Jason L. Freedman, MD, MSCE

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Jason L. Freedman, MD, MSCE, is an attending physician in the Division of Oncology at Children's Hospital of Philadelphia.

Areas of Expertise: Supportive care, Hematologic malignancies, Blood and marrow transplantation, Quality improvement
Locations: Main Hospital

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - State University of NY Upstate Medical University, Syracuse, NY

Internship

Pediatrics - Children's Hospital of New York-Presbyterian, Columbia University Medical Center, New York, NY

Residency

Pediatrics - Children's Hospital of New York-Presbyterian, Columbia University Medical Center, New York, NY
Chief Resident in Pediatrics - Children's Hospital of New York-Presbyterian, Columbia University Medical Center, New York, NY

Fellowship

Pediatric Hematology/Oncology - Children’s Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Hematology-Oncology
Pediatrics

Graduate Degree

Masters of Science in Clinical Epidemiology (MSCE) - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Attending Physician

Inpatient Medical Director, Oncology/Stem Cell Translant

Assistant Professor of Clinical Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Publications

Papers

2021

Triebwasser MP, Barrett DM, Bassiri H, Bunin N, Elgarten C, Fisher B, Freedman J, Lambert MP, Olson T, Paessler M, Petrosa W, Reilly AF, Romberg N, Sullivan K, Behrens E, and Teachey, DT. Combined use of Emapalumab and Ruxolitinib in a Patient with Refractory HLH was Effective, Safe, and Associated with Rapid Engraftment after Hematopoietic Stem Cell Transplant. Pediatric Blood & Cancer 2021 Mar 22;e29026. doi: 10.1002/pbc.29026. Online ahead of print.

Traube C, Gerber L, Mauer E….Freedman JL,….Zinter M, Greenwald B, Silver S, Boulad F. Delirium in Children Undergoing Hematopoietic Cell Transplantation: a multi-institutional point prevalence study. Frontiers in Oncology 2021 Apr 22; 11. doi: 10.3389/fonc.2021.627726

Patel, T, Conrad M, Moser E, Field NS, Maurer K, Dawany N, Giraudo CG, Henrickson S, Wherry J, Devoto M, Bunin N, Freedman J, Heimall J, Arnold D, Markowitz J, Oliver P, Sullivan J, Kelsen J. Novel Treatment of Itch Deficiency in Very Early-Onset Inflammatory Bowel Disease with Hematopoietic Stem Cell Transplantation. Journal of Allergy and Clinical Immunology (JACI), Accepted for Publication April 2021.

2020

Phillips CA, Bailer J, Foster E, Li Y, Dogan P, Smith E, Reilly A & Freedman J. Evaluation of an automated pediatric malnutrition screen using anthropometric measurements in the electronic health record: a quality improvement initiative. Supportive Care in Cancer 28, 1659-1666(2020). https://doi.org/10.1007/s00520-019-04980-1. (PMID: 31286235).

Seif AE, Li Y, Monos DS, Heidemann SC, Aplenc R, Barrett D, Casper JT, Freedman JL, Grupp SA, Margolis DA, Olson TO, Teachey DT, Keever-Taylor CA, Wang Y, Talano J, Bunin NJ. Partially CD3+-depleted unrelated and haploidentical donor PSCT has favorable GVHD and survival rates in pediatric hematologic malignancy. Biol Blood Marrow Transplant 2020 Mar;26(3):493-501. DOI: 10.1016/j.bbmt.2019.11.022  (PMID: 31765697).

2019

Phillips CA, Bailer J, Foster E, Dogan P, Flaherty P, Baniewicz D, Smith E, Reilly A & Freedman J. Implementation of an Automated Pediatric Malnutrition Screen Using Anthropometric Measurements in the Electronic Health Record. Journal of the Academy of Nutrition and Dietetics 2019 Aug 1;119(8):1243-1249. DOI: 10.1016/j.jand.2018.07.014 (PMID: 30297315).

Paw Cho Sing E, Robinson PD, Flank J, Holdsworth M, Thackray J, Freedman, J,…Sung L, Dupuis LL. Classification of the acute emetogenicity of chemotherapy in pediatric patients: A clinical practice guideline. Pediatric Blood & Cancer, 2019 May; 66(5). DOI: 10.1002/pbc.27646 (PMID: 30729654).

2018

Elgarten CW, Levy EM, Mattei P, Fisher BT, Olson TS, Freedman JL. Successful treatment of Pulmonary Mucormycosis in Two Pediatric Hematopoietic Cell Transplant Patients. Pediatric Transplantation, November 2018; 22(7): e13270. https://doi.org/10.1111/petr.13270 (PMID: 30014584).

2017

Satwani P, Freedman JL, Sonali C, Zhezhen J, Foca M, Krajewski J, Talekar MK, Gardenswartz A, Hayes M, Chang A, Dvorak C. A Multicenter Study of Impact of Bacterial Blood Stream Infections (BBSI) and Antibiotic Resistance on Transplant Related Mortality (TRM) Following Allogeneic Hematopoietic Cell Transplantation (alloHCT) in Children. Biol Blood Marrow Transplant 2017 Apr;23(4):642-647 (PMID: 28104513).

Patel P, Robinson PD, Thackray J, Flank J, Holdsworth MT, Gibson P, Orsey A, Portwine C, Freedman J, Madden JR, Phillips R, Sung L, Dupuis LL. Guideline for the prevention of acute chemotherapy-induced nausea and vomiting in pediatric cancer patients: A focused update. Pediatric Blood & Cancer, 2017 Oct;64(10) (PMID: 28453189).

Books

2021

Freedman J, Elgarten C, Rheingold SR. “Management of Oncologic Emergencies.” In: P. Lanzkowsky (Ed). Manual of Pediatric Hematology and Oncology, 7th Edition. Elsevier Health Sciences (In final revisions, April 2021).

2020

Rheingold SR, Li A, Freedman JL. “Oncologic Emergencies.” In: P.A. Pizzo and D.G. Poplack (Eds). Principles and Practice of Pediatric Oncology, 8th Edition. Philadelphia, PA: Lippincott, Williams, and Wilkins (2020). 

2018

Talekar M and Freedman J. Chapter 12: “Engraftment Syndrome and Associated Cytokine Storm and Capillary Leak Syndrome.” In: V. Brown (Ed). Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist-Oncologist, 1st Edition: Elsevier Health Sciences (2018).

Gurunathan A, Bailer J and Freedman J. Chapter 13: “Nutrition in Hematopoietic Stem Cell Transplant.” In: V. Brown (Ed). Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist-Oncologist, 1st Edition: Elsevier Health Sciences (2018).

Gurunathan A, Patel NS, and Freedman J. Chapter 14: “Mucositis and Pain in Hematopoietic Stem Cell Transplant.” In: V. Brown (Ed). Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist-Oncologist, 1st Edition: Elsevier Health Sciences (2018).

Bride K, Patel NS, and Freedman J. Chapter 17: “Acute Graft Versus Host Disease: Diagnosis, Prophylaxis and Treatment.” In: V. Brown (Ed). Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist-Oncologist, 1st Edition: Elsevier Health Sciences (2018).

Bride K, Levy E, Wohlschlaeger A, and Freedman J. Chapter 18: “Infectious Complications in Hematopoietic Stem Cell Transplant.” In: V. Brown (Ed). Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist-Oncologist, 1st Edition: Elsevier Health Sciences (2018).

2017

Kerman C, Freedman J. Acute complications of cancer therapy. In: Rauch DA and Gershel JC (Eds).  Caring for the Hospitalized Child: 2st Edition – A Handbook of Inpatient Pediatrics. Elk Grove, IL: American Academy of Pediatrics (2017).

Posters and Presentations

2021

Ghuman A, Perry-Milligan M, Freedman J. Hospital Physicians in Pediatric Oncology/Stem Cell Transplant: Successes & Opportunities. American Society of Pediatric Hematology/Oncology (ASPHO) Annual Meeting, Fort Worth, TX, May 2020 (Poster presentation, deferred until 2021).

Teachey DT, Devidas M, Wood BL, Chen Z, Hayashi RJ, Annett R, Asselin B, August K, Cho S, Dunsmore K, Fisher BT, Freedman JL, Galardy PJ, Harker-Murray P, Hermiston M, Horton T, Jaju AI, Lam A, Messinger YH, Miles RR, Okada N, Patel SI, Rao KW, Schafer ES, Schechter-Finkelstein T, Shimano KA, Singh N, Steele AC, Sulis ML, Vargas SL, Winter S, Wood C, Zweidler-McKay PA, Bollard CM, Loh ML*, Hunger SP*, and Raetz EA*. Children’s Oncology Group (COG) Trial AALL1231: Cranial Radiation Can Be Eliminated in Most Children with T-cell Acute Lymphoblastic Leukemia (T-ALL) and Bortezomib Potentially Improves Survival in Children with T-cell Lymphoblastic Lymphoma (T-LL).American Society of Hematology (ASH) Annual Meeting, Virtual, December 2020, platform presentation).

Haddadin Z, Hamdan L,… Freedman J and Halasa N. Laboratory-Confirmed Influenza in Vaccinated Pediatric Hematopoietic Cell Transplant Recipients. Infections in the Immunocompromised Host (ICHS), Virtual, February 2021, Selected for Best Abstracts; (Poster Presentation).

Davidow K, Bunin N, Goldfarb S, Freedman J. Pulmonary Outcomes After Autologous Stem Cell Transplant for Hodgkin Lymphoma. American Society of Pediatric Hematology/Oncology (ASPHO) Annual Meeting, Virtual, April 2021 (Poster Presentation).

2020

Levy E, Wohlschlaeger A, Fisher B, Heimall J, Foster E, Bunin NJ, Grupp S, Freedman, J. Delivering Post Hematopoietic Stem Cell Transplant (HSCT) Vaccines in a Pediatrician's Office Versus Specialty Care Setting. American Society of Transplantation and Cellular Therapy, Orlando, Florida, February 2020 (Oral Presentation).

Sacks, N, Bailer J, Squillante B, McGowan S, Vicente C, Wilhelm D, Gaunt D, Divito D, Thorpe J, Freedman J, Phillips C. Implementation of a standardized process to increase follow-up with registered dietitian nutritionists (RDN) in a pediatric oncology outpatient clinic post-discharge. Oncology Nutrition Dietetic Practice Group Symposium April 2020, Chicago, IL (Poster presentation).

2019

Kurnaz S, Loaiza-Bonilla A, Freedman JL, Arango B, Johnson K, Bonilla-Reyes P, Culcuoglu C. SYNERGY-AI: Artificial Intelligence based precision oncology clinical trial matching and registry. ASCO Gastrointestinal Cancers Symposium 2019, cal. January 2019 (Poster Presentation).

Levy E, Wohlschlaeger A, Fisher B, Heimall J, Foster E, Bunin NJ, Grupp S, Freedman, J. Establishing a Post Pediatric Hematopoietic Stem Cell Transplant Immunization Clinic in a Specialty Care Center.  Transplantation &  Cellular Therapy Meetings (ASBMT/CIBMTR), Houston, Texas, February 2019 (Poster Presentation).

Elgarten CW, Myers RM, Levy E, Freedman JL, Bunin NJ, Fisher BT, Olson TS. Cytomegalovirus Reactivation in Children with Hemoglobinopathies Who Undergo Hematopoietic Cell Transplantation with Distal Alemtuzumab. Transplantation & Cellular Therapy Meetings (ASBMT/CIBMTR), Houston, Texas, February 2019 (Poster Presentation).

Patel T, Conrad MA, Shraim R, Merz A, Maurer K, Dawany N, Devoto M, Behrens E, Bunin NJ, Freedman JL, Giraudo C, Sullivan KE, Kelsen JR. Integration of Clinical, Immunologic and Genomic Data in Children with Very-Early Onset Inflammatory Bowel Disease Leads to Identification of Candidates for Curative Therapy with Stem Cell Transplantation. Digestive Disease Week. San Diego, CA. May 2019 (Oral presentation).

Levy E, Wohlschlaeger A, Fisher B, Heimall J, Foster E, Bunin NJ, Grupp S, Freedman, J. Pediatric Hematopoietic Stem Cell Transplant Immunization Clinic in a Specialty Care Center. Annual Quality & Patient Safety Day, Children’s Hospital of Philadelphia, May 2019 (Poster Presentation).

Hoegg C, Shanahan A, Disciullo B, Nghe M, Lamaina J, Higginson T, Menzoni M, Karley P, Freedman J, Handy L. Implementation of a Cleaning Process Flow Map to Decrease Clostridiodes Difficile Infections in a Pediatric Oncology Population. Annual Quality & Patient Safety Day, Children’s Hospital of Philadelphia, May 2019 (Poster Presentation).

Batarseh E, Hamdan L, Stewart L, Dulek, D, Kitko C, Munoz F, Moulton E, Coffin S, Freedman J, Harrison C, Schuster J, Danziger-Isakov L, Grimley M, Ardura M, Auletta J, Englund J, Carpenter P, Maron G, Allison K, Wattier R, Truong K, Pediatric HSCT Flu Network, and Halasa N. Respiratory Viral Infections in Pediatric Hematopoietic Stem Cell Transplant Recipients After Receiving Two Doses of Flu Vaccine. Fred Hutch Infectious Disease Symposium 13th Symposium on Infectious Diseases in the Immunocompromised Host in Seattle, WA, June 10-11, 2019. (Poster presentation).

Hamdan L, Batarseh E, , Stewart L, Dulek, D, Speiker A, Kitko C, Munoz F, Bocchini C, Coffin S, Freedman J, Harrison C, Schuster J, Danziger-Isakov L, Grimley M, Ardura M, Auletta J, Englund J, Carpenter P, Maron G, Allison K, Wattier R, Truong K, Pediatric HSCT Flu Network, and Halasa N. Safety of Influenza Vaccination in Pediatric Hematopoietic Stem Cell Transplant Recipients. The 3rd Symposium on Infectious Diseases in the Immunocompromised Host; Seattle, WA, June 10-11, 2019 (Poster presentation).

Schuster JE, Spieker A, Hamdan L, Batarseh E, Stewart LS, Dulek D, Kitko CL, Munoz FM, Bocchini C, Danziger-Isakov L, Grimley M, Goyal R, Coffin S, Freedman JL, Englund JA, Carpenter PA, Ardura MI, Auletta J, Wattier R, Truong K, Maron G, Allison KJ, Pediatric HSCT Flu Network, and Halasa N.  Immunogenicity of inactivated influenza vaccines given early vs late after pediatric allogeneic hematopoietic cell transplantation.  ID Week 2019, Washington, DC (Poster presentation).

Patel T, Conrad MA, Moser E, Field NS, Maurer K, Dawany N, Giraudo CC, Henrickson S, Wherry EJ, Devoto M, Bunin NJ, Freedman JL, Heimall J, Arnold DE, Markowitz J, Oliver P, Sullivan KE, Kelsen JR. Novel Treatment of Itch Deficiency in Very Early-Onset Inflammatory Bowel Disease with Hematopoietic Stem Cell Transplantation. Submitted for consideration. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Annual Meeting. Chicago, IL. October 2019.

Galetaki D, Hayes M, Newman A, Boge C, Elgarten C, Freedman J, Olson T, Fisher B. Retrospective cohort analysis to determine the incidence of CMV infection and disease in allogeneic hematopoietic cell transplant recipients at an academic children’s hospital. ID Week 2019, Washington, DC, Oct. 2-6, 2019 (Poster presentation).

2018

Phillips C, Bailer J, Flaherty P, Foster E, Baniewicz D, Smith E, Dogan P, Reilly A, Freedman JL. Improving and Standardizing the Recognition and Documentation of Malnutrition for Inpatient Pediatric Oncology and Stem Cell Transplant. Annual Quality & Patient Safety Day, Children’s Hospital of Philadelphia, May 2018 (Poster Presentation).

Phillips C, Bailer J, Flaherty P, Foster E, Baniewicz D, Smith E, Dogan P, Reilly A, Freedman JL. Improving Recognition and Documentation of Malnutrition in Pediatric Oncology. 2018 Food & Nutrition Conference & Expo (FNCE). Washington, DC, October 2018 (Poster Presentation).

Hayes M, Newman A, Boge CL, Freedman J, Fisher BT. A Retrospective Cohort Analysis to Determine the Incidence of CMV Viremia and Progression to CMV Disease in Pediatric Patients Receiving Allogeneic Hematopoietic Cell Transplantation at an Academic Children’s Hospital. Infectious Diseases Society of America National Conference (ID Week), San Francisco, California, October 2018. (Poster Presentation).

Invited Lectures

2021

Supportive Care in Pediatric Oncology, Congreso Internacional Del Colegio de Pediatría, Virtual

Establishing a Wellness Program at a Large Academic Center, American Society of Pediatric Hematology/Oncology (ASPHO), Annual Meeting, Virtual.

2020

Hematopoietic Stem Cell Transplant: Current State and Innovations, Open Medical Institute American Austrian Foundation, Virtual

Implementing Guideline Congruent Care for prevention of Chemotherapy Induced Nausea and Vomiting: A quality improvement initiative. Children’s Oncology Group, Annual Meeting, Antiemetic Committee & Guideline Committee Presentations

2019

Approach to Lymphadenopathy, Congreso Internacional Del Colegio de Pediatría, Monterrey, Mexico

Innovations in Stem Cell Transplant and Cellular Therapies, Congreso Internacional Del Colegio de Pediatría, Monterrey, Mexico

Quality Improvement in Pediatrics: A Primer, Congreso Internacional Del Colegio de Pediatría, Monterrey, Mexico

2018

Monitoring Infections in Pediatric T-ALL: ALL Outcomes Children’s Oncology Group, ALL Outcomes Committee

Adverse Event Reporting and Monitoring Toxicities in Pediatric T-ALL Children’s Oncology Group, Spring Meeting, Dallas, Texas

Other Lectures and Presentations

2021

Oncology Top 5, Resident Educational Series, 5 lectures/year, Children’s Hospital of Philadelphia

Clinical Preceptor for Pediatric Residents – Stem Cell Transplant Individualized Educational Unit (IEU), weekly, Division of Oncology, Children’s Hospital of Philadelphia

Gastrointestinal Manifestations of Oncologic Disease. GI Fellow Education Day, Division of Gastroenterology, Children’s Hospital of Philadelphia

2020

Harm Prevention in Action: Achieving a Harm-Free Admission Interprofessional Morbidity & Mortality Conference, Children’s Hospital of Philadelphia

2019

Disaster Rounds Series, Oncology Topics, Twice yearly – Department of Pediatrics, Children’s Hospital of Philadelphia

Center or Childhood Cancer Research Summer Student Series: Intro to Stem Cell Transplant & Careers in Pediatric Oncology

Radiation for Leukemia and Stem Cell Transplant in Pediatrics University of Pennsylvania Radiation Oncology Residents Lecture Series

2018

Oncologic Emergencies, PICU Fellow Lecture Series, Children’s Hospital of Philadelphia

Awards and Honors

2014, Faculty Honor Roll, The Children's Hospital Of Philadelphia

2013, Hyundai Hope on Wheels Scholar Grant Recipient

2013, American Society of Clinical Oncology Merit Award Recipient, Quality Care Symposium

2011, William Potash Fellow Teacher of the Year, The Children's Hospital of Philadelphia

2010, Nominee, Attending of the Year, Children’s Hospital of NY-Presbyterian, Columbia University

2009, American Society of Hematology Travel Award Recipient, Annual Meeting

2008, AAP International Health Travel Grant Recipient

2007, Nominee, President’s Circle of Excellence, Teaching Award, Children’s Hospital of NY-Presbyterian, Columbia University

2006, SUNY Chancellor’s Award for Student Excellence

2006, Stuart I. Gurman, MD Scholastic Achievement Award, SUNY Upstate Medical University

2006, Bruce Farrell, MD Leadership Award, SUNY Upstate Medical University

Outstanding Senior, Class of 2002, Cornell University

National Collegiate Scholar, Cornell University

Kappa Omicron Nu Honor Society

Golden Key International Honor Society

Editorial and Academic Positions

Editorial positions

2021–present, Associate Editor, BMJ Supportive & Palliative Care

2019–present, Manuscript Reviewer, Pediatrics

2015-present, Manuscript Reviewer, Supportive Care in Cancer

2015-present, Manuscript Reviewer, Pediatric Blood & Cancer

2015–present, Manuscript Reviewer, Pediatric Blood & Cancer

2015–present, Manuscript Reviewer, Supportive Care in Cancer

2014-present, Manuscript Reviewer, Journal of Palliative Medicine

Institutional committees

2014, Co-leader, Root Cause Analysis in Pediatric Oncology, Patient Safety Committee, Children's Hospital of Philadelphia

2014-present, Co-chair, Blood & Marrow Transplant Quality Improvement Committee, Children's Hospital of Philadelphia

2014-present, Blood & Marrow Transplant Standard Operating Procedures Committee, Children's Hospital of Philadelphia

2012-present, Oncology Quality Improvement Committee, Children's Hospital of Philadelphia

2012 – 2014, Schwartz Center Rounds Planning Committee, Children's Hospital of Philadelphia

2012 – 2013, Oncology Care Coordination Committee, Children's Hospital of Philadelphia

2011-present,  Pediatric Hematology/Oncology Fellowship Committee, Children's Hospital of Philadelphia

Clinical practice guideline reviewer

January 2020, Children’s Oncology Group (COG). Review of the American Society of Clinical Oncology (ASCO) Guideline “Platelet Transfusions for Patients with Cancer” for endorsement by COG

November 2020, American Society of Clinical Oncology (ASCO). Review of the Pediatric Sections of “Antiemetics: ASCO Guideline Update (2020)” 

Leadership and Memberships

Memberships in Professional Organizations
International Societies

2012 – present, Multinational Association of Supportive Care in Cancer

National Societies

2005 – present, Alpha Omega Alpha

2006 – present, American Academy of Pediatrics

2012 – present, American Society of Bone Marrow Transplantation

2012 – present, American Society of Clinical Oncology

2011 – present, American Society of Hematology

2011 – present, American Society of Pediatric Hematology/Oncology

2011 – present, Children’s Oncology Group

Scientific Committees

2012 – present, Member, Pediatric Workgroup, Multinational Association of Supportive Care in Cancer

2012 – present, Member, Cancer Control Steering Committee, Children’s Oncology Group

2014 – present, Member, Antiemetics Committee, Children’s Oncology Group

2014 – present Member, AALL 1231 Committee