Holly L. Hedrick, MD, FACS

Holly L. Hedrick, MD, FACS

Holly Hedrick, MD, is an attending pediatric and fetal surgeon in the Division of Pediatric General, Thoracic and Fetal Surgery at Children’s Hospital of Philadelphia. She holds the Louise Schnaufer Endowed Chair in Pediatric Surgery.

Areas of Expertise: Clinical applications of fetal diagnosis and therapy, ECMO, Laparoscopy and thoracoscopy, Neonatal Surgery, Oncology, Thoracic Surgery
Locations: Main Campus
Phone: 215-590-2730

Background

Dr. Holly Hedrick is an attending surgeon in the Division of Pediatric General, Thoracic and Fetal Surgery at Children’s Hospital of Philadelphia (CHOP) and the Louise Schnaufer Endowed Chair in Pediatric Surgery. She is also the Surgical Director of the Extracorporeal Membrane Oxygenation (ECMO) Center, Co-director of the Neonatal Surgical Team and Director of the Pulmonary Hypoplasia Program. In addition, she is an investigator in the Center for Fetal Research and an associate professor of Surgery at the University of Pennsylvania School of Medicine. 

Dr. Hedrick completed her pediatric surgery fellowship at CHOP and joined the staff as an attending surgeon 1999. “I felt grateful and honored to be trained at CHOP,” she says. “It is a dream come true to work here.” Dr. Hedrick’s areas of interest include neonatal surgery, ECMO, thoracic surgery, and minimally invasive techniques including laparoscopy and thoracoscopy.

Her clinical specialty is treating children with congenital diaphragmatic hernia (CDH), a birth defect in which a hole in the diaphragm allows abdominal organs to migrate into the chest, restricting development of the lungs. Concerned with improving outcomes after surgical repair for these fragile infants, who suffer long-term complications including pulmonary hypoplasia, Dr. Hedrick sought to create a specialized program offering the most complete and current care tailored to the specific needs of patients with compromised lung function. The result was the Hospital’s unique Pulmonary Hypoplasia Program (PHP), founded in 2004, which unites specialists from various disciplines including neonatology, cardiology, pulmonology, audiology and gastroenterology, to provide comprehensive care for CDH patients well into school age. Today, more than 230 patients are followed in the PHP Program.

“It’s been thrilling to work with this truly interdisciplinary team,” she says. “We are very challenged by these diagnoses, but we find it rewarding to see these babies through. It’s not enough to deliver a survivor. We want to give them a high quality of life.”

Dr. Hedrick earned her bachelor’s degree from Indiana University and her medical degree from Duke University School of Medicine. She completed her general surgery residency at Brigham & Women’s Hospital/Harvard Medical School and her residency and fellowship in pediatric surgery at The Children’s Hospital of Philadelphia. Dr. Hedrick also completed research fellowships at Duke University School of Medicine and Harvard Medical School.

In spring 2015, Dr. Hedrick appeared in a three-part documentary series airing on PBS called TWICE BORN: Stories from the Special Delivery Unit. The Emmy® Award-winning documentary offered a look inside the Center for Fetal Diagnosis and Treatment at Children’s Hospital of Philadelphia, and its unique Garbose Family Special Delivery Unit.

To contact the Center for Fetal Diagnosis and Treatment, call 1-800-468-8376 (1-800-IN-UTERO).

Education and Training

Medical School

MD - Duke University School of Medicine, Durham, NC

Internship

General Surgery - Brigham and Women's Hospital, Boston, MA

Residency

Pediatric Surgery - The Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

Research - Indiana University School of Medicine Biomedical Research Program, Krannert Institute of Cardiology, Bloomington, IN
Research - Duke University School of Medicine, Surgical Oncology Research Facility, Durham, NC

Board Certification

Pediatric Surgery
Surgery

Titles and Academic Titles

Attending Surgeon

Surgical Director, ECMO Center

Co-director, Neonatal Surgical Team

Director, Pulmonary Hypoplasia Program

Louise Schnaufer Endowed Chair in Pediatric Surgery

Associate Professor of Surgery, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Publications

Papers

2018

Riley JS, Antiel RM, Rintoul NE, Ades AM, Waqar LN, Lin N, Herkert LM, D'Agostino JA, Hoffman C, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Reduced oxygen concentration for the resuscitation of infants with congenital diaphragmatic hernia. J Perinatol. 2018 Jun 11. [Epub ahead of print]

Lawrence KM, Hedrick HL, Monk HM, Herkert L, Waqar LN, Hanna BD, Peranteau WH, Rintoul NE, Hopper RK. Treprostinil Improves Persistent Pulmonary Hypertension Associated with Congenital Diaphragmatic Hernia. J Pediatr. 2018 May 18. [Epub ahead of print] PMID: 29784517 

Baumgarten HD, Gebb JS, Khalek N, Moldenhauer JS, Johnson MP, Peranteau WH, Hedrick HL, Adzick NS, Flake AW. Preemptive Delivery and Immediate Resection for Fetuses with High-Risk Sacrococcygeal Teratomas. Fetal Diagn Ther. 2018 May 7;:1-8. [Epub ahead of print] PMID: 29734172 

Partridge EA, Davey MG, Hornick M, Dysart KC, Olive A, Caskey R, Connelly JT, Hedrick HL, Peranteau WH, Flake AW. Pumpless arteriovenous extracorporeal membrane oxygenation: A novel mode of respiratory support in a lamb model of congenital diaphragmatic hernia. J Pediatr Surg. 2018 Mar 9;. [Epub ahead of print] PMID: 29605270

Laje P, Fraga MV, Peranteau WH, Hedrick HL, Khalek N, Gebb JS, Moldenhauer JS, Johnson MP, Flake AW, Adzick NS. Complex gastroschisis: Clinical spectrum and neonatal outcomes at a referral center. J Pediatr Surg. 2018 Mar 14;. [Epub ahead of print] PMID: 29628208 

Swarr DT, Peranteau WH, Pogoriler J, Frank DB, Adzick NS, Hedrick HL, Morley M, Zhou S, Morrisey EE. Novel Molecular and Phenotypic Insights into Congenital Lung Malformations. Am J Respir Crit Care Med. 2018 Jan 12. doi: 10.1164/rccm.201706-1243OC. [Epub ahead of print] PubMed PMID: 29328793.

2017

Kim AG, Danzer E, Moldenhauer JS, Khalek N, McClain LE, Waqar LN, Hedrick HL, Johnson MP, Adzick NS, Peranteau WH, Flake AW. Amniotic Fluid Concentrations of Glial Fibrillary Acidic Protein Do Not Correlate with Prenatal Metrics in Fetuses with Myelomeningocele. Fetal Diagn Ther. 2017 Jul 29. Doi: 10.1159/000478258. [Epub ahead of print].

Partridge EA, Davey MG, Hornick MA, McGovern PE,  Mejaddam AY, Vrecenak JD, Mesas-Burgos C, Olive A, Caskey RC, Weiland TR, Han J, Schupper AJ, Connelly JT, Dysart KC, Rychik J, Hedrick HL, Peranteau WH, Flake AW. Corrigendum: An extra-uterine system to physiologically support the extreme premature lamb. Nat Commun. 2017 May 23;8:15794. Doi: 10.1038/ncomms15794.

Emily A. Partridge, Marcus G. Davey, Matthew A. Hornick, Patrick E. McGovern, Ali Y. Mejaddam, Jesse D. Vrecenak, Carmen Mesas-Burgos, Aliza Olive, Robert C. Caskey, Theodore R. Weiland III, Jiancheng Han, James T. Connelly, Kevin C. Dysart, Alexander J. Schupper, Jack Rychik, Holly L. Hedrick, William H. Peranteau, and Alan W. Flake. “An extra-uterine physiologic support system for the extreme premature lamb.” Nature Communications. Published online April 25, 2017. Read the abstract.

Victoria T, Danzer E, Oliver ER, Edgar JC, Iyoob S, Partridge EA, Johnson AM, Peranteau WH, Coleman BG, Flake AW, Johnson MP, Hedrick H, Adzick NS. Right Congenital Diaphragmatic Hernias: Is There a Correlation between Prenatal Lung Volume and Postnatal Survival, as in Isolated Left Diaphragmatic Hernias? Fetal Diagn Ther. 2017 Mar 21. Doi:10.1159/000464246. [Epub ahead of print]

Danzer E, Hoffman C, D’Agostino JA, Gerdes M, Bernbaum J, Antiel RM, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcomes at 5 years of age in congenital diaphragmatic hernia. J Pediatr Surg. 2017 Mar;52(3):437-443.

Peranteau WH, Iyoob SD, Boelig MM, Khalek N, Moldenhauer JS, Johnson MP, Hedrick HL, Flake AW, Coleman BG, Adzick NS. Prenatal growth characteristics of lymphatic malformations. J Pediatr Surg. 2017 Jan;52(1):65-68.

2016

Rychik J, Khalek N, Gaynor JW, Johnson MP, Adzick NS, Flake AM, Hedrick HL. Fetal intrapericardial teratoma: natural history and management including successful in utero surgery. Am J Obstet Gynecol. 2016 Dec;215(6):780.e1-780.e7.

Bamat NA, Tharakan SJ, Connelly JT, Hedrick HL, Lorch SA, Rintoul NE, Williams SB, Dysart KC. Venoarterial extracorporeal life support for neonatal respiratory failure: indications and impact on mortality. ASAIO J. 2016 Dec 13. Doi:10.1097/MAT.0000000000000495 [Epub ahead of print]

Danzer E, Hoffman C, D'Agostino JA, Gerdes M, Bernbaum J, Antiel RM, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcomes at 5 years of age in congenital diaphragmatic hernia. J Pediatr Surg. 2016 Aug 30. pii: S0022-3468(16)30284-6. doi: 10.1016/j.jpedsurg.2016.08.008. Read the abstract.

Rychik J, Khalek N, Gaynor JW, Johnson MP, Adzick NS, Flake AW, Hedrick HL. Fetal Intrapericardial Teratoma: Natural History and Management Including Successful In Utero Surgery. Am J Obstet Gynecol. 2016 Aug 13. pii: S0002-9378(16)30575-0. doi: 10.1016/j.ajog.2016.08.010. Read the abstract.

Laje P, Tharakan SJ, Hedrick HL. Immediate operative management of the fetus with airway anomalies resulting from congenital malformations. Semin Fetal Neonatal Med. 2016 Aug;21(4):240-5.

Partridge EA, Peranteau WH, Herkert L, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Rate of increase of lung-to-head ratio over the course of gestation is predictive of survival in left-sided congenital diaphragmatic hernia. J Pediatr Surg. 2016 May;51(5):703-5.

Laje P, Hedrick HL, Flake AW, Adzick NS, Peranteau WH. Delayed abdominal closure after congenital diaphragmatic hernia repair. J Pediatr Surg. 2016 Feb;51(2):240-3.

Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Herkert LM, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Younger gestational age is associated with increased risk of adverse neurodevelopmental outcome during infancy in congenital diaphragmatic hernia. J Pediatr Surg. 2016 Jan 5. Read the abstract.

Peranteau WH, Boelig MM, Khalek N, Moldenhauer JS, Martinez-Poyer J, Hedrick HL, Flake AW, Johnson MP, Adzick NS. Effect of single and multiple courses of maternal betamethasone on prenatal congenital lung lesion growth and fetal survival. J Pediatr Surg. 2016 Jan;51(1):28-32.

Antiel RM, Riley JS, Cahill PJ, Campbell RM, Waqar L, Herkert LM, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Management and outcomes of scoliosis in children with congenital diaphragmatic hernia. J Pediatr Surg. 2016;51(12):1921-1925.

2015

Laje P, Hedrick HL, Flake AW, Adzick NS, Peranteau WH. Delayed abdominal closure after congenital diaphragmatic hernia repair. J Pediatr Surg. 2015 Nov 11. Read the abstract.

Partridge EA, Victoria T, Coleman BG, Martinez-Poyer J, Laje P, Hedrick HL, Flake AW, Adzick NS. Prenatal diagnosis of esophageal bronchus - first report of a rare foregut malformation in utero. J Pediatr Surg. 2015 Feb;50(2):306-10. Epub 2014 Nov 10. Read the abstract.

Laje P, Pearson EG, Simpao AF, Rehman MA, Sinclair T, Hedrick HL, Adzick NS, Flake AW. The first 100 infant thoracoscopic lobectomies: Observations through the learning curve and comparison to open lobectomy. J Pediatr Surg. 2015 Nov;50(11):1811-6.

Peranteau WH, Boelig MM, Khalek N, Moldenhauer JS, Martinez-Poyer J, Hedrick HL, Flake AW, Johnson MP, Adzick NS. Effect of single and multiple courses of maternal betamethasone on prenatal congenital lung lesion growth and fetal survival. J Pediatr Surg. 2015 Oct 23. Read the abstract.

Partridge EA, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Frequency and complications of inguinal hernia repair in giant omphalocele. J Pediatr Surg. 2015 Oct;50(10):1673-5.

Peranteau WH, Tharakan SJ, Partridge E, Herkert L, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Systemic hypertension in giant omphalocele: An underappreciated association. J Pediatr Surg. 2015 Sep;50(9):1477-80.

Moldenhauer JS, Soni S, Rintoul NE, Spinner SS, Khalek N, Martinez-Poyer J, Flake AW, Hedrick HL, Peranteau WH, Rendon N, Koh J, Howell LJ, Heuer GG, Sutton LN, Johnson MP, Adzick NS. Fetal Myelomeningocele Repair: The Post-MOMS Experience at the Children's Hospital of Philadelphia. Fetal Diagn Ther. 2015;37(3):235-40. Epub 2014 Aug 15.

Partridge EA, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Frequency and complications of inguinal hernia repair in giant omphalocele. J Pediatr Surg. 2015 Oct;50(10):1673-5. doi: 10.1016/j.jpedsurg.2015.05.001. Epub 2015 May 29. Read the abstract.

Peranteau WH, Tharakan SJ, Partridge E, Herkert L, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Systemic hypertension in giant omphalocele: An underappreciated association. J Pediatr Surg. 2015 Sep;50(9):1477-80. Read the abstract.

Panitch HB, Weiner DJ, Feng R, Perez MR, Healy F, McDonough JM, Rintoul N, Hedrick HL. Lung function over the first 3 years of life in children with congenital diaphragmatic hernia. Pediatr Pulmonol. 2015 Sep;50(9):896-907.

Healy F, Lin W, Feng R, Hanna BD, Hedrick H, Panitch HB. An association between pulmonary hypertension and impaired lung function in infants with congenital diaphragmatic hernia. Pediatr Pulmonol. 2015 Jul;50(7):672-82.

Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Herkert L, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcome at one year of age in congenital diaphragmatic hernia infants not treated with extracorporeal membrane oxygenation. J Pediatr Surg. 2015 Jun;50(6):898-903. doi: 10.1016. Read the abstract.

Laje P, Pearson EG, Simpao AF, Rehman MA, Sinclair T, Hedrick HL, Adzick NS, Flake AW. The first 100 infant thoracoscopic lobectomies: Observations through the learning curve and comparison to open lobectomy. J Pediatr Surg. 2015 Jun 3. pii: S0022-3468(15)00369-3. pii: S0022-3468(15)00369-3. doi: 10.1016. Read the abstract.

Danzer E, Gerdes M, D’Agostino JA, Bernbaum J, Hoffman C, Herkert L, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcome at one year of age in congenital diaphragmatic hernia infants not treated with extracorporeal membrane oxygenation. J Pediatr Surg. 2015 Jun;50(6):898-903.

Laje P, Peranteau WH, Hedrick HL, Flake AW, Johnson MP, Moldenhauer JS, Adzick NS. Ex utero intrapartum treatment (EXIT) in the management of cervical lymphatic malformation. J Pediatr Surg. 2015 Feb;50(2):311-4. doi: 10.1016/j.jpedsurg.2014.11.024. Epub 2014 Nov 10.

Partridge EA, Peranteau WH, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Timing of repair of congenital diaphragmatic hernia in patients supported by extracorporeal membrane oxygenation (ECMO). J Pediatr Surg. 2015 Feb;50(2):260-2. Read the abstract.

Partridge EA, Hanna BD, Rintoul NE, Herkert L, Flake AW, Adzick NS, Hedrick HL, Peranteau WH. Brain-type natriuretic peptide levels correlate with pulmonary hypertension and requirement for extracorporeal membrane oxygenation in congenital diaphragmatic hernia. J Pediatr Surg. 2015 Feb;50(2):263-6. Read the abstract.

Peranteau WH, Scott Adzick N, Boelig MM, Alan W F, Hedrick HL, Howell LJ, Moldenhauer JS, Khalek N, Martinez-Poyer J, Johnson MP. Thoracoamniotic shunts for the management of fetal lung lesions and pleural effusions: a single-institution review and predictors of survival in 75 cases. J Pediatr Surg. 2015 Feb;50(2):301-5. Read the abstract.

Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Patient characteristics are important determinants of neurodevelopmental outcome during infancy in giant omphalocele. Early Hum Dev. 2015 Feb 9;91(3):187-193. Read the abstract.

Partridge EA, Victoria T, Coleman BG, Martinez-Poyer J, Laje P, Hedrick HL, Flake AW, Adzick NS. Prenatal diagnosis of esophageal bronchus: first report of a rare foregut malformation in utero. J Pediatr Surg. 2015 Feb;50(2):306-10.

Laje P, Peranteau WH, Hedrick HL, Flake AW, Johnson MP, Moldenhauer JS, Adzick NS. Ex utero intrapartum treatment (EXIT) in the management of cervical lymphatic malformation. J Pediatr Surg. 2015 Feb;50(2):311-4.

Partridge EA, Hanna BD, Rintoul NE, Herkert L, Flake AW, Adzick NS, Hedrick HL, Peranteau WH. Brain-type natriuretic peptide levels correlate with pulmonary hypertension and requirement for extracorporeal membrane oxygenation in congenital diaphragmatic hernia. J Pediatr Surg. 2015 Feb;50(2):263-6.

Partridge EA, Peranteau WH, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Timing of repair of congenital diaphragmatic hernia in patients supported by extracorporeal membrane oxygenation (ECMO). J Pediatr Surg. 2015 Feb;50(2):260-2.

Rychik J, Cohen D, Tran KM, Szwast A, Natarajan SS, Johnson MP, Moldenhauer JS, Khalek N, Martinez-Poyer J, Flake AW, Hedrick HL, Adzick NS. The role of echocardiography in the intraoperative management of the fetus undergoing myelomeningocele repair. Fetal Diagn Ther. 2015;37(3):172-8.

Moldenhauer JS, Soni S, Rintoul NE, Spinner SS, Khalek N, Martinez-Poyer J, Flake AW, Hedrick HL, Peranteau WH, Rendon N, Koh J, Howell LJ, Heuer GG, Sutton LN, Johnson MP, Adzick NS. Fetal myelomeningocele repair: the post-MOMS experience at the Children’s Hospital of Philadelphia. Fetal Diagn Ther. 2015;37(3):235-40.

2014

Vrecenak JD, Howell LJ, Khalek N, Moldenhauer JS, Johnson MP, Coleman BG, Victoria T, Hedrick HL, Peranteau WH, Flake AW, Adzick NS. Outcomes of prenatally diagnosed lung lesions in multigestational pregnancies. Fetal Diagn Ther. 2014 Dec;36(4):312-9.

Partridge EA, Hanna BD, Panitch HB, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Pulmonary hypertension in giant omphalocele infants. J Pediatr Surg. 2014 Dec;49(12):1767-70.

Danzer E, Hedrick HL. Controversies in the management of severe congenital diaphragmatic hernia. Semin Fetal Neonatal Med. 2014 Dec;19(6):376-84.

Bebbington M, Victoria T, Danzer E, Moldenhauer J, Khalek N, Johnson M, Hedrick H, Adzick NS. Comparison of ultrasound and magnetic resonance imaging parameters in predicting survival in isolated left-sided congenital diaphragmatic hernia. Ultrasound Obstet Gynecol. 2014 Jun;43(6):670-4.

Partridge EA, Bridge C, Donaher JG, Herkert LM, Grill E, Danzer E, Gerdes M, Hoffman CH, D’Agostino JA, Bernbaum JC, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Incidence and factors associated with sensorineural and conductive hearing loss among survivors of congenital diaphragmatic hernia. J Pediatr Surg. 2014 Jun;49(6):890-4.

Tsai J, Blinman TA, Collins JL, Laje P, Hedrick HL, Adzick NS, Flake AW. The contribution of hiatal hernia to severe gastroesophageal reflux disease in patients with gastroschisis. J Pediatr Surg. 2014 Mar;49(3):395-8.

Simpao AF, Wong R, Ferrara TJ, Hedrick HL, Schwartz AJ, Snyder TL, Tharakan SJ, Bailey PD Jr. From simulation to separation surgery: a tale of two twins. Anesthesiology. 2014 Jan;120(1):110.

Partridge EA, Canning D, Long C, Peranteau WH, Hedrick HL, Adzick NS, Flake AW. Urologic and anorectal complications of sacrococcygeal teratomas: prenatal and postnatal predictors. J Pediatr Surg. 2014 Jan;49(1):139-43.

Peranteau WH, Moldenhauer JS, Khalek N, Martinez-Poyer JL, Howell LJ, Johnson MP, Flake AW, Adzick NS, Hedrick HL. Open fetal surgery for central bronchial atresia. Fetal Diagn Ther. 2014;35(2):141-7.

2013

Danzer E, Gerdes M, D’Agostino JA, Hoffman C, Bernbaum J, Bebbington MW, Siegle J, Sulkowski J, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Longitudinal neurodevelopmental and neuromotor outcome in congenital diaphragmatic hernia patients in the first 3 years of life. J Perinatol. 2013 Nov;33(11):893-8.

Laje P, Howell LJ, Johnson MP, Hedrick HL, Flake AW, Adzick NS. Perinatal management of congenital oropharyngeal tumors: the ex utero intrapartum treatment (EXIT) approach. J Pediatr Surg. 2013 Oct;48(10):2005-10.

 

2012

Danzer E, Zarnow D, Gerdes M, D'Agostino JA, Siegle J, Bebbington MW, et al. Abnormal brain development and maturation on magnetic resonance imaging in survivors of severe congenital diaphragmatic hernia. J Pediatr Surg. 2012 Mar;47(3):453-61. Cited in PubMed; PMID:22424337. Read the abstract

Laje P, Johnson MP, Howell LJ, Bebbington MW, Hedrick HL, Flake AW, et al. Ex utero intrapartum treatment in the management of giant cervical teratomas. J Pediatr Surg. 2012 Jun;47(6):1208-16. Cited in PubMed; PMID:22703795. Read the abstract 

Books

Chapters

2015

Laje P, Hedrick HL. Operative Surgical Management of Fetuses with CHAOS: Management at Delivery. In: Sobol S, Lioy J, ed. Disorders of the Neonatal Airway. New York: Springer; 2015. p. 181-188.