Elizabeth B. Rand, MD, is a pediatric gastroenterologist in the Division of Gastroenterology, Hepatology and Nutrition at Children's Hospital of Philadelphia (CHOP). She is the Medical Director of CHOP's Liver Transplant Program, Director of the Gastroenterology Fellowship Program and Director of the Advanced Transplant Hepatology Program.
Areas of Expertise:
Liver transplant, Care for children after transplant, Acute liver failure, End-stage liver disease of any kind, Biliary atresia, Alagille syndrome, Autoimmune hepatitis, Secondary diseases of the liver Locations:Main Hospital; Buerger Center for Advanced Pediatric Care
Dr. Rand's interests are in the clinical care of children with liver disease, particularly Alagille syndrome, biliary atresia and liver transplantation. Research interests include clinical studies of biliary atresia and studies of immunization, immune suppression and long-term outcome after transplantation. Basic science interests in liver development and fibrosis are carried out as collaborations with FSBLC scientists who utilize the liver tissue bank.
Education and Training
MD - University of Chicago, Pritzker School of Medicine, Chicago, IL
Rychik J, Dodds KM, Goldberg D, Glatz AC, Fogel, M, Rossano J, Chen J, Pinto E, Ravishankar C, Rand E, Rome JJ, Dori Y. Protein Losing Enteropathy After Fontan Operation: Glimpses of Clarity Through the Lifting Fog. World Journal for Ped and Congenital Heart Surgery 2020 11(1): 92-96
Wehrman A, Waisbourd-Zinman O, Shah A, Hilmara D, Lin H, Rand EB. Steroid Free Treatment of Autoimmune Hepatitis in Selected Children. J Pediatr. 2019 Apr;207:244-247 PMID: 30723013
Gurnaney HG, Cook-Sather SD, Shaked A, Olthoff KM, Rand EB, Lingappan AM, Rehman MA. Extubation in the operating room after pediatric liver transplant: A retrospective cohort study. Paediatr Anaesth. 2018 Feb;28(2):174-178. doi: 10.1111/pan.13313. Epub 2018 Jan 8. PMID: 2931600
Waisbourd-Zinman O, Shah A, Lin HC, Rand EB Splenic Rupture in Children With Portal Hypertension. J Pediatr Gastroenterol Nutr. 2018 Mar;66(3):447-450. PMID: 29470319
Goldberg DJ, Surrey LF, Glatz AC, Dodds K, O'Byrne ML, Lin HC, Fogel M, Rome JJ, Rand EB, Russo P, Rychik J. Hepatic Fibrosis Is Universal Following Fontan Operation, and Severity is Associated With Time From Surgery: A Liver Biopsy and Hemodynamic Study. J Am Heart Assoc. 2017 Apr 26;6(5). pii: e004809. doi: 10.1161/JAHA.116.004809. PMID:28446492
Saubermann LJ, Deneau M, Falcone RA, Murray KF, Ali S, Kohli R, Ekong UD, Valentino PL, Grossman AB, Rand EB, Jonas MM, Saeed SA, Kamath BM. Hepatic Issues and Complications Associated With Inflammatory Bowel Disease: A Clinical Report From the NASPGHAN Inflammatory Bowel Disease and Hepatology Committees. J Pediatr Gastroenterol Nutr. 2017 Apr;64(4):639-652. doi: 10.1097/MPG.0000000000001492. PMID: 27984347
Surrey LF, Russo P, Rychik J, Goldberg DJ, Dodds K, O'Byrne ML, Glatz AC, Rand EB, Lin HC. Defining the role of liver biopsy in the assessment of liver fibrosis in patients with Fontan circulation-reply Hum Pathol. 2017 Jun 8. pii: S0046-8177(17)30213-7. doi: 10.1016/j.humpath.2017.04.029. [Epub ahead of print] No abstract available. PMID: 28603067
Daniels CJ, Bradley EA, Landzberg MJ, Aboulhosn J, Beekman RH 3rd, Book W, Gurvitz M, John A, John B, Marelli A, Marino BS, Minich LL, Poterucha JJ, Rand EB, Veldtman GR Fontan-Associated Liver Disease: Proceedings from the American College of Cardiology Stakeholders Meeting, October 1 to 2, 2015, Washington DC. J Am Coll Cardiol. 2017 Dec 26;70(25):3173-3194. doi: 10.1016/j.jacc.2017.10.045 PMID: 2928929
Shneider BL, Magee JC, Karpen SJ, Rand EB, Narkewicz MR, Bass LM, Schwarz K, Whitington PF, Bezerra JA, Kerkar N, Haber B, Rosenthal P, Turmelle YP, Molleston JP, Murray KF, Ng VL, Wang KS, Romero R, Squires RH, Arnon R, Sherker AH, Moore J, Ye W, Sokol RJ; Childhood Liver Disease Research Network (ChiLDReN). Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia. J Pediatr. 2016 Mar;170:211-7.e1-2.
Surrey LF, Russo P, Rychik J, Goldberg DJ, Dodds K, O'Byrne ML, Glatz AC, Rand EB, Lin HC. Prevalence and characterization of fibrosis in surveillance liver biopsies of patients with Fontan circulation. Hum Pathol. 2016 Nov;57:106-115. doi: 10.1016/j.humpath.2016.07.006.PMID: 27476041
Schwartz MC, Glatz AC, Daniels K, Goldberg DJ, Rand E, Epelman MS, Cohen MS. Hepatic Abnormalities Are Present Before and Early After the Fontan Operation. Ann Thorac Surg. 2015 Sep 4. pii: S0003-4975(15)01107-8. doi: 10.1016/j.athoracsur.2015.06.071. [Epub ahead of print. PMID: 26343976]
Schwartz MC, Sullivan LM, Glatz AC, Rand E, Russo P, Goldberg DJ, Rome JJ, Cohen MS. Portal and Sinusoidal Fibrosis are Common on Liver Biopsy After Fontan Surgery. Pediatr Cardiol. 2013 Jan;34(1):135-42
Squires RH, Dhawan A, Alonso E, Narkewicz MR, Shneider BL, Rodriguez-Baez N, Olio DD, Karpen S, Bucuvalas J, Lobritto S, Rand E, Rosenthal P, Horslen S, Ng V, Subbarao G, Kerkar N, Rudnick D, James Lopez M, Schwarz K, Romero R, Elisofon S, Doo E, Robuck PR, Lawlor S, Belle SH; for the Pediatric Acute Liver Failure Study Group. Intravenous N-acetylcysteine in pediatric patients with non-acetaminophen acute liver failure: A placebo-controlled clinical trial. Hepatology. 2013 Apr;57(4):1542-9
Mohammad S, Grimberg A, Rand E, Anand R, Yin W, Alonso EM; Studies of Pediatric Liver Transplantation Research Consortium. Long-term linear growth and puberty in pediatric liver transplant recipients. J Pediatr. 2013 Nov;163(5):1354-60.e1-7. doi: 10.1016/j.jpeds.2013.06.039. Epub 2013 Aug 2
Rychik J, Goldberg D, Rand E, Semeao E, Russo P, Dori Y, Dodds K. End-organ consequences of the Fontan operation: liver fibrosis, protein-losing enteropathy and plastic bronchitis. Cardiol Young. 2013 Dec;23(6):831-40. doi: 10.1017/S1047951113001650.
Patel RR, Hodinka RL, Kajon AE, Klieger S, Oikonomopoulou Z, Petersen H, Rand E, Attiyeh EF, Fisher BT. A Case of Adenovirus Viremia in a Pediatric Liver Transplant Recipient With Neutropenia and Lymphopenia: Who and When Should We Treat? J Pediatric Infect Dis Soc. 2015 Mar;4(1):e1-5. doi: 10.1093/jpids/pit081. Epub 2013 Dec 10
Schwartz MC, Sullivan L, Cohen MS, Russo P, John AS, Guo R, Guttenberg Ma, Rand EB: Hepatic pathology may develop before the Fontan operation in children with functional single ventricle: an autopsy study. The Journal of Thoracic and Cardiovascular Surgery 143(4): 904-9, Apr 2012.
Kamath Binita M, Yin Wanrong, Miller Heather, Anand Ravinder, Rand Elizabeth B, Alonso Estella, Bucuvalas John: Outcomes of liver transplantation in alagille syndrome: The split experience. Liver Transplantation 18(8): 940-948, August 2012.
Cui R, Fayek SA, Rand EB, Feygin T, Khrichenko D, Shaked A: Central pontine myelinolysis: a case report and clinical-pathological review. Pediatric Transplantation 16(6): E251-6, Sept 2012.
Rychik J, Veldtman G, Rand E, Russo P, Rome JJ, Krok K, Goldberg DJ, Cahill AM, Wells RG: The Precarious State of the Liver After a Fontan Operation: Summary of a Multidisciplinary Symposium. Pediatr Cardiol 33(7): 1001-12, Oct 2012.
Akimova T, Kamath BM, Goebel J W, Meyers KEC, Rand EB, Hawkins A, Levine MH, Bucuvalas JC, Hancock WW: Differing effects of rapamycin or calcineurin inhibitor on T-regulatory cells in pediatric liver and kidney transplant recipients. American Journal of Transplantation 12(12): 3449-61, Dec 2012.
Goldberg DJ, Dodds K, Avitabile CM, Glatz AC, Brodsky JL, Semeao EJ, Rand EB, Mancilla EE, Rychik J: Children With Protein-Losing Enteropathy After the Fontan Operation Are at Risk for Abnormal Bone Mineral Density. Pediatric Cardiology 33(8), Dec 2012.
Ruebner R L, Reese P P, Denburg M R, Rand E B, Abt P L, Furth S L: Risk factors for end-stage kidney disease after pediatric liver transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 12(12): 3398-405, Dec 2012.
Cárdenas Agustín M, Epelman Monica, Darge Kassa, Rand Elizabeth B, Anupindi Sudha A: Pre- and postoperative imaging of the Rex shunt in children: what radiologists should know. AJR. American journal of roentgenology 198(5): 1032-7, May 2012.
Rand EB, Karpen S, Kelly S, Mack C, Houck W, Malatack J, Romero R, Sundaram SS, Sokol R, and Whitington PF. Treatment of neonatal hemochromatosis with exchange transfusion and intravenous immunoglobulin. J Pediatr. 2009 Oct;155(4):566-71.
Diaz R, Kim JW, Hui JJ, Li Z, Swain DP, Fong KS, Csiszar K, Russo PA, Rand EB, Furth EE, Wells RG. Evidence for the epithelial to mesenchymal transition in biliary atresia fibrosis. Hum Pathol, 2008 39(1):102-115.
Diaz R, Kelly JA, Ruchelli E, Rand EB, Mamula P. A 10-year-old girl with mild elevation of liver transaminases. Medscape J Med, 2008 5;10(2):28.
Mattei P, von Allmen D, Piccoli D, Rand E. Relief of intractable pruritis in Alagille syndrome by partial external biliary diversion. J Ped Surg 2006 41:104-107.
Khan S, Erlichman J, Rand EB. Live virus immunization following pediatric liver transplantation. Pediatric Transplantation, 2006 10:78-82.
Rand EB, Bunin NB, Cochran W, Ruchelli E, Olthoff KM. Sequential liver and bone marrow transplantation for treatment of erythropoietic protoporphyria. Pediatrics, 2006 118(6):e1896-e1899.
McGuire BM, Bonkovsky HL, Carithers RL, Chung RT, Goldstein LI, Lake JR, Lok AS, Potter CJ, Rand EB, Voight MD, Davis PR and Bloomer JR. Liver transplantation for erythropoietic protoporphyria liver disease. Liver Transpl. 2005 Dec;11(12):1590-1596.
Abt PL, Rapaport-Kelz R, Desai NM, Frank A, Sonnad S, Rand E, Markmann JF, Shaked A, Olthoff KM. Survival among pediatric liver transplant recipients: impact of segmental grafts. Liver Transpl. 2004 Oct;10(10):1287-93.
Rand EB, Olthoff KM. Overview of Pediatric Liver Transplantation. Gastroenterol Clin North Am. 2003 Sep;32(3):913-29
Perlmutter DH. Lopez MJ. Martin M. Rand E. Research agenda for pediatric gastroenterology, hepatology and nutrition: molecular basis of gastrointestinal diseases. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation. Journal of Pediatric Gastroenterology & Nutrition. 35 Suppl 3:S237-41, 2002.
Matthews RT, Russo P, Berry GT, Piccoli DA, Rand EB. Biliary atresia associated with a fatty acid oxidation defect. JPGN; 35(5):624-628, 2002.
Krasinskas AM, Ruchelli ED, Rand EB, Chittams JL, Furth EE. Central venulitis in pediatric liver allografts. Hepatology; 33:1141-1147, 2001.
Singer AL, Olthoff KM, Kim H, Rand EB, Zamir G, Shaked A. The role of plasmapheresis in the management of acute hepatic failure in children. Annals of Surgery 234(3):418-421, 2001.
Emerick KM, Rand EB, Goldmuntz E, Krantz ID, Spinner NB, Piccoli DA. Features of Alagille Syndrome in 92 patients: frequency and relation to prognosis. Hepatology; 29:822-829, 1999.
Xue Y, Gao X, Lindsell CE, Chang B, Hicks C, Gendron-Maguire M, Davison MT, Rand EB, Weinmaster G, Gridley T. Vascular defects in mice lacking the Notch ligand Jagged1. Human Molecular Genetics; 8:723-730, 1999.
Marcucci L, Shaked A, Maller ES, Rand EB, Hahn ES, Higuchi NH, Barker CF, Olthoff KM. Supraceliac aortic pseudoaneurysms following liver transplantation in infants. Transplantation, 1999.
Louis A, Van Eyken P, Haber BA, Hicks C, Weinmaster G, Taub R, Rand EB. Hepatic Jagged1 expression studies. Hepatology; 30:1269-1275, 1999.
Zamir GA. Olthoff KM. Nunes FA. Markmann JF. Zeldin GA. Stewart CA. Weinreib RM. Rand EB. Maller ES. Lucey MR. Shaked A. Liver transplantation at the University of Pennsylvania and the Children's Hospital of Philadelphia. Clinical Transplants 223-9, 1999.
Rand EB. The genetic basis of Alagille syndrome (selected summary). J Ped Gastroenterol Nutr; 26(2):234-236, 1998.
Allen KJ, Rand EB, Hart J, Whitington PF. Prognostic implications of centrilobular necrosis in pediatric liver transplant recipients. Transplantation; 65:692-698, 1998.
Krantz ID, Colliton RP, Genin A, Rand EB, Li L, Piccoli DA, Spinner NB. Spectrum and frequency of Jagged1 (Jag1) mutations in Alagille syndrome patients and their families. Am J Hum Genet; 62:1361-1369, 1998.
Krantz ID, Rand EB, Genin A, Hunt P, Jones M, Louis AA, Graham Jm, Bhatt S, Piccoli DA, Spinner NB. Deletions of 20p12 in Alagille Syndrome: Frequency and Molecular Characterization. Am. J. Med. Genet. 70:80-86, 1997.
Li L, Krantz ID, Deng Y, Genin A, Banta AB, Collins CC, Qi M, Trask GJ, Kuo WL, Cochran J, Costa T, Pierpont MEM, Rand EB, Piccoli DA, Hood L, Spinner NB. Alagille syndrome is caused by mutations in Jagged1, a ligand for Notch1. Nature Genetics, 16(3):243-251,1997.
Wasserman D, Hoekstra JH, Tolia V, Taylor CJ, Kirschnr BS, Takeda J, Bell GI, Taub R, Rand EB. Molecular analysis of the fructose transporter gene (GLUT5) in isolated fructose malabsorption. J. Clin. Invest. 98:2398-2402, 1996.
Rand EB, Spinner NB, Piccoli DA, Whitington PF, and Taub R. Molecular Analysis of 24 Alagille syndrome families identifies a single submicroscopic deletion and further localizes the Alagille region within 20/12. Am J Hum Genet. 57:1068-1073, 1995.
Spinner NB, Rand EB, Fortina P, Genin A, Taub R, Semeraro A, and Piccoli D. Cytologically balanced t(2;20) in a two generation family with Alagille syndrome: cytogenetic and molecular studies. Am J Hum Genet. 55:238-243, 1994.
Rand EB, DePaoli A, Davidson N, Bell GI and Burant C. Isolation and characterization of the rat fructose transporter. Am J Physiol.264(6 Pt 1):G1169-G1176, 1993.
Rand EB, McCarthy C and Whitington PF. Measles vaccination following orthotopic liver transplantation. J Pediatr. 123(1):87-89,1993.
Gonzalez-Vallina R, Alonso EM, Rand EB, Black DD and Whitington PF. Outpatient percutaneous liver biopsy in children. J Pediatr Gastoenterol Nutr. 17:370-375, 1993.
Rand EB and Whitington PF Successful orthotopic liver transplantation in two patients with sclerosing cholangitis in the setting of Histiocytosis X. J Pediatr Gastroenterol Nutr. 15(2):202-207, 1992.
Rand EB and Whitington PF Neonatal hemochromatosis: Report of successful orthotopic liver transplantation. J Pediatr Gastroenterol Nutr. 15(3):325-329, 1992.
Bernstein EF (now Rand, EB) and Whitington PF Successful treatment of atypical sprue in an infant with cyclosporine. Gastroenterology 95:199-204, 1988.
Hsu E, Rand EB. Liver Transplant in Alagille syndrome. In: Alagille syndrome. Kamath and Loomes Eds. 2018.
Kriegermeier A, Rand EB. Systemic diseases affecting the liver. In: Pediatric Gastroenterology, Hepatology, & Nutrition, 2nd Edition. Sundaram and Bass Eds. CCGMP Pubs, 2016
Ruchelli, E., Wen, J., Rand, E. : Hepatitis and liver failure in infancy and childhood. Pathology of Pediatric Gastrointestinal and Liver Disease, 2nd e. Russo, P., Ruchelli, E., Piccoli, D. (eds.). Springer, 2013.
Kamath BM, Muir A, Rand EB: Nutritional Considerations in Pediatric Liver Transplant. Nutrition, Diet Therapy and the Liver. Preedy, Lakshman, Srirajaskanthan, and Watson (eds.). Taylor and Francis Group/CRC Press Publishers, Page: 307-319, 2010.
Ryan MJ, Rand E: Primary Sclerosing Cholangitis. Pediatric Gastroenterology: The requisites in pediatrics. Liacouras and Piccoli (eds.). Mosby Elsevier Publishing, Page: 285-299, 2008.
Kamath BM and Rand EB: Evaluation of the liver transplant candidate. Pediatric Solid Organ Transplantation. Fine, Ebber, Olthoff, Kelly and Harmon (eds.). Blackwell Publishing, Page: 207-212, 2007.
Emerick Organ Transplant 16(5): 499-504, October 2011.M, Chrisant MA and Rand EB: Transplant Emergencies. Textbook of Pediatric Emergency Medicine. Fleisher, Ludwig & Henretig (eds.). Lippincott Williams & Wilkins, Page: 1727-1736, 2006.
Rand EB and Olthoff KA: Pediatric Liver Transplantation. Liver Transplantation. Michael Lucey (eds.). 2002.
Rand EB: Biliary Atresia, Obstructive Jaundice. Fetal and Neonatal Secrets, Hanely & Belfus. Polin (eds.). June 2001.
Rand EB: Gastroenterology. Nutrition. The Harriet Lane Handbook, (12th Edition). Greene M (eds.). Year Book Medical Publishers Inc., Chicago, Page: 47-50 and 337-348, 1990.
Posters and Presentations
Bernstein EF. AASLD Pediatric SIG (Fontan associated liver disease) 11/2018; Moderator Pediatric SIG meeting; San Francisco CA
Bernstein EF. AASLD Post Graduate Course (case analysis 14 year old with Fontan hepatopathy) 11/2018
Bernstein EF. Canadian Cardiology Congress, (Fontan liver disease), Toronto CA 10/21/18
Awards and Honors
2015, CHOP resident’s graduation speaker
2014, Joanne Decker MD Mentor Award, Children's Hospital of Philadelphia
2013, GI Fellows Faculty Teaching Award
2012-2014, GI Fellows Faculty Honor Roll Awarded Annually 2012 and 2013
2007, Children's Hospital of Philadelphia, Master Clinician Award
2005, American Liver Foundation Physician of the Year Award
1998-2016, Faculty Honor Roll, CHOP Department of Pediatrics
1998-2013, Pediatric Residents Faculty Honor Roll Awarded Annually
1996-2011, Invited to the Senior Dinner for graduating residents, Children's Hospital of Philadelphia, 1996, 1997, 2010, 2011
1994, Lawrence M. Gartner Fellowship Award for Excellence in Pediatric Research
1993, Postgraduate Biomedical Research Symposium, 1st Prize Basic Science Research Award, University of Chicago
1993-1994, MAPS Scholar, Molecular Approaches to Pediatric Science, The Joseph Stokes, Jr. Research Institute of The Children's Hospital of Philadelphia
1991-1993, Pediatric Scientist Development Award, The University of Chicago
1990-1991, Johnny Genna Fellowship Award, University of Chicago
1987, Richard Reilly Award for Outstanding Senior in Gastroenterology, University of Chicago
2015-present, Clinical Documentation Standards Committee
2009-present, Transplant Center Quality Assurance Committee
2009-present, Transplant Center Steering Committee
2000-present, Graduate Medical Education Committee
Leadership and Memberships
2003-present, American Society for Transplantation (AST)
2000-present, UNOS (CHOP Representative)
1993-present, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
1992-present, American Association for the Study of Liver Diseases (AASLD)
Patient Experience Ratings
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