Gary W. Nace, Jr., MD, FACS, FAAP

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Gary W. Nace, Jr., MD, FACS, FAAP, is an attending pediatric surgeon with the Division of Pediatric General, Thoracic and Fetal Surgery, and the Trauma Center at Children's Hospital of Philadelphia.

Areas of Expertise: Minimally invasive surgery, Thoracic Surgery, Hirschsprung's disease and other anorectal malformations, Trauma surgery, Neonatal Surgery, Oncologic Surgery, Pediatric colorectal surgery, Inguinal and umbilical hernia repair, Chest wall deformities
Locations: Specialty Care & Surgery Center, Voorhees; Specialty Care, Princeton at Plainsboro; Main Hospital

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Temple University School of Medicine, Philadelphia, PA


General Surgery - University of Pittsburgh Medical Center, Pittsburgh, PA


General Surgery - University of Pittsburgh Medical Center, Pittsburgh, PA


Pediatric Surgery - Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA

Board Certification

General Surgery – American Board of Surgery
Pediatric Surgery – American Board of Surgery

Titles and Academic Titles

Attending Surgeon

Conditions Treated

Departments and Services




Swendiman RA, Hatchimonji JS, Allukian M 3rd, Blinman TA, Nance ML, Nace GW. Pediatric firearm injuries: Anatomy of an epidemic [published online ahead of print, 2020 Apr 20]. Surgery. 2020;S0039-6060(20)30108-2. doi:10.1016/j.surg.2020.02.023

Hatchimonji JS, Swendiman RA, Goldshore MA, Blinman, TA, Nance ML, Allukian, M, Nace GW. Pediatric firearm mortality in the United States, 2010 to 2016: A National Trauma Data Bank analysis. J Trauma Acute Care Surg. 2020;88(3):402‐407. doi:10.1097/TA.0000000000002573


De La Torre L, Cogley K, Calisto J, Nace G, Correa C. Primary sigmoidectomy and appendicostomy for chronic idiopathic constipation. Pediatr Surg Int. 2016 Aug;32(8):767- 72. Pubmed PMID: 27372298.


Leeper CM, Nace G, Scholz S. Gallbladder and Biliary Tract; In: Diagnostic and Interventional Ultrasound in Pediatrics and Pediatric Surgery. Scholz S & Jarboe M, Eds. Springer, 2015.


Tohme S, Sukato D, Nace GW, Zajko A, Amesur N, Orons P, Chalhoub D, Marsh JW,Geller DA, Tsung A. Survival and tolerability of liver radioembolization: a comparison of elderly and younger patients with metastatic colorectal cancer. HPB (Oxford). 2014 Dec;16(12):1110-6. PubMed PMID: 25123597.


Huang H*, Nace GW*, McDonald KA, Tai S, Klune JR, Rosborough BR, Ding Q, Loughran P, Zhu X, Beer-Stolz D, Chang EB, Billiar T, Tsung A. Hepatocyte specific HMGB1 deletion worsens the injury in liver ischemia/reperfusion: A role for intracellular HMGB1 in cellular protection. Hepatology. 2013 Dec 21. [Epub ahead of print] PubMed PMID: 24375466.

Huang H, Chen HW, Evankovich J, Yan W, Rosborough BR, Nace GW, Ding Q, Loughran P, Beer-Stolz D, Billiar TR, Esmon CT, Tsung A. Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury. J Immunol. 2013 Sep 1;191(5):2665-79. PubMed PMID: 23904166.

Nace GW, Huang H, Klune JR, Eid RE, Rosborough BR, Korff S, Li S, Shapiro RA, Stolz DB, Sodhi CP, Hackam DJ, Geller DA, Billiar TR, Tsung A. Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice. Hepatology. 2013 Jul;58(1):374-87. doi: 10.1002/hep.26346. Epub 2013 May 27. PubMed PMID: 23460269; PubMed Central PMCID: PMC3688695.

Tsung A, Nace GW, Geller DA. Pituitary adenylate cyclase-activating polypeptide: a neuromodulator of hepatic ischemia-reperfusion injury? Hepatology. 2013 Mar;57(3):878- 80. doi: 10.1002/hep.25902. PubMed PMID: 22729815.


Chang Y, Yan W, He X, Zhang L, Li C, Huang H, Nace G, Geller DA, Lin J, Tsung A. miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions. Gastroenterology. 2012 Jul;143(1):177-87.e8. doi: 10.1053/j.gastro.2012.04.009. Epub 2012 Apr 12. PubMed PMID: 22504094.

Klune JR, Dhupar R, Kimura S, Ueki S, Cardinal J, Nakao A, Nace G, Evankovich J, Murase N, Tsung A, Geller DA. Interferon regulatory factor-2 is protective against hepatic ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 1;303(5):G666-73. doi: 10.1152/ajpgi.00050.2012. Epub 2012 Jun 28. PubMed PMID: 22744333; PubMed Central PMCID: PMC3468551.

Zhang L, Cardinal JS, Bahar R, Evankovich J, Huang H, Nace G, Billiar TR, Rosengart MR, Pan P, Tsung A. Interferon regulatory factor-1 regulates the autophagic response in LPS-stimulated macrophages through nitric oxide. Mol Med. 2012 Mar 27;18(1):201-8. doi: 10.2119/molmed.2011.00282. PubMed PMID: 22105605; PubMed Central PMCID: PMC3320143.


Nace G, Evankovich J, Eid R, Tsung A. Dendritic cells and damage-associated molecular patterns: endogenous danger signals linking innate and adaptive immunity. J Innate Immun. 2012;4(1):6-15. Epub 2011 Nov 11. Review. PubMed PMID: 22086146.

Huang H, Evankovich J, Yan W, Nace G, Zhang L, Ross M, Liao X, Billiar T, Xu J, Esmon CT, Tsung A. Endogenous histones function as alarms in in sterile inflammatory liver injury through Toll-like receptor 9 in mice. Hepatology. 2011 Sep 2;54(3):999-1008. doi: 10.1002/hep.24501. PubMed PMID: 21721026; PubMed Central PMCID: PMC3213322

Nace GW, Steel JL, Amesur N, Zajko A, Nastasi BE, Joyce J, Sheetz M, Gamblin TC. Yttrium-90 radioembolization for colorectal cancer liver metastases: a single institution experience. Int J Surg Oncol. 2011;2011:571261. Epub 2011 Mar 20. PubMed PMID: 22312513; PubMed Central PMCID: PMC3263679.


Nace G, Lee K, Bartels C. Endocrine Pancreas; In: Surgical Oncology: Fundamentals, Evidence Based Approaches and New Technologies. Bartlett D, Ed. Jaypee Brothers medical publishers, 2010.


Nace, Gary and Gamblin, Clark. 90-Yttrium Microsphere Radioembolization in the Treatment of Primary and Metastatic Liver Tumors. US Gastroenterology. 2009; 4:36-38.


Chen CY, Nace GW, Solow B, Fratamico P. Complete nucleotide sequences of 84.5- and 3.2-kb plasmids in the multi-antibiotic resistant Salmonella enterica serovar Typhimurium U302 strain G8430. Plasmid. 2007 Jan;57(1):29-43. Epub 2006 Jul 7. PubMed PMID: 16828159.


Chen CY, Nace GW, Irwin PL. A 6 x 6 drop plate method for simultaneous colony counting and MPN enumeration of Campylobacter jejuni, Listeria monocytogenes, and Escherichia coli. J Microbiol Methods. 2003 Nov;55(2):475-9. PubMed PMID: 14529971.


Book Chapters


Nace GW, Nance ML. Trauma in Children; In: The Trauma Manual: Trauma and Acute Care Surgery. Peitzman AB, Yealy DM, Fabian TC, Schwab CW, Eds. Wolters Kluwer, 2020.

Boelig MM, Nace GW. Abdominal Pain, Vomiting, and Fever in a 3-Year-Old Female; In: Surgery Morning Report: Beyond the Pearls. Willams AD, Gefen JY, Mann BD Eds. Elsevier, 2020.


Leeper CM, Nace G, Scholz S. Gallbladder and Biliary Tract; In: Diagnostic and Interventional Ultrasound in Pediatrics and Pediatric Surgery. Scholz S & Jarboe M, Eds. Springer, 2015.

Awards and Honors

2018, Top Physicians, South Jersey Magazine

2011, “Best Poster” at 3rd International HMGB1 Conference, Pittsburgh, PA

2010, Association for Academic Surgery Foundation Fellowship Research Award

2007, W. Emory Burnett Prize in Surgery

2005, Augustin Peale Award for Excellence in Pathology

2004, Benjamin and Mary Siddons Measey Foundation Medical Student Scholarship

2004, John Franklin Huber Award in Anatomy