Michelle Denburg, MD, MSCE, is board certified in pediatric nephrology and is director of Research for the Division of Nephrology at CHOP. She is an associate professor of Pediatrics and Epidemiology and Senior Scholar in the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania Perelman School of Medicine. She is a faculty member of the Clinical Futures, a CHOP Research Institute Center of Emphasis. She is an Attending Physician in the Cancer Survivorship Program and the CHOP-Penn Glomerular Clinic.
Dr. Denburg leads a multidisciplinary research program focused on complications of childhood kidney diseases, including chronic kidney disease (CKD), glomerular disease, and kidney stone disease, with a particular interest in bone health and altered mineral metabolism. Her research includes analyses of large electronic health record databases, and observational, translational, and interventional patient-oriented studies.
Dr. Denburg is the co-director of the Penn-CHOP Kidney Innovation Center. She is the associate director for the Pediatric Center of Excellence in Nephrology supported by funding from the National Institute of Diabetes and Digestive and Kidney Disease. She also served as co-PI in the NIDDK CKD Biomarkers Consortium to identify novel biomarkers for CKD progression in children. She initiated and leads GLEAN (Glomerular Learning Network), a multi-institutional collaborative focused on outcomes improvement in children with glomerular disease and is co-PI of the PRESERVE study (Preserving Kidney Function in Children with Chronic Kidney Disease) that is leveraging the health data resources of 16 centers to address evidence gaps in blood pressure management for children with CKD.
Dr. Denburg is committed to mentoring trainees and junior investigators engaged in clinical research. Mentees have included clinical fellows and junior faculty members in multiple subspecialties, medical students, residents, and biostatistics graduate students.
Education and Training
MD - Weill Medical College of Cornell University, New York, NY
Pediatrics - Children’s Hospital of New York, New York, NY
Pediatric Nephrology - The Children's Hospital of Philadelphia, Philadelphia, PA
Pediatric Nephrology – American Board of Pediatrics
MS in Clinical Epidemiology - University of Pennsylvania, Philadelphia, PA
Titles and Academic Titles
Distinguished Endowed Chair in the Department of Pediatrics
Co-Director, Penn-CHOP Kidney Innovation Center
Associate Director, Pediatric Center of Excellence in Nephrology
Director of Research, Division of Nephrology
Associate Professor of Pediatrics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania
Sharma S, Ehlayel AM, Copelovitch L. Chapter 50: Management of Fluids and Electrolytes. Nelson's Pediatric Board Review. Certification and Recertification. Elsevier, Philadelphia, PA. 2019.
Posters and Presentations
Koepsell K, Denburg M, Lee JJ, Bittinger K, Tasian G. Decreased butyrate-production and oxalate-degradation of the gut microbiome in children and adolescents with calcium oxalate kidney stone disease. Oral presentation at the Societies for Pediatric Urology’s 67th Annual Meeting, Chicago, IL, May 2019.
Vajravelu RK, Copelovitch L, Osterman MT, Scott FI, Mamtani R, Lewis JD, Denburg MR. Relative hazard of chronic kidney disease among patients with inflammatory bowel disease varies by age. Poster presentation at Digestive Diseases Week, San Diego, CA, May 2019.
Koepsell K, Denburg M, Lee JJ, Bittinger K, Tasian G. Unique intestinal tract metabolites in calcium oxalate kidney stone disease. Oral presentation at the Societies for Pediatric Urology’s 67th Annual Meeting, Chicago, IL, May 2019.
Kakajiwala A, Rogers R, Pasch A, Copelovitch L, Hoofnagle A, Philipose S, Furth SL, Leonard MB, Denburg MR. Serum calcification propensity in children on chronic hemodialysis. Poster presentation at the Pediatric Academic Societies/American Society of Pediatric Nephrology Annual Meeting, Baltimore, MD, April 2019.
Greenberg J, Abraham A, Xu Y, Schelling J, Feldman H, Sabbisetti V, Cardenas-Gonzalez M, Coca S, Warady B, Kimmel P, Bonventre J, Denburg M, Parikh C, Furth S. Plasma biomarkers of chronic kidney disease progression in the CKiD Study. Poster presentation at the Pediatric Academic Societies/American Society of Pediatric Nephrology Annual Meeting, Baltimore, MD, April 2019.
Levy Erez D, Meyers M, Raman S, Thomas M, Forrest C, Furth S, Denburg M. The impact of pediatric peritoneal dialysis on caregivers’ self-reported health and well-being. Poster presentation at the Pediatric Academic Societies/American Society of Pediatric Nephrology Annual Meeting, Baltimore, MD, April 2019.
Thomas M, Raman S, Levy Erez D, Meyers MR, Furth S, Forrest CB, Denburg M. The impact of pediatric peritoneal dialysis on caregivers’ self-reported health and well-being. Oral presentation at the Eastern Society for Pediatric Research Scientific Meeting, Philadelphia, PA, March 2019.
Coresh J, Abraham AG, Denburg M, Furth S, Chen J, Rebholz C, Rhee E, Feldman H, Kimmel P, Ramachandran V, Warady B, Grams, M, Inker L, Levey AS. Concordance of metabolite correlations with measured GFR in children and adults. Poster presentation at the 51st Annual Meeting of the American Society of Nephrology, San Diego, CA, October 2018.
Brunson C, Huang L, Shults J, Furth SL, Denburg M, Hartung EA. Serum metabolomic biomarkers associated with neurocognitive dysfunction in youth with chronic kidney disease. Poster presentation at the 51st Annual Meeting of the American Society of Nephrology Meeting, San Diego, CA, October 2018.
Denburg, MR, Abraham AG, Coresh J, Chen J, Grams M, Feldman HI, Kimmel PL, Rebholz C, Rhee EP, Ramachandran VS, Warady BA, Furth SL. Metabolite predictors of chronic kidney disease progression in children. Poster presentation at the 51st Annual Meeting of the American Society of Nephrology, San Diego, CA, October 2018.
Sethna CB, Leonard MB, Meyers KE, Brady TM, Hoofnagle AN, Wolf M, Denburg M. FGF-23, hypertension, and dyslipidemia in glomerular disease. Poster presentation at the 51st Annual Meeting of the American Society of Nephrology, San Diego, CA, October 2018.
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