Gary W. Nace, Jr., MD, FACS, FAAP

Locations: Specialty Care, Princeton at Plainsboro; Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)
MD - Temple University School of Medicine, Philadelphia, PA
General Surgery - University of Pittsburgh Medical Center, Pittsburgh, PA
General Surgery - University of Pittsburgh Medical Center, Pittsburgh, PA
Pediatric Surgery - Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA
General Surgery – American Board of SurgeryPediatric Surgery – American Board of Surgery
Attending Surgeon
Director, Pediatric Surgery Clerkship
Associate Director, Pediatric Trauma Program
Assistant Professor of Surgery, Perelman School of Medicine at the University of Pennsylvania
Hatchimonji JS, Luks VL, Swendiman RA, Allukian M 3rd, Nance ML, Nace GW Jr. Settling the Score: Injury Severity Score Fails to Capture Nuances in Pediatric Trauma. Pediatr Emerg Care. 2022 Feb 1;38(2):e828-e832. doi: 10.1097/PEC.0000000000002363. PMID: 35100783.
Abramov A, Luks VL, De Bie F, Hwang R, Allukian M 3rd, Nace GW Jr. Pneumatosis intestinalis in children beyond the neonatal period: is it always benign? Pediatr Surg Int. 2021 Nov 27. doi: 10.1007/s00383-021-05048-0. Epub ahead of print. PMID: 34837497.
Toto R, Friedlaender EY, Nace GW, Arkader A, Levin LS. Arterial Fat Embolism in a Pediatric Patient with Femur Fracture: A Case Report. JBJS Case Connect. 2021 Jul 9;11(3). doi: 10.2106/JBJS.CC.20.00485. PMID: 34237039.
Swendiman RA, Abramov A, Fenton SJ, Russell KW, Nance ML, Nace GW Jr, Iii MA. Use of angioembolization in pediatric polytrauma patients: WITH BLUNT SPLENIC INJURY Angioembolization in Pediatric Blunt Splenic Injury. J Pediatr Surg. 2021 Apr 24:S0022-3468(21)00324-9. doi: 10.1016/j.jpedsurg.2021.04.014. Epub ahead of print. PMID: 34034882.
Swendiman RA, Goldshore MA, Allukian M 3rd, Nace GW Jr, Nance ML. In reply to "Abdominal angiography is associated with reduced in-hospital mortality among pediatric patients with blunt splenic and hepatic injury: A propensity-score-matching study from the national trauma registry in Japan". J Pediatr Surg. 2021 Mar 23:S0022-3468(21)00247-5. doi: 10.1016/j.jpedsurg.2021.03.014. Epub ahead of print. PMID: 33840501.
Kashyap MV, Reisen B, Hornick MA, Nace GW, Laje P: Same-day discharge after laparoscopic appendectomy for non-perforated appendicitis is safe and cost effective. Pediatric Surgery International Mar. 10 2021 (Epub) Notes: doi: 10.1007/s00383-021-04880-8.
Nace GW, Nance ML: Early cryoprecipitate use— Time to change our pediatric massive transfusion protocol? JAMA Surgery Feb. 17 2021 (Epub) Notes: doi: 10.1001/jamasurg.2020.7266.
Swendiman RA, Luks VL, Hatchimonji JS, Nayyar MG, Goldshore MA, Nace GW Jr, Nance ML, Allukian M 3rd. Mortality After Adolescent Firearm Injury: Effect of Trauma Center Designation. J Adolesc Health. 2020 Oct 13:S1054-139X(20)30525-5. doi: 10.1016/j.jadohealth.2020.09.004. Epub ahead of print. PMID: 33067151.
Swendiman RA, Hatchimonji JS, Allukian M 3rd, Blinman TA, Nance ML, Nace GW. Pediatric firearm injuries: Anatomy of an epidemic [published online ahead of print, 2020 Apr 20]. Surgery. 2020;S0039-6060(20)30108-2. doi:10.1016/j.surg.2020.02.023
Hatchimonji JS, Swendiman RA, Goldshore MA, Blinman, TA, Nance ML, Allukian, M, Nace GW. Pediatric firearm mortality in the United States, 2010 to 2016: A National Trauma Data Bank analysis. J Trauma Acute Care Surg. 2020;88(3):402‐407. doi:10.1097/TA.0000000000002573
De La Torre L, Cogley K, Calisto J, Nace G, Correa C. Primary sigmoidectomy and appendicostomy for chronic idiopathic constipation. Pediatr Surg Int. 2016 Aug;32(8):767- 72. Pubmed PMID: 27372298.
Leeper CM, Nace G, Scholz S. Gallbladder and Biliary Tract; In: Diagnostic and Interventional Ultrasound in Pediatrics and Pediatric Surgery. Scholz S & Jarboe M, Eds. Springer, 2015.
Tohme S, Sukato D, Nace GW, Zajko A, Amesur N, Orons P, Chalhoub D, Marsh JW,Geller DA, Tsung A. Survival and tolerability of liver radioembolization: a comparison of elderly and younger patients with metastatic colorectal cancer. HPB (Oxford). 2014 Dec;16(12):1110-6. PubMed PMID: 25123597.
Huang H*, Nace GW*, McDonald KA, Tai S, Klune JR, Rosborough BR, Ding Q, Loughran P, Zhu X, Beer-Stolz D, Chang EB, Billiar T, Tsung A. Hepatocyte specific HMGB1 deletion worsens the injury in liver ischemia/reperfusion: A role for intracellular HMGB1 in cellular protection. Hepatology. 2013 Dec 21. [Epub ahead of print] PubMed PMID: 24375466.
Huang H, Chen HW, Evankovich J, Yan W, Rosborough BR, Nace GW, Ding Q, Loughran P, Beer-Stolz D, Billiar TR, Esmon CT, Tsung A. Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury. J Immunol. 2013 Sep 1;191(5):2665-79. PubMed PMID: 23904166.
Nace GW, Huang H, Klune JR, Eid RE, Rosborough BR, Korff S, Li S, Shapiro RA, Stolz DB, Sodhi CP, Hackam DJ, Geller DA, Billiar TR, Tsung A. Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice. Hepatology. 2013 Jul;58(1):374-87. doi: 10.1002/hep.26346. Epub 2013 May 27. PubMed PMID: 23460269; PubMed Central PMCID: PMC3688695.
Tsung A, Nace GW, Geller DA. Pituitary adenylate cyclase-activating polypeptide: a neuromodulator of hepatic ischemia-reperfusion injury? Hepatology. 2013 Mar;57(3):878- 80. doi: 10.1002/hep.25902. PubMed PMID: 22729815.
Chang Y, Yan W, He X, Zhang L, Li C, Huang H, Nace G, Geller DA, Lin J, Tsung A. miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions. Gastroenterology. 2012 Jul;143(1):177-87.e8. doi: 10.1053/j.gastro.2012.04.009. Epub 2012 Apr 12. PubMed PMID: 22504094.
Klune JR, Dhupar R, Kimura S, Ueki S, Cardinal J, Nakao A, Nace G, Evankovich J, Murase N, Tsung A, Geller DA. Interferon regulatory factor-2 is protective against hepatic ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 1;303(5):G666-73. doi: 10.1152/ajpgi.00050.2012. Epub 2012 Jun 28. PubMed PMID: 22744333; PubMed Central PMCID: PMC3468551.
Zhang L, Cardinal JS, Bahar R, Evankovich J, Huang H, Nace G, Billiar TR, Rosengart MR, Pan P, Tsung A. Interferon regulatory factor-1 regulates the autophagic response in LPS-stimulated macrophages through nitric oxide. Mol Med. 2012 Mar 27;18(1):201-8. doi: 10.2119/molmed.2011.00282. PubMed PMID: 22105605; PubMed Central PMCID: PMC3320143.
Nace G, Evankovich J, Eid R, Tsung A. Dendritic cells and damage-associated molecular patterns: endogenous danger signals linking innate and adaptive immunity. J Innate Immun. 2012;4(1):6-15. Epub 2011 Nov 11. Review. PubMed PMID: 22086146.
Huang H, Evankovich J, Yan W, Nace G, Zhang L, Ross M, Liao X, Billiar T, Xu J, Esmon CT, Tsung A. Endogenous histones function as alarms in in sterile inflammatory liver injury through Toll-like receptor 9 in mice. Hepatology. 2011 Sep 2;54(3):999-1008. doi: 10.1002/hep.24501. PubMed PMID: 21721026; PubMed Central PMCID: PMC3213322
Nace GW, Steel JL, Amesur N, Zajko A, Nastasi BE, Joyce J, Sheetz M, Gamblin TC. Yttrium-90 radioembolization for colorectal cancer liver metastases: a single institution experience. Int J Surg Oncol. 2011;2011:571261. Epub 2011 Mar 20. PubMed PMID: 22312513; PubMed Central PMCID: PMC3263679.
Nace G, Lee K, Bartels C. Endocrine Pancreas; In: Surgical Oncology: Fundamentals, Evidence Based Approaches and New Technologies. Bartlett D, Ed. Jaypee Brothers medical publishers, 2010.
Nace, Gary and Gamblin, Clark. 90-Yttrium Microsphere Radioembolization in the Treatment of Primary and Metastatic Liver Tumors. US Gastroenterology. 2009; 4:36-38.
Chen CY, Nace GW, Solow B, Fratamico P. Complete nucleotide sequences of 84.5- and 3.2-kb plasmids in the multi-antibiotic resistant Salmonella enterica serovar Typhimurium U302 strain G8430. Plasmid. 2007 Jan;57(1):29-43. Epub 2006 Jul 7. PubMed PMID: 16828159.
Chen CY, Nace GW, Irwin PL. A 6 x 6 drop plate method for simultaneous colony counting and MPN enumeration of Campylobacter jejuni, Listeria monocytogenes, and Escherichia coli. J Microbiol Methods. 2003 Nov;55(2):475-9. PubMed PMID: 14529971.
Nace GW. Pediatric Trauma Society 7th Annual Meeting – Disparities in Isolated, Serious, Blunt Splenic Injury Outcomes for Pediatric Patients. Nov 2021.
Nace GW. 2021 ACS Quality and Safety Conference - An Expedited Feeding Protocol Safely Reduces Length of Stay after Gastrostomy Tube Insertion: A QI Initiative. July 2021.
Nace GW. Pediatric Trauma Society 6th Annual Meeting – The Clinical Significance of Firearm-related Extremity Injuries in Pediatric Patients. Nov 2020.
Nace GW. Pediatric Trauma Society 6th Annual Meeting – Settling the Score: Mortality Differences in Pediatric and Adult Trauma Relative to Injury Severity Score. Nov 2020.
Nace GW. American College of Surgeons Clinical Congress – Management of Pneumatosis Intestinalis Beyond the Neonatal Period. Oct 2020.
Nace, G.W. (2022). Trauma Resuscitation. In: Mattei, P. (eds) Fundamentals of Pediatric Surgery. Springer, Cham. https://doi.org/10.1007/978-3-031-07524-7_17
Nace GW, Nance ML. Trauma in Children; In: The Trauma Manual: Trauma and Acute Care Surgery. Peitzman AB, Yealy DM, Fabian TC, Schwab CW, Eds. Wolters Kluwer, 2020.
Boelig MM, Nace GW. Abdominal Pain, Vomiting, and Fever in a 3-Year-Old Female; In: Surgery Morning Report: Beyond the Pearls. Willams AD, Gefen JY, Mann BD Eds. Elsevier, 2020.
Leeper CM, Nace G, Scholz S. Gallbladder and Biliary Tract; In: Diagnostic and Interventional Ultrasound in Pediatrics and Pediatric Surgery. Scholz S & Jarboe M, Eds. Springer, 2015.
2018, 2020, Top Physicians, South Jersey Magazine
2011, “Best Poster” at 3rd International HMGB1 Conference, Pittsburgh, PA
2010, Association for Academic Surgery Foundation Fellowship Research Award
2007, W. Emory Burnett Prize in Surgery
2005, Augustin Peale Award for Excellence in Pathology
2004, Benjamin and Mary Siddons Measey Foundation Medical Student Scholarship
2004, John Franklin Huber Award in Anatomy
2020-present, Journal of Trauma and Acute Care Surgery, Ad hoc reviewer
2020-present, Journal of Surgical Research, Ad hoc reviewer
2019-present, Journal of Pediatric Surgery, Ad hoc reviewer
2018-present, Pediatric Emergency Care, Ad hoc reviewer
American College of Surgeons, Fellow
American Academy of Pediatrics, Fellow
- 2021-present, Delivery of Surgical Care Committee
Pediatric Trauma Society
- 2021-present, Educational Committee
- 2020-present, Injury Prevention Committee
- 2020-present, Guidelines Committee
American Pediatric Surgical Association
- 2020-present, Quality & Safety Committee
Association for Academic Surgery
Alpha Omega Alpha, Honor Medical Society