Melanie A. Ruffner, MD, PhD, FAAAAI, FACAAI

2026

Anvari S, Baker MG, Bingemann T, Bird JA, Brown-Whitehorn T, Cianferoni A, Durban R, Gupta M, Hosein E, Konstantinou G, Leonard S, Ruffner MA, Schaible A, Scurlock AM, Varshney P, Muraro A, Fiocchi A, Santos AF, Arasi S, Vazquez-Ortiz M, Morita H, Nomura I, Upton JEM, Levin M, Lee E, Galvan C, Hoyos-Bachiloglu R, Chatchatee P, Beyer K, du Toit G, Gonzalez-Delgado P, Wong LSY, Groetch M, Nowak-Wegrzyn A. Age-Appropriate Low Dosing for FPIES Oral Food Challenges: Proposing a Standardized Approach. J Allergy Clin Immunol Pract. 2026 Apr 16:S2213-2198(26)00321-1. doi: 10.1016/j.jaip.2026.03.035. Epub ahead of print. PMID: 41999915.

Gautam R, Lal M, Carroll MC, Mrozek Z, Trachsel T, Beers J, Ruffner MA. Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils. Pediatr Allergy Immunol. 2026 Mar;37(3):e70315. doi: 10.1111/pai.70315. PMID: 41760554; PMCID: PMC12948656.

Lal M, Burk CM, Gautam R, Mrozek Z, Canziani KE, Trachsel T, Beers J, Carroll MC, Morgan DM, Muir AB, Shreffler WG, Ruffner MA. Interferon-γ Signaling in Eosinophilic Esophagitis Affects Epithelial Barrier Function and Programmed Cell Death. Cell Mol Gastroenterol Hepatol. 2025;19(5):101466. doi: 10.1016/j.jcmgh.2025.101466. Epub 2025 Jan 28. PMID: 39884574; PMCID: PMC11964763.

2024

Ruffner MA, Shoda T, Lal M, Mrozek Z, Muir AB, Spergel JM, Dellon ES, Rothenberg ME. Persistent esophageal changes after histologic remission in eosinophilic esophagitis. J Allergy Clin Immunol. 2024 Apr;153(4):1063-1072. doi: 10.1016/j.jaci.2023.12.012. Epub 2023 Dec 27. PMID: 38154664; PMCID: PMC11151730.

Anvari S, Ruffner MA, Bingemann T, Bird JA, Nowak-Węgrzyn A. Allergist-reported diagnosis and management of adult food protein-induced enterocolitis syndrome. Ann Allergy Asthma Immunol. 2024 Mar;132(3):393-395. doi: 10.1016/j.anai.2023.11.013. Epub 2023 Nov 19. PMID: 37984708.

2022

Tran P, Gober L, Garabedian EK, Fuleihan RL, Puck JM, Sullivan KE, Spergel JM, Ruffner MA. Eosinophilic gastrointestinal disorders in patients with inborn errors of immunity: Data from the USIDNET registry. Front Immunol. 2022 Sep 23;13:987895. doi: 10.3389/fimmu.2022.987895. PMID: 36211419; PMCID: PMC9539548.

Ruffner MA, Cotton CC, Dellon ES. Posttreatment Gene Scores Support Histologic and Endoscopic Response Thresholds in Eosinophilic Esophagitis. Am J Gastroenterol. 2022 Sep 1;117(9):1519-1522. doi: 10.14309/ajg.0000000000001802. Epub 2022 Apr 26. PMID: 35470295; PMCID: PMC9437112.

Spergel BL, Ruffner MA, Godwin BC, Liacouras CA, Cianferoni A, Gober L, Hill DA, Brown-Whitehorn TF, Chaiboonma K, Aceves SA, Muir AM, Spergel JM. Improvement in eosinophilic esophagitis when using dupilumab for other indications or compassionate use. Ann Allergy Asthma Immunol. 2022 May;128(5):589-593. doi: 10.1016/j.anai.2022.01.019. Epub 2022 Jan 25. PMID: 35085819.

2021

Ruffner MA, Zhang Z, Maurer K, Muir AB, Cianferoni A, Sullivan KE, Spergel JM. RNA sequencing identifies global transcriptional changes in peripheral CD4+ cells during active oesophagitis and following epicutaneous immunotherapy in eosinophilic oesophagitis. Clin Transl Immunology. 2021 Jul 22;10(7):e1314. doi: 10.1002/cti2.1314. PMID: 34322233; PMCID: PMC8296633.

Ruffner MA, Hu A, Dilollo J, Benocek K, Shows D, Gluck M, Spergel JM, Ziegler SF, Hill DA, Cerosaletti K. Conserved IFN Signature between Adult and Pediatric Eosinophilic Esophagitis. J Immunol. 2021 Mar 15;206(6):1361-1371. doi: 10.4049/jimmunol.2000973. Epub 2021 Feb 8. PMID: 33558373; PMCID: PMC7946729.

2020

Ruffner MA, Wang KY, Dudley JW, Cianferoni A, Grundmeier RW, Spergel JM, Brown-Whitehorn TF, Hill DA. Elevated Atopic Comorbidity in Patients with Food Protein-Induced Enterocolitis. J Allergy Clin Immunol Pract. 2020 Mar;8(3):1039-1046. doi: 10.1016/j.jaip.2019.10.047. Epub 2019 Nov 20. PMID: 31759160; PMCID: PMC7064432.

2018

Godwin B, Liacouras C, Mehta V, Eisenberg J, Agawu A, Brown-Whitehorn TF, Ruffner MA Verma R, Cianferoni A, Spergel JM, Muir AB: A Review of Tertiary Referrals for Management of Pediatric Esophageal Eosinophilia Frontiers Pediatrics June 2018 Notes: https://doi.org/10.3389/fped.2018.00173.

Ruffner Melanie A, USIDNET Body Weight Group, Sullivan Kathleen E: Complications associated with underweight primary immunodeficiency patients: prevalence and associations within the USIDNET Registry Journal of Clinical Immunology 38(3): 283-293, April 2018.

Fahey Lisa, Guzek Ryan, Ruffner Melanie, Sullivan Kathleen, Spergel Jonathan, Cianferoni Antonella: EMSY is Increased and Activates TSLP & CCL5 Expression in Eosinophilic Esophagitis. Pediatric Allergy and Immunology April 2018.

Cianferoni Antonella, Ruffner Melanie A, Guzek Ryan, Guan Shabao, Brown-Whitehorn Terri, Spergel Jonathan M: Activated Th2 cells and milk-specific Th2 cells are increased in milk-induced eosinophilic esophagitis. Annals of Allergy, Asthma & Immunology 120(2): 177-183.e2, February 2018. PMCID: PMC5875940

Crowley Terrence B, Ruffner Melanie A, McDonald-McGinn Donna M, Sullivan Kathleen E: Variable immune deficiency related to deletion size in chromosome 22q11.2 deletion syndrome. American Journal of Medical Genetics, Part A January 2018 Notes: https://doi.org/10.1002/ajmg.a.38597.

2017

Ruffner MA, Aksamit TR, Thomashow B, Choate R, DiMango A, Turino GM, O'Donnell AE, Johnson MM, Olivier KN, Fennelly K, Daley CL, Winthrop KL, Metersky ML, Salathe MA, Knowles MR, Daniels MLA, Noone PG, Tino G, Griffith DE, Sullivan KE.: Frequency of untreated hypogammaglobulinemia in bronchiectasis. Ann Allergy Asthma Immunol May 2017.

Ruffner Melanie A, Brown-Whitehorn Terri F, Verma Ritu, Cianferoni Antonella, Gober Laura, Shuker Michele, Muir Amanda B, Liacouras Chris A, Spergel Jonathan M: Clinical tolerance in eosinophilic esophagitis. The Journal of Allergy and Clinical Immunology: In Practice 6(2): 661-3, March 2017.

2013

Ruffner Melanie A, Ruymann Kathryn, Barni Simona, Cianferoni Antonella, Brown-Whitehorn Terri, Spergel Jonathan M: Food protein-induced enterocolitis syndrome: insights from review of a large referral population. The Journal of Allergy and Clinical Immunology. In practice 1(4): 343-9, Jul-Aug 2013.

2012

Yang Chenjie, Ruffner Melanie A, Kim Seon-Hee, Robbins Paul D: Plasma-derived MHC class II+ exosomes from tumor-bearing mice suppress tumor antigen-specific immune responses. European journal of immunology 42(7): 1778-84, Jul 2012. PMCID: PMC3471134

2011

Ruffner Melanie A, Finegold David N, MacGinnitie Andrew J: Infant with unusual food reactions. Acta paediatrica (Oslo, Norway : 1992) 100(10): 1289, 1394-5, Oct 2011.

2010

Ruffner Melanie A, Robbins Paul D: Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice. PloS one 5(7): e11848, Jul 2010. PMCID: PMC2912295

2009

Ruffner Melanie A, Kim Seon Hee, Bianco Nicole R, Francisco Loise M, Sharpe Arlene H, Robbins Paul D: B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function. European journal of immunology 39(11): 3084-90, Nov 2009. PMCID: PMC3075967

Bianco Nicole R, Kim Seon Hee, Ruffner Melanie A, Robbins Paul D: Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models. Arthritis and rheumatism 60(2): 380-9, Feb 2009. PMCID: PMC3491653

2003

Kim T-K, Sharma B, Williams C G, Ruffner M A, Malik A, McFarland E G, Elisseeff J H: Experimental model for cartilage tissue engineering to regenerate the zonal organization of articular cartilage. Osteoarthritis and cartilage 11(9): 653-64, Sep 2003.

2018

Ruffner MA and Brown-Whitehorn TF: "A 5-month old with vomiting, lethargy, and pallor" Pediatric Allergy and Clinical Immunology. Nima Rezaei (eds.). Springer, 2018.

2010

Ruffner MA, Plevy SE, Cheung AT: "Applications of Nucleotide-based Therapy in the Treatment of Inflammatory Bowel Disease." Gene Therapy for Autoimmune and Inflammatory Diseases Y. Chernajovsky and P. Robbins (eds.). Basel, Switzerland: Birkhäuser Verlag AG, Page: 19-34, 2010.

Gaddy DF, Ruffner MA, and Robbins PD: "Autoimmune disorders" A Guide to Human Gene Therapy. R. Herzog and S. Zolotukhin (eds.). New Jersey, USA: World Scientific, Page: 295-308, 2010.

2006

Elisseeff J, Ruffner MA, Kim TK, Williams CG. : "Cellular Photoencapsulation in Hydrogels" Culture of Cells for Tissue Engineering I. Freshney and G. Vunjak-Novakovic (eds.). New Jersey, USA: John Wiley & Sons, Page: 214-236, 2006.