Dr. Aplenc's primary focus is on the treatment of pediatric acute myelogenous leukemia (AML). One of Dr. Aplenc's first patients had acute myeloid leukemia (AML). His experience caring for her changed the path of his career.
Areas of Expertise:
Acute myeloid leukemia, Novel therapies, Leukemia Locations:Main Hospital
Dr. Richard Aplenc is a Professor of Pediatrics in the Department of Pediatrics and a core faculty member of the Center for Pediatric Clinical Effectiveness at CHOP. He holds the Mai and Harry F. West Endowed Chair in Pediatric Research. Dr. Aplenc’s research focuses on improving the outcomes of children with cancer, particularly acute myeloid leukemia (AML.) His work involves the treatment of AML in children and the use of genetic data to predict treatment response to therapeutic interventions. Dr. Aplenc has NIH funded research efforts in pediatric AML focused on determining the genetic predictors of treatment response (specifically relapse and infection risk) and using administrative/billing data to augment NCI funded cooperative oncology group clinical trials. He is currently leading a genome-wide genotyping effort to discover genetic variations that change the risks of relapse, life-threatening infections, and heart complications in children treated for AML. He also leads several efforts to use administrative data sets to improve the care of children with AML, particularly focusing on antibiotic and intensive care use.
Dr. Aplenc leads a large, Phase III trial for children with acute myeloid leukemia in the Children’s Oncology Group and serves as the Vice-Chair of the COG AML Committee. In addition to this work, Dr. Aplenc also leads Phase I trials for children whose cancers have not responded to standard therapy. These trials include gemtuzumab, dasatinib and obatoclax. He is the Primary Investigator at Children’s Hospital of Philadelphia for multiple Phase I trials that are offered through the Children’s Oncology Group and he helps lead the Hematologic Malignancies Program and Experimental Therapeutics Program here at CHOP.
The Children's Hospital of Philadelphia has a long tradition of embracing the total care of patients and their families. Every child receiving complex cancer therapy needs the expertise of more than one provider. That is why Dr. Aplenc works with other CHOP physicians, nurses and social workers to provide a team approach to total care. This kind of collaboration with the family and patient helps provide the best, most modern and sophisticated care — not only nationally, but in the world.
Education and Training
University of Virginia School of Medicine (MD)
Pediatric Hematology-Oncology – American Board of Pediatrics
University of California, San Diego. Calif.
Master of Science in Clinical Epidemiology, University of Pennsylvania (MS)
The Children's Hospital of Philadelphia, Philadelphia, Pa.
Titles and Academic Titles
Assistant Vice President and Chief Clinical Research Officer
Mai and Harry F. West Endowed Chair in Pediatric Research
Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Bride KL, Vincent TL, Im SY, Aplenc R, Barrett DM, Carroll WL, Carson R, Dai Y, Devidas M, Dunsmore KP, Fuller T, Glisovic-Aplenc T, Horton TM, Hunger SP, Loh ML, Maude SL, Raetz EA, Winter SS, Grupp SA, Hermiston ML, Wood BL, Teachey DT. Preclinical efficacy of daratumumab in T-cell acute lymphoblastic leukemia. Blood. 2018 Mar 1;131(9):995-999. doi: 10.1182/blood-2017-07-794214. Epub 2018 Jan 5.
Vujkovic M, Attiyeh EF, Ries RE, Goodman EK, Ding Y, Kavcic M, Alonzo TA, Wang YC, Gerbing RB, Sung L, Hirsch B, Raimondi S, Gamis AS, Meshinchi S, Aplenc R. Genomic architecture and treatment outcome in pediatric acute myeloid leukemia: a Children’s Oncology Group report. Blood. 2017;129(23):3051-3058.
Maude SL, Fitzgerald JC, Fisher BT, Li Y, Huang YS, Torp K, Seif AE, Kavcic M, Walker DM, Leckerman KH, Kilbaugh TJ, Rheingold SR, Sung L, Zaoutis TE, Berg RA, Nadkarni VM, Thomas NJ, Aplenc R. Outcome of pediatric acute myeloid leukemia patients receiving intensive care in the United States. Pediatr Crit Care Med. 2014 Feb;15(2):112-20.http://www.ncbi.nlm.nih.gov/pubmed/24366507
Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy. Teachey DT, Rheingold SR, Maude SL, Zugmaier G, Barrett DM, Seif AE, Nichols KE, Suppa EK, Kalos M, Berg RA, Fitzgerald JC, Aplenc R, Gore L, Grupp SA. Blood. 2013 Jun 27;121(26):5154-7.
2022, Philadelphia Magazine's Top Doctors in Pediatric Hematology-Oncology
Editorial and Academic Positions
2009-present, Biology of Blood and Marrow Transplantation
2009-present, Journal of the American Medical Association
2007-present, People Living With Cancer (PLWC.org), Editorial Board Member
2007-present, Cancer Research
2005-present, Bone Marrow Transplant
2005-present, Annals of Hematology
2005-present, American Journal of Epidemiology
2004-present, Journal of Clinical Oncology
2004-present, Journal of the National Cancer Institute
2003-present, Cancer Epidemiology, Biomarkers and Prevention
2003-present, International Journal of Cancer
2003-present, Pediatric Blood and Cancer
2002-present, Clinical Cancer Research
2001-present, Medical and Pediatric Oncology
2001-present, Journal of Pediatric Hematology-Oncology
2009-present, Clinical Research Quality Assurance Committee
2007-present, Hematopoietic Malignancies Clinical Steering Committee
2003-present, Certificate Program Working Group, Center for Clinical Epidemiology and Biostatistics
1999-present, Institutional Review Board, The Children's Hospital of Philadelphia
Leadership and Memberships
CHOP Clinical Trials Research Affinity Group, Advisory committee member
Patient Experience Ratings
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