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Precision Medicine at CHOP

Precision medicine at CHOP

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Precision medicine uses various tools — such as cutting-edge research and big data analysis — to develop diagnostics and treatment plans tailored to individual patients.

Diagnostic and manufacturing services

CHOP is a leader in providing services such as viral vector manufacturing and advanced genetic testing that enable precision medicine practices at CHOP and at other institutions.

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Precision medicine in practice

Genetic testing drives Rowan’s thyroid cancer therapy

CHOP experts in pediatric thyroid conditions and rare pediatric cancers successfully integrated precision medicine into Rowan’s treatment plan.

Research-based programs

CHOP is advancing research discoveries in precision medicine by conducting clinical trials, harnessing the power of omics and more.

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Clinical programs offering forms of precision medicine

CHOP has multiple programs for children facing serious illness for which cell and gene therapies or other precision medicine approaches are the optimal way to treat their specific illness.

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  • Surgical Planning Using Virtual Reality

    Reena Ghosh, MD: So, this is a virtual reality for patient CC. The green is the tricuspid valve, pulmonary anulus is in blue. There you can see the malalignment defect. To our right underneath the, or rather within the RVOT and just beneath it, you can see one of the anterior muscular defects.

    This one that we’re pointing at right now is the true anterior muscular defect. The one up at the top is actually a fake out. If you made an incision in the RVOT, the distance from that anterior muscular defect to the pulmonary anulus is about a two and a half, 2.7 centimeters and that’s the multiplanar reconstruction showing the same thing.

    Now, we’re going to take a look at the defects from the LV side. The yellow is the mitral anulus, or sorry the mitral valve leaflets. Again, there you see the malalignment defect and the pink is the aortic anulus. Here we’re looking at all three defects. The more inferior and apical of the defects, that one right there is pretty small. It’s about two millimeters measured on the LV side.

    If you made an RVOT incision this is what you’d see. So, there’s the anulus and then as we showed in that previous measurement, it’s about two and a half centimeters down and remember that that more superior pole that you’ll see just underneath the anulus, like around a centimeter and a half is actually the false lumen. The RV side of the smaller defect you should be able to see on the other videos. And that’s it.

Transcript Transcript
A CHOP cardiac surgeon reviews a patient’s heart anatomy in virtual reality to create an individualized surgical plan.
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