Gregory Heuer, MD, PhD

Papers

2022

Kalmar, C.L., Lang, S.S., Heuer, G.G., Schreiber, J.E., Tucker, A.M., Swanson, J.W., Beslow, L.A.  Neurocognitive outcomes of children with non-syndromic single-suture craniosynostosis.  Childs Nervous System, 38(5), 893-901, 2022.

Kalmar, C.L., Carlson, A.R., Kosyk, M.S., Zapatero, Z.D., Heuer, G.G., Taylor, J.A.  Endoscopic-Assisted Fronto-Orbital Distraction Osteogenesis: Initial Patient Report.  Journal of Craniofacial Surgery, 33(1):117-120, 2022.

Kalmar, C.L., Humphries, L.S., McGeehan, B., Ying, G.S., Heuer, G.G., Liu, G.T., Avery, R.A., Bartlett, S.P., Taylor, J.A., Lang, S.S., Swanson, J.W.  Elevated Intracranial Pressure in Patients with Craniosynostosis by Optical Coherence Tomography. Plastic and Reconstructive Surgery, 149(3):677-690, 2022.

Villavisanis, D.F., Cho, D.Y., Shakir, S., Kalmar, C.L., Wagner, C.S., Cheung, L., Blum, J.D., Lang, S.S., Heuer, G.G., Madsen, P.J., Bartlett, S.P., Swanson, J.W., Taylor, J.A., Tucker, A.M.  Parietal bone thickness for predicting operative transfusion and blood loss in patients undergoing spring-mediated cranioplasty for nonsyndromic sagittal craniosynostosis.  Journal of Neurosurgery: Pediatrics, 29(4), 419-426, 2022.

Retrouvey, M., Vossough, A., Zandifar, A., Bellah, R.D., Heuer, G.G., Flibotte, J., Tierradentro-Garcia, L.O., Saade-Lemus, S., Kim, J.D.U., Back, S.J., Kaplan, S.L.  Validation of Sonographic Fronto-Occipital Ratio Based on Anatomical Landmarks Compared to MR/CT-Derived Indexes in Children with Chiari II and Ventriculomegaly.  Pediatric Neurosurgery, 57(2), 71-77, 2022.

2021

Kalmar, C.L., Zapatero, Z.D., Kosyk, M.S., Carlson, A.R., Bartlett, S.P., Heuer, G.G., Tucker, A.M., Taylor, J.A., Lang, S.S., Swanson, J.W.  Elevated intracranial pressure with craniosynostosis: a multivariate model of age, syndromic status, and number of involved cranial sutures.  Journal of Neurosurgery: Pediatrics, 28(6), 716-723, 2021.

Zapatero, Z.D., Kalmar, C.L., Kosyk, M.S., Humphries, L.S., Swanson, J.W., Bartlett, S.P., Heuer, G.G., Taylor, J.A.  The Expanding Role of Posterior Vault Distraction Osteogenesis in Idiopathic Intracranial Hypertension and Slit Ventricle Syndrome.  Journal of Craniofacial Surgery, 32(8), 2641-2645, 2021.

Lang, S.S., Kilbaugh, T., Friess, S., Sotardi, S., Kim, C.T., Mazandi, V., Zhang, B., Storm, P.B., Heuer, G.G., Tucker, A., Ampah, S.B., Griffis, H. Raghupathi, R., Huh, J.W. Trajectory of Long-Term Outcome in Severe Pediatric Diffuse Axonal Injury: An Exploratory Study.  Frontiers in Neurology, 12, eprint, 2021.

Flanders, T.M., Lang, S.S., Ko, T.S., Andersen, K.N., Jahnavi, J., Flibotte, J.J., Licht, D.J., Tasian, G.E., Sotardi, S.T., Yodh, A.G., Lynch, J.M, Kennedy, B.C., Storm, P.B., White, B.R., Heuer, G.G., Baker, W.B. Optical Detection of Intracranial Pressure and Perfusion Changes in Neonates with Hydrocephalus. Journal of Pediatrics, 54-61, 237, 2021.

Lang, S.S., Meier, P.M., Paden, W.Z., Storm, P.B., Heuer, G.G., Bartlett, S.P., Taylor, J.A., Swanson, J.W., Meara, J.G., Proctor, M., Okunowo, O., Stricker, P.A., Pediatric Craniofacial Collaborative Group. Spring-mediated cranioplasty versus endoscopic strip craniectomy for sagittal craniosynostosis. Journal of Neurosurgery: Pediatrics, 28(4), 416-424, 2021

CreveCoeur, T.S., Yahanda, A.T., Maher, C.O., Johnson, G.W., Ackerman, L.L., Heuer, G.G. et al. Occipital-Cervical Fusion and Ventral Decompression in the Surgical Management of Chiari-1 Malformation and Syringomyelia: Analysis of Data From the Park-Reeves Syringomyelia Research Consortium. Neurosurgery, 88(2), 332-341, 2021.

2020

Badger, C.A., Lopez, A.J., Heuer, G.G., Kennedy, B.C. Systematic review of corpus callosotomy utilizing MRI guided laser interstitial thermal therapy.  Journal of Clinical Neuroscience, 76, 67-73, 2020.

Pisapia, J.M., Akbari, H., Rozycki, M., Thawani, J.P., Storm, P.B., Avery, R.A., Vossough, A., Fisher, M.J., Heuer, G.G., Davatzikos, C. Predicting pediatric optic pathway glioma progression using advanced magnetic resonance image analysis and machine learning.  Neuro-Oncology Advances, 2(1), ePrint, 2020.

Patel, V., Shakir, S., Yang, R., Humphries, L.S., McKenna, R.A., Heuer, G.G., Lang, S-S.,Bartlett, S.P., Taylor, J.A., Swanson, J.W., Perioperative Outcomes in the Treatment of Isolated Sagittal Synostosis: Cranial Vault Remodeling Versus Spring Mediated Cranioplasty. Journal of Craniofacial Surgery, 31(7), 2106-2111, 2020.

Hale, A.T., P. Adelson, P.D., Albert, G.W., Aldana, P.R., Alden, T.D., Heuer, G.G., et al. Factors associated with syrinx size in pediatric patients treated for Chiari malformation type I and syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium. Journal of Neurosurgery: Peditrics, 25 (6), 1-11, 2020.

Chih Jin, S., Dong, W., Kundishora, A.J., Panchagnula, S., Moreno-De-Luca, A., Heuer, G.G., et al.  Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus.  Nature Medicine, 26(11), 1754-1765, 2020.

Lang, S-S., Khanna, O., Atkin, N.J., Palma, J.E., Yuan, I., Storm, P.B., Heuer, G.G., Kennedy, B., Waanders, A.J., Li, Y., Huh, J.W. Peri-operative Near-Infrared Spectroscopy (NIRS) cerebral oxygen saturation in symptomatic pediatric hydrocephalus patients at risk for intracranial hypertension. Journal of Neurosurgery, Pediatrics, in press.

Flanders, T.M., Alier, F., Lott, C., Anari, J.B., Storm, P.B., Heuer, G.G. Prophylactic Decompression for Cervical Stenosis in Jeune's Syndrome. Spine, 5(13), E781-E786, 2020.

Moldenhauer, J.S., Soni, S., Jatres, J., Gebb, J., Khalek, N., Teefey, C.P., Johnson, M.P., Flake, A.W., Hedrick H.L., Peranteau, W.H., Heuer, G.G., Adzick, N.S. Open Fetal Surgical Outcomes for Myelomeningocele Closure Stratified by Maternal Body Mass Index in a Large Single-Center Cohort. Fetal Diagnosis and Therapy 2020 9;47(12):889-893, 2020.

Church, P.T., Castillo, H., Castillo, J., Berndl, A., Brei, T., Heuer, G.G., Howell, L.J., Merkens, M. Prenatal counseling: Guidelines for the care of people with spina bifida. Journal of Pediatric Rehabilitation Medicine, 13(4):461-466, 2020.

Flanders, T.M., Kimmel, A.C., Lang, S.S., Bellah, R., Chuo, J., Wellons, J.C., Flibotte, J.J., Heuer, G.G.  Standardizing treatment of preterm infants with post-hemorrhagic hydrocephalus at a single institution with a multidisciplinary team. Child’s Nervous System, 36(8), 1737-1744, 2020.

Madsen, J.R., Hameed, M.Q., Boyle, T.P., Neuman, M.I., Park, E., Tamber, M.S., Hickey, R.W., Heuer, G.G., Zorc, J., Leonard, J.R., Leonard, J.C., Keating, R., Chamberlain, J., Frim, D.M., Zakrzewshi, P., Klinge, P., Merck, L.H., Piatt, J.H., Bennett, J.E., Sandberg, D.I., Boop, F.A. Non-invasive Thermal Flow Evaluation of Ventriculoperitoneal Shunt Flow Improves Diagnostic Accuracy of Shunt Malfunction: A Prospective, Multi-Site, Operator-Blinded Study.  Neurosurgery, 87(5), 939–948, 2020.

Flanders T.M., Heuer G.G., Madsen P.J., Buch V.P., Mackell C.M., Alexander E., Moldenhauer J.S., Zarnow D.M., Flake A.W., Adzick N.S. Detailed analysis of hydrocephalus and hindbrain herniation after prenatal and postnatal myelomeningocele closure: Report from a single institution. Neurosurgery, 86(5), 637-645, 2020.

Jin, S.C., Dong, W., Kundishora, A.J.,  Panchagnula, S., Moreno-De-Luca, A., Heuer, G.G., et al. Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Nature Medicine 26 (11), 1754–1765, 2020.

Didier, R.A., Martin-Saavedra, J.S., Oliver, E.R., DeBari, S.E., Bilaniuk, L.T., Howell, L.J., Moldenhauer, J.S., Adzick, N.S., Heuer, G.G., Coleman, B.G, Fetal Intraventricular Hemorrhage in Open Neural Tube Defects: Prenatal Imaging Evaluation and Perinatal Outcomes.  American Journal of Neuroradiology, 41(10), 1923-1929, 2020.

Oliver, E.R., Heuer, G.G., Thom, E.A., Burrows, P.K., Didier, R.A., DeBari, S.E., Martin-Saavedra, J.S., Moldenhauer, J.S., Jatres, J., Howell, L.J., Adzick, N.S., Coleman, B.G. Myelomeningocele sac associated with worse lower-extremity neurological sequelae: evidence for. prenatal neural stretch injury? Ultrasound Obstetrics and Gynecology. 55(6), 740-746, 2020.

Madsen, P.J., Heuer, G.G., Taylor, J.A. Commentary: Craniopagus separation, a model for innovation in surgery. Surgery, 168(2), 231- 232, 2020.

Flanders, T.M., Madsen, P.J., Pisapia, J.M., Hudgins, E.D., Mackell, C.M., Alexander, E.E., Moldenhauer, J.S., Zarnow, D.M., Flake, A.W., Adzick, N.S., Heuer, G.G. Improved post-operative metrics with modified myofascial closure in fetal myelomeningocele repair.  Operative Neurosurgery, 18(2), 158-165, 2020.

Flanders, T.M., Franco, A.J., Hines, S.J., Taylor, J.A., Heuer, G.G. Neonatal intraoperative neuromonitoring in thoracic myelocystocele: A case report.  Child’s Nervous System, 36(2), 435-439, 2020.

Pascal, H., Su, Y.S., Flanders, T.M., Storm, P.B., Heuer, G.G., Pablo, L. Laparoscopy Assisted Ventriculoperitoneal Shunt Placement in Children. Journal of Pediatric Surgery, 55(2), 296-299, 2020.

Swanson, J.W., Xu, W., Ying, G.-S., Pan, W., Lang, S.-S., Heuer, G.G., Bartlett, S.P., Taylor, J.A. Intracranial pressure patterns in children with craniosynostosis utilizing optical coherence tomography. Child’s Nervous System, 36(3), 1-7, 2020.

2019

Foss S, Flanders TM, Heuer GH, Schreiber JE. Neurobehavioral outcomes in patients with myelomeningocele. Neurosurg Focus. 2019 Oct 1;47 (4):E6.

Weiss DA, Lee AS, Flanders TM, Long CJ, Van Batavia JP, Zderic SA , Heuer GH. Neurological dysfunction of the bladder from myelomeningocele. Neurosurg Focus. 2019 Oct 1;47 (4):E7.

Heuer GG, Madsen PJ, Flanders TM, Kennedy BC, Storm PB, Taylor JA. Separation of Craniopagus Twins by a Multidisciplinary Team. N Engl J Med. 2019 Jan 24;380(4):358-364. doi: 10.1056/NEJMoa1805132.

2018

Tomlinson SB, Khambhati AN, Bermudez C, Kamens RM, Heuer GG, Porter BE, Marsh ED. Alterations of network synchrony after epileptic seizures: An analysis of post-ictal intracranial recordings in pediatric epilepsy patients. Epilepsy Res. 2018 Apr 5;143:41-49. [Epub ahead of print] PMID: 29655171 

2017

Pisapia JM, Akbari H, Rozycki M, Goldstein H, Bakas S, Rathore S, Moldenhauer JS, Storm PB, Zarnow DM, Anderson RCE, Heuer GG, Davatzikos C. Use of Fetal Magnetic Resonance Image Analysis and Machine Learning to Predict the Need for Postnatal Cerebrospinal Fluid Diversion in Fetal Ventriculomegaly. JAMA Pediatr. 2017 Dec 18. doi: 10.1001/jamapediatrics.2017.3993. [Epub ahead of print]

Heuer GG, Moldenhauer JS, Adzick NS. Prenatal surgery for myelomeningocele: review of the literature and future directions. Childs Nerv Syst. 2017 Jul;33(7):1149-1155. Doi: 10.1007/s00381-017-3440-z. Epub 2017 May 17.

Pisapia JM, Rozycki M, Akbari H, Bakas S, Thawani JP, Moldenhauer JS, Storm PB, Zarnow DM, Davatzikos C, Heuer GG. Correlations of atrial diameter and frontooccipital horn ratio with ventricle size in fetal ventriculomegaly. J Neurosurg Pediatr. 2017 Mar;19(3):300-306.

2015

Moldenhauer JS, Soni S, Rintoul NE, Spinner SS, Khalek N, Martinez-Poyer J, Flake AW, Hedrick HL, Peranteau WH, Rendon N, Koh J, Howell LJ, Heuer GG, Sutton LN, Johnson MP, Adzick NS. Fetal Myelomeningocele Repair: The Post-MOMS Experience at the Children's Hospital of Philadelphia. Fetal Diagn Ther. 2015;37(3):235-40. Epub 2014 Aug 15.

Heuer GG, Adzick NS, Sutton LN. Fetal myelomeningocele closure: technical considerations. Fetal Diagn Ther. 2015 Apr;37(3):166-71.

2014

Lang SS, Goldberg E, Zarnow D, Johnson MP, Storm PB, Heuer GG. Prenatal diagnosis of hemimegalencephaly. World Neurosurg. 2014 Jul-Aug;82(1-2):241.e5-8.

Jackson EM, Schwartz DM, Sestokas AK, Zarnow DM, Adzick NS, Johnson MP, Heuer GG, Sutton LN. Intraoperative neurophysiological monitoring in patients undergoing tethered cord surgery after fetal myelomeningocele repair. J Neurosurg Pediatr. 2014 Apr;13(4):355-61.

Tsai J, Blinman TA, Collins JL, Laje P, Hedrick HL, Adzick NS, Flake AW. The contribution of hiatal hernia to severe gastroesophageal reflux disease in patients with gastroschisis. J Pediatr Surg. 2014 Mar;49(3):395-8.

Books

Chapters

2022

Heuer, G.G., Crino, P. Malformations of Cortical Development. In: Youmans Neurological Surgery: Eighth Edition. Winn, H.R. (eds), W.B. Saunders Company, 2022.

Pisapia, J.M., Heuer, G.G., Baltuch, G.H. Vagal Nerve Stimulation. In: Operative Techniques in Epilepsy Surgery, second edition. Baltuch, G., Cukiert, A. (eds). In press.

2020

Adzick, N.S., Moldenhauer, J.S., Heuer, G.G. Neural Tube Anomalies: Clinical Management by Open Fetal Surgery. In: Fetal Therapy. Kilby, M.D., Johnson, A., Oepkes, D. (eds), Cambridge University Press 2020.

Baltuch, G., Pisapia, J.M., Heuer, G.G., Intracranial monitoring: subdural grid and strip recording. In: Youmans Neurological Surgery: Seventh Edition. Winn, H.R. (eds), W.B. Saunders Company, In press.

Heuer, G.G., Taylor, J.A. Myelomeningocele: Postnatal Repair. In: Operative Techniques in Plastic Surgery. Chung, K.C.. (eds), SPi Global, In press.

Heuer, G.G., Adzick, N.S. Myelomeningocele: Prenatal (Fetal) Repair. In: Operative Techniques in Plastic Surgery. Chung, K.C. (eds), SPi Global, In press.

Adzick, N.S., Moldenhauer, J.S., Heuer, G.G. Neural Tube Anomalies: Clinical Management by Open Fetal Surgery. In: Fetal Therapy. Kilby, M.D., Johnson, A., Oepkes, D. (eds), Cambridge University Press 2020.

2018

Hong, J., Pisapia, J.M., Al,i Z., Niziolek, P., Heuer, G.G., Zhang, P., Khoury, V., Zager, E.L. Malignant peripheral nerve sheath tumors. In: Manual of Peripheral Nerve Surgery. Ed. Socolovsky, Thieme, 2018.

2017

Heuer, G.G., Kilbaugh, T.J., Huh, J.W. Acute Head Trauma: In: Fundamentals of Pediatric Surgery: Third Edition. Mattei, P.A. (eds), Springer, 2017.

Lang, S.S, Heuer, G.G. Intracerebral Hemorrhage in Neonates and Children: In: Pediatric Stroke Rehabilitation: An Interprofessional and Collaborative Approach: First Edition. Smith, S. (eds.), SLACK Incorporated, 2017.

Vaughan, K.A., Franco, A.J., Heuer, G.G., Pediatric intraoperative monitoring.: In: Pediatric Electromyography: Concepts and Clinical Applications.  First Edition. McMillian, H., Kang, O. (eds), Springer, 2017.

Pisapia, J.M., Ali, Z.S., Heuer, G.G., Zager, E.L. Adult Upper Trunk Brachial Plexus Injury. Chapter In: Peripheral Nerve Surgery. Yang, L., Wilson, T. (eds). Oxford, 2017.

2016

Ranalli, N.J., Ali, Z.S., Heuer, G.G., Zager, E.L. Nerve Sheath Tumors. International Neurology Second Edition, Lisak, R.P., Truong, D.D., Carroll, W.M., Bhidayasiri), R (eds). John Wiley & Sons, 2016.

Ali, Z.S., Heuer, G.G., Zager, E.L.: Evaluation and treatment of traumatic peripheral nerve injuries. In: Atlas of Neurosurgical Techniques: Spine and Peripheral Nerves, Second Edition, Thieme, 2016.

Ali, Z., Pisapia, J.M., Ma, T.S., Zager, E.L., Heuer, G.G., Khoury, V.  Ultrasound evaluation of peripheral nerves.  In: Surgery of Brachial Plexus.  Ed. Mahapatra, A.H., Midha, R., Sinha, S. (eds). Thieme, 2016.

2015

Ali, Z.S., Heuer, G.G., Zager, E.L., Nerve Compression/Entrapment Sites of the Upper Limb. In: Nerve and Nerve Injuries, Second Edition 2015.

2013

Beslow, L.A., Heuer, G.G., Jordan, L.C. Nontraumatic Intracerebral Hemorrhage. In: Pediatric Neurocritical Care. Abend, N.S., Helfaer, M. (eds), Demos Medical Publishing, 2013.

2012

Heuer, G.G., Hurst, R.W. Diagnosis and Management of Pediatric Cerebrovascular Disease. In: Neurointerventional Management: Diagnosis and Treatment: Second Edition. Hurst, R.W and Rosenwasser, R.H., (eds), Informa, 2012.

Hurst, R.W., Heuer, G.G., Ichord, R. Storm, P.B. Vein of Galen Aneurysmal Malformations: Diagnosis and Management. In: Surgical Endovascular Neuroradiology: First Edition. Prestigiacomo. C. (eds), Thieme, 2012.

2011

Heuer GG, Storm PB. Head trauma. In: Mattei PA, editor. Fundamentals of Pediatric Surgery. 2nd edition. New York: Springer; 2011.

Heuer GG, Storm PB. Ventricular shunts for hydrocephalus. In: Mattei PA, editor. Fundamentals of Pediatric Surgery. 2nd edition. New York:Springer; 2011.

Jacob A, Heuer GG, Grady MS. Initial resuscitation, pre-hospital care, and emergency room care of traumatic brain injury. In: Winn HR, editor. Youmans Neurological Surgery. 6th edition. Philadelphia: W.B. Saunders Company; 2011.

Heuer GG, Crino P. Malformations of cortical development. In: Winn HR, editor. Youmans Neurological Surgery. 6th edition. Philadelphia: W.B. Saunders Company; 2011.

Heuer GG, Lawton M, Winn HR, LeRoux PD. Surgical approaches to intracranial aneurysms. In: Winn HR, editor. Youmans Neurological Surgery. 6th edition. Philadelphia: W.B. Saunders Company; 2011.

Heuer GG, Storm PB. Non-communicating hydrocephalus: ventriculoperitoneal shunting. In: Jallo G, Kothbauer KF, Pradilla G, editors. Controversies in pediatric neurosurgery. 1st edition. New York: Thieme; 2010.

2009

Heuer GG, Storm PB. Hemispherectomy. In: Baltuch GH, Vellemure JG, editors. Operative Techniques in Epilepsy Surgery. 1st edition. New York: Thieme; 2009. 

Heuer GG, Bauman J, Storm PB, Baltuch GH. Invasive EEG studies: PEG, strip and grid implantation. In: Baltuch GH, Vellemure JG, editors. Operative Techniques in Epilepsy Surgery. 1st edition. New York: Thieme; 2009. 

Heuer GG, Stiefel MF, LeRoux PD. Trauma flap/hemicraniectomy. In: Connolly ES, McKhann GM II, Huang J, Choudhri TF, editors. Operative Techniques in Epilepsy Surgery. 1st edition. New York: Thieme; 2009. 

2007

Heuer, G.G., Jaggi, J.L., Baltuch, G.H., Lee, J.Y.K. Frameless Stereotaxy for Placement of Deep Brain Stimulators. In: Deep Brain Stimulation for Parkinson's Disease: First Edition. Baltuch, G.H.  and Stern, M.B, (eds), Informa Healthcare, 2007.

2006

Heuer, G.G., Reiter, G.T., Stiefel, M.F., Judy, K.D. Neurosurgery. In: The Surgical Review (second edition), Atluri, P., Karakousis, G.C., Porrett, P.M., and Kaiser, L.R. (eds), Lippincott, Williams and Wilkins, 2006.

Baltuch, G.H., Heuer G.G. Surgical treatment of seizures originating outside the temporal lobe. In: Gilman S, editor. MedLink Neurology. San Diego: MedLink Corporation. 2006

Posters and Presentations

Invited Lectures

2022

Heuer, G.G. Craniosynostosis and Chiari 1 Malformations in Hypophosphatasia. HPP TeleECHO Session, April 8, 2022.

Heuer, G.G. Open Fetal MMC Repair: Experience at the Children’s Hospital of Philadelphia, World Federation of Neurological Surgeons, Bogota, Columbia, March 13, 2022.

Heuer, G.G. Updates on Myelomeningocele (MMC)- Neurosurgery related issues.  Children’s Hospital of Philadelphia Fetal Fireside Lecture Series.  March 9, 2022.

Heuer, G.G., Flanders, T.M.  Neurosurgical Outcomes from Open Fetal Myelomeningocele Repair.  Surgery Grand Rounds, Children’s Hospital of Philadelphia. March 3, 2022.

2021

Heuer, G.G. Neurosurgical Outcomes from Open Fetal Myelomeningocele Repair.  Fetology Chicago: Practice and Discovery: September 9, 2021

2020

Heuer, G.G. Neurosurgery Conjoined Twins: Innovating in the Operating Theater.  Neurosurgery Grand Rounds, University of Pennsylvania, October 15, 2020.

Heuer, G.G. Myelomeningocele- Fetal Closure.  AANS/CNS Section on Pediatric Neurologic Surgery ACPNF Fellow Bootcamp, December 1, 2020

Heuer, G.G. Spina Bifida Surgical Treatment: Information for the Primary Care Physician.  CHOP at Virtua Fall Pediatric Symposium. Voorhees, NJ. September 11, 2020.