Gary W. Nace, Jr., MD, FACS, FAAP

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Gary W. Nace, Jr., MD, FACS, FAAP, is an attending pediatric surgeon with the Division of Pediatric General, Thoracic and Fetal Surgery, and the Trauma Center at Children's Hospital of Philadelphia.

Areas of Expertise: Minimally invasive surgery, Thoracic Surgery, Hirschsprung's disease and other anorectal malformations, Trauma surgery, Neonatal Surgery, Oncologic Surgery, Pediatric colorectal surgery, Inguinal and umbilical hernia repair, Chest wall deformities
Locations: Specialty Care, Princeton at Plainsboro; Main Hospital

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Temple University School of Medicine, Philadelphia, PA

Internship

General Surgery - University of Pittsburgh Medical Center, Pittsburgh, PA

Residency

General Surgery - University of Pittsburgh Medical Center, Pittsburgh, PA

Fellowship

Pediatric Surgery - Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA

Board Certification

General Surgery – American Board of Surgery
Pediatric Surgery – American Board of Surgery

Titles and Academic Titles

Attending Surgeon

Director, Pediatric Surgery Clerkship

Associate Director, Pediatric Trauma Program

Assistant Professor of Surgery, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Publications

Papers

2022

Hatchimonji JS, Luks VL, Swendiman RA, Allukian M 3rd, Nance ML, Nace GW Jr. Settling the Score: Injury Severity Score Fails to Capture Nuances in Pediatric Trauma. Pediatr Emerg Care. 2022 Feb 1;38(2):e828-e832. doi: 10.1097/PEC.0000000000002363. PMID: 35100783.

2021

Abramov A, Luks VL, De Bie F, Hwang R, Allukian M 3rd, Nace GW Jr. Pneumatosis intestinalis in children beyond the neonatal period: is it always benign? Pediatr Surg Int. 2021 Nov 27. doi: 10.1007/s00383-021-05048-0. Epub ahead of print. PMID: 34837497.

Toto R, Friedlaender EY, Nace GW, Arkader A, Levin LS. Arterial Fat Embolism in a Pediatric Patient with Femur Fracture: A Case Report. JBJS Case Connect. 2021 Jul 9;11(3). doi: 10.2106/JBJS.CC.20.00485. PMID: 34237039.

Swendiman RA, Abramov A, Fenton SJ, Russell KW, Nance ML, Nace GW Jr, Iii MA. Use of angioembolization in pediatric polytrauma patients: WITH BLUNT SPLENIC INJURY Angioembolization in Pediatric Blunt Splenic Injury. J Pediatr Surg. 2021 Apr 24:S0022-3468(21)00324-9. doi: 10.1016/j.jpedsurg.2021.04.014. Epub ahead of print. PMID: 34034882.

Swendiman RA, Goldshore MA, Allukian M 3rd, Nace GW Jr, Nance ML. In reply to "Abdominal angiography is associated with reduced in-hospital mortality among pediatric patients with blunt splenic and hepatic injury: A propensity-score-matching study from the national trauma registry in Japan". J Pediatr Surg. 2021 Mar 23:S0022-3468(21)00247-5. doi: 10.1016/j.jpedsurg.2021.03.014. Epub ahead of print. PMID: 33840501.

Kashyap MV, Reisen B, Hornick MA, Nace GW, Laje P: Same-day discharge after laparoscopic appendectomy for non-perforated appendicitis is safe and cost effective. Pediatric Surgery International Mar. 10 2021 (Epub) Notes: doi: 10.1007/s00383-021-04880-8.

Nace GW, Nance ML: Early cryoprecipitate use— Time to change our pediatric massive transfusion protocol? JAMA Surgery Feb. 17 2021 (Epub) Notes: doi: 10.1001/jamasurg.2020.7266.

2020

Swendiman RA, Luks VL, Hatchimonji JS, Nayyar MG, Goldshore MA, Nace GW Jr, Nance ML, Allukian M 3rd. Mortality After Adolescent Firearm Injury: Effect of Trauma Center Designation. J Adolesc Health. 2020 Oct 13:S1054-139X(20)30525-5. doi: 10.1016/j.jadohealth.2020.09.004. Epub ahead of print. PMID: 33067151.

Swendiman RA, Hatchimonji JS, Allukian M 3rd, Blinman TA, Nance ML, Nace GW. Pediatric firearm injuries: Anatomy of an epidemic [published online ahead of print, 2020 Apr 20]. Surgery. 2020;S0039-6060(20)30108-2. doi:10.1016/j.surg.2020.02.023

Hatchimonji JS, Swendiman RA, Goldshore MA, Blinman, TA, Nance ML, Allukian, M, Nace GW. Pediatric firearm mortality in the United States, 2010 to 2016: A National Trauma Data Bank analysis. J Trauma Acute Care Surg. 2020;88(3):402‐407. doi:10.1097/TA.0000000000002573

2016

De La Torre L, Cogley K, Calisto J, Nace G, Correa C. Primary sigmoidectomy and appendicostomy for chronic idiopathic constipation. Pediatr Surg Int. 2016 Aug;32(8):767- 72. Pubmed PMID: 27372298.

2015

Leeper CM, Nace G, Scholz S. Gallbladder and Biliary Tract; In: Diagnostic and Interventional Ultrasound in Pediatrics and Pediatric Surgery. Scholz S & Jarboe M, Eds. Springer, 2015.

2014

Tohme S, Sukato D, Nace GW, Zajko A, Amesur N, Orons P, Chalhoub D, Marsh JW,Geller DA, Tsung A. Survival and tolerability of liver radioembolization: a comparison of elderly and younger patients with metastatic colorectal cancer. HPB (Oxford). 2014 Dec;16(12):1110-6. PubMed PMID: 25123597.

2013

Huang H*, Nace GW*, McDonald KA, Tai S, Klune JR, Rosborough BR, Ding Q, Loughran P, Zhu X, Beer-Stolz D, Chang EB, Billiar T, Tsung A. Hepatocyte specific HMGB1 deletion worsens the injury in liver ischemia/reperfusion: A role for intracellular HMGB1 in cellular protection. Hepatology. 2013 Dec 21. [Epub ahead of print] PubMed PMID: 24375466.

Huang H, Chen HW, Evankovich J, Yan W, Rosborough BR, Nace GW, Ding Q, Loughran P, Beer-Stolz D, Billiar TR, Esmon CT, Tsung A. Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury. J Immunol. 2013 Sep 1;191(5):2665-79. PubMed PMID: 23904166.

Nace GW, Huang H, Klune JR, Eid RE, Rosborough BR, Korff S, Li S, Shapiro RA, Stolz DB, Sodhi CP, Hackam DJ, Geller DA, Billiar TR, Tsung A. Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice. Hepatology. 2013 Jul;58(1):374-87. doi: 10.1002/hep.26346. Epub 2013 May 27. PubMed PMID: 23460269; PubMed Central PMCID: PMC3688695.

Tsung A, Nace GW, Geller DA. Pituitary adenylate cyclase-activating polypeptide: a neuromodulator of hepatic ischemia-reperfusion injury? Hepatology. 2013 Mar;57(3):878- 80. doi: 10.1002/hep.25902. PubMed PMID: 22729815.

2012

Chang Y, Yan W, He X, Zhang L, Li C, Huang H, Nace G, Geller DA, Lin J, Tsung A. miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions. Gastroenterology. 2012 Jul;143(1):177-87.e8. doi: 10.1053/j.gastro.2012.04.009. Epub 2012 Apr 12. PubMed PMID: 22504094.

Klune JR, Dhupar R, Kimura S, Ueki S, Cardinal J, Nakao A, Nace G, Evankovich J, Murase N, Tsung A, Geller DA. Interferon regulatory factor-2 is protective against hepatic ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 1;303(5):G666-73. doi: 10.1152/ajpgi.00050.2012. Epub 2012 Jun 28. PubMed PMID: 22744333; PubMed Central PMCID: PMC3468551.

Zhang L, Cardinal JS, Bahar R, Evankovich J, Huang H, Nace G, Billiar TR, Rosengart MR, Pan P, Tsung A. Interferon regulatory factor-1 regulates the autophagic response in LPS-stimulated macrophages through nitric oxide. Mol Med. 2012 Mar 27;18(1):201-8. doi: 10.2119/molmed.2011.00282. PubMed PMID: 22105605; PubMed Central PMCID: PMC3320143.

2011

Nace G, Evankovich J, Eid R, Tsung A. Dendritic cells and damage-associated molecular patterns: endogenous danger signals linking innate and adaptive immunity. J Innate Immun. 2012;4(1):6-15. Epub 2011 Nov 11. Review. PubMed PMID: 22086146.

Huang H, Evankovich J, Yan W, Nace G, Zhang L, Ross M, Liao X, Billiar T, Xu J, Esmon CT, Tsung A. Endogenous histones function as alarms in in sterile inflammatory liver injury through Toll-like receptor 9 in mice. Hepatology. 2011 Sep 2;54(3):999-1008. doi: 10.1002/hep.24501. PubMed PMID: 21721026; PubMed Central PMCID: PMC3213322

Nace GW, Steel JL, Amesur N, Zajko A, Nastasi BE, Joyce J, Sheetz M, Gamblin TC. Yttrium-90 radioembolization for colorectal cancer liver metastases: a single institution experience. Int J Surg Oncol. 2011;2011:571261. Epub 2011 Mar 20. PubMed PMID: 22312513; PubMed Central PMCID: PMC3263679.

2010

Nace G, Lee K, Bartels C. Endocrine Pancreas; In: Surgical Oncology: Fundamentals, Evidence Based Approaches and New Technologies. Bartlett D, Ed. Jaypee Brothers medical publishers, 2010.

2009

Nace, Gary and Gamblin, Clark. 90-Yttrium Microsphere Radioembolization in the Treatment of Primary and Metastatic Liver Tumors. US Gastroenterology. 2009; 4:36-38.

2007

Chen CY, Nace GW, Solow B, Fratamico P. Complete nucleotide sequences of 84.5- and 3.2-kb plasmids in the multi-antibiotic resistant Salmonella enterica serovar Typhimurium U302 strain G8430. Plasmid. 2007 Jan;57(1):29-43. Epub 2006 Jul 7. PubMed PMID: 16828159.

2003

Chen CY, Nace GW, Irwin PL. A 6 x 6 drop plate method for simultaneous colony counting and MPN enumeration of Campylobacter jejuni, Listeria monocytogenes, and Escherichia coli. J Microbiol Methods. 2003 Nov;55(2):475-9. PubMed PMID: 14529971.

Abstracts

2021

Nace GW. Pediatric Trauma Society 7th Annual Meeting – Disparities in Isolated, Serious, Blunt Splenic Injury Outcomes for Pediatric Patients. Nov 2021.

Nace GW. 2021 ACS Quality and Safety Conference - An Expedited Feeding Protocol Safely Reduces Length of Stay after Gastrostomy Tube Insertion: A QI Initiative. July 2021.

2020

Nace GW. Pediatric Trauma Society 6th Annual Meeting – The Clinical Significance of Firearm-related Extremity Injuries in Pediatric Patients. Nov 2020.

Nace GW. Pediatric Trauma Society 6th Annual Meeting – Settling the Score: Mortality Differences in Pediatric and Adult Trauma Relative to Injury Severity Score. Nov 2020.

Nace GW. American College of Surgeons Clinical Congress – Management of Pneumatosis Intestinalis Beyond the Neonatal Period. Oct 2020.

Books

Book Chapters

2020

Nace GW, Nance ML. Trauma in Children; In: The Trauma Manual: Trauma and Acute Care Surgery. Peitzman AB, Yealy DM, Fabian TC, Schwab CW, Eds. Wolters Kluwer, 2020.

Boelig MM, Nace GW. Abdominal Pain, Vomiting, and Fever in a 3-Year-Old Female; In: Surgery Morning Report: Beyond the Pearls. Willams AD, Gefen JY, Mann BD Eds. Elsevier, 2020.

2015

Leeper CM, Nace G, Scholz S. Gallbladder and Biliary Tract; In: Diagnostic and Interventional Ultrasound in Pediatrics and Pediatric Surgery. Scholz S & Jarboe M, Eds. Springer, 2015.

Awards and Honors

2018, 2020, Top Physicians, South Jersey Magazine

2011, “Best Poster” at 3rd International HMGB1 Conference, Pittsburgh, PA

2010, Association for Academic Surgery Foundation Fellowship Research Award

2007, W. Emory Burnett Prize in Surgery

2005, Augustin Peale Award for Excellence in Pathology

2004, Benjamin and Mary Siddons Measey Foundation Medical Student Scholarship

2004, John Franklin Huber Award in Anatomy

Editorial and Academic Positions

Editorial Positions

2020-present, Journal of Trauma and Acute Care Surgery, Ad hoc reviewer

2020-present, Journal of Surgical Research, Ad hoc reviewer

2019-present, Journal of Pediatric Surgery, Ad hoc reviewer

2018-present, Pediatric Emergency Care, Ad hoc reviewer

Leadership and Memberships

Memberships in Professional Organizations

American College of Surgeons, Fellow
American Academy of Pediatrics, Fellow
 - 2021-present, Delivery of Surgical Care Committee
Pediatric Trauma Society
 - 2021-present, Educational Committee
 - 2020-present, Injury Prevention Committee
 - 2020-present, Guidelines Committee
American Pediatric Surgical Association
 - 2020-present, Quality & Safety Committee
Association for Academic Surgery
Alpha Omega Alpha, Honor Medical Society