Applying machine learning techniques to electronic medical data to delineate novel disease trajectories and develop seizure prediction models to guide the care of neonates and children with epilepsy. Additional research interests include SYNGAP1-related neurodevelopmental disorder and data-driven approaches to identifying candidates for epilepsy surgery.
Galer PD, Parthasarathy S, Xian J, McKee JL Ganesan S, Lewis-Smith D, Kaufman MC, Ruggiero SM, Cohen SR, Haag S, Gonzalez AK, Wilmarth O, Ellis CA, Litt B, Helbig I. (2022) Clinical signatures of childhood epilepsies preceding genetic diagnoses: A retrospective study of electronic medical records in 32,000 individuals. Under Review at Brain.
Clatot J, Parthasarathy S, Cohen S, McKee JL, Massey S, Somarowthu A, Goldberg EM, Helbig I. (2022) The SCN1A Philadelphia variant – a gain-of-function mutation causing an early-onset epileptic encephalopathy. bioRxiv. 2022.06.29.498154
Kaufman MC, Xian J, Galer PD, Parthasarathy S, Gonzalez AK, McKee JL, Prelack MS, Fitzgerald MP, Helbig I, CHOP Neuroscience Center - Telemedicine Research Group. (2022) Child neurology telemedicine: Analyzing 14 820 patient encounters during the first year of the COVID-19 pandemic. Dev Med Child Neurol. 00:1-10.
Tucker A, Kaul A, McKee JL, et al. (2021) Surgical treatment of upper extremity segmental myoclonus in an adolescent with chiari malformation and cervicothoracic syrinx. Pediatric Neurosurgery. 56(4):1-6.
*Kulick-Soper CV, *McKee JL, Wolf RL, et al. (2020) Pearls & Oy-sters: Bilateral globus pallidus lesions in a patient with COVID-19. Neurology. 95(10):454-457. *Co-first authors.
Lim S, McKee JL, Woloszyn L, Amit Y, Freedman DJ, Sheinberg D, Brunel N. (2015) Inferring learning rules from distribution of firing rates in cortical neurons. Nature Neuroscience. 18: 1804-1810.
McKee JL. (2014) A comparison of inferior temporal, perirhinal and prefrontal cortices in visual recognition and learning. Graduate Dissertation. Committee on Computational Neuroscience, The Division of the Biological Sciences & the Pritzker School of Medicine, The University of Chicago.
McKee JL, Riesenhuber M, Miller EK, Freedman DJ. (2014) Task dependence of visual and category representations in prefrontal and inferior temporal cortices. J Neurosci. 34(48): 16065–75.
Beraneck M, McKee JL, Aleisa M, and Cullen KE. (2008) Asymmetric recovery in cerebellar– deficient mice following unilateral labyrinthectomy. J Neurophysiol. 100: 945–958.
Xian J, Ruggiero, SM, McKee JL, Fitch E, Cosico M, Thalwitzer KM, Sullivan KR, Kaufman MC, Brimble E, Fitter N, and Helbig I. (Dec. 2022) A natural history study of STXBP1-related disorders through reconstructed medical records. AES, Nashville, TN.
McKee JL, Xian J, Ginn N, Fitzgerald MP, Goldeberg EM, and Helbig I. (Dec. 2022) A data-driven approach to reconstructing disease trajectories in SYNGAP1-related disorder. AES, Nashville, TN.
McKee JL, et al. (Sept 7th, 2022) Neonatal seizure prediction algorithms based on EMR-embedded standardized EEG reporting. ICCN 2022, Geneva, Switzerland, 387.
McKee JL, et al. (Dec 4th, 2021) Neonatal seizure prediction algorithms based on EMR-embedded standardized EEG reporting. AES 2021, Chicago IL, 1.189.
Xian J, Ruggiero SM, McKee JL, and Helbig I. (Nov 8th, 2021) A data-driven analysis of changes in anti-seizure medications after genetic diagnosis in 1,598 individuals with genetic epilepsies. MidAtlantic Bioinformatics Conference 2021, Philadelphia, PA.
Awards and Honors
2022-2024, Omics Maximizing Grant recipient Identifying disease trajectories in pediatric epilepsy through integration of multi-omics data
2021, Zeritsky Clinical Research Award, University of Pennsylvania, Department of Neurology
2021, American Epilepsy Society, Fellow
2020, Pellock Fellowship, Child Neurology Society
2018-2021, Zeritsky Clinical Research Award
2007-2016, Pritzker scholarship, University of Chicago, Prtizker School of Medicine
2007, Dr. Kathleen Terroux Prize in Physiology
Leadership and Memberships
Memberships in Professional Organizations
2021-present, American Epilepsy Society
2020-present, Child Neurology Society
2018-present, American Academy of Neurology
2004-present, Golden Key International Honor Society
2014-present, American College of Physicians
Patient Experience Ratings
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