Gregory Heuer, MD, PhD, is an Associate Professor and the Director of Prenatal and Neonatal Surgery in the Division of Neurosurgery at Children’s Hospital of Philadelphia. He holds the Endowed Chair in Pediatric Neurosurgery.
Areas of Expertise:
Brachial plexus and peripheral nerve lesions, Chiari malformations, Complex spine, Congenital brain and spine malformations, Fetal evaluation and treatment, Hydrocephalus, Myelomeningocele repair (fetal and postnatal), Quality improvement, Spinal dysraphism Locations:Main Hospital
Dr. Heuer was born and raised in Prior Lake, Minnesota. He studied Genetics and Cell Biology at the University of Minnesota and then received his MD and PhD degrees from the Perelman School of Medicine at the University of Pennsylvania. He completed his neurosurgery residency at the Hospital of the University of Pennsylvania and his fellowship training in pediatric neurosurgery at the Children's Hospital of Philadelphia.
Dr. Heuer holds the Children’s Hospital of Philadelphia Endowed Chair in Pediatric Neurosurgery and serves as CHOP’s Pediatric Neurosurgery Fellowship Director. He is a Fellow of the American Academy of Neurosurgery and the College of Physicians of Philadelphia. He is a member of the American Society of Pediatric Neurosurgeons, Neurosurgical Society of America, Congress of Neurosurgeons, and the International Society for Pediatric Neurosurgery.Clinically, Dr. Heuer has a broad interest in all areas of pediatric neurosurgery but has a special focus on conditions that affect children before and just after birth. This includes surgery for hydrocephalus, congenital malformations of the brain, and various forms of spina bifida
Dr. Heuer collaborates with the Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment (CFDT), aiming to improve outcomes of children suffering from conditions discovered before birth. These conditions include hydrocephalus, lipomyelomeingoceles, meningoceles, myelomeningoceles, and encephaloceles. In addition to his clinical work, Dr. Heuer’s has an interest in and leads many efforts in patient outcomes and quality improvement initiatives.
When not at work, Dr. Heuer’s primary focus is his family, including his wife and daughter.
Education and Training
MD - University of Pennsylvania, Philadelphia, PA
Pediatric Neurosurgery - Hospital of the University of Pennsylvania, Philadelphia, PA
Neurosurgery - Hospital of the University of Pennsylvania, Philadelphia, PA
Pediatric Neurosurgery - The Children's Hospital of Philadelphia, Philadelphia, PA
PhD in Cell and Molecular Biology - University of Pennsylvania, Philadelphia, PA
Titles and Academic Titles
Endowed Chair, Pediatric Neurosurgery
Fellowship Director, Division of Neurosurgery
Director of Resident Education, Division of Neurosurgery
Director of Prenatal and Neonatal Neurosurgery
Associate Professor of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania
Kalmar, C.L., Humphries, L.S., McGeehan, B., Ying, G.S., Heuer, G.G., Liu, G.T., Avery, R.A., Bartlett, S.P., Taylor, J.A., Lang, S.S., Swanson, J.W. Elevated Intracranial Pressure in Patients with Craniosynostosis by Optical Coherence Tomography. Plastic and Reconstructive Surgery, 149(3):677-690, 2022.
Villavisanis, D.F., Cho, D.Y., Shakir, S., Kalmar, C.L., Wagner, C.S., Cheung, L., Blum, J.D., Lang, S.S., Heuer, G.G., Madsen, P.J., Bartlett, S.P., Swanson, J.W., Taylor, J.A., Tucker, A.M. Parietal bone thickness for predicting operative transfusion and blood loss in patients undergoing spring-mediated cranioplasty for nonsyndromic sagittal craniosynostosis. Journal of Neurosurgery: Pediatrics, 29(4), 419-426, 2022.
Retrouvey, M., Vossough, A., Zandifar, A., Bellah, R.D., Heuer, G.G., Flibotte, J., Tierradentro-Garcia, L.O., Saade-Lemus, S., Kim, J.D.U., Back, S.J., Kaplan, S.L. Validation of Sonographic Fronto-Occipital Ratio Based on Anatomical Landmarks Compared to MR/CT-Derived Indexes in Children with Chiari II and Ventriculomegaly. Pediatric Neurosurgery, 57(2), 71-77, 2022.
Kalmar, C.L., Zapatero, Z.D., Kosyk, M.S., Carlson, A.R., Bartlett, S.P., Heuer, G.G., Tucker, A.M., Taylor, J.A., Lang, S.S., Swanson, J.W. Elevated intracranial pressure with craniosynostosis: a multivariate model of age, syndromic status, and number of involved cranial sutures. Journal of Neurosurgery: Pediatrics, 28(6), 716-723, 2021.
Zapatero, Z.D., Kalmar, C.L., Kosyk, M.S., Humphries, L.S., Swanson, J.W., Bartlett, S.P., Heuer, G.G., Taylor, J.A. The Expanding Role of Posterior Vault Distraction Osteogenesis in Idiopathic Intracranial Hypertension and Slit Ventricle Syndrome. Journal of Craniofacial Surgery, 32(8), 2641-2645, 2021.
Lang, S.S., Kilbaugh, T., Friess, S., Sotardi, S., Kim, C.T., Mazandi, V., Zhang, B., Storm, P.B., Heuer, G.G., Tucker, A., Ampah, S.B., Griffis, H. Raghupathi, R., Huh, J.W. Trajectory of Long-Term Outcome in Severe Pediatric Diffuse Axonal Injury: An Exploratory Study. Frontiers in Neurology, 12, eprint, 2021.
Flanders, T.M., Lang, S.S., Ko, T.S., Andersen, K.N., Jahnavi, J., Flibotte, J.J., Licht, D.J., Tasian, G.E., Sotardi, S.T., Yodh, A.G., Lynch, J.M, Kennedy, B.C., Storm, P.B., White, B.R., Heuer, G.G., Baker, W.B. Optical Detection of Intracranial Pressure and Perfusion Changes in Neonates with Hydrocephalus. Journal of Pediatrics, 54-61, 237, 2021.
CreveCoeur, T.S., Yahanda, A.T., Maher, C.O., Johnson, G.W., Ackerman, L.L., Heuer, G.G. et al. Occipital-Cervical Fusion and Ventral Decompression in the Surgical Management of Chiari-1 Malformation and Syringomyelia: Analysis of Data From the Park-Reeves Syringomyelia Research Consortium. Neurosurgery, 88(2), 332-341, 2021.
Badger, C.A., Lopez, A.J., Heuer, G.G., Kennedy, B.C. Systematic review of corpus callosotomy utilizing MRI guided laser interstitial thermal therapy. Journal of Clinical Neuroscience, 76, 67-73, 2020.
Pisapia, J.M., Akbari, H., Rozycki, M., Thawani, J.P., Storm, P.B., Avery, R.A., Vossough, A., Fisher, M.J., Heuer, G.G., Davatzikos, C. Predicting pediatric optic pathway glioma progression using advanced magnetic resonance image analysis and machine learning. Neuro-Oncology Advances, 2(1), ePrint, 2020.
Patel, V., Shakir, S., Yang, R., Humphries, L.S., McKenna, R.A., Heuer, G.G., Lang, S-S.,Bartlett, S.P., Taylor, J.A., Swanson, J.W., Perioperative Outcomes in the Treatment of Isolated Sagittal Synostosis: Cranial Vault Remodeling Versus Spring Mediated Cranioplasty. Journal of Craniofacial Surgery, 31(7), 2106-2111, 2020.
Hale, A.T., P. Adelson, P.D., Albert, G.W., Aldana, P.R., Alden, T.D., Heuer, G.G., et al. Factors associated with syrinx size in pediatric patients treated for Chiari malformation type I and syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium. Journal of Neurosurgery: Peditrics, 25 (6), 1-11, 2020.
Chih Jin, S., Dong, W., Kundishora, A.J., Panchagnula, S., Moreno-De-Luca, A., Heuer, G.G., et al. Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Nature Medicine, 26(11), 1754-1765, 2020.
Lang, S-S., Khanna, O., Atkin, N.J., Palma, J.E., Yuan, I., Storm, P.B., Heuer, G.G., Kennedy, B., Waanders, A.J., Li, Y., Huh, J.W. Peri-operative Near-Infrared Spectroscopy (NIRS) cerebral oxygen saturation in symptomatic pediatric hydrocephalus patients at risk for intracranial hypertension. Journal of Neurosurgery, Pediatrics, in press.
Moldenhauer, J.S., Soni, S., Jatres, J., Gebb, J., Khalek, N., Teefey, C.P., Johnson, M.P., Flake, A.W., Hedrick H.L., Peranteau, W.H., Heuer, G.G., Adzick, N.S. Open Fetal Surgical Outcomes for Myelomeningocele Closure Stratified by Maternal Body Mass Index in a Large Single-Center Cohort. Fetal Diagnosis and Therapy 2020 9;47(12):889-893, 2020.
Church, P.T., Castillo, H., Castillo, J., Berndl, A., Brei, T., Heuer, G.G., Howell, L.J., Merkens, M. Prenatal counseling: Guidelines for the care of people with spina bifida. Journal of Pediatric Rehabilitation Medicine, 13(4):461-466, 2020.
Flanders, T.M., Kimmel, A.C., Lang, S.S., Bellah, R., Chuo, J., Wellons, J.C., Flibotte, J.J., Heuer, G.G. Standardizing treatment of preterm infants with post-hemorrhagic hydrocephalus at a single institution with a multidisciplinary team. Child’s Nervous System, 36(8), 1737-1744, 2020.
Flanders T.M., Heuer G.G., Madsen P.J., Buch V.P., Mackell C.M., Alexander E., Moldenhauer J.S., Zarnow D.M., Flake A.W., Adzick N.S. Detailed analysis of hydrocephalus and hindbrain herniation after prenatal and postnatal myelomeningocele closure: Report from a single institution. Neurosurgery, 86(5), 637-645, 2020.
Jin, S.C., Dong, W., Kundishora, A.J., Panchagnula, S., Moreno-De-Luca, A., Heuer, G.G., et al. Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Nature Medicine 26 (11), 1754–1765, 2020.
Didier, R.A., Martin-Saavedra, J.S., Oliver, E.R., DeBari, S.E., Bilaniuk, L.T., Howell, L.J., Moldenhauer, J.S., Adzick, N.S., Heuer, G.G., Coleman, B.G, Fetal Intraventricular Hemorrhage in Open Neural Tube Defects: Prenatal Imaging Evaluation and Perinatal Outcomes. American Journal of Neuroradiology, 41(10), 1923-1929, 2020.
Heuer GG, Madsen PJ, Flanders TM, Kennedy BC, Storm PB, Taylor JA. Separation of Craniopagus Twins by a Multidisciplinary Team. N Engl J Med. 2019 Jan 24;380(4):358-364. doi: 10.1056/NEJMoa1805132.
Tomlinson SB, Khambhati AN, Bermudez C, Kamens RM, Heuer GG, Porter BE, Marsh ED. Alterations of network synchrony after epileptic seizures: An analysis of post-ictal intracranial recordings in pediatric epilepsy patients. Epilepsy Res. 2018 Apr 5;143:41-49. [Epub ahead of print] PMID: 29655171
Pisapia JM, Akbari H, Rozycki M, Goldstein H, Bakas S, Rathore S, Moldenhauer JS, Storm PB, Zarnow DM, Anderson RCE, Heuer GG, Davatzikos C. Use of Fetal Magnetic Resonance Image Analysis and Machine Learning to Predict the Need for Postnatal Cerebrospinal Fluid Diversion in Fetal Ventriculomegaly. JAMA Pediatr. 2017 Dec 18. doi: 10.1001/jamapediatrics.2017.3993. [Epub ahead of print]
Heuer GG, Moldenhauer JS, Adzick NS. Prenatal surgery for myelomeningocele: review of the literature and future directions. Childs Nerv Syst. 2017 Jul;33(7):1149-1155. Doi: 10.1007/s00381-017-3440-z. Epub 2017 May 17.
Pisapia JM, Rozycki M, Akbari H, Bakas S, Thawani JP, Moldenhauer JS, Storm PB, Zarnow DM, Davatzikos C, Heuer GG. Correlations of atrial diameter and frontooccipital horn ratio with ventricle size in fetal ventriculomegaly. J Neurosurg Pediatr. 2017 Mar;19(3):300-306.
Moldenhauer JS, Soni S, Rintoul NE, Spinner SS, Khalek N, Martinez-Poyer J, Flake AW, Hedrick HL, Peranteau WH, Rendon N, Koh J, Howell LJ, Heuer GG, Sutton LN, Johnson MP, Adzick NS. Fetal Myelomeningocele Repair: The Post-MOMS Experience at the Children's Hospital of Philadelphia. Fetal Diagn Ther. 2015;37(3):235-40. Epub 2014 Aug 15.
Lang SS, Goldberg E, Zarnow D, Johnson MP, Storm PB, Heuer GG. Prenatal diagnosis of hemimegalencephaly. World Neurosurg. 2014 Jul-Aug;82(1-2):241.e5-8.
Jackson EM, Schwartz DM, Sestokas AK, Zarnow DM, Adzick NS, Johnson MP, Heuer GG, Sutton LN. Intraoperative neurophysiological monitoring in patients undergoing tethered cord surgery after fetal myelomeningocele repair. J Neurosurg Pediatr. 2014 Apr;13(4):355-61.
Tsai J, Blinman TA, Collins JL, Laje P, Hedrick HL, Adzick NS, Flake AW. The contribution of hiatal hernia to severe gastroesophageal reflux disease in patients with gastroschisis. J Pediatr Surg. 2014 Mar;49(3):395-8.
Heuer, G.G., Kilbaugh, T.J., Huh, J.W. Acute Head Trauma: In: Fundamentals of Pediatric Surgery: Third Edition. Mattei, P.A. (eds), Springer, 2017.
Lang, S.S, Heuer, G.G. Intracerebral Hemorrhage in Neonates and Children: In: Pediatric Stroke Rehabilitation: An Interprofessional and Collaborative Approach: First Edition. Smith, S. (eds.), SLACK Incorporated, 2017.
Vaughan, K.A., Franco, A.J., Heuer, G.G., Pediatric intraoperative monitoring.: In: Pediatric Electromyography: Concepts and Clinical Applications. First Edition. McMillian, H., Kang, O. (eds), Springer, 2017.
Heuer GG, Stiefel MF, LeRoux PD. Trauma flap/hemicraniectomy. In: Connolly ES, McKhann GM II, Huang J, Choudhri TF, editors. Operative Techniques in Epilepsy Surgery. 1st edition. New York: Thieme; 2009.
Heuer, G.G., Jaggi, J.L., Baltuch, G.H., Lee, J.Y.K. Frameless Stereotaxy for Placement of Deep Brain Stimulators. In: Deep Brain Stimulation for Parkinson's Disease: First Edition. Baltuch, G.H. and Stern, M.B, (eds), Informa Healthcare, 2007.
Heuer, G.G., Reiter, G.T., Stiefel, M.F., Judy, K.D. Neurosurgery. In: The Surgical Review (second edition), Atluri, P., Karakousis, G.C., Porrett, P.M., and Kaiser, L.R. (eds), Lippincott, Williams and Wilkins, 2006.
Baltuch, G.H., Heuer G.G. Surgical treatment of seizures originating outside the temporal lobe. In: Gilman S, editor. MedLink Neurology. San Diego: MedLink Corporation. 2006
Posters and Presentations
Heuer, G.G. Craniosynostosis and Chiari 1 Malformations in Hypophosphatasia. HPP TeleECHO Session, April 8, 2022.
Heuer, G.G. Open Fetal MMC Repair: Experience at the Children’s Hospital of Philadelphia, World Federation of Neurological Surgeons, Bogota, Columbia, March 13, 2022.
Heuer, G.G. Updates on Myelomeningocele (MMC)- Neurosurgery related issues. Children’s Hospital of Philadelphia Fetal Fireside Lecture Series. March 9, 2022.
Heuer, G.G., Flanders, T.M. Neurosurgical Outcomes from Open Fetal Myelomeningocele Repair. Surgery Grand Rounds, Children’s Hospital of Philadelphia. March 3, 2022.
Heuer, G.G. Neurosurgical Outcomes from Open Fetal Myelomeningocele Repair. Fetology Chicago: Practice and Discovery: September 9, 2021
Heuer, G.G. Neurosurgery Conjoined Twins: Innovating in the Operating Theater. Neurosurgery Grand Rounds, University of Pennsylvania, October 15, 2020.
Heuer, G.G. Myelomeningocele- Fetal Closure. AANS/CNS Section on Pediatric Neurologic Surgery ACPNF Fellow Bootcamp, December 1, 2020
Heuer, G.G. Spina Bifida Surgical Treatment: Information for the Primary Care Physician. CHOP at Virtua Fall Pediatric Symposium. Voorhees, NJ. September 11, 2020.
Awards and Honors
2009, “Best Clinical Oral Abstract” Pennsylvania Neurosurgical Society Annual Meeting
2009, Top Ten Abstract, Congress of Neurological Surgeons Annual Meeting, 2009
2007, “Best Poster Award” Pennsylvania Neurosurgical Society Annual Meeting
2001, Mary Ellis Bell Prize for research in medicine
1995, University of Minnesota, summa cum laude
1995, Elected to Golden Key Honor Society
1995, Elected to Phi Kappa Phi Honor Society
1994, Nominated to Sigma Xi Research Society
1994, George T. Walker Prize for undergraduate research in chemistry, Sigma Xi
Editorial and Academic Positions
Journal of Neurological Sciences, Ad hoc reviewer
Journal of Pediatric Rehabilitation Medicine, Ad hoc reviewer
Neuroradiology, Ad hoc reviewer
Neurosurgery, Ad hoc reviewer
Obstetrics and Gynecology, Ad hoc reviewer
PLUSone, Ad hoc reviewer
Polish Journal of Neurosurgery, Ad hoc reviewer
World Neurosurgery, Ad hoc reviewerpu
Academic and Institutional Committees
Surgical Education Committee, Department of Surgery
Peer Review Committee
Quality Improvement Committee
- Clinical Quality Improvement- Shunt Clinical Pathway, Co-Team Leader
- Clinical Quality Improvement- Post-hemorrhagic Hydrocephalus Pathway
- Shunt Checklist Development, Co-Team Leader
- Clinical Quality Improvement- Pathway for treatment of elevated intracranial pressure in pediatric patients with severe traumatic brain injury
Children’s Surgical Associates Quality Improvement Committee
Surgical Site Infection Committee, Team Sponsor
Dandy-Walker Alliance, Advisory Board
Leadership and Memberships
Memberships in Professional Organizations
International Society for Pediatric Neurosurgery
American Association of Neurosurgeons
American Society of Pediatric Neurosurgeons
Congress of Neurosurgeons
Neurosurgical Society of America
Patient Experience Ratings
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