Genetic Testing is Unrevealing". Mar 2020.
Henrickson SE. "Why so many viral infections?" International Alliance for Primary Immunodeficiency Societies; Lisbon, Portugal). Jan 2020.
2021, AAAAI Leadership Institute
2018-2023, Burroughs-Wellcome Fund CAMS grant recipient
2021, Young Physician Scientist Award (ASCI)
2018-2021, AAAAI Foundation Faculty Development Grant
2017, CHOP Children’s Health Research Center (CHRC) K12 grant
2017, Annual Research Day Poster Prize, CHOP
2016-2018, CIS/Horizon Fellow Award
2015, Selected for CIS Primary Immunodeficiency Summer School
2015-2017, CHOP Institutional Training Grant in Pediatric Research (T32 HD43021)
2014, CHOP Foerderer Grant for Excellence
2012, American Association of Immunology Annual Meeting Trainee Travel Award and Oral Presentation
2011-2012, Fred Lovejoy Resident Research Fund Awards
2011, James Tolbert Shipley Prize for Research and Scholarship (HMS Commencement Prize)
2011, Elected to the Aesculapian Club of Harvard Medical School
2010-2011, Oral Presentation and Travel Awards for Keystone Symposia (on Vaccines, Seattle, 2010 and Immunological Memory, Banff, 2011)
2009, Jeffrey Modell Prize for excellence in graduate work and PhD dissertation in Immunology
2009, HMS Soma Weiss Student Research Day, chosen as one of four oral presenters
2008, MD/PhD -- Leader Program Grand Rounds, selected as inaugural speaker
2008-2009, Osaka University Immunology Frontier Research Center Postdoctoral Fellowship
2008, Martha Gray Prize for Excellence in Research, Imaging and Optics category
2008, Federation Of Clinical Immunology Societies (FOCiS) Travel Award for 2008 Annual Conference
2006, Teaching Award: Promoted to “Instructor-G” status as a TA for teaching achievement
2005, Selected to present a plenary lecture at HMS Medical Education Day
2001, summa cum laude, Harvard University, Cambridge, MA
1998, US Patent # 5,845,746. S. Henrickson, R. Goel and B. Conaway. Wheelchair Dynamic Braking System (1998)
1997, Westinghouse Semifinalist; National Merit Scholarship Finalist; National Junior Sciences and Humanities Symposium Winner; International Science and Engineering Fair, Second Place, Physics
2021-present, Review Editor, Editorial Board of T Cell Biology (specialty section) Frontiers in Immunology
2020-present, Ad hoc reviewer, Journal of Clinical Immunology
2018-present, Ad hoc reviewer, Clinical Immunology
2018-present, Ad hoc reviewer, Respiratory Research
2018-present, Ad hoc reviewer, Journal of Clinical Virology
2017-present, Ad hoc reviewer, JACI
2017-present, Associate Editor, Science Immunology
2021-present, UPenn Trainee Advocacy Alliance member
2021-present, Data Science Strategy Committee
2021-present, UPenn Institute for Immunology Weekly Symposium Coordinator (with Prof. Will Bailis)
2021-present, Arcus Scientific Advisory Committee
2020-present, Research Institute Research Restart Taskforce (COVID-19)
2020-present, Academic Training Advisory Council
2020-present, UPenn MD/PhD admissions committee
2018-present, Arcus Advisory Committee
2018-present, Faculty Development Advisory Committee
2017-present, High Utilizer Asthma Committee
2021-present, American Society for Clinical Investigation
- 2021-present, Physician Scientist Development Committee
2015-present, Clinical Immunology Society
- 2020-present, Women’s Committee, Co-Chai
- 2018-present, Women’s Committee
2014-present, American Association of Allergy, Asthma and Immunology
- 2018-present, Primary Immunodeficiency Committee
- 2021-present, Genetics, Molecular Biology & Epidemiology Committee, Vice Chair
- 2018-present, Genetics, Molecular Biology & Epidemiology Committee
2014-present, American College of Allergy, Asthma and Immunology
2010-present, American Pediatric Association
2008-present, Federation of Clinical Immunology Societies
2006-present, American Association of Immunologists
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