Emily A. Partridge, MD, PhD, MHS

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Emily A. Partridge, MD, PhD, MHS, is an attending pediatric surgeon with the Division of Pediatric General, Thoracic and Fetal Surgery at Children’s Hospital of Philadelphia.

Areas of Expertise: General and Thoracic Surgery, Neonatal Surgery, Minimally invasive surgery, Congenital diaphragmatic hernia (CDH), Extracorporeal membrane oxygenation (ECMO), Critical Care
Locations: Main Campus

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - University of Toronto, Faculty of Medicine, Toronto, Ontario, Canada

Residency

General Surgery - University of Toronto, Department of General Surgery, Toronto, Ontario, Canada

Fellowship

Pediatric Surgery - The Children's Hospital of Philadelphia, Division of General, Thoracic & Fetal Surgery, Philadelphia, PA
Postdoctoral Research Fellow - The Children's Hospital of Philadelphia, Philadelphia, PA

Graduate Degree

PhD in Philosophy - University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Ontario, Canada
MHS - University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Ontario, Canada

Titles and Academic Titles

Attending Pediatric Surgeon

Assistant Professor of Surgery, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2019

Lawrence KM, Berger K, Herkert L, Franciscovich C, O'Dea CLH, Waqar LN, Partridge E, Hanna BD, Peranteau WH, Avitabile CM, Hopper RK, Rintoul NE, Hedrick HL: Use of prostaglandin E1 to treat pulmonary hypertension in congenital diaphragmatic hernia. Journal of Pediatric Surgery 54(1): 55-59, Jan. 2019 Notes: Epub Oct. 5, 2018.

Mejaddam AY, Hornick MA, McGovern PE, Baumgarten HD, Lawrence KM, Rossidis AC, Hwang G, Young K, Abdulmalik O, Partridge EA, Peranteau WH, Davey MG, Flake AW: Erythropoietin prevents anemia and transfusions in extremely premature lambs supported by an EXTrauterine Environment for Neonatal Development (EXTEND). Fetal Diagnosis & Therapy Page: 1-7, Jan. 31 2019 (Epub) Notes: doi: 10.1159/000493680.

2018

Victoria T, Danzer E, Oliver ER, Edgar JC, Iyoob S, Partridge EA, Johnson AM, Peranteau WH, Coleman BG, Flake AW, Johnson MP, Hedrick HH, Adzick NS.: Right congenital diaphragmatic hernias: Is there a correlation between prenatal lung volume and postnatal survival, as in isolated left diaphragmatic hernias? Fetal Diagnosis & Therapy  43(1): 12-18  2018 Notes: Epub Mar. 21, 2017.

Partridge EA, Davey MG, Hornick M, Dysart KC, Olive A, Caskey R, Connelly JT, Hedrick HL, Peranteau WH, Flake AW: Pumpless arterio-venous extracorporeal membrane oxygenation: A novel mode of respiratory support in a lamb model of congenital diaphragmatic hernia. Journal of Pediatric Surgery 53(8): 1453-1460, Aug. 2018 Notes: Epub Mar. 9, 2018.

Hornick MA, Davey MG, Partridge EA, Medaddam AY, McGovern PE, Olive AM, Hwang G, Kim J, Castillo O, Young K, Han J, Zhao S, Connelly JT, Dysart KC, Rychik J, Peranteau WH, Flake AW: Umbilical cannulation optimizes circuit flows in premature lambs supported by the EXTra-uterine Environment for Neonatal Development (EXTEND). Journal of Physiology 596(9): 1575-1585, May 1 2018 Notes: Epub Mar. 2, 2018.

2017

Partridge EA, Davey MG, Hornick MA, Peranteau WH, Dysart KC, Flake AF: Pumpless extracorporeal support of the preterm infant: Bridging fetal and postnatal physiology. NeoReviews 18(5): 2-17, 2017.

Partridge EA, Davey MG, Hornick MA, Vrecenak JD, Mesas-Burgos C, Olive A, Caskey RC, Weiland TR, Jiancheng H, Connelly JT, Dysart KC, Rychik J, Hedrick HL, Peranteau WH, Flake AW: An extra-uterine system to physiologically support the extreme premature lamb. Nature Communications 8: 15112, Apr. 25 2017 Notes: Corrigendum published: Nature Communications 8:15794, May 23, 2017 (PMID 28534492).

Davey MG, Riley JS, Andrews A, Tyminski A, Limberis M, Pogoriler JE, Partridge E, Olive A, Hedrick HL, Flake AW, Peranteau WH: Induction of immune tolerance to foreign protein via adeno-associated viral vector gene transfer in mid-gestation fetal sheep. PLOS One 12(1): e0171132, Jan. 31 2017.

2016

Partridge EA, Peranteau WH, Herkert L, Rendon N, Smith H, Rintoul NE, Flake AW, Adzick NS, Hedrick HL: Right- versus left-sided congenital diaphragmatic hernia: A comparative outcomes analysis. Journal of Pediatric Surgery 51(6): 900-902, June 2016 Notes: Epub Mar. 3, 2016.

Partridge EA, Peranteau WH, Herkert L, Rintoul NE, Flake AW, Adzick NS, Hedrick HL: Rate of increase of lung-to-head ratio over the course of gestation is predictive of survival in congenital diaphragmatic hernia. Journal of Pediatric Surgery 51(5): 703-705, May 2016 Notes: Epub Feb. 11, 2016.

2015

Partridge EA, Peranteau WH, Flake AW, Adzick NS, Hedrick HL: Frequency and complications of inguinal hernia repair in giant omphalocele. Journal of Pediatric Surgery 50(10): 1673-1675, Oct. 2015 Notes: Epub May 29, 2015.

Peranteau WH, Tharakan SJ, Partridge EA, Herkert L, Rintoul NE, Flake AW, Adzick NS, Hedrick HL: Systemic hypertension in giant omphalocele: an underappreciated association. Journal of Pediatric Surgery 50(9): 1477-1480, Sept. 2015 Notes: Epub Feb. 23, 2015.

2014

Partridge EA, Peranteau WH, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL: Timing of repair of congenital diaphragmatic hernia in patients supported by extracorporeal membrane oxygenation (ECMO). Journal of Pediatric Surgery 50(2): 260-262, Feb. 2015 Notes: Epub Nov. 7, 2014.

Partridge EA, Hanna BD, Rintoul NE, Herkert L, Alan W. Flake AW, N. Scott Adzick NS, Hedrick HL, Peranteau WH: Brain-type natriuretic peptide levels correlate with pulmonary hypertension and requirement for extracorporeal membrane oxygenation in congenital diaphragmatic hernia. Journal of Pediatric Surgery 50(2): 263-266, Feb. 2015 Notes: Epub Nov. 7, 2014.

Partridge EA, Hanna BD, Panitch HB, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL: Pulmonary hypertension in giant omphalocele infants. Journal of Pediatric Surgery 49(12): 1767-1770, Dec. 2014 Notes: Epub Nov. 14, 2014.

Partridge EA, Bridge C, Donaher JG, Herkert LM, Grill E, Danzer E, Gerdes M, Hoffman CH, D'Agostino JA, Bernbaum JC, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL: Incidence and factors associated with sensorineural and conductive hearing loss among survivors of congenital diaphragmatic hernia. Journal of Pediatric Surgery 49(6): 890-894, June 2014 Notes: Epub Jan. 31, 2014.

2013

Partridge EA, Canning D, Long C, Peranteau WH, Hedrick HL, Adzick NS, Flake AW: Urologic and anorectal complications of sacrococcygeal teratomas: Prenatal and postnatal predictors. Journal of Pediatric Surgery 49(1): 139-142, Jan.  2014 Notes: Epub Oct. 8, 2013.

Danzer E, Gerdes M, D'Agostino JA, Partridge EA, Hoffman-Craven CH, Bernbaum J, Rintoul NE, Flake AW, Adzick NS, Hedrick HL: Preschool neurological assessment in congenital diaphragmatic hernia survivors: Outcome and perinatal factors associated with neurodevelopmental impairment. Early Human Development 89(6): 393-400, June  2013 Notes: Epub Jan. 17, 2013.

2007

Mendelsohn R, Cheung P, Berger L, Partridge E, Lau K, Datti A, Pawling J, Dennis JW: Complex N-glycan and metabolic control in tumour cells. Cancer Research 67(20): 9771-9780, Oct. 15 2007.

Lajoie P, Partridge EA, Guay G, Goetz JG, Pawling J, Lagana A, Joshi B, Dennis JW, Nabi IR: Plasma membrane domain organization regulates EGFR signaling in tumour cells. Journal of Cell Biology 179(2): 341-356, Oct. 22 2007 Notes: Epub Oct. 15, 2007.

Cheung P, Pawling J, Partridge EA, Sukhu B, Grynpas M, Dennis JW: Metabolic homeostasis and tissue renewal are dependent on beta-1,6GlcNAc-branched N-glycans. Glycobiology 17(8): 828-837, Aug. 2007 Notes: Epub May 4, 2007.

Lau K, Partridge EA, Grigorian A, Silvescu C, Reinhold VN, Demitriou M,  Dennis JW: Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. Cell 129(1): 123-134, Apr. 6 2007.

2006

Park HJ, Partridge E, Cheung P, Pawling J, Donovan R, Wrana JL, Dennis JW: Chemical enhancers of cytokine signaling that suppress microfilament turnover and tumour cell growth. Cancer Research 66(7): 3558-3566, Apr. 1 2006.

2005

Rittenberg B, Partridge E, Baker G, Clokie C, Zohar R, Dennis JW, Tenenbaum HC: Regulation of BMP-induced ectopic bone formation by Ahsg. Journal of Orthopaedic Research 23(3): 653-662, May 2005.

2004

Partridge EA, Le Roy C, Di Guglielmo GM, Pawling J, Cheung P, Granovsky M, Nabi IR, Wrana JL, Dennis JW: Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science 306(5693): 120-124, Oct. 1 2004.

Swallow CJ, Partridge EA, Macmillan JC, Tajirian T, DiGuglielmo GM, Hay K, Szweras M, Jahnen-Dechent W, Wrana JL, Redston M, Gallinger S, Dennis JW: α2HS-glycoprotein, an antagonist of transforming growth factor beta in vivo, inhibits intestinal tumor progression. Cancer Research 64(18): 6402-6409, Sept. 15 2004.

2002

Szweras M, Liu D, Partridge EA, Pawling J, Sukhu B, Clokie C, Jahnen-Dechent W, Tenenbaum HC, Swallow CJ, Grynpas MD, Dennis JW: α2HS-glycoprotein, a TGF-beta-BMP-binding protein, regulates postnatal bone growth and remodeling. Journal of Biological Chemistry 277(22): 19991-19997, May 31 2002 Notes: Epub Mar. 18, 2002.

1999

Fusé M, Zhang JR, Partridge E, Nachman RJ, Orchard I, Bendena WG, Tobe SS: Effects of an allatostatin and a myosuppressin on midgut carbohydrate enzyme activity in the cockroach Diploptera punctata. Peptides 20(11): 1285-1293, Nov. 1999.

Books

Chapters

2019

Partridge EA, Flake AW: Fetal surgery. Operative Pediatric Surgery, 8th Edition. Davenport M, Geiger JD (eds.). Boca Raton, FL: CRC Press, 2019.

Posters and Presentations

Invited Lectures

2019

Partridge EA. Development of the Artificial Womb—Challenges and Milestones. 37th Symposium on Perinatology, February 8 to 9, 2019, at the Osaka International Conference Center in Osaka, Japan.

2018

Partridge EA. Development of the Artificial Womb—Challenges, Progress and Clinical Applications.  SSR Annual Meeting - New Orleans, July 10-13, 2018

Editorial and Academic Positions

Editorial Positions

2016-present, Manuscript Reviewer, Journal of Pediatric Surgery