Michele Lambert, MD, received her undergraduate degree in Biology from Rensselaer Polytechnic Institute and attended medical school at Rutgers New Jersey Medical School. She did her residency in Pediatrics at St. Christopher’s Hospital for Children followed by a year as Chief Resident and then a Hematology/Oncology Fellowship at The Children’s Hospital of Philadelphia. She is now an Associate Professor of Pediatrics in The Perelman School of Medicine at the UPENN and a Pediatric Hematologist at the Children’s Hospital of Philadelphia where she is the clinical director of the special coagulation laboratory and co-director of the Frontier Program in Immune Dysregulation as well as the director of the Pediatric Platelet Disorder Program at CHOP. Her particular clinical interest is in the inherited and acquired platelet disorders and in the interplay between genetics and disease.
Her current research focuses on understanding the role of genetics in this space. She is a member of the ClinGen Hemostasis and Thrombosis clinical domain working group and a Co-Chair of the ClinGen Hemostasis and Thrombosis Hemostasis and Thrombosis Gene Curation Expert Panel as well as the current Chair of the pediatric ITP Consortium of North America. By understanding the drivers of differences in biology in platelet disorders, Dr. Lambert hopes to develop targeted therapies to improve outcomes.
Quote: The person who removes a mountain begins by carrying away small stones.
Education and Training
MD - University of Medicine and Dentistry of New Jersey, Newark, NJ
Pediatrics - St. Christopher's Hospital for Children, Philadelphia, PA
Pediatrics - St. Christopher's Hospital for Children, Philadelphia, PA (Chief Resident)
Pediatric Hematology/Oncology - The Children's Hospital of Philadelphia, Philadelphia, PA
Pediatric Hematology-Oncology – American Board of PediatricsPediatrics – American Board of Pediatrics
MSTR - University of Pennsylvania, Philadelphia, PA
Titles and Academic Titles
Medical Director, Special Coagulation Laboratory
Associate Clinical Director, Frontier Program in Immune Dysregulation
Associate Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Nelson O, Wu L, Swanson JW, Hsu G, Lambert MP, Obstfeld A, Thottathil P, Wohler BL, Stricker PA, Simpao AF, Galvez JA.: Thromboelastography Changes of Whole Blood Compared to Blood Component Transfusion in Infant Craniosynostosis Surgery. J Craniofac Surg 2022.
Oved JH, Lambert MP, Kowalska MA, Poncz M, Karczewski KJ.: Population based frequency of naturally occurring loss-of-function variants in genes associated with platelet disorders. J Thromb Haemost 19: 248-254, Jan 2021.
Blatz AM, Oboite M, Chiotos K, Castelo-Soccio L, Odom John AR; Children's Hospital of Philadelphia MIS-C Research Collaborative.: Cutaneous Findings in SARS-CoV-2-Associated Multisystem Inflammatory Disease in Children. Open Forum Infect Dis 8: ofab074, Feb 2021. PMCID: PMC7928560
Michael P. Triebwasser David M. Barrett Hamid Bassiri Nancy Bunin Caitlin Elgarten Jason Freedman Abdallah S. Geera Dimitri Monos Michele P. Lambert Timothy Olson Alix E. Seif Michele Paessler Whitney Petrosa Anne F. Reilly Neil Romberg Kathleen E. Sullivan Ghazal Z. Quinn Edward Behrens David T. Teachey: Combined use of emapalumab and ruxolitinib in a patient with refractory hemophagocytic lymphohistiocytosis was safe and effective. Pediatr Blood Cancer. Wiley, ediatr Blood Cancer, March 2021.
Si SJ, Tasian SK, Bassiri H, Fisher BT, Atalla J, Patel R, Romberg N, Lambert MP, Paessler M, Behrens EJ, Teachey DT, Sullivan KE.: Diagnostic Challenges in Pediatric Hemophagocytic Lymphohistiocytosis. J Clin Immunol Clin Immunol, March 2021. PMCID: PMC7988244
Lee EJ, Cines DB, Gernsheimer T, Kessler C, Michel M, Tarantino MD, Semple JW, Arnold DM, Godeau B, Lambert MP, Bussel JB.: Thrombocytopenia following Pfizer and Moderna SARS-CoV-2 vaccination. Am J Hematol 96: 534-537, May2021. PMCID: PMC8014568
Crowley TB, Campbell IM, Liebling EJ, Lambert MP, Levitt Katz LE, Heimall J, Bailey A, McGinn DE, McDonald McGinn DM, Sullivan KE.: Distinct immune trajectories in patients with chromosome 22q11.2 deletion syndrome and immunemediated diseases. J Allergy Clin Immunol Jun 2021.
Doshi BS, Kamdar A, Lambert MP, Obstfeld AE.: Hemolysis After Medication Exposure in Pediatric Patients With G6PD Deficiency. J Pediatr Hematol Oncol Oct 2021.
Diorio C, Shraim R, Vella LA, Giles JR, Baxter AE, Oldridge DA, Canna SW, Henrickson SE, McNerney KO, Balamuth F, Burudpakdee C, Lee J, Leng T, Farrel A, Lambert MP, Sullivan KE, Wherry EJ, Teachey DT, Bassiri H, Behrens EM.: Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction. Nat Commun 12: 7222, Dec 2021. PMCID: PMC8664884
Grimes AB, Kim TO, Kirk S, Flanagan J, Lambert MP, Grace RF, Despotovic JM.: Refractory autoimmune cytopenias in pediatric evans syndrome with underlying systemic immune dysregulation. Eur J Haematol ur J Haematol, 2021.
Shimano KA, Neunert C, Bussel JB, Klaassen RJ, Bhat R, Pastore YD, Lambert MP, Bennett CM, Despotovic JM, Forbes P, Grace RF.: Quality of life is an important indication for second-line treatment in children with immune thrombocytopenia. Pediatr Blood Cancer ediatr Blood Cancer, 2021.
Bury Loredana, Megy Karyn, Stephens Jonathan C, Grassi Luigi, Greene Daniel, Gleadall Nick, Althaus Karina, Allsup David, Bariana Tadbir K, Bonduel Mariana, Butta Nora V, Collins Peter, Curry Nicola, Deevi Sri Vv, Downes Kate, Duarte Daniel, Elliott Kim, Falcinelli Emanuela, Furie Bruce, Keeling David, Lambert Michele P, Linger Rachel, Mangles Sarah, Mapeta Rutendo, Millar Carolyn M, Penkett Christopher, Perry David J, Stirrups Kathleen E, Turro Ernest, Westbury Sarah K, Wu John, BioResource Nihr, Gomez Keith, Freson Kathleen, Ouwehand Willem H, Gresele Paolo, Simeoni Ilenia: Next-generation sequencing for the diagnosis of MYH9-RD: predicting pathogenic variants. Human mutation 41(1): 277-290, Jan 2020. PMCID: PMC6972977
Kim Taylor Olmsted, Flanagan Jonathan M, Habibi Ali, Arulselvan Abinaya, Lambert Michele P, Grace Rachael F, Despotovic Jenny M: Genetic variants in toll-like receptor 4 are associated with lack of steroid-responsiveness in pediatric ITP patients. Am J Hematol m J Hematol: 395-400, Jan 2020.
Thom Christopher S, Devine Matthew, Kleinman Stacey, Jensen Erik A, Lambert Michele P, Padula Michael A: Neonatal platelet count trends during inhaled nitric oxide therapy. Br J Haematol 188(3): e28-e30, Feb 2020. PMCID: PMC6982552 55. Thom Christopher S, Brandsma Erik, Lambert Michele P: Thrombocytosis in an infant with a TRPV4 mutation: a case report. Platelets 32: 1-3, Apr 2020. PMCID: PMC7577995
Cirasino Lorenzo, Robino Anna M, Podda GianMarco, Andrès Emmanuel, Despotovic Jenny M, Elalfy Mohsen, Holbro Andreas, Kondo Tadakazu, Lambert Michele P, Loggetto Sandra R, McCrae Keith R, Lee Jong Wook, Cattaneo Marco: Report of a 'consensus' on the lines of therapy for primary immune thrombocytopenia in adults, promoted by the Italian Gruppo di Studio delle Piastrine. Platelets 31(4): 461-473, May 2020.
Kim TO, Grimes AB, Kirk SE, Gilbert MM, Reed HD, Staggers KA, Walker LA, Arulselvan A, Cohen AS, Lambert MP, Despotovic JM.: Racial variation in ITP prevalence and chronic disease phenotype suggests biological differences. Blood 136: 640-643, Jul 2020. PMCID: PMC8212348
Otto WR, Behrens EM, Teachey DT, Lamson DM, Barrett DM, Bassiri H, Lambert MP, Mount S, Petrosa WL, Romberg N, Sullivan KE, Topjian AA, Fisher BT, Kajon AE.: Human Adenovirus 7-Associated Hemophagocytic Lymphohistiocytosis-Like Illness: Clinical and Virological Characteristics in a Cluster of Five Pediatric Cases. Clin Infect Dis lin Infect Dis, Aug 2020.
Thom CS, Echevarria E, Osborne AD, Carr L, Rubey K, Salazar E, Callaway D, Pawlowski T, Devine M, Kleinman S, Witmer C, Flibotte J, Lambert MP.: Extreme thrombocytosis is associated with critical illness and young age, but not increased thrombotic risk, in hospitalized pediatric patients. J Thromb Haemost 18: 3352-3358, Sept 2020. PMCID: PMC7855272
Grace RF, Klaassen RJ, Shimano KA, Lambert MP, Grimes A, Bussel JB, Breakey VR, Pastore YD, Black V, Overholt K, Bhat R, Forbes PW, Neunert C.: Fatigue in children and adolescents with immune thrombocytopenia. Br J Haematol 191: 98-106, Oct 2020.
Oved JH, Babushok DV, Lambert MP, Wolfset N, Kowalska MA, Poncz M, Karczewski KJ, Olson TS.: Human mutational constraint as a tool to understand biology of rare and emerging bone marrow failure syndromes. Blood Adv 4: 5232-5245, Oct 2020. PMCID: PMC7594375
Diorio C, Anderson EM, McNerney KO, Goodwin EC, Chase JC, Bolton MJ, Arevalo CP, Weirick ME, Gouma S, Vella LA, Henrickson SE, Chiotos K, Fitzgerald JC, Kilbaugh TJ, John ARO, Blatz AM, Lambert MP, Sullivan KE, Tartaglione MR, Zambrano D, Martin M, Lee JH, Young P, Friedman D, Sesok- Pizzini DA, Hensley SE, Behrens EM, Bassiri H, Teachey DT.: Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome. Pediatr Blood Cancer 67: e28693, Nov 2020. PMCID: PMC7734626
Diorio C, Henrickson SE, Vella LA, McNerney KO, Chase J, Burudpakdee C, Lee JH, Jasen C, Balamuth F, Barrett DM, Banwell BL, Bernt KM, Blatz AM, Chiotos K, Fisher BT, Fitzgerald JC, Gerber JS, Gollomp K, Gray C, Grupp SA, Harris RM, Kilbaugh TJ, John ARO, Lambert M, Liebling EJ, Paessler ME, Petrosa W, Phillips C, Reilly AF, Romberg ND, Seif A, Sesok-Pizzini DA, Sullivan KE, Vardaro J, Behrens EM, Teachey DT, Bassiri H.: Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2. J Clin Invest 130: 5967-5975, Nov 2020. PMCID: PMC7598044
Cuker A, Despotovic JM, Grace RF, Kruse C, Lambert MP, Liebman HA, Lyons RM, McCrae KR, Pullarkat V, Wasser JS, Beenhouwer D, Gibbs SN, Yermilov I, Broder MS.: Tapering thrombopoietin receptor agonists in primary immune thrombocytopenia: Expert consensus based on the RAND/UCLA modified Delphi panel method. Res Pract Thromb Haemost 5: 69-80, Dec 2020. PMCID: PMC7845076
Diorio C, McNerney KO, Lambert M, Paessler M, Anderson EM, Henrickson SE, Chase J, Liebling EJ, Burudpakdee C, Lee JH, Balamuth FB, Blatz AM, Chiotos K, Fitzgerald JC, Giglia TM, Gollomp K, Odom John AR, Jasen C, Leng T, Petrosa W, Vella LA, Witmer C, Sullivan KE, Laskin BL, Hensley SE, Bassiri H, Behrens EM, Teachey DT: Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations. Blood Adv 4(23): 6051-6063, Dec 2020. PMCID: PMC7724906
Romberg N, Le Coz C, Glauzy S, Schickel JN, Trofa M, Nolan BE, Paessler M, Xu ML, Lambert MP, Lakhani SA, Khokha MK, Jyonouchi S, Heimall J, Takach P, Maglione PJ, Catanzaro J, Hsu FI, Sullivan KE, Cunningham-Rundles C, Meffre E.: Patients with common variable immunodeficiency with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses. J Allergy Clin Immunol 143: 258-265, Jan 2019. PMCID: PMC6400323
Dorjbal Batsukh, Stinson Jeffrey R, Ma Chi A, Weinreich Michael A, Miraghazadeh Bahar, Hartberger Julia M, Frey-Jakobs Stefanie, Weidinger Stephan, Moebus Lena, Franke Andre, Schäffer Alejandro A, Bulashevska Alla, Fuchs Sebastian, Ehl Stephan, Limaye Sandhya, Arkwright Peter D, Briggs Tracy A, Langley Claire, Bethune Claire, Whyte Andrew F, Alachkar Hana, Nejentsev Sergey, DiMaggio Thomas, Nelson Celeste G, Stone Kelly D, Nason Martha, Brittain Erica H, Oler Andrew J, Veltri Daniel P, Leahy T Ronan, Conlon Niall, Poli Maria C, Borzutzky Arturo, Cohen Jeffrey I, Davis Joie, Lambert Michele P, Romberg Neil, Sullivan Kathleen E, Paris Kenneth, Freeman Alexandra F, Lucas Laura, Chandrasakan Shanmuganathan, Savic Sinisa, Hambleton Sophie, Patel Smita Y, Jordan Michael B, Theos Amy, Lebensburger Jeffrey, Atkinson T Prescott, Torgerson Troy R, Chinn Ivan K, Milner Joshua D, Grimbacher Bodo, Cook Matthew C, Snow Andrew L: Hypomorphic CARD11 mutations associated with diverse immunologic phenotypes with or without atopic disease. J Allergy Clin Immunol 143(4): 1482-1495, Apr 2019. PMCID: PMC6395549
Grace Rachael F, Shimano Kristin A, Bhat Rukhmi, Neunert Cindy, Bussel James B, Klaassen Robert J, Lambert Michele P, Rothman Jennifer A, Breakey Vicky R, Hege Kerry, Bennett Carolyn M, Rose Melissa J, Haley Kristina M, Buchanan George R, Geddis Amy, Lorenzana Adonis, Jeng Michael, Pastore Yves D, Crary Shelley E, Neier Michelle, Neufeld Ellis J, Neu Nolan, Forbes Peter W, Despotovic Jenny M: Second-Line Treatments in Children with Immune Thrombocytopenia: Effect on Platelet Count and Patient-Centered Outcomes. Am J Hematol 94(7): 741-750, Apr 2019. PMCID: PMC6527349
Kim Taylor Olmsted, Grimes Amanda B, Kirk Susan, Arulselvan Abinaya, Lambert Michele P, Grace Rachael F, Despotovic Jenny M: Association of a positive direct antiglobulin test with chronic immune thrombocytopenia and use of second line therapies in children: A multi-institutional review. Am J Hematol 94(4): 461-466, Apr 2019.
Le Coz Carole, Bengsch Bertram, Khanna Caroline, Trofa Melissa, Ohtani Takuya, Nolan Brian E, Henrickson Sarah E, Lambert Michele P, Kim Taylor Olmsted, Despotovic Jenny M, Feldman Scott, Fadugba Olajumoke O, Takach Patricia, Ruffner Melanie, Jyonouchi Soma, Heimall Jennifer, Sullivan Kathleen E, Wherry E John, Romberg Neil: Common variable immunodeficiency-associated endotoxemia promotes early commitment to the T follicular lineage. J Allergy Clin Immunol 144(6): 1660-1673, Dec 2019. PMCID: PMC6900457
Megy K, Downes K, Simeoni I, Bury L, Morales J, Mapeta R, Bellissimo DB, Bray PF, Goodeve AC, Gresele P, Lambert M, Reitsma P, Ouwehand WH, Freson K; Subcommittee on Genomics in Thrombosis and Hemostasis.: Curated diseasecausing genes for bleeding, thrombotic, and platelet disorders: Communication from the SSC of the ISTH. J Thromb Haemost 2019. PMCID: PMC6852472
Jalagadugula Gauthami, Goldfinger Lawrence E, Mao Guangfen, Lambert Michele P, Rao A Koneti: Defective RAB1B-related megakaryocytic ER-to-Golgi transport in RUNX1 haplodeficiency: impact on von Willebrand factor. Blood advances 2(7): 797-806, Apr 2018.
Grace Rachael F, Despotovic Jenny M, Bennett Carolyn M, Bussel James B, Neier Michelle, Neunert Cindy, Crary Shelley E, Pastore Yves D, Klaassen Robert J, Rothman Jennifer A, Hege Kerry, Breakey Vicky R, Rose Melissa J, Shimano Kristin A, Buchanan George R, Geddis Amy, Haley Kristina M, Lorenzana Adonis, Thompson Alexis, Jeng Michael, Neufeld Ellis J, Brown Travis, Forbes Peter W, Lambert Michele P: Physician Decision Making in Selection of Second-Line Treatments in Immune Thrombocytopenia in Children. American journal of hematology 93(7): 882-888, Apr 2018.
Romberg Neil, Le Coz Carole, Glauzy Salomé, Schickel Jean-Nicolas, Trofa Melissa, Nolan Brian E, Paessler Michele, Xu Mina L, Lambert Michele P, Lakhani Saquib A, Khokha Mustafa K, Jyonouchi Soma, Heimall Jennifer, Takach Patricia, Maglione Paul J, Catanzaro Jason, Hsu F Ida, Sullivan Kathleen E, Cunningham-Rundles Charlotte, Meffre Eric: Patients with common variable immunodeficiency with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses. The Journal of allergy and clinical immunology Jun 2018.
Denard Jérôme, Rouillon Jérémy, Leger Thibaut, Garcia Camille, Lambert Michele P, Griffith Graziella, Jenny Christine, Camadro Jean-Michel, Garcia Luis, Svinartchouk Fedor: AAV-8 and AAV-9 Vectors Cooperate with Serum Proteins Differently Than AAV-1 and AAV-6. Molecular therapy. Methods & clinical development 10: 291-302, Sep 2018. PMCID: PMC6111067
Gollomp Kandace, Kim Minna, Johnston Ian, Hayes Vincent, Welsh John, Arepally Gowthami M, Kahn Mark, Lambert Michele P, Cuker Adam, Cines Douglas B, Rauova Lubica, Kowalska M Anna, Poncz Mortimer: Neutrophil accumulation and NET release contribute to thrombosis in HIT. JCI insight 3(18): e99445, Sep 2018. PMCID: PMC6237233
Campbell IM, Sheppard SE, Crowley TB, McGinn DE, Bailey A, McGinn MJ, Unolt M, Homans JF, Chen EY, Salmons HI, Gaynor JW, Goldmuntz E, Jackson OA2, Katz LE, Mascarenhas MR, Deeney VFX, Castelein RM, Zur KB, Elden L, Kallish S, Kolon TF, Hopkins SE, Chadehumbe MA, Lambert MP, Forbes BJ, Moldenhauer JS, Schindewolf EM1, Solot CB, Moss EM, Gur RE, Sullivan KE, Emanuel BS, Zackai EH, McDonald-McGinn DM. What is new with 22q? An update from the 22q and You Center at the Children's Hospital of Philadelphia. Am J Med Genet A. 2018 Oct;176(10):2058-2069. doi: 10.1002/ajmg.a.40637.
Leibowitz M, Wolfe H, Flynn A, Waanders A, Burlingame C, Aumaier B, Friedman D, Lambert MP.: Standardization of prophylactic platelet transfusion dosing in a
pediatric oncology population: a quality improvement project. Transfusion 58:
2836-2840, Dec 2018.
Samelson-Jones BJ, Kramer PM, Chicka M, Gunning III WT, Lambert MP: MYH9-macrothrombocytopenia caused by a novel variant (E1421K) initially presenting as apparent neonatal alloimmune thrombocytopenia. Pediatric blood & cancer 65(4), Dec 2017.
Romasko Edward J, Devkota Batsal, Biswas Sawona, Jayaraman Vijayakumar, Rajagopalan Ramakrishnan, Dulik Matthew C, Thom Christopher S, Choi Jiwon, Jairam Sowmya, Scarano Maria I, Krantz Ian D, Spinner Nancy B, Conlin Laura K, Lambert Michele P: Utility and limitations of exome sequencing in the molecular diagnosis of pediatric inherited platelet disorders. American journal of hematology 93(1): 8-16, Sep 2017.
McDonnell A, Bride K]L, Lim D, Paessler M, Witmer CM, Lambert MP: Utility of the immature platelet fraction in pediatric immune thrombocytopenia: Differentiating from bone marrow failure and predicting bleeding risk. Pediatric blood & cancer 65(2), Sep 2017.
Westbury SK, Canault M, Greene D, Bermejo E, Hanlon K, Lambert MP, Millar CM, Nurden P, Obaji SG, Revel-Vilk S, Van Geet C, Downes K, Papadia S, Tuna S, Watt C, Consortium Nihr BioResource-Rare Diseases, Freson K, Laffan MA, Ouwehand WH, Alessi MC, Turro E, Mumford AD: Expanded repertoire of RASGRP2 variants responsible for platelet dysfunction and severe bleeding. Blood 130(8): 1026-1030, Jun 2017.
Orsini Sara, Noris Patrizia, Bury Loredana, Heller Paula G, Santoro Cristina, Kadir Rezan A, Butta Nora C, Falcinelli Emanuela, Cid Ana Rosa, Fabris Fabrizio, Fouassier Marc, Miyazaki Koji, Lozano Maria Luisa, Zuñiga Pamela, Flaujac Claire, Podda Gian Marco, Bermejo Nuria, Favier Remi, Henskens Yvonne, De Maistre Emmanuel, De Candia Erica, Mumford Andrew D, Ozdemir Nihal G, Eker Ibrahim, Nurden Paquita, Bayart Sophie, Lambert Michele P, Bussel James, Zieger Barbara, Tosetto Alberto, Melazzini Federica, Glembotsky Ana C, Pecci Alessandro, Cattaneo Marco, Schlegel Nicole, Gresele Paolo: Bleeding risk of surgery and its prevention in patients with inherited platelet disorders. The Surgery in Platelet disorders And Therapeutic Approach (SPATA) study. Haematologica 102(7): 1192-1203, Apr 2017.
Lambert Michele P, Witmer Char M, Kwiatkowski Janet L: Therapy Induced Iron Deficiency in Children Treated with Eltrombopag for Immune Thrombocytopenia. American journal of hematology 92(6): E88-E91, Feb 2017.
Mao G F, Goldfinger L E, Fan D C, Lambert M P, Jalagadugula G, Freishtat R, Rao A K: Dysregulation of PLDN (Pallidin) is a mechanism for platelet dense granule deficiency in RUNX1 haplodeficiency. Journal of thrombosis and haemostasis : JTH 15(4): 792-801, Jan 2017.
Cuker A, Husseinzadeh H, Lebedeva T, Marturano JE, Massefski W, Lowery TJ, Lambert MP, Abrams CS, Weisel JW, Cines DB: Rapid Evaluation of Platelet Function With T2 Magnetic Resonance. American journal of clinical pathology 146(6): 681-693, Dec 2016.
Neunert C, Despotovic J, Haley K, Lambert MP, Nottage K, Shimano K, Bennett C, Klaassen R, Stine K, Thompson A, Pastore Y, Brown T, Forbes PW, Grace RF: Thrombopoietin Receptor Agonist Use in Children: Data From the Pediatric ITP Consortium of North America ICON2 Study. Pediatric blood & cancer 63(8): 1407-13, Aug 2016.
Simeoni I, Stephens JC, Hu F, Deevi SVV, Megy K, Bariana TK, Lentaigne C, Schulman S, Sivapalaratnam S, Vries MJA, Westbury SK, Greene D, Papadia S, Alessi M-C, Attwood AP, Ballmaier M, Baynam G, Bermejo E, Bertoli M, Bray PF, Bury L, Cattaneo M, Collins P, Daugherty LC, Favier R, French DL, Furie B, Gattens M, Germeshausen M, Ghevaert C, Goodeve AC, Guerrero JA, Hampshire DJ, Hart DP, Heemskerk JWM, Henskens YMC, Hill M, Hogg N, Jolley JD, Kahr WH, Kelly AM, Kerr R, Kostadima M, Kunishima S, Lambert MP, Liesner R, López JA, Mapeta RP, Mathias M, Millar CM, Nathwani A, Neerman-Arbez M, Nurden AT, Nurden P, Othman M, Peerlinck K, Perry DJ, Poudel P, Reitsma P, Rondina MT, Smethurst PA, Stevenson W, Szkotak A, Tuna S, van Geet Cl, Whitehorn D, Wilcox D, Zhang B, Revel-Vilk S, Gresele P, Bellissimo DB, Penkett CJ, Laffan MA, Mumford AD, Rendon A, Gomez K, Freson K, Ouwehand WH, Turro E: A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders. Blood 127(23): 2791-803, Jun 2016.
Turro E, Greene D, Wijgaerts A, Thys C, Lentaigne C, Bariana T, Westbury S, Kelly AM, Selleslag D, Stephens JC, Papadia S, Simeoni I, Penkett CJ, Ashford S, Attwood AP, Austin S, Bakchoul T, Collins P, Deevi SVV, Favier R, Kostadima M, Lambert MP, Mathias M, Millar CM, Peerlink K, Perry DJ, Schulman S, Whitehorn D, Wittevrongel C, DeMaeyer M, Rendon A, Gomez K, Erber WN, Mumford AD, Nurden P, Stirrups K, Bradley JR, Raymond FL, Laffan MA, Van Geet, C, Richardson S, Freson, K, Ouwehand WH: A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies. Science translational medicine 8(328):328ra30-328ra30. March 2016. PMID: 26936507.
Neunert CN, Despotovic JM, Bennett CM, Lambert MP, Grace RE on behalf of the Pediatric ITP Consortium of North America: Thrombopoietin Receptor Agonist Use in Children: Data from the Pediatric ITP Consortium of North America ICON2 Study. Pediatric Blood and Cancer Epub: March 2016.
Stritt S, Nurden P, Favier R, Favier M, Ferioli S, Gotru S, van Eeuwijk JMM, Schulze H, Nurden A, Lambert MP, Turro E, Burger-Stritt S, Matsushita M, Mittermeier L, Ballerini P, Zierler S, Laffan M, Chubanov V, Gudermann T, Nieswandt T, Braun A: Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture. Nature Communications. Nature Communications 7:11097. March 2016. PMID: 27020697.
Witmer C, Lambert MP, O’Brien S, Neunert C. Multicenter Cohort Study Comparing US Management of Inpatient Pediatric Immune Thrombocytopenia to Current Treatment Guidelines. Pediatric Blood and Cancer. Epub. February 2016. PMID: 26929009.
Stritt S, Nurden P, Turro E, Greene D, Jansen SB, Westbury SK, Petersen R, Astle WJ, Marlin S, Bariana TK, Kostadima M, Lentaigne C, Maiwald S, Papadia S, Kelly AM, Stephens JC, Penkett CJ, Ashford S, Tuna S, Austin S, Bakchoul T, Collins P, Favier R, Lambert MP, Mathias M, Millar CM, Mapeta R, Perry DJ, Schulman S, Simeoni I, Thys C, Consortium Bridge-Bpd, Gomez K, Erber WN, Stirrups K, Rendon A, Bradley JR, van Geet C, Raymond FL, Laffan MA, Nurden AT, Nieswandt B, Richardson S, Freson K, Ouwehand WH, Mumford AD: A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss. Blood Epub, Feb 2016. PMID: 26912466.
Bride KL, Vincent T, Smith-Whitley K, Lambert MP, Bleesing JJ, Seif AE, Manno CS, Casper J, Grupp SA, Teachey DT. Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial. Blood. 2016 Jan 7;127(1):17-28
Schultz CL, Mitra N, Schapira MM, Lambert MP: Influence of the American Society of Hematology guidelines on the management of newly diagnosed childhood immune thrombocytopenia. JAMA pediatrics 168(10): e142214, Oct 2014.
Greene TK, Lyde RB, Bailey SC, Lambert MP, Zhai L, Sabatino DE, Camire RM, Arruda VR, Poncz M: Apoptotic Effects of Platelet Factor VIII on Megakaryopoiesis: Implications for a Modified Human Factor VIII for Platelet-based Gene Therapy. Journal of thrombosis and haemostasis : JTH 12(12): 2102-12, Oct 2014.
Bruns I, Lucas D, Pinho S, Ahmed J, Lambert MP, Kunisaki Y, Scheiermann C, Schiff L, Poncz M, Bergman A, Frenette PS: Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion. Nature medicine 20(11): 1315-20, Oct 2014.
Sullivan SK, Mills JA, Koukouritaki SB, Vo KK, Lyde RB, Paluru P, Zhao G, Zhai L, Sullivan LM, Wang Y, Kishore S, Gharaibeh EZ, Lambert MP, Wilcox DA, French DL, Poncz M, Gadue P.: High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia. Blood. 123(5): 753-7, Jan 2014. PMCID: PMC3907760
Lambert MP, Reznikov A, Grubbs A, Nguyen Y, Xiao L, Aplenc R, Raouva L, Poncz M: Platelet Factor 4 Platelet Levels Are Inversely Correlated with Steady-State Platelet Counts and with Platelet Transfusion Needs in Pediatric Leukemia Patients. Journal of thrombosis and haemostasis : JTH 10(7): 1442-6, May 2012.
Lambert MP, Jiang J, Batra V, Wu C, Tong W: A novel mutation in MPL (Y252H) results in increased thrombopoietin sensitivity in essential thrombocythemia. American journal of hematology 87(5): 532-4, May 2012.
Despotovic JM, Lambert MP, Herman JH, Gernsheimer TB, McCrae KR, Tarantino MD, Bussel JB: RhIG for the treatment of immune thrombocytopenia: consensus and controversy. Transfusion 52(5): 1126-1136, Oct 2011.
Lambert MP, Xiao L, Nguyen Y, Kowalska MA, Poncz M: The role of platelet factor 4 in radiation-induced thrombocytopenia. International journal of radiation oncology, biology, physics 80(5): 1533-40, Aug 2011.
Grace RF, Bennett CM, Ritchey AK, Jeng Ml, Thornburg CD, Lambert MP, Neier M, Recht M, Kumar M, Blanchette V, Klaassen RJ, Buchanan GR, Kurth MH, Nugent DJ, Thompson A A, Stine K, Kalish LA, Neufeld EJ: Response to steroids predicts response to rituximab in pediatric chronic immune thrombocytopenia. Pediatric blood & cancer 58(2): 221-5, Jun 2011.
Lambert MP, Jackson LG, Clark D, Kaur M, Krantz I D, Deardorff MA: The incidence of thrombocytopenia in children with Cornelia de Lange syndrome. American journal of medical genetics. Part A 155(1): 33-7, Jan 2011.
Lambert MP, Wang Y, Bdeir KH, Nguyen Y, Kowalska MA, Poncz M: Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes. Blood 114(11): 2290-8, Sep 2009.
Lambert MP, Shields C, Meadows AT: A retrospective review of hearing in children with retinoblastoma treated with carboplatin-based chemotherapy. Pediatric blood & cancer 50(2): 223-6, Feb 2008.
Kowalska MA, Mahmud SA, Lambert MP, Poncz M, Slungaard A: Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge. Blood 110(6): 1903-5, Sep 2007.
Lambert MP, Rauova L, Bailey M, Sola-Visner MC, Kowalska MA, Poncz M: Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications. Blood 110(4): 1153-60, Aug 2007.
Pessler F, Paessler M E, Lambert M, Morgan Dewitt E, Sherry D D: Polyarthritis in a child with Rosai-Dorfman disease. Clinical and experimental rheumatology 25(4): 645-8, Jul-Aug 2007.
Laemle L K, Puszkarczuk M, Feinberg R N: Apoptosis in early ocular morphogenesis in the mouse. Brain research. Developmental brain research 112(1): 129-33, Jan 1999 Notes: This was published under her former name, Puszkarczuk.
Lambert MP: Chapter 3: Special Disease Considerations in the Neonate. Neonatal Transfusion Practices. D. Sesok-Pizzini (eds.). Springer International, 2017.
Lyde RB, Poncz M, Lambert MP: Chapter 5.5 Platelet Transfusion. Platelets in Thrombotic and Non-thrombotic Disorders. Paolo Gresele, José A. López, Neal S. Kleiman, Clive P. Page (eds.). Springer, 2017.
George LA, Lambert MP: Coagulation Cascade and Fibrinolysis Pathway: Assessment in the Laboratory. Nonmalignant Hematology Expert Clinical Review: Questions and Answers. Abutalib AA, Connors JM, Ragni MV (eds.). Springer International Publishing, 2016.
Lambert, M: Autoimmune Hemolytic Anemia. The 5-Minute Pediatric Consult. Schwartz, MW, Bell, LM, Bingham, PM, Chung, EK, Friedman, DF, Tanel, RE, Mamula, P, Loomes, KM and Mascarenhas, M (eds.). Lippincott, Williams & Wilkins, 5th edition, 2008, 2012.
Lambert, M: Glucose-6 Phosphate Dehydrogenase Deficiency. The 5-Minute Pediatric Consult. Schwartz, MW, Bell, LM, Bingham, PM, Chung, EK, Friedman, DF, Tanel, RE, Mamula, P, Loomes, KM and Mascarenhas, M (eds.). Lippincott, Williams & Wilkins, 5th edition, 2008, 2012.
Lambert, MP: Anemia of Chronic Disease. The 5-Minute Pediatric Consult. Schwartz, MW, Bell, LM, Bingham, PM, Chung, EK, Friedman, DF, Tanel, RE, Mamula, P, Loomes, KM and Mascarenhas, M (eds.). Lippincott, Williams & Wilkins, 5th edition, 2008, 2012.
Lambert, MP: Hereditary Spherocytosis. The 5-Minute Pediatric Consult. Schwartz, MW, Bell, LM, Bingham, PM, Chung, EK, Friedman, DF, Tanel, RE, Mamula, P, Loomes, KM and Mascarenhas, M (eds.). Lippincott, Williams & Wilkins, 5th edition, 2008, 2012.
Posters and Presentations
Chiem M, Rauova L, Diorio C, McNerney K, Bassiri H, Behrens EM, Sullivan KS, Teachey DT, Lambert MP: The Role of PF4 Antibodies in Pediatric SARS-CoV-2. American Society of Hematology Annual Meeting, Atlanta, GA (Poster) December 2021.
Diorio C, Shraim R, Myers R, Chakkapong B, Barz-Leahy A, Aplenc R, Lambert MP, Bassiri H, Behrens EM, Lacey SF, Gonzalez V, Chen F, Levine BL,Maude S, Dinofia A, Seif A, Melenhorst J, June CH, Barrett D, Grupp S, Teachey DT: Comprehensive Secretome Profiling Elucidates Novel Disease Biology and Identifies Pre-Infusion Candidate Biomarkers to Predict the Development of Severe Cytokine Release Syndrome in Pediatric Patients Receiving CART19 American Society of Hematology Annual Meeting, Atlanta, GA (Poster) December 2021.
Gilbert M, Olmstead T, Kirk S, HyoJeong H, Grace RF, Neunert C, Lambert MP, Despotovic JM, Grimes A: Pre-medication with hydrocortisone increases risk of adverse drug events and return to medical care among pediatric ITP patients treated with IVIG. American Society of Hematology Annual Meeting, Atlanta, GA (Poster) December 2021.
Harris EM, Lambert MP, Despotovic JM, Kirk S, Arulselvan A, Basara M, Cannon B, King S, Williams D, Grace RF: Immature Platelet Fraction Does Not Correlate with Treatment Response in Immune Thrombocytopenia American Society of Hematology Annual Meeting, Atlanta, GA (Poster) December 2021.
Kuter DJ, Bussel JB, Cooper N, Gernsheimer T, Lambert MP, Liebman HA, Tarantino MD, Bandman O, Arora P, Neale A, Burns R, Yao M, Ghanima W.: LUNA3 Phase III Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial of the Oral BTK Inhibitor Rilzabrutinib in Adults and Adolescents with Persistent or Chronic Immune Thrombocytopenia. American Society of Hematology Annual Meeting, Atlanta, GA (Poster) December 2021.
Oved JH, Elgarten CW, Daniel SG, Denu L, Silverman MS, Bittinger K, Olson TS, Lambert MP: Pediatric Patients with Immune Thrombocytopenic Purpura Have a Dysbiotic Gut Microbiome At Time of Diagnosis American Society of Hematology Annual Meeting, Atlanta, GA (Poster) December 2021.
Gauthami S. Jalagadugula, PhD, Guangfen Mao, MD, Lawrence E. Goldfinger, PhD, Jeremy Wurtzel, MS, Michele P. Lambert, MD and A. Koneti Rao, MBBS: Defective RAB31-Mediated Endosomal Trafficking in RUNX1 Haplodeficiency. International Society of Thrombosis and Haemostasis Meeting (Virtual due to COVID), (Oral) July 2020.
Witmer C, Lambert MP: Organized sports participation and injury in pediatric patients with chronic ITP. International Society of Thrombosis and Haemostasis Meeting (Virtual due to COVID19), (Poster) July 2020.
Cuker A, Despotovic JM, Grace RF, Kruse C, Lambert MP, Liebman H, LyonsRM, McCrae KR, Pullarkat VA, Wasser J, Beenhouwer D, Gibbs SN, Yermilov I, Brode MS: Tapering Thrombopoietin Receptor Agonists in Primary Immune Thrombocytopenia: Recommendations Based on the RAND/UCLA Modified Delphi Panel Method. American Society of Hematology Annual Meeting (Virtual due to COVID19) (Poster) Dec 2020.
Diorio C, McNerney KO, Lambert MP, Paessler M, Chase J,Gollomp K,Laskin BJ, Vella LA, Henrickson SE, Liebling E, Burudpakdee C, Jessica Lee J, Balamuth F, Blatz AM, Chiotos K, Fitzgerald JC, Giglia T, Odom John AR, Petrosa W, Sullivan K, Witmer CM, Bassiri H, Behrens EM, Teachey DT: Evidence of Microangiopathy in Children with Sars-Cov-2 Regardless of Clinical Presentation. American Society of Hematology Annual Meeting (Virtual due to COVID19) (Poster) Dec 2020.
Diraimo J, Kruse C, Lambert MP, Kruse A: Anxiety in Adult Patients Living with ITP Stratified across Different Treatment Types and Groups. American Society of Hematology Annual Meeting (Virtual due to COVID19) (Poster) Dec 2020.
Diraimo J, Kruse C, Lambert MP, Kruse A: Impact of Therapy Choice on Fatigue in Adults with Immune Thrombocytopenia. American Society of Hematology Annual Meeting (Virtual due to COVID19) (Poster) Dec 2020.
Songdej N, Fabiola Del carpio-cano F, Mao G, Jeremy Wurtzel J, Goldfinge L, Lambert MP, Rao AK: Transcription Factor RUNX1 Regulates Factor FXIIIA Subunit (F13A1) Expression in Megakaryocytic Cells and Platelet F13A1 Expression is Downregulated in RUNX1 Haplodeficiency. American Society of Hematology Annual Meeting (Virtual due to COVID19) (Oral) Dec 2020.
Lambert MP. "Challenging Hematology Consults: Diagnosing Chronic Thrombocytopenia: Update on the Genetics of Inherited Thrombocytopenia," American Society of Pediatric. May 2022.
Lambert MP. "Inherited and Acquired Thrombocytopathies," Leukemia, Lymphoma and Myeloma Congress, New York, NY (Virtual). Oct 2021.
Lambert MP. ITP Diagnosis and Misdiagnosis: ITP Summit Conference, Niagaraon-the-Lake, Canada (virtual). Oct 2021.
Lambert MP. "RUNX1- A Case for Early HSCT Transplant?" RUNX1 Research Foundation, Annual RUNX1 Research Conference (Virtual). Sept 2021.
Lambert MP. "Consumptive Thrombohemorrhagic Disorders (DIC, HUS, TTP)", 2020 Hematology and Medical Oncology Best Practices Course, Washington, DC (Virtual due to COVID). Aug 2021.
Lambert MP. Pediatric ITP: Sports, school and other vexing questions. PDSA Annual Meeting, Seattle, Washington (Virtual Due to COVID19). Jul 2021.
Lambert MP. "Is it Really ITP?", in Inherited Thrombocytopenia:What Is It, Whom To Test and How To Test? Webinar sponsored by RUNX1 Research Program, Foundation for Women and Girls with Blood Disorders and Platelet Disorder Support Association (Virtual Webinar). Jun 2021.
Lambert MP. "Qualitative Platelet Defects," ASH Hematology Review Series and live review session subject matter expert, Webinar. May 2021.
Lambert MP. "Immune dysregulation and Platelets" Platelets International Symposium, Wellesley, MA (Postponed due to COVID19). May 2021.
Lambert MP. "Management of bleeding in patients on antithrombotic therapy", ISTH Webinar on Antithrombotic Treatment of Patients with Chronic Kidney Disease. Feb 2021.
Lambert MP. "Improving Interpretation of Genetic Testing for Hereditary Hemorrhagic, Thrombotic, and Platelet Disorders", American Society of Hematology, San Diego, CA (Virtual due to COVID19). Dec 2020.
Lambert MP. "Executive Summary for Advances in the Laboratory Assessment of Hemostatic and Thrombotic Disorders", American Society of Hematology, San Diego, CA (Virtual due to COVID19). Dec 2020.
Lambert MP. "Improving Interpretation of Genetic Testing for Hereditary Hemorrhagic, Thrombotic, and Platelet Disorders", American Society of Hematology, San Diego, CA. Dec 2020.
Lambert MP. "Immune Dysregulation in Pediatric Immune Cytopenias", 3rd Beijing Congress of Thrombosis and Hemostasis & 1st Beijing Annual Symposium of Hematologic Malignancy and Immunohematology, Beijing, China (Virtual Meeting due to COVID19). Oct 2020.
Lambert MP."Consumptive Thrombohemorrhagic Disorders: TTP, HUS and DIC," George Washington University Best Practices in Hematology/Oncology, Washington, DC (Virtual). Aug 2020.
Lambert MP. "Questions and answers in pediatric ITP," Platelet Disorder Support Association Meeting, Seattle, WA (Virtual meeting due to COVID19). Aug 2020.
Lambert MP. Clinical versus genetic approaches to the diagnosis of inherited platelet disorders, International Society for Thrombosis and Haemostasis, Virtual Meeting in place of Annual Meeting in Milan, Italy. Jul 2020.
Lambert MP. "Immune dysregulation in Evans Syndrome," Pediatric Immune Cytopenias, Houston, Texas (Cancelled due to COVID19). Jul 2020.
Lambert MP. "Platelets and bleeding in Jacobsen Syndrome; 11q-", Jacobsen Family Symposium, Washington, DC (postponed due to COVID19). Jul 2020.
Lambert MP. "Clinical versus the Genetic Diagnosis of Inherited Platelet Disorders - State of the Art Presentation," International Society of Thrombosis and Haemostasis Meeting, Milan, Italy (Virtual Due to COVID19). Jul 2020.
Lambert MP. "Platelet Counts in Patients with 22Q11.2DS Demonstrate Accelerated Decline in First Two Decades of Life Compared to Non-deleted Populations." 22q11.2 Deletion Syndrome Society Biannual Meeting, Split, Croatia (postponed due to COVID19). Jun 2020.
Lambert MP. "Immune dysregulation in Pediatric Immune Thrombocytopenia," 3rd Beijing Forum of Thrombosis and Hemostasis & 1st Chinese Annual Congress of Hematologic Malignancy and Immunohematology, Beijing, China (postponed due to COVID19). Apr 2020.
Lambert MP. "2020 Hematology and Medical Oncology Best Practices Course", Hematology Update Symposium, Washington, DC. Feb 2020.
Awards and Honors
2016, Early Career Investigator Travel Award, Radiation Research Society
2011, International Society on Thrombosis and Haemostasis New Investigator Travel Award
2009, International Society of Thrombosis and Haemostasis Young Investigator Travel Award
2006, American Society of Pediatric Hematology/Oncology Young Investigator Travel Award
2005, American Society of Hematology Young Investigator Travel Award
1998, UMDNJ-NJMS Alumni Association Award in honor of Dr. Franklin Behrle
1997, UMDNJ-NJMS Alumni Association Scholarship
1985-1998, UMDNJ-NJMS Joseph Muscarelli Memorial Scholarship
1995, Alpha Epsilon Delta - Premedical honor society
Editorial and Academic Positions
2021-present, Journal of Thrombosis and Haemostasis, Editorial Board
2020-present, HRB Definitive Intervention and Feasibility Awards Grant Review Board; Ireland; Ad Hoc Reviewer
2011-present, Journal Pediatric Hematology Oncology, Ad Hoc Reviewer
2009-present, Pediatric Blood and Cancer, Ad Hoc Reviewer
2009-present, Blood, Ad Hoc Reviewer
2018-present, ClinGen Platelet Disorder Expert Panel
2017-present, ClinGen Hematology/Thrombosis Clinical Domain Working Group
2013-present, Pediatric ITP Consortium of North America (ICON)
- 2016-present, Patient Centered Outcomes Committee, Co-Chair
- 2013-present, Biology Committee
- 2013-present, Operational Committee
2008-present, 22q and You Foundation
2007-present, International Society of Thrombosis and Haemostasis
- 2014-present, Thrombogenomics Scientific Subcommittee, Co-Chair
2015-present, Radiation Research Society
2013-present, Hemostasis and Thrombosis Research Society
2011-present, Society for Pediatric Research/Pediatric Academic Society
2008-present, Platelet Disorder Support Association
- 2015-present, Medical Advisory Board
2008-present, Cornelia De Lange Foundation
- 2008-present, Member Medical Advisory Board
2007-present, American Society of Pediatric Hematology/Oncology
2007-present, American Society of Hematology
1999-present, American Medical Association
Patient Experience Ratings
About the Patient Experience Rating System
The Patient Experience Rating is an average of all responses to the care provider related questions shown above from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.
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