CHOP Researchers Develop Allogeneic CART for Relapsed or Refractory T-ALL Using Base Editing
Published on in CHOP News
CHOP researchers have tested and developed an “off-the-shelf” chimeric antigen receptor T-cell (CART) using base editing.
Cell and Gene Therapy Collaborative News and Updates
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Children’s Hospital of Philadelphia Awards Gold Medal to Dr. Katherine High, Gene Therapy Pioneer
Published on in CHOP News
Prestigious award recognizes Dr. High’s contribution to improving children’s health through her gene therapy research, which began during her time at CHOP.
Emily Whitehead, First Pediatric Patient to Receive CAR T-Cell Therapy, Celebrates Cure 10 Years Later
Whitehead received life-saving treatment at CHOP, under the care of Dr. Stephan Grupp, transforming the field of cancer immunotherapy.
Read moreFirst Child to Receive Revolutionary CAR T Therapy Celebrates 10 Years Cancer Free
Published on in CHOP News
Emily Whitehead, now 17, received life-saving treatment at CHOP, transforming the field of cancer immunotherapy.
CHOP Brings Together Experts to Discuss Precision Medicine in Pediatric Cancer Care
Published on in CHOP News
More than 250 experts gathered in Philadelphia and virtually to discuss the latest scientific advancements and breakthroughs in pediatric precision medicine oncology.
CHOP/Penn Study Shows CAR-T Cells Remain Active a Decade After Infusion
Published on in CHOP News
A new study in Nature has documented the longest persistence of CAR T cell therapy to date.
Aberrant Splicing of CD22 in Acute Lymphoblastic Leukemia Underlies Resistance to Immunotherapy
Published on in CHOP News
Aberrant splicing leads to downregulation of CD22 in pediatric B-ALL, rendering malignant cells resistant to the effects of CD22-directed immunotherapies.
Study Finds Sequencing Bone Marrow DNA after CAR-T Can Accurately and Sensitively Predict Leukemia Relapse
Published on in CHOP News
A new study involving CHOP researchers shows next-generation DNA sequencing can predict which patients with ALL treated with CAR T therapy will relapse.
CHOP-led Study Shows Novel Gene Therapy for Hemophilia A Leads to Sustained Expression of Clotting Factor and Reduced Bleeding Events
Published on in CHOP News
Results from multicenter study are first to show improved production of coagulation factor VIII over prolonged period, leading to reduction or complete elimination of bleeding events.
CHOP Researchers Develop a New Class of CAR-T Cells that Target Previously Untargetable Cancer Drivers
Published on in CHOP News
CHOP researchers have developed a novel cancer therapy that targets proteins inside cancer cells that are essential for tumor growth and survival but have been historically impossible to reach.