Michele P. Lambert, MD, MSTR

Michele P. Lambert, MD, MSTR

Michele P. Lambert, MD, MSTR, is medical director of the Special Coagulation Laboratory and an attending physician in the Division of Hematology at Children's Hospital of Philadelphia.

Areas of Expertise: Congenital platelet disorders, General hematology
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Michele Lambert, MD, is the medical director of the Clinical Coagulation Laboratory with a special interest in inherited and acquired platelet disorders and the interplay between genetic disorders and hematologic disease. Her clinical and research focus has been on the diagnosis and management of platelet related bleeding disorders.

Education and Training

Medical School

MD - University of Medicine and Dentistry of New Jersey, Newark, NJ

Internship

Pediatrics - St. Christopher's Hospital for Children, Philadelphia, PA

Residency

Pediatrics - St. Christopher's Hospital for Children, Philadelphia, PA (Chief Resident)

Fellowship

Pediatric Hematology/Oncology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Hematology/Oncology
Pediatrics

Graduate Degree

MSTR - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Attending Physician

Medical Director, Special Coagulation Laboratory

Associate Clinical Director, Frontier Program in Immune Dysregulation

Associate Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Publications

Papers

2018

Romberg Neil, Le Coz Carole, Glauzy Salomé, Schickel Jean-Nicolas, Trofa Melissa, Nolan Brian E, Paessler Michele, Xu Mina L, Lambert Michele P, Lakhani Saquib A, Khokha Mustafa K, Jyonouchi Soma, Heimall Jennifer, Takach Patricia, Maglione Paul J, Catanzaro Jason, Hsu F Ida, Sullivan Kathleen E, Cunningham-Rundles Charlotte, Meffre Eric: Patients with common variable immunodeficiency with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses. The Journal of allergy and clinical immunology Jun 2018.

Tkaczynski Elizabeth, Arulselvan Abinaya, Tkaczynski John, Avery Stephen, Xiao Liqing, Torok-Storb Beverly, Abrams Kraig, Rao Narayanam V, Johnson Gregory, Kennedy Thomas P, Poncz Mortimer, Lambert Michele P: 2-O, 3-O desulfated heparin mitigates murine chemotherapy- and radiation-induced thrombocytopenia. Blood advances 2(7): 754-761, Apr 2018.

Jalagadugula Gauthami, Goldfinger Lawrence E, Mao Guangfen, Lambert Michele P, Rao A Koneti: Defective RAB1B-related megakaryocytic ER-to-Golgi transport in RUNX1 haplodeficiency: impact on von Willebrand factor. Blood advances 2(7): 797-806, Apr 2018.

Grace Rachael F, Despotovic Jenny M, Bennett Carolyn M, Bussel James B, Neier Michelle, Neunert Cindy, Crary Shelley E, Pastore Yves D, Klaassen Robert J, Rothman Jennifer A, Hege Kerry, Breakey Vicky R, Rose Melissa J, Shimano Kristin A, Buchanan George R, Geddis Amy, Haley Kristina M, Lorenzana Adonis, Thompson Alexis, Jeng Michael, Neufeld Ellis J, Brown Travis, Forbes Peter W, Lambert Michele P: Physician Decision Making in Selection of Second-Line Treatments in Immune Thrombocytopenia in Children. American journal of hematology 93(7): 882-888, Apr 2018.

2017

Samelson-Jones BJ, Kramer PM, Chicka M, Gunning III WT, Lambert MP: MYH9-macrothrombocytopenia caused by a novel variant (E1421K) initially presenting as apparent neonatal alloimmune thrombocytopenia. Pediatric blood & cancer 65(4), Dec 2017.

Romasko Edward J, Devkota Batsal, Biswas Sawona, Jayaraman Vijayakumar, Rajagopalan Ramakrishnan, Dulik Matthew C, Thom Christopher S, Choi Jiwon, Jairam Sowmya, Scarano Maria I, Krantz Ian D, Spinner Nancy B, Conlin Laura K, Lambert Michele P: Utility and limitations of exome sequencing in the molecular diagnosis of pediatric inherited platelet disorders. American journal of hematology 93(1): 8-16, Sep 2017.

McDonnell A, Bride K]L, Lim D, Paessler M, Witmer CM, Lambert MP: Utility of the immature platelet fraction in pediatric immune thrombocytopenia: Differentiating from bone marrow failure and predicting bleeding risk. Pediatric blood & cancer 65(2), Sep 2017.

Westbury SK, Canault M, Greene D, Bermejo E, Hanlon K, Lambert MP, Millar CM, Nurden P, Obaji SG, Revel-Vilk S, Van Geet C, Downes K, Papadia S, Tuna S, Watt C, Consortium Nihr BioResource-Rare Diseases, Freson K, Laffan MA, Ouwehand WH, Alessi MC, Turro E, Mumford AD: Expanded repertoire of RASGRP2 variants responsible for platelet dysfunction and severe bleeding. Blood 130(8): 1026-1030, Jun 2017.

Orsini Sara, Noris Patrizia, Bury Loredana, Heller Paula G, Santoro Cristina, Kadir Rezan A, Butta Nora C, Falcinelli Emanuela, Cid Ana Rosa, Fabris Fabrizio, Fouassier Marc, Miyazaki Koji, Lozano Maria Luisa, Zuñiga Pamela, Flaujac Claire, Podda Gian Marco, Bermejo Nuria, Favier Remi, Henskens Yvonne, De Maistre Emmanuel, De Candia Erica, Mumford Andrew D, Ozdemir Nihal G, Eker Ibrahim, Nurden Paquita, Bayart Sophie, Lambert Michele P, Bussel James, Zieger Barbara, Tosetto Alberto, Melazzini Federica, Glembotsky Ana C, Pecci Alessandro, Cattaneo Marco, Schlegel Nicole, Gresele Paolo: Bleeding risk of surgery and its prevention in patients with inherited platelet disorders. The Surgery in Platelet disorders And Therapeutic Approach (SPATA) study. Haematologica 102(7): 1192-1203, Apr 2017.

Lambert Michele P, Witmer Char M, Kwiatkowski Janet L: Therapy Induced Iron Deficiency in Children Treated with Eltrombopag for Immune Thrombocytopenia. American journal of hematology 92(6): E88-E91, Feb 2017.

Mao G F, Goldfinger L E, Fan D C, Lambert M P, Jalagadugula G, Freishtat R, Rao A K: Dysregulation of PLDN (Pallidin) is a mechanism for platelet dense granule deficiency in RUNX1 haplodeficiency. Journal of thrombosis and haemostasis : JTH 15(4): 792-801, Jan 2017.

2016

Cuker A, Husseinzadeh H, Lebedeva T, Marturano JE, Massefski W, Lowery TJ, Lambert MP, Abrams CS, Weisel JW, Cines DB: Rapid Evaluation of Platelet Function With T2 Magnetic Resonance. American journal of clinical pathology 146(6): 681-693, Dec 2016.

Neunert C, Despotovic J, Haley K, Lambert MP, Nottage K, Shimano K, Bennett C, Klaassen R, Stine K, Thompson A, Pastore Y, Brown T, Forbes PW, Grace RF: Thrombopoietin Receptor Agonist Use in Children: Data From the Pediatric ITP Consortium of North America ICON2 Study. Pediatric blood & cancer 63(8): 1407-13, Aug 2016.

Simeoni I, Stephens JC, Hu F, Deevi SVV, Megy K, Bariana TK, Lentaigne C, Schulman S, Sivapalaratnam S, Vries MJA, Westbury SK, Greene D, Papadia S, Alessi M-C, Attwood AP, Ballmaier M, Baynam G, Bermejo E, Bertoli M, Bray PF, Bury L, Cattaneo M, Collins P, Daugherty LC, Favier R, French DL, Furie B, Gattens M, Germeshausen M, Ghevaert C, Goodeve AC, Guerrero JA, Hampshire DJ, Hart DP, Heemskerk JWM, Henskens YMC, Hill M, Hogg N, Jolley JD, Kahr WH, Kelly AM, Kerr R, Kostadima M, Kunishima S, Lambert MP, Liesner R, López JA, Mapeta RP, Mathias M, Millar CM, Nathwani A, Neerman-Arbez M, Nurden AT, Nurden P, Othman M, Peerlinck K, Perry DJ, Poudel P, Reitsma P, Rondina MT, Smethurst PA, Stevenson W, Szkotak A, Tuna S, van Geet Cl, Whitehorn D, Wilcox D, Zhang B, Revel-Vilk S, Gresele P, Bellissimo DB, Penkett CJ, Laffan MA, Mumford AD, Rendon A, Gomez K, Freson K, Ouwehand WH, Turro E: A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders. Blood 127(23): 2791-803, Jun 2016.

Turro E, Greene D, Wijgaerts A, Thys C, Lentaigne C, Bariana T, Westbury S, Kelly AM, Selleslag D, Stephens JC, Papadia S, Simeoni I, Penkett CJ, Ashford S, Attwood AP, Austin S, Bakchoul T, Collins P, Deevi SVV, Favier R, Kostadima M, Lambert MP, Mathias M, Millar CM, Peerlink K, Perry DJ, Schulman S, Whitehorn D, Wittevrongel C, DeMaeyer M, Rendon A, Gomez K, Erber WN, Mumford AD, Nurden P, Stirrups K, Bradley JR, Raymond FL, Laffan MA, Van Geet, C, Richardson S, Freson, K, Ouwehand WH: A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies. Science translational medicine 8(328):328ra30-328ra30. March 2016. PMID: 26936507.

Neunert CN, Despotovic JM, Bennett CM, Lambert MP, Grace RE on behalf of the Pediatric ITP Consortium of North America: Thrombopoietin Receptor Agonist Use in Children: Data from the Pediatric ITP Consortium of North America ICON2 Study. Pediatric Blood and Cancer Epub: March 2016.

Stritt S, Nurden P, Favier R, Favier M, Ferioli S, Gotru S, van Eeuwijk JMM, Schulze H, Nurden A, Lambert MP, Turro E, Burger-Stritt S, Matsushita M, Mittermeier L, Ballerini P, Zierler S, Laffan M, Chubanov V, Gudermann T, Nieswandt T, Braun A: Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture. Nature Communications. Nature Communications 7:11097. March 2016. PMID: 27020697.

Witmer C, Lambert MP, O’Brien S, Neunert C. Multicenter Cohort Study Comparing US Management of Inpatient Pediatric Immune Thrombocytopenia to Current Treatment Guidelines. Pediatric Blood and Cancer. Epub. February 2016. PMID: 26929009.

Stritt S, Nurden P, Turro E, Greene D, Jansen SB, Westbury SK, Petersen R, Astle WJ, Marlin S, Bariana TK, Kostadima M, Lentaigne C, Maiwald S, Papadia S, Kelly AM, Stephens JC, Penkett CJ, Ashford S, Tuna S, Austin S, Bakchoul T, Collins P, Favier R, Lambert MP, Mathias M, Millar CM, Mapeta R, Perry DJ, Schulman S, Simeoni I, Thys C, Consortium Bridge-Bpd, Gomez K, Erber WN, Stirrups K, Rendon A, Bradley JR, van Geet C, Raymond FL, Laffan MA, Nurden AT, Nieswandt B, Richardson S, Freson K, Ouwehand WH, Mumford AD: A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss. Blood Epub, Feb 2016. PMID: 26912466.

Bride KL, Vincent T, Smith-Whitley K, Lambert MP, Bleesing JJ, Seif AE, Manno CS, Casper J, Grupp SA, Teachey DT. Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial. Blood. 2016 Jan 7;127(1):17-28

2014

Schultz CL, Mitra N, Schapira MM, Lambert MP: Influence of the american society of hematology guidelines on the management of newly diagnosed childhood immune thrombocytopenia. JAMA pediatrics 168(10): e142214, Oct 2014.

Greene TK, Lyde RB, Bailey SC, Lambert MP, Zhai L, Sabatino DE, Camire RM, Arruda VR, Poncz M: Apoptotic Effects of Platelet Factor VIII on Megakaryopoiesis: Implications for a Modified Human Factor VIII for Platelet-based Gene Therapy. Journal of thrombosis and haemostasis : JTH 12(12): 2102-12, Oct 2014.

Bruns I, Lucas D, Pinho S, Ahmed J, Lambert MP, Kunisaki Y, Scheiermann C, Schiff L, Poncz M, Bergman A, Frenette PS: Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion. Nature medicine 20(11): 1315-20, Oct 2014.

Sullivan SK, Mills JA, Koukouritaki SB, Vo KK, Lyde RB, Paluru P, Zhao G, Zhai L, Sullivan LM, Wang Y, Kishore S, Gharaibeh EZ, Lambert MP, Wilcox DA, French DL, Poncz M, Gadue P.: High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia. Blood. 123(5): 753-7, Jan 2014. PMCID: PMC3907760

2012

Lambert MP, Reznikov A, Grubbs A, Nguyen Y, Xiao L, Aplenc R, Raouva L, Poncz M: Platelet Factor 4 Platelet Levels Are Inversely Correlated with Steady-State Platelet Counts and with Platelet Transfusion Needs in Pediatric Leukemia Patients. Journal of thrombosis and haemostasis : JTH 10(7): 1442-6, May 2012.

Lambert MP, Jiang J, Batra V, Wu C, Tong W: A novel mutation in MPL (Y252H) results in increased thrombopoietin sensitivity in essential thrombocythemia. American journal of hematology 87(5): 532-4, May 2012.

2011

Despotovic JM, Lambert MP, Herman JH, Gernsheimer TB, McCrae KR, Tarantino MD, Bussel JB: RhIG for the treatment of immune thrombocytopenia: consensus and controversy. Transfusion 52(5): 1126-1136, Oct 2011.

Lambert MP, Xiao L, Nguyen Y, Kowalska MA, Poncz M: The role of platelet factor 4 in radiation-induced thrombocytopenia. International journal of radiation oncology, biology, physics 80(5): 1533-40, Aug 2011.

Grace RF, Bennett CM, Ritchey AK, Jeng Ml, Thornburg CD, Lambert MP, Neier M, Recht M, Kumar M, Blanchette V, Klaassen RJ, Buchanan GR, Kurth MH, Nugent DJ, Thompson A A, Stine K, Kalish LA, Neufeld EJ: Response to steroids predicts response to rituximab in pediatric chronic immune thrombocytopenia. Pediatric blood & cancer 58(2): 221-5, Jun 2011.

Lambert MP, Jackson LG, Clark D, Kaur M, Krantz I D, Deardorff MA: The incidence of thrombocytopenia in children with Cornelia de Lange syndrome. American journal of medical genetics. Part A 155(1): 33-7, Jan 2011.

2009

Lambert MP, Wang Y, Bdeir KH, Nguyen Y, Kowalska MA, Poncz M: Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes. Blood 114(11): 2290-8, Sep 2009.

2008

Lambert MP, Shields C, Meadows AT: A retrospective review of hearing in children with retinoblastoma treated with carboplatin-based chemotherapy. Pediatric blood & cancer 50(2): 223-6, Feb 2008.

2007

Kowalska MA, Mahmud SA, Lambert MP, Poncz M, Slungaard A: Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge. Blood 110(6): 1903-5, Sep 2007.

Lambert MP, Rauova L, Bailey M, Sola-Visner MC, Kowalska MA, Poncz M: Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications. Blood 110(4): 1153-60, Aug 2007.

Pessler F, Paessler M E, Lambert M, Morgan Dewitt E, Sherry D D: Polyarthritis in a child with Rosai-Dorfman disease. Clinical and experimental rheumatology 25(4): 645-8, Jul-Aug 2007.

1999

Laemle L K, Puszkarczuk M, Feinberg R N: Apoptosis in early ocular morphogenesis in the mouse. Brain research. Developmental brain research 112(1): 129-33, Jan 1999 Notes: This was published under her former name, Puszkarczuk.

Abstracts

2018

Obstfeldt A, Doshi B, Wax A, Arulselvan A, Lambert MP: Clinical Experience Evaluating Platelet Function by Whole Blood Impedance Lumi-aggregometry in a pediatric population. International Society of Thrombosis and Haemostasis SSC, Dublin July 2018.

Adentunji M, Arulselvan A, McDonnel A, Lambert MP: Evaluation of Immature Platelet Fraction for Distinguishing Inherited Macrothrombocytopenia from ITP in Children. Thrombosis and Hemostasis Society of North America, San Diego, CA March 2018.

2017

Olmsted T, Grimes A, Kirk S, Arulselvan A, Lambert MP, GraceR, Despotovic J: Positive Direct Antiglobulin Test is Predictive of Development of Chronic Immune Thrombocytopenia: Data from the ITP Consortium of North America American Society of Hematology Annual Meeting, Atlanta, GA December 2017.

Grimes A, Olmsted T, Kirk S, Lambert MP, Despotovic J.: Re-presentation to Medical Care due to Adverse Effects of IVIG Therapy in Pediatric ITP Patients. American Society of Hematology Annual Meeting, Atlanta, GA December 2017.

Tkaczynski E, Arulselvan A, Lambert MP: Platelet Factor 4 levels correlate with platelet count and ability to inhibit megakaryopoiesis in patients with ITP.  ISTH XXVI Congress, Berlin, Germany July 2017.

Doshi B, Arruda VR, Lambert MP, George LA, Raffini LR: Anti-CD20 and sirolimus for immune tolerance in congenital hemophilia A with inhibitors. ISTH XXVI Congress, Berlin, Germany July 2017.

Obstfeld A, Lambert MP: Use of a Clinical Data Warehouse for validation of Partial Thromboplastin Time (PTT) and Prothrombin Time (PT) sensitivity to coagulation factor concentration  International Society of Laboratory Hematology, Honolulu, HI May 2017.

2016

Romasko EJ, Biswas S, Devkota B, JayaramanV,  Jairam S, Thom CS, Dulik MC, Conlin LK, Spinner NB, Krantz ID, Lambert MP: Utility of Whole Exome Sequencing in Diagnosis of Pediatric Platelet Disorders: A Subanalysis of the PediSeq study. American Society of Hematology Annual Meeting, San Diego, CA December 2016.

Doshi BD, Kamdar A, Smith-Whitley K, Lambert MP, Obstfeld A: Incidence of hemolytic events after exposure to triggering medications in pediatric patients with G6PD deficiency. American Society of Hematology Annual Meeting, San Diego, CA December 2016.

Lambert MP, Kwiatkowski J: Iron Deficiency is a significant complication of Eltrombopag Treatment for ITP in Pediatric Patients Thrombosis and Hemostasis Societies of North America Meeting, Chicago, IL. Platform Presentation, April 2016.

Romasko EJ, Devkota B, Jayaraman V, Jairam S, Scarano MI, Biswas S, Thom CS, Dulik MC, Conlin LK, Spinner NB, Krantz ID, Lambert MP: Utility and Limitations of Exome Sequencing in the Diagnosis of Pediatric Platelet Disease Annual Clinical Genetics Meeting, Tampa, FL. Poster Presentation, March 2016.

2014

Ben J. Samelson-Jones, Michele P. Lambert: Use of Recombinant Factor VIIa (rVIIa) in Glanzmann's Thrombasthenia: A Systematic Review of the Literature. American Society of Hematology/Oncology Annual Meeting, Chicago, IL April 2014.

2013

Ingmar Bruns, MD, Daniel Lucas, PhD, Sandra Pinho, PhD, Jalal Ahmed, Michele P Lambert, MD, Christoph Scheiermann, PhD, Yuya Kunisaki, MD, PhD, Mortimer Poncz, MD and Paul S. Frenette, MD: Megakaryocytes Regulate Hematopoietic Stem Cell Quiescence Via PF4 Secretion. American Society of Hematology Plenary Session December 2013.

David T. Teachey, MD, TIffaney Vincent, Kim Smith-Whitley, MD, Michele P Lambert, MD, Alix E. Seif, MD, MPH, James T. Casper, MD and Stephan A Grupp, MD, PhD: Targeting mTOR Signaling Leads To Complete and Durable Responses In Children With Multi-Lineage Autoimmune Cytopenias, Including ALPS, SLE, Evans and CVID. American Society of Hematology, Oral Presentation December 2013.

Corinna L. Schultz, MD and Michele P Lambert, MD: Influence Of Updated ASH Guidelines On Practice Patterns In Management Of Newly Diagnosed Childhood ITP, 2007-2012. American Society of Hematology, Oral Presentation December 2013.

Cassie N. Kline, MD; Richard Hodinka, MD; Michele P. Lambert, MD: Investigating correlation between common upper respiratory and gastrointestinal viral infections and Idiopathic Thrombocytopenic Purpura. American Society of Pediatric Hematology/Oncology annual meeting; Poster presentation Apr 2013.

2012

Michele P. Lambert, Donna McDonald-McGinn, Elaine Zakai: Hematologic Manifestations of 22qDS. 22qDeletion Syndrome meeting, Lake Buena Vista, FL July 2012.

Xiao L, Poncz M, Lambert MP: Platelet Factor 4 (PF4) causes cell cycle arrest in megakaryocytes by inactivating CDC2 (CDK1) and CDK2 Gordon Research Conference on Hemostasis March 2012.

Lambert MP, Xiao L, Meng R, Marks M, Poncz M: Alpha-granule protein recycling during megakaryopoiesis: Platelet factor 4 (PF4) is taken up by megakaryocytes (Megs) through a lipoprotein receptor related protein-1 (LRP1) dependent process and is available for release by stimulated Megs Platelets 2012; 7th International Platelet Symposium March 2012.

Books

Chapters

2013

Lambert, MP, Poncz, M: Inherited Thrombocytopenias. Platelets. Michelson, AD (eds.). Elsevier Science, 2nd edition; 3rd edition: 985-998, 2007, 2013.

2012

Lambert, M: Autoimmune Hemolytic Anemia. The 5-Minute Pediatric Consult. Schwartz, MW, Bell, LM, Bingham, PM, Chung, EK, Friedman, DF, Tanel, RE, Mamula, P, Loomes, KM and Mascarenhas, M (eds.). Lippincott, Williams & Wilkins, 5th edition, 2008, 2012.

Lambert, M: Glucose-6 Phosphate Dehydrogenase Deficiency. The 5-Minute Pediatric Consult. Schwartz, MW, Bell, LM, Bingham, PM, Chung, EK, Friedman, DF, Tanel, RE, Mamula, P, Loomes, KM and Mascarenhas, M (eds.). Lippincott, Williams & Wilkins, 5th edition, 2008, 2012.

Lambert, MP: Anemia of Chronic Disease. The 5-Minute Pediatric Consult. Schwartz, MW, Bell, LM, Bingham, PM, Chung, EK, Friedman, DF, Tanel, RE, Mamula, P, Loomes, KM and Mascarenhas, M (eds.). Lippincott, Williams & Wilkins, 5th edition, 2008, 2012.

Lambert, MP: Hereditary Spherocytosis. The 5-Minute Pediatric Consult. Schwartz, MW, Bell, LM, Bingham, PM, Chung, EK, Friedman, DF, Tanel, RE, Mamula, P, Loomes, KM and Mascarenhas, M (eds.). Lippincott, Williams & Wilkins, 5th edition, 2008, 2012.

Posters and Presentations

2016

Tkaczynski E, Arulselvan A, Avery S, Abrams K, Torok-Storb B, Johnson G, Kennedy T, Lambert MP: 2-O, 3-O Desulfated heparin modulates inflammation and improves post radiation survival when injected subcutaneously: one molecule and two pathways. Radiation Research Society Annual Meeting, Kona, HI October 2016 Notes: Poster Presentation, received Early Career Investigator Travel Award.

Grace RF, Despotovic JM, Bennett CM, Rothman JA, Lambert MP, Breakey VP, Bussel JB, Buchanan GR, Rose M, Geddis A, Shimano KA, Hege K, Haley K, Lorenzana A, Neunert CE, Thompson AA, Pastore YD, Jeng M, Stine K, Neier M, Neufeld EJ, Brown T, Forbes P, Klaassen RJ: Fatigue in Pediatric Immune Thrombocytopenia (ITP): Baseline Prevalence in Patients Starting Second Line Therapies in the First ITP Consortium of North America Research Study (ICON1). American Society of Pediatric Hematology/Oncology, Minneapolis, MN. Poster Presentation, May 2016.

Romasko EJ, Devkota B, Jayaraman V, Jairam S, Scarano MI, Biswas S, Thom CS, Dulik MC, Conlin LK, Spinner NB, Krantz ID, Lambert MP:: Utility and Limitations of Exome Sequencing in the Diagnosis of Pediatric Platelet Disease Annual Clinical Genetics Meeting, Tampa, FL. Poster Presentation, March 2016 Notes: Poster Presentation.

Invited Lectures

2018

Lambert MP. "Inherited Platelet Disorders, Biology and Management, " NHF Bleeding Disorders Conference, Orlando, FL. Oct, 2018.

Lambert MP. "Bleeding in patients with 22q11.2DS and congenital heart disease," 22q11.2 Society Meeting, Whistler Canada. Jul, 2018.

Lambert MP. "Children and ITP: Sports, School and Treatment," PDSA annual meeting, Cleveland, OH. Jul, 2018.

Lambert MP. "Unraveling inherited platelet disorders: the role of exome sequencing in clinical diagnosis." Cardeza Seminar, Thomas Jefferson University School of Medicine, Philadelphia, PA. Apr, 2018.

Lambert MP. "Controversies in Platelet Granule Disorders," Thrombosis & Hemostasis Societies of North America (THSNA), San Diego, CA. Mar, 2018.

2017

Lambert MP. "Health Related Quality of Life and Fatigue Improve on Second Line Treatments in Pediatric Immune Thrombocytopenia (ITP)," American Society of Hematology, Atlanta, GA. Dec, 2017.

Lambert MP. "Health Related Quality of Life and Fatigue Improve on Second Line Treatments in Pediatric Immune Thrombocytopenia (ITP)," American Society of Hematology Annual Meeting, Atlanta, GA (presented by Rachael Grace). Dec, 2017.

Lambert MP. "Inherited Disorders of Platelets and Megakaryocytes," Philadelphia Hemostasis Education Workshop, Philadelphia, PA. Nov, 2017.

Lambert MP. "22q: A Hematologist's Perspective", 22q and Boo, Philadelphia, PA. Oct, 2017.

Lambert MP. "Children with ITP: Treatments, School & Sports," Platelet Disorder Support Association Meeting, Chandler, AZ. Jul, 2017.

Lambert MP. "Advance Clinical Parameters (ACPs) in Clinical Practice" ISLH, Honolulu. May, 2017.

Lambert MP. "Using Heparin to Reduce Chemotherapy and Radiation Induced Thrombocytopenia," Texas Children's Hospital, Houston, TX. Feb, 2017.

2016

Lambert MP. "Platelets in Liver and Renal Disease", American Society of Hematology, San Diego, CA. Dec, 2016.

Lambert MP. "Physician Factors Determining Treatment Decisions in Selecting Second Line Agents for Pediatric ITP," American Society of Hematology Annual Meeting, San Diego, CA. Dec, 2016.

Lambert MP. "Case Studies: Congenital Platelet Disorders", ISTH Advanced Training Course, Atlanta, GA. Nov, 2016.

Lambert MP. "Diagnosis and treatment of inherited platelet disorders",The International Society on Thrombosis and Haemostasis (ISTH) Advanced Training Course, Atlanta, GA. Nov, 2016.

Lambert MP. "An Update on Pediatric Immune Thrombocytopenia (ITP): Guidelines and Biology," Grand Rounds at Goryeb Children's Hospital at Morristown Medical Center, Morristown, NJ. Sep, 2016.

Lambert MP. "An Update on Pediatric Immune Thrombocytopenia (ITP): Guidelines and Biology, " Grand Rounds at Goryeb Children's Hospital at Overlook Medical Center, Summit, NJ. Sep, 2016.

Lambert MP. "Management of Childhood ITP", Platelet Disorder Support Association (PDSA) Annual Meeting, Orlando, FL. Jul, 2016.

Lambert MP. "The Frequency of Transfusion During Surgery for Congenital Heart Disease in Patients with 22q11.2 Deletion," 10th Biennial International 22q11.2 Conference, Sirmione, Italy. Jul, 2016.

Lambert MP. "The Increased Prevalence of Malignancy in Twins with 22q11.2 Deletion Syndrome," 10th Biennial International 22q11.2 Conference, Sirmione, Italy. Jul, 2016.

Lambert MP. "How I Treat: Guidelines for the Use of Second-Line Therapies in ITP," PDSA presentation at the Thrombosis, Hemostasis Societies of North America Meeting, Chicago, IL. Apr, 2016.

Lambert MP. "Iron Deficiency is a significant complication of Eltrombopag Treatment for ITP in Pediatric Patients," Thrombosis and Hemostasis Societies of North America Meeting, Chicago, IL. Apr, 2016.

Lambert MP. "Progress in the Development of ODSH as a Medical Countermeasure for Acute Radiation Syndrome," National Institute of Allergy and Infectious Diseases (NIAID), Rockville, MD. Jan, 2016.

Awards and Honors

2016, Early Career Investigator Travel Award, Radiation Research Society
2011, International Society on Thrombosis and Haemostasis New Investigator Travel Award
2009, International Society of Thrombosis and Haemostasis Young Investigator Travel Award
2006, American Society of Pediatric Hematology/Oncology Young Investigator Travel Award
2005, American Society of Hematology Young Investigator Travel Award
1998, UMDNJ-NJMS Alumni Association Award in honor of Dr. Franklin Behrle
1997, UMDNJ-NJMS Alumni Association Scholarship
1985-1998, UMDNJ-NJMS Joseph Muscarelli Memorial Scholarship
1995, Alpha Epsilon Delta - Premedical honor society

Editorial and Academic Positions

Editorial positions

2011-present, Journal Pediatric Hematology Oncology, Ad Hoc Reviewer

2009-present, Pediatric Blood and Cancer, Ad Hoc Reviewer

2009-present, Blood, Ad Hoc Reviewer

Academic and institutional committees

2008-2012, Member IRB-C, The Children's Hospital of Philadelphia

Leadership and Memberships

Memberships in Professional Organizations

International

2018-present, ClinGen Platelet Disorder Expert Panel

2017-present, ClinGen Hematology/Thrombosis Clinical Domain Working Group

2013-present, Pediatric ITP Consortium of North America (ICON)

 - 2016-present, Patient Centered Outcomes Committee, Co-Chair

 - 2013-present, Biology Committee

 - 2013-present, Operational Committee

2008-present, 22q and You Foundation

2007-present, International Society of Thrombosis and Haemostasis

 - 2014-present, Thrombogenomics Scientific Subcommittee, Co-Chair

National

2015-present, Radiation Research Society

2013-present, Hemostasis and Thrombosis Research Society

2011-present, Society for Pediatric Research/Pediatric Academic Society

2008-present, Platelet Disorder Support Association

 - 2015-present, Medical Advisory Board

2008-present, Cornelia De Lange Foundation

 - 2008-present, Member Medical Advisory Board

2007-present, American Society of Pediatric Hematology/Oncology

2007-present, American Society of Hematology

1999-present, American Medical Association