MD - Wayne State University, Detroit, MI
Pediatrics, Research Track - Johns Hopkins University, Baltimore, MD
Hematology/Oncology - Johns Hopkins University, Baltimore, MD / National Institutes of Health, Bethesda, MD (Chief Fellow)
PhD in Chemistry and Biochemistry - Wayne State University, Detroit, MI
Senior Research Scientist
Director, Translational Research, Center of Childhood Cancer Research
Associate Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Bailey, K. M., Cost, C. R., Davis, I. J., Glade-Bender, J., Grohar, P. J., Houghton, P. J., Isakoff, M. S., Stewart, E., Laack, N., Yustein, J. T., Reed, D. R., Janeway, K. A., Gorlick, R., Lessnick, S. L., DuBois, S. G., Hingorani, P.: Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children's Oncology Group (COG) new agents for Ewing sarcoma task force. F1000Res. 2019 Apr 15;8. pii: F1000 Faculty Rev-493. doi: 10.12688/f1000research.18139.1. eCollection 2019.
Harlow ML, Chasse MH, Boguslawski EA, Sorensen KM, Gedminas JM, Kitchen-Goosen SM, Rothbart SB5, Taslim C6, Lessnick SL, Peck AS, Madaj ZB, Bowman MJ, Grohar PJ: Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule Dependent Manner. Clin Cancer Res. 2019 Feb 5. doi: 10.1158/1078-0432.CCR-18-3511. [Epub ahead of print]
Grohar PJ, Janeway KA, Mase LD, Schiffman JD. 2017. Advances in treatment of pediatric sarcomas. Am Soc Clin Oncol Educ Book 37:725–735.
Grohar Patrick J, Glod John, Peer Cody J, Sissung Tristan M, Arnaldez Fernanda I, Long Lauren, Figg William D, Whitcomb Patricia, Helman Lee J, Widemann Brigitte C: A phase I/II trial and pharmacokinetic study of mithramycin in children and adults with refractory Ewing sarcoma and EWS-FLI1 fusion transcript. Cancer chemotherapy and pharmacology 80(3): 645-652, Sep 2017.
Pridgeon Matthew G, Grohar Patrick J, Steensma Matthew R, Williams Bart O: Wnt Signaling in Ewing Sarcoma, Osteosarcoma, and Malignant Peripheral Nerve Sheath Tumors. Current osteoporosis reports 15(4): 239-246, Aug 2017.
Herzog J, von Klot-Heydenfeldt F, Jabar S, Ranft A, Rossig C, Dirksen U, Van den Brande J, D’Incalci M, von Leuttichau I, Grohar PJ, Berdel WE, Burdach S. 2016. Trabectedin followed by irinotecan can stabilize disease in advanced translocation-positive sarcomas. Sarcoma.
Kovar H, Amatruda J, Brunet E, Burdach S, Cidre-Aranaz F, de Alava E, Dirksen U, van der Ent W, Grohar PJ, Grünewald TG, Helman L, Houghton P, Iljin K, Korsching E, Ladanyi M, Lawlor E, Lessnick S, Ludwig J, Meltzer P, Metzler M, Mora J, Moriggl R, Nakamura T, Papamarkou T, Radic Sarikas B, Rédini F, Richter GH, Rossig C, Schadler K, Schäfer BW, Scotlandi K, Sheffield NC, Shelat A, Snaar-Jagalska E, Sorensen P, Stegmaier K, Stewart E, Sweet-Cordero A, Szuhai K, Tirado OM, Tirode F, Toretsky J, Tsafou K, Üren A, Zinovyev A, Delattre O. 2016. The second European interdisciplinary Ewing sarcoma research summit—A joint effort to deconstructing the multiple layers of a complex disease. Oncotarget 7:8613–8624.
Harlow Matt L, Maloney Nichole, Roland Joseph, Guillen Navarro Maria Jose, Easton Matthew K, Kitchen-Goosen Susan M, Boguslawski Elissa A, Madaj Zachary B, Johnson Ben K, Bowman Megan J, D'Incalci Maurizio, Winn Mary E, Turner Lisa, Hostetter Galen, Galmarini Carlos María, Aviles Pablo M, Grohar Patrick J: Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus. Cancer research 76(22): 6657-6668, Nov 2016.
Herzog J, von Klot-Heydenfeldt F, Jabar S, Ranft A, Rossig C, Dirksen U, Van den Brande J, D'Incalci M, von Luettichau I, Grohar P J, Berdel W E, Burdach St: Trabectedin Followed by Irinotecan Can Stabilize Disease in Advanced Translocation-Positive Sarcomas with Acceptable Toxicity. Sarcoma Page: 7461783, Oct 24 2016 Notes: Epub only.
Osgood Christy L, Tantawy Mohammed N, Maloney Nichole, Madaj Zachary B, Peck Anderson, Boguslawski Elissa, Jess Jennifer, Buck Jason, Winn Mary E, Manning H Charles, Grohar Patrick J: F-FLT Positron Emission Tomography (PET) is a Pharmacodynamic Marker for EWS-FLI1 Activity and Ewing Sarcoma. Scientific reports 6(1): 33926, Sep 2016.
Osgood Christy L, Maloney Nichole, Kidd Christopher G, Kitchen-Goosen Susan, Segars Laura, Gebregiorgis Meti, Woldemichael Girma M, He Min, Sankar Savita, Lessnick Stephen L, Kang Min, Smith Malcolm, Turner Lisa, Madaj Zachary B, Winn Mary E, Núñez Luz-Elena, González-Sabín Javier, Helman Lee J, Morís Francisco, Grohar Patrick J: Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor. Clinical cancer research : an official journal of the American Association for Cancer Research 22(16): 4105-18, Aug 2016.
Caropreso Vittorio, Darvishi Emad, Turbyville Thomas J, Ratnayake Ranjala, Grohar Patrick J, McMahon James B, Woldemichael Girma M: Englerin A Inhibits EWS-FLI1 DNA Binding in Ewing Sarcoma Cells. The Journal of biological chemistry 291(19): 10058-66, May 2016.
Grohar Patrick J, Kim Suntae, Rangel Rivera Guillermo O, Sen Nirmalya, Haddock Sara, Harlow Matt L, Maloney Nichole K, Zhu Jack, O'Neill Maura, Jones Tamara L, Huppi Konrad, Grandin Magdalena, Gehlhaus Kristen, Klumpp-Thomas Carleen A, Buehler Eugen, Helman Lee J, Martin Scott E, Caplen Natasha J: Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma. Cell reports 14(3): 598-610, Jan 2016.
Tancredi R, Zambelli A, DaPrada G A, Fregoni V, Pavesi L, Riccardi A, Burdach S, Grohar P J, D'Incalci M: Targeting the EWS-FLI1 transcription factor in Ewing sarcoma. Cancer chemotherapy and pharmacology 75(6): 1317-20, Jun 2015.
Grohar Patrick J, Segars Laure E, Yeung Choh, Pommier Yves, D'Incalci Maurizio, Mendoza Arnulfo, Helman Lee J: Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth. Clinical cancer research : an official journal of the American Association for Cancer Research 20(5): 1190-203, Mar 2014.
Yeung C L, Ngo V N, Grohar P J, Arnaldez F I, Asante A, Wan X, Khan J, Hewitt S M, Khanna C, Staudt L M, Helman L J: Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth. Oncogene 32(47): 5429-38, Nov 2013.
Grohar Patrick J, Helman Lee J: Prospects and challenges for the development of new therapies for Ewing sarcoma. Pharmacology & therapeutics 137(2): 216-24, Feb 2013.
Grohar PJ, Griffin LB, Yeung C, Chen QR, Pommier Y, Khanna C, Khan J, Helman LJ. 2011. Ecteinascidin 743 (ET-743) interferes with the activity of EWS-FLI1 in Ewing’s sarcoma cells. Neoplasia 13(2):145–153.
Grohar Patrick J, Woldemichael Girma M, Griffin Laurie B, Mendoza Arnulfo, Chen Qing-Rong, Yeung Choh, Currier Duane G, Davis Sean, Khanna Chand, Khan Javed, McMahon James B, Helman Lee J: Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening. Journal of the National Cancer Institute 103(12): 962-78, Jun 2011.
Grohar Patrick J, Griffin Laurie B, Yeung Choh, Chen Qing-Rong, Pommier Yves, Khanna Chand, Khan Javed, Helman Lee J: Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells. Neoplasia (New York, N.Y.) 13(2): 145-53, Feb 2011.
Wan X, Harkavy B, Shen N, Grohar P, Helman L J: Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 26(13): 1932-40, Mar 2007.
Ge Yubin, Jensen Tanya L, Stout Mark L, Flatley Robin M, Grohar Patrick J, Ravindranath Yaddanapudi, Matherly Larry H, Taub Jeffrey W: The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines. Cancer research 64(2): 728-35, Jan 2004.
Schroeder M C, Hamby J M, Connolly C J, Grohar P J, Winters R T, Barvian M R, Moore C W, Boushelle S L, Crean S M, Kraker A J, Driscoll D L, Vincent P W, Elliott W L, Lu G H, Batley B L, Dahring T K, Major T C, Panek R L, Doherty A M, Showalter H D: Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity. Journal of medicinal chemistry 44(12): 1915-26, Jun 2001.
Meroueh M, Grohar P J, Qiu J, SantaLucia J, Scaringe S A, Chow C S: Unique structural and stabilizing roles for the individual pseudouridine residues in the 1920 region of Escherichia coli 23S rRNA. Nucleic acids research 28(10): 2075-83, May 2000.
Grohar, P.J., Chow, C.S. : A practical synthesis of the modified RNA nucleoside pseudouridine. Tetrahedron Lett 40(1): 2049 - 2052, Mar 1999.
Dirksen, U., Grohar, P.J.,DuBois, S., Davidson, D.,Hogendoorn, P.C.W., Lessnick, S.L.: Ewing Sarcoma. Pediatric Oncology. Pizzo and Poplack (eds.). Page: In press, 2019.
Gedminas J.M., Boguslawski E., Kitchen-Goosen S.M., Chasse M.H., Beddows I., Grohar P.J.: Lurbinectedin targets the EWS-WT1 transcription factor in desmoplastic small round cell tumor. Peer Reviewed Poster Presentation, Annual meeting of the American Society of Pediatric Hematology-Oncology, New Orleans, LA May 2019.
Flores, G., Kitchen-Goosen, S., Oswald, B.M., Boguslawski, E.A., Adams, M., Beddows, I., Madaj, Z.B., Grohar, P.J.: Mithramycin impedes EWS-FLI1 driven transcription by preventing target promoter clearance. Peer reviewed Poster Presentation at the Annual Meeting of the American Association for Cancer Research, Atlanta GA April 2019 Notes: AACR Minority Scholar-in-Training *Award.
Gedminas J.M., Boguslawski E., Kitchen-Goosen S.M., Chasse M.H., Beddows I., Grohar P.J.: Lurbinectedin inhibits the expression of EWS-WT1 in desmoplastic small round cell tumor. Peer Reviewed Poster Presentation Invited for an Oral Presentation at the 18th Annual State of Michigan Pediatric Research Day, East Lansing MI March 2019 Notes: Won Best Overall Poster Presentation.
Chasse, M.H., Johnson, B.K., Boguslawski, E.A., Sorensen, K.M., Beddows, I., Madaj, Z.B., Foxa, G.E., Rybski, K.J., Kitchen-Goosen, S.M., Williams, B.O., Triche Jr., T.J., Grohar, P.J.: Mithramycin evicts SWI/SNF from chromatin to induce epigenetic reprogramming in rhabdoid tumor. Peer Reviewed Poster Presentation Invited for an Oral Presentation at the 18th Annual State of Michigan Pediatric Research Day, East Lansing MI March 2019.
Sorensen, K., Jess, J., Kitchen-Goosen, S.M., Flores, G.,Madaj, Z.B., Boguslawski, E.,Grohar, P.J. : Oxiliplatin and ATR inhibitors show strong synergy in Ewing sarcoma cells. Peer Reviewed Poster Presentation at the Annual Meeting of the American Association for Cancer Research, Chicago, IL April 2018.
Kitchen-Goosen, S.M., Bowman, M.J., Adams, M., Berger, P., Grohar, P.J. : The EWS-FLI1 transcriptome is characterized by marked heterogeneity across cell lines Peer Reviewed Poster Presentation at the Annual Meeting of the American Association for Cancer Research, Chicago, IL April 2018.
Flores, G., Everett, J., Oswald, B.,Caplen, N., Helman, L.J., Madaj, Z.B., Grohar, P.J.: Suppression of EWS-FLI1 transcription using a combination therapy of mithramycin and cyclin dependent kinase 9 inhibition. Peer Reviewed Poster Presentation for Pediatric Cancer at the Annual Meeting of the American Association for Cancer Research, Chicago, IL April 2018.
Chasse, M.H., Boguslawski, El, Wernette, C.E., Kitchen-Goosen, S.M., Grohar, P.J.: Mithramycin amplifies the imbalance between the BAF and PRC2 complexes to drive apoptosis in rhabdoid tumor. Peer Reviewed Oral Presentation, Annual Meeting of the American Association for Cancer Research, Chicago, IL April 2018 Notes: AACR Margaret Foti Scholar-in-Training Award in Pediatric Cancer Research.
Grohar PJ. "Development of a Pharmacodynamic Marker of EWS-FLI1 Activity to Aid in the Clinical Translation of Targeted Therapies in EWS", In Alex's Lemonade Stand Innovation Summit, Philadelphia, PA. Sept 2019.
Grohar PJ. "A bench-to-bedside approach targeting EWS-FLI1 for Ewing sarcoma", MD Anderson Cancer Center Pediatric Grand Rounds, Houston, TX. Jan 2019.
Grohar PJ. "A bedside-to-bench approach targeting EWS-FLI1 for Ewing sarcoma" In Memorial Sloan Kettering Pediatric Oncology Grand Rounds, New York, New York. Sep, 2018.
Grohar PJ. "A bench-to-bedside approach targeting EWS-FLII for Ewing sarcoma" In Research Seminar, Emory University Division of Pediatric Hematology Oncology, Atlanta, GA. Aug, 2018.
Grohar PJ. "Development and translation of EWS-FLI1 targeted therapy for Ewing sarcoma" In Research Seminar, University of Michigan Division of Pediatric Hematology Oncology, Ann Arbor, MI. Jul, 2018.
Grohar PJ. "A bench-to-bedside approach to the therapeutic targeting of EWS-FLil for Ewing sarcoma" In Grand Rounds, Georgetown University Lombardi Cancer, Washington, D.C. May, 2018.
Grohar PJ. "Therapeutic targeting of EWS-FLIl for Ewing sarcoma" In Children's Oncology Group Spring Meeting; Combined Sarcoma Biology Session, St. Louis MO. Apr, 2018.
Grohar PJ. "A bench-to-bedside approach to the therapeutic targeting of EWS-FLII for Ewing sarcoma" In Children's Hospital of Philadelphia, Research Seminar, Philadelphia, PA. Apr, 2018.
Grohar PJ. "A bench to bedside approach targeting EWS-FLI1 for Ewing sarcoma" In University of Kansas Comprehensive Cancer Center Research Symposium, Overland Park, Kansas. Dec, 2017.
Grohar PJ. "Development of targeted therapies for EWS-FLII and Ewing sarcoma" In Sarcoma Alliance for Research Through Collaboration Bi-annual Meeting, Maui, HI. Nov, 2017.
Grohar PJ. "Translocation positive Ewing sarcoma: An opportunity for targeted therapy" In American Society for Clinical Oncology Annual Meeting, Chicago, IL. Jun, 2017.
Grohar PJ. "Molecular targeting of the EWS-FLI1 transcription factor for Ewing sarcoma" In University of Kentucky Cancer Center Seminar Series, Lexington, KY. Apr, 2017.
Grohar PJ. "Sustained suppression of EWS-FLI1 in Ewing sarcoma" In Children's Oncology Group Spring Meeting, St. Louis MO. Mar, 2017.
2019, Best Overall Poster Presentation, 18th Annual State of Michigan Pediatric Research Day
2013-2015, Junior Faculty Development Program, Vanderbilt University School of Medicine
2011, Fellows Award for Research Excellence (FARE), National Institutes of Health
2010, Finalist, American Association for Cancer Research (AACR) Scholar in Training Award
2008-2010, Pediatric Oncology Branch Research Competition - 1st Place: Fellows Post Docs (Annually for three years), Johns Hopkins University/National Institutes of Health
2006-2011, Competitive National Institutes of Health Loan Repayment Program for General Research (5 renewals awarded)
2001-2003, Graduation with Distinction in Biomedical Research, Wayne State University
2001-2003, Aesculapians Medical Student Service Honor Society
1997, Phi Lambda Upsilon National Chemistry Honor Society
2011-present, PLOS one
2011-present, Frontiers in Medicine
2011-present, Cancer Research
2011-present, BMC Cancer
2011-present, Frontiers in Pediatrics
2011-present, Clinical Cancer Research
2011-present, International Journal of Nanomedicine
2011-present, Journal of Clinical Investigation
2011-present, Genes and Cancer
2011-present, Molecular Cancer Research
2011-present, Children's Oncology Group
- 2019-present, Vice Chair, Bone Tumor Committee
- 2019-present, Chair, Ewing Sarcoma Biology Committee
- 2019-present, Drugs for Osteosarcoma Task Force
- 2018-present, Co-Chair, Combined Sarcoma Biology Committee
- 2017-present, Drugs for Ewing Sarcoma Task Force
- 2017-present, AEWS07B1 Research Committee
- 2016-present, Quad-W Biospecimen Committee
- 2015-present, Vice Chair, Ewing Sarcoma Biology Committee
- 2015-present, Bone Tumor Steering Committee
- 2011-present, Ewing Sarcoma Biology Committee
2019-present, Ad hoc reviewer, Drug Discovery and Molecular Pharmacology (DMP) Study Section, NIH
2016-present, Medical Director, Sean Karl Foundation - Ewing Sarcoma Foundation
2011-present, Grant Reviewer, Liddy Shriver Sarcoma Foundation
2011-present, Grant Reviewer, Alex's Lemonade Stand Foundation
2010-present, Sarcoma Alliance for Research Through Collaboration
- 2016-present, Developmental Therapeutics Committee
2010-present, Connective Tissue Oncology Society
2009-present, American Association for Cancer Research
1997-present, Phi Lambda Upsilon National Chemistry Honor Society
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