David A. Hill, MD, PhD

David A. Hill, MD, PhD

David A. Hill, MD, PhD, is an attending physician with the Division of Allergy at Children's Hospital of Philadelphia.

Areas of Expertise: Food allergy, Eosinophilic esophagitis, Severe allergy/anaphylaxis
Locations: Buerger Center for Advanced Pediatric Care
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - University of Pennsylvania, Philadelphia PA

Internship

Pediatrics - Children’s Hospital of Philadelphia, Philadelphia, PA

Residency

Pediatrics - Children’s Hospital of Philadelphia, Philadelphia, PA

Fellowship

Pediatric Allergy and Immunology - Children’s Hospital of Philadelphia, Philadelphia, PA

Graduate Degree

PhD - University of Pennsylvania, Philadelphia PA

Titles and Academic Titles

Attending Physician

Instructor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Food allergy
Allergic march
Transcriptional regulation of innate immune cells

Publications

Papers

2018

Hill DA, Spergel JM. Epithelial acid imbalance in eosinophilic esophagitis. J Allergy Clin Immunol. 2018 Oct 10. pii: S0091-6749(18)31435-0. doi: 10.1016/j.jaci.2018.09.026. [Epub ahead of print]

Hill DA, Grundmeier RW, Ramos M, Spergel JM. Eosinophilic Esophagitis Is a Late Manifestation of the Allergic March. J Allergy Clin Immunol Pract. 2018 Sep - Oct;6(5):1528-1533. doi: 10.1016/j.jaip.2018.05.010. Epub 2018 Jun 25.

Nelson VL, Nguyen HCB, Garcìa-Cañaveras JC, Briggs ER, Ho WY, DiSpirito JR, Marinis JM, Hill DA, Lazar MA. PPARγ is a nexus controlling alternative activation of macrophages via glutamine metabolism. Genes Dev. 2018 Aug 1;32(15-16):1035-1044. doi: 10.1101/gad.312355.118. Epub 2018 Jul 13.

Hill DA, Camargo CA Jr, Paller AS, Spergel JM. A march by any other name. Ann Allergy Asthma Immunol. 2018 Jul;121(1):137-138. doi: 10.1016/j.anai.2018.04.014.

Nelson VL, Nguyen HCB, Garcìa-Cañaveras JC, Briggs ER, Ho WY, DiSpirito JR, Marinis JM, Hill DA, Lazar MA. PPAR is a nexus controlling alternative activation of macrophages via glutamine metabolism. Genes and Development. 2018. Jul 13. PMID: 30006480.

Hill DA*, Grundmeier RW, Ramos M, Spergel JM. Eosinophilic esophagitis is a late manifestation of the allergic march. Journal of Allergy and Clinical Immunology: In Practice. 2018. Jun 13. PMID: 29954692.

Hill DA, Lim HW, Kim YH, Ho WY, Foong YH, Nelson VL, Nguyen HCB, Chegireddy K, Kim J, Habertheuer A, Vallabhajosyula P, Kambayashi T, Won KJ, Lazar MA. Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue. Proceedings of the National Academy of Sciences USA. 2018 May 29; 115(22):E5096-E5105. PMID: 29760084. PMCID: PMC5984532.

Raje N, Snyder BL, Hill DA, Streicher JL, Sullivan KE. Severe immunodeficiency associated with acute lymphoblastic leukemia and its treatment. Annals of Allergy, Asthma and Immunology. 2018 May; 120(5):537-538. PMID: 29563054. PMCID: PMC5975371.

Hill DA, Spergel JM. The atopic march: Critical evidence and clinical relevance. Ann Allergy Asthma Immunol. 2018 Feb;120(2):131-137. doi: 10.1016/j.anai.2017.10.037.

Hill DA, Spergel JM. Is eosinophilic esophagitis a member of the atopic march? Ann Allergy Asthma Immunol. 2018 Feb;120(2):113-114. doi: 10.1016/j.anai.2017.10.003.

Hill DA*, Barz Leahy A, Sciasci J, O’Neill SP, Reilly A, Balamuth N, Seeholzer SH, Spergel JM, Brown-Whitehorn TF. Medication contaminants as a potential cause of anaphylaxis to vincristine. Pediatric Blood and Cancer. 2018 Jan;65(1). PMID: 28834048. PMCID: PMC5978699.

2017

Hill DA, Dudley JW, Spergel JM. The prevalence of eosinophilic esophagitis in pediatric patients with IgE-mediated food allergy. Journal of Allergy and Clinical Immunology: In Practice. 2017 Mar-Apr;5(2):369-375. PMID: 28042003. PMCID: PMC5346349.

2016

Papazyan R, Sun Z, Hoon Kim Y, Titchenell PM, Hill DA, Lu W, Damle M, Wan M, Zhang Y, Briggs ER, Rabinowitz JD, Lazar MA. Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. Cell Metabolism. 2016 Dec 13;24(6):863-874. PMID: 27866836. PMCID: PMC5159233.

Hill DA*, Grundmeier RW, Ram G, Spergel JM. The epidemiologic characteristics of healthcare provider-diagnosed eczema, asthma, allergic rhinitis, and food allergy in children: a retrospective cohort study. BMC Pediatrics. 2016 Aug 20;16:133. PMID: 27542726. PMCID: PMC4992234.

Hill DA, Spergel JM. The Immunologic Mechanisms of Eosinophilic Esophagitis. Curr Allergy Asthma Rep. 2016 Feb;16(2):9. doi: 10.1007/s11882-015-0592-3.

2015

Hill DA*, Shuker M, Cianferoni A, Wong T, Ruchelli E, Spergel JM, Brown-Whitehorn TF. The development of IgE-mediated immediate hypersensitivity after the diagnosis of eosinophilic esophagitis to the same food. Journal of Allergy and Clinical Immunology: In Practice. 2015 Jan-Feb;3(1):123-4. PMID: 25577634. PMCID: PMC5598762.

2014

Hill DA, Siracusa MD, Ruymann KR, Tait Wojno ED, Artis D, Spergel JM. Omalizumab therapy is associated with reduced circulating basophil populations in asthmatic children. Allergy. 2014 May;69(5):674-7. PMID: 24611974. PMCID: PMC3981884.

Maggadottir SM, Hill DA, Ruymann KR, Brown-Whitehorn TF, Cianferoni A, Shuker M, Wang ML, Chikwava K, Verma R, Liacouras CA, Spergel JM. Resolution of acute IgE-mediated allergy with development of eosinophilic esophagitis triggered by the same food. Journal of Allergy and Clinical Immunology. 2014 May;133(5):1487-9. PMID: 24636092.

2013

Noti M, Wojno ED, Kim BS, Siracusa MC, Giacomin PR, Nair MG, Benitez AJ, Ruymann KR, Muir AB, Hill DA, Chikwava KR, Moghaddam AE, Sattentau QJ, Alex A, Zhou C, Yearley JH, Menard-Katcher P, Kubo M, Obata-Ninomiya K, Karasuyama H, Comeau MR, Brown-Whitehorn T, de Waal Malefyt R, Sleiman PM, Hakonarson H, Cianferoni A, Falk GW, Wang ML, Spergel JM, Artis D. Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis. Nature Medicine. 2013 Aug;19(8):1005-13. PMID: 23872715. PMCID: PMC3951204.

Hill DA, Artis D. The influence of commensal bacteria-derived signals on basophil-associated allergic inflammation. Gut Microbes. 2013 Jan-Feb;4(1):76-83. doi: 10.4161/gmic.22759. Epub 2012 Nov 8.

2012

Carvalho LP, Petritus P, Trochtenberg A, Hill DA, Artis D, Scott P. Leishmania major induced lymph node hypertrophy is dependent upon TLR9. Journal of Immunology. 2012 Aug;188(3):1394-401. PMID: 22205030. PMCID: PMC3262876.

Dollive S, Peterfreund G, Sherrill-Mix S, Bittinger K, Sinha R, Nabel C, Hill DA, Artis D, Bachman M, Custers-Allen R, Grunberg S, Wu G, Lewis J, Bushman FD. A tool kit for quantifying eukaryotic rRNA gene sequences from human microbiome samples. Genome Biology. 2012 Jul;13(7):R60. PMID: 22759449. PMCID: PMC4053730.

Hill DA, Siracusa MC, Abt MC, Kim BK, Kobuley D, Kubo M, Kambayashi T, LaRosa DF, Renner ED, Orange JS, Bushman FD, Artis D. Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nature Medicine. 2012 Mar;18(4):538-46. PMID: 22447074. PMCID: PMC3321082. Cited >300 times.

Carvalho LP, Petritus PM, Trochtenberg AL, Zaph C, Hill DA, Artis D, Scott P. Lymph node hypertrophy following Leishmania major infection is dependent on TLR9. J Immunol. 2012 Feb 1;188(3):1394-401. doi: 10.4049/jimmunol.1101018. Epub 2011 Dec 28.

2011

Siracusa MC, Saenz SA, Hill DA, Kim BS, Headley MB, Doering TA, Wherry EJ, Jessup HK, Siegel LA, Kambayashi T, Dudek EC, Kubo M, Cianferoni A, Spergel JM, Ziegler SF, Comeau MR, Artis D. TSLP promotes IL-3-independent basophil hematopoiesis and type 2 inflammation. Nature. 2011 Aug;447(7363):229-33. PMID: 21841801. PMCID: PMC3263308.

2010

Hill DA, Artis D. Intestinal bacteria and the regulation of immune cell homeostasis. Annu Rev Immunol. 2010;28:623-67. doi: 10.1146/annurev-immunol-030409-101330.

Hill DA, Hoffmann C, Abt MC, Du Y, Kobuley D, Kirn TJ, Bushman FD, Artis D. Metagenomic analyses reveal antibiotic-induced temporal and spatial changes in intestinal microbiota with associated alterations in immune cell homeostasis. Mucosal Immunology. 2010 Mar;3(2):148-58. PMID: 19940845. PMCID: PMC2824244. Cited >250 times.

Hill DA, Desai SA. Malaria parasite mutants with altered erythrocyte permeability: a new drug resistance mechanism and important molecular tool. Future Microbiol. 2010 Jan;5(1):81-97. doi: 10.2217/fmb.09.109.

2009

Hill DA, Artis D. Maintaining diplomatic relations between mammals and beneficial microbial communities. Sci Signal. 2009 Nov 24;2(98):pe77. doi: 10.1126/scisignal.298pe77.

Hoffmann C, Hill DA, Minkah N, Kirn T, Troy A, Artis D, Bushman, F. Community-Wide Response of the Gut Microbiota to Enteropathogenic Citrobacter rodentium Infection Revealed by Deep Sequencing. Infection and Immunity. 2009 Oct;77(10):4668-78. PMID: 19635824. PMCID: PMC2747949.

2007

Alkhalil A, Hill DA, Desai SA. Babesia and plasmodia increase host erythrocyte permeability through distinct mechanisms. Cellular Microbiology. 2007 Apr;9(4):851-60. PMID: 17087736.

Staines HM, Alkhalil A, Allen RJ, De Jonge HR, Derbyshire E, Hill DA, et al. Electrophysiological studies of malaria parasite-infected erythrocytes: current status. Int J Parasitol. 2007 Apr;37(5):475-82. Epub 2007 Jan 9.

Hill DA, Pillai AD, Nawaz F, Hayton K, Doan L, Lisk G, Desai SA. A blasticidin S-resistant Plasmodium falciparum mutant with a defective plasmodial surface anion channel. Proceedings of the National Academy of Sciences USA. 2007 Jan;104(3):1063-8. PMID: 17213308. PMCID: PMC1783364. Cited >50 times.

Posters and Presentations

2018

Hill DA, Grundmeier RW, Ramos M, Spergel JM. Eosinophilic Esophagitis is a Late Manifestation of the Atopic March. JACI. 141(2):AB86, Feb. 2018. Oral presentation. AAAAI National Meeting. Orlando, FL. Mar. 2018.

Hill DA, Grundmeier RW, Ramos M, Spergel JM. The role of Eosinophilic Esophagitis in the Atopic March. Poster presentation. Gordon Research Conference: Mechanisms, Prevention of, and Emerging Therapies for Food Allergy. Ventura, CA. Jan. 2018.

2017

Hill DA, Lim HW, Foong YH, Nelson VL, Won KJ, Lazar MA. Obesity disrupts tissue-protective macrophage populations in the adipose and lung. AAAI. 119(5):S6, Nov. 2017. Oral presentation. ACAAI National Meeting. Boston, MA. Oct. 2017.

Hill DA, Barz A, Sciasci J, O’Neill SP, Reilly A, Balamuth N, Seeholzer SH, Spergel JM, Brown-Whitehorn TF. A case series of eight patients with clinical anaphylaxis in the setting of vincristine administration. JACI. 139(2):AB40, Feb. 2017. Poster presentation. AAAAI National Meeting. Atlanta, GA. Mar. 2017.

2016

Hill DA, Dudley JW, Spergel JM. The prevalence of eosinophilic esophagitis in patients with IgE-mediated food allergy: Implications for oral immunotherapy. AAAI. 117(5):S12, Nov. 2016. Oral presentation. ACAAI National Meeting. San Francisco, CA. Nov. 2016.

Hill DA, Ram G, Grundmeier RW, Spergel JM. The epidemiologic characteristics of childhood eczema, asthma, rhinitis, and food allergy in a large primary care cohort. JACI. 137(2):AB156, Jan. 2016. Poster presentation. AAAAI National Meeting. Los Angeles, CA. Mar. 2016.

Invited Lectures

2018

Hill DA. Pediatric Food Allergy. Pediatric Resident Lecture Series, CHOP. Phila., PA. Jul. 31th, 2018.

Hill DA. Adipose tissue inflammation in obesity. Pediatric Grand Rounds, CHOP. Phila., PA. May 30th, 2018.

2017

Hill DA. NIAID guidelines on peanut allergy. Primary Care Network Lecture Series, CHOP. Phila., PA. Sept. 19th, 2017.

Hill DA. Pediatric Food Allergy. Pediatric Resident Lecture Series, CHOP. Phila., PA. Aug. 7th, 2017.

Hill DA. Allergy/Immunology/Rheumatology Platform Session, Co-Chair. Eastern Society of Pediatric Research. Phila., PA. March 25th, 2017.

Hill DA. Pediatric Allergy and Immunology. Medical student lecture series, Perelman SOM. Phila., PA. Mar. 10th, 2017.

2016

Hill DA. Pediatric Allergic Rhinitis. Resident Lecture Series, CHOP. Phila., PA. Aug. 17th, 2016.

Hill DA. Pediatric Food Allergy. Resident Lecture Series, CHOP. Phila., PA. Jul. 22nd, 2016.

Hill DA. The epidemiology of allergic conditions in the CHOP primary care network. Pediatric Grand Rounds, CHOP. Phila., PA. May 18th, 2016.

Hill DA. Food Allergy and Anaphylaxis. Pediatric Resident Lecture Series, CHOP. Phila., PA. May 3rd, 2016.

Hill DA. Allergic conditions in the CHOP primary care network. Primary Care Network Lecture Series, CHOP. Phila., PA. May 3rd, 2016.

Hill DA. Pediatric Allergy and Immunology. Medical student lecture series, Perelman SOM. Phila., PA. Jan. 8th, 2016.

Awards and Honors

2018, Outstanding Pediatric Abstract Award, AAAAI AAP Section on Allergy and Immunology
2017, Clemens Von Pirquet Award, ACAAI
2017, Award for Outstanding Patient-Oriented Research, CHOP Research Symposium
2016, Clemens Von Pirquet Award, American College of Allergy, Asthma & Immunology (ACAAI)
2016, Senior Resident Research Award, CHOP
2016, Award for Outstanding Patient-Oriented Research, Children’s Hospital of Philadelphia (CHOP) Research Symposium
2016, Outstanding Pediatric Abstract Award, AAAAI AAP Section on Allergy and Immunology
2014, Section on Allergy & Immunology Award, American Academy of Pediatrics (AAP) Annual Meeting
2014, Chrysalis Award, American Academy of Allergy, Asthma & Immunology (AAAAI)
2013, Henrietta and Jacob Lowenburg Prize in Pediatrics, Perelman SOM
2012, Saul Winegrad Outstanding Dissertation Award, Perelman SOM
2011, Mary Ellis Bell Prize for Medical Research, Perelman SOM
2011, Penn Flow Cytometry Award, Perelman SOM
2010, Immunology Graduate Group Award, Perelman SOM
2006, MSTP, Perelman School of Medicine (SOM)
2005, Post-baccalaureate Intramural Research Training Award, NIAID
2005, Andrew Carnegie Society Scholar, Carnegie Mellon University
2002, Toyota National Scholar

Editorial and Academic Positions

Editorial Positions

2018-present, Associate Editor, BMC Pediatrics
2018-present, Faculty, Medscape Education
2017-present, Ad hoc reviewer, Journal of Asthma and Allergy
2017-present, Ad hoc reviewer, Pediatric Emergency Care

Leadership and Memberships

Memberships in Professional Organizations

International

2017-present, Junior Member, World Allergy Organization

National

2017-present, Eastern Society for Pediatric Research
2016-present, Institute for Diabetes, Obesity, and Metabolism, Perelman SOM
2016-present, Clinical Immunology Society
2016-present, American Academy of Allergy, Asthma, and Immunology (AAAAI)
- 2016-present, Mediators of Allergic Inflammation Committee
- 2016-present, Eosinophilic GI Disorders Committee
2016-present, American College of Allergy, Asthma, and Immunology (ACAAI)
- 2016-present, Asthma Committee
2013-present, American Academy of Pediatrics (AAP)
- 2013-present, Allergy and Immunology Section
2011-present, Institute for Immunology, Perelman SOM