Pablo Laje, MD

Pablo Laje, MD

Pablo Laje, MD, is an attending pediatric surgeon in the Division of General, Thoracic and Fetal Surgery at Children's Hospital of Philadelphia. 

Areas of Expertise: Hyperhidrosis, Minimally invasive surgery, Neonatal Surgery
Locations: Main Campus; Specialty Care & Surgery Center, King of Prussia, S. Goddard Blvd.; Specialty Care, Princeton at Plainsboro
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Dr. Pablo Laje is an attending surgeon in the Division of Pediatric General, Thoracic and Fetal Surgery at Children’s Hospital of Philadelphia (CHOP) and an assistant professor of surgery at the Perelman School of Medicine at the University of Pennsylvania.

His areas of interest include neonatal surgery and minimally invasive surgery. Dr Laje earned his medical degree at the University of Buenos Aires in 1999. He completed his residency in Pediatric Surgery at the J.P. Garrahan National Pediatric Hospital in Buenos Aires, Argentina, one of the largest pediatric hospitals in the world, before continuing on to complete a fellowship in pediatric surgery.

Dr. Laje came to CHOP in 2005 to serve as a research fellow in the Center for Fetal Research, where he worked alongside Dr. Alan W. Flake to develop innovative methods of performing gene therapy on hematopoietic stem cells for fetal transplantation. After two years as a clinical pediatric surgery fellow at CHOP, he was appointed attending surgeon in 2011. Dr. Laje performs more than 500 operations a year.

“Working at CHOP is a privilege,” he says. “The expertise that our hospital has in every aspect of pediatric healthcare is second to none, and I know that if there is anything under the sun that can be done to help a suffering child, it can be done here at CHOP.”

Dr. Laje has authored several pediatric surgery textbook chapters and published more than 25 articles in scientific journals, including the Journal of Pediatric Surgery, Fetal Diagnosis and Therapy, Prenatal Diagnosis, and Blood. He also serves as a fellow of the American College of Surgeons.

Education and Training

Medical School

MD - University of Buenos Aires, Buenos Aires, Argentina

Internship

General Surgery – J.A. Fernandez Hospital, Buenos Aires, Argentina

Residency

Pediatric Surgery – J.P. Garrahan National Pediatric Hospital, Buenos Aires, Argentina

Fellowship

Pediatric Surgery – The Children’s Hospital of Philadelphia, Philadelphia, PA
Fetal Surgery Research – The Children’s Hospital of Philadelphia, Philadelphia, PA
Pediatric Surgery – J.P. Garrahan National Pediatric Hospital, Buenos Aires, Argentina

Board Certification

Pediatric Surgery

Titles and Academic Titles

Attending Surgeon

Assistant Professor, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Publications

Papers

2018

Laje P, Fraga MV, Peranteau WH, Hedrick HL, Khalek N, Gebb JS, Moldenhauer JS, Johnson MP, Flake AW, Adzick NS. Complex gastroschisis: Clinical spectrum and neonatal outcomes at a referral center. J Pediatr Surg. 2018 Mar 14;. [Epub ahead of print] PMID: 29628208 

2016

Burgos CM, Pearson EG, Davey M, Riley J, Jia H, Laje P, Flake AW, Peranteau WH. Improved pulmonary function in the nitrofen model of congenital diaphragmatic hernia following prenatal maternal dexamethasone and/or sildenafil. Pediatr Res. 2016 Oct;80(4):577-85.

Laje P, Tharakan SJ, Hedrick HL. Immediate operative management of the fetus with airway anomalies resulting from congenital malformations. Semin Fetal Neonatal Med. 2016 Aug;21(4):240-5.

2015

Laje P, Hedrick HL, Flake AW, Adzick NS, Peranteau WH. Delayed abdominal closure after congenital diaphragmatic hernia repair. J Pediatr Surg. 2015 Nov 11.

Laje P, Pearson EG, Simpao AF, Rehman MA, Sinclair T, Hedrick HL, Adzick NS, Flake AW. The first 100 infant thoracoscopic lobectomies: Observations through the learning curve and comparison to open lobectomy. J Pediatr Surg. 2015 Jun 3. pii: S0022-3468(15)00369-3. pii: S0022-3468(15)00369-3. doi: 10.1016. Read the abstract.

Olive A, Moldenhauer JS, Laje P, Johnson MP, Coleman BG, Victoria T, Flake AW, Adzick NS. Axillary lymphatic malformations: Prenatal evaluation and postnatal outcomes. J Pediatr Surg. 2015 Apr 29. pii: S0022-3468(15)00312-7. doi: 10.1016. Read the abstract

Laje P, Peranteau WH, Hedrick HL, Flake AW, Johnson MP, Moldenhauer JS, Adzick NS. Ex utero intrapartum treatment (EXIT) in the management of cervical lymphatic malformation. J Pediatr Surg. 2015 Feb;50(2):311-4. doi: 10.1016/j.jpedsurg.2014.11.024. Epub 2014 Nov 10.

Partridge EA, Victoria T, Coleman BG, Martinez-Poyer J, Laje P, Hedrick HL, Flake AW, Adzick NS. Prenatal diagnosis of esophageal bronchus - first report of a rare foregut malformation in utero. J Pediatr Surg. 2015 Feb;50(2):306-10. Epub 2014 Nov 10.Read the abstract.

2014

Burgos CM, Pearson EG, Davey M, Riley J, Jia H, Laje P, Flake AW, Peranteau WH. Improved pulmonary function in the nitrofen model of congenital diaphragmatic hernia following prenatal maternal dexamethasone and/or sildenafil. Pediatr Res. 2016 Oct;80(4):577-85.

2013

Laje P, States LJ, Zuang H, Becker SA, Palladino AA, Stanley CA, Adzick NS: The accuracy of PET/CT scan in the diagnosis of the focal form of congenital hyperinsulinism. J Pediatr Surg 48:388-393, 2013.

Laje P, Bhatti TR, Adzick NS: Solid pseudopapillary neoplasm of the pancreas in children: A 15 year experience and identification of a unique immunohistochemical marker. J Pediatr Surg 48:2054-2060, 2013.

Laje P, Adzick NS: Modified Puestow for the management of chronic pancreatitis in children. J Pediatr Surg 48:2271-2275, 2013.

Laje P, Palladino AA, Bhatti TR, States LJ, Stanley CA, Adzick NS: Pancreatic surgery in Infants with Beckwith-Wiedemann Syndrome and Hyperinsulinism. J Pediatric Surg 48:2511-2516, 2013.

2012

Roybal JL, Laje P, Vrecenak JD, Flake AW. Use of manipulated stem cells for prenatal therapy. Methods Mol Biol. 2012;891:169-81. Cited in PubMed; PMID:22648772. Read the abstract

Laje P, Johnson MP, Howell LJ, Bebbington MW, Hedrick HL, Flake AW, et al. Ex utero intrapartum treatment in the management of giant cervical teratomas. J Pediatr Surg. 2012 Jun;47(6):1208-16.Cited in PubMed; PMID:22703795 . Read the abstract

Laje P, Stanley CA, Palladino AA, Becker SA, Adzick NS: Pancreatic head resection and Roux-en-Y pancreaticojejunostomy for the treatment of the focal form of congenital hyperinsulinism. J Pediatr Surg 47:130-135, 2012. 

2010

Laje P, Halaby L, Adzick NS, Stanley CA: Necrotizing enterocolitis in neonates receiving octreotide for the management of congenital hyperinsulinism. Pediatric Diabetes 11:142-147, 2010.

Laje P, Stanley CA, Adzick NS: Intussusception after pancreatectomy in children: A case series. J Pediatr Surg 45:1496-1499, 2010.

Books

Chapters

2017

Adzick NS, Laje P: Pancreatic Neoplasms in Children. In: Grosfeld J, Carachi R (eds): The Surgery of Childhood Tumors. 3rd Edition, Springer-Verlag, 2017, pp 303-321.

2016

Laje P, Adzick NS: Pancreas disorders. In: Mattei P, Nichol PF, Rollins MD, Muratore CS (eds): Fundamentals of Pediatric Surgery, 3rd Edition. Springer-Verlag, 2016, pp 675-686.

Adzick NS, Laje P: Congenital hyperinsulinism. In: Mattei P, Nichol PF, Rollins MD, Muratore CS (eds): Fundamentals of Pediatric Surgery, 3rd Edition. Springer-Verlag, 2016, pp 667-674.

2015

Laje P, Hedrick H. Operative Surgical Management of Fetuses with CHAOS: Management at Delivery. In: Sobol S, Lioy J, ed. Disorders of the Neonatal Airway. New York: Springer; 2015. p. 181-188.

2012

Adzick NS, Laje P: Pancreatic Neoplasms in Children. In: Grosfeld J, Carachi R (eds): The Surgery of Childhood Tumors. 3rd Edition, Springer-Verlag, 2017, pp 303-321.

2010

Laje P, Martinez-Ferro M. Acute abdomen. In: Sinha CK, Davenport M, editors. Handbook of pediatric surgery. London: Springer-Verlag: 2010. p. 173-76.

Laje P, Nichol P. Laparoscopic and open small bowel resection. In: Chen H, editor. Illustrative handbook of general surgery. London: Springer-Verlag; 2010. p. 127-33.

Posters and Presentations

2010

Laje P, Zoltick PW, Flake AW. SLAM-enriched hematopoietic stem cells maintain long-term repopulating capacity after lentiviral transduction using an abbreviated protocol [presentation]. American Society of Gene Therapy 10th Annual Meeting; 2007 May 30 - Jun 3; Seattle, WA.