Holly L. Hedrick, MD, FACS

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Holly Hedrick, MD, is an attending pediatric and fetal surgeon in the Division of Pediatric General, Thoracic and Fetal Surgery at Children’s Hospital of Philadelphia. She holds the Louise Schnaufer Endowed Chair in Pediatric Surgery.

Areas of Expertise: Clinical applications of fetal diagnosis and therapy, Congenital diaphragmatic hernia (CDH), ECMO, Laparoscopy and thoracoscopy, Minimally invasive surgery, Neonatal Surgery, Oncology, Pulmonary hypoplasia, Thoracic Surgery
Locations: Main Hospital

Appointments and Referrals (800-IN UTERO): 800-468-8376

Background

Dr. Holly Hedrick is an attending surgeon in the Division of Pediatric General, Thoracic and Fetal Surgery at Children’s Hospital of Philadelphia (CHOP) and the Louise Schnaufer Endowed Chair in Pediatric Surgery. She is also the Surgical Director of the Extracorporeal Membrane Oxygenation (ECMO) Center, Co-director of the Neonatal Surgical Team and Director of the Pulmonary Hypoplasia Program. In addition, she is an investigator in the Center for Fetal Research and a Professor of Surgery at the University of Pennsylvania School of Medicine. 

Dr. Hedrick completed her pediatric surgery fellowship at CHOP and joined the staff as an attending surgeon 1999. “I felt grateful and honored to be trained at CHOP,” she says. “It is a dream come true to work here.” Dr. Hedrick’s areas of interest include neonatal surgery, ECMO, thoracic surgery, and minimally invasive techniques including laparoscopy and thoracoscopy.

Providing Expert CDH Care

Screenshot from Lillian Jane's CDH video

This video follows one family’s journey from prenatal diagnosis of CDH through delivery and CDH surgery to discharge home.

Her clinical specialty is treating children with congenital diaphragmatic hernia (CDH), a birth defect in which a hole in the diaphragm allows abdominal organs to migrate into the chest, restricting development of the lungs. Concerned with improving outcomes after surgical repair for these fragile infants, who suffer long-term complications including pulmonary hypoplasia, Dr. Hedrick sought to create a specialized program offering the most complete and current care tailored to the specific needs of patients with compromised lung function. The result was the Hospital’s unique Pulmonary Hypoplasia Program (PHP), founded in 2004, which unites specialists from various disciplines including neonatology, cardiology, pulmonology, audiology and gastroenterology, to provide comprehensive care for CDH patients well into school age. Today, more than 230 patients are followed in the PHP Program.

“It’s been thrilling to work with this truly interdisciplinary team,” she says. “We are very challenged by these diagnoses, but we find it rewarding to see these babies through. It’s not enough to deliver a survivor. We want to give them a high quality of life.”

Dr. Hedrick earned her bachelor’s degree from Indiana University and her medical degree from Duke University School of Medicine. She completed her general surgery residency at Brigham & Women’s Hospital/Harvard Medical School and her residency and fellowship in pediatric surgery at The Children’s Hospital of Philadelphia. Dr. Hedrick also completed research fellowships at Duke University School of Medicine and Harvard Medical School.

In spring 2015, Dr. Hedrick appeared in a three-part documentary series airing on PBS called TWICE BORN: Stories from the Special Delivery Unit. The Emmy® Award-winning documentary offered a look inside the Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment at Children’s Hospital of Philadelphia, and its unique Garbose Family Special Delivery Unit.

To contact the Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment, call 1-800-468-8376 (1-800-IN-UTERO).

Education and Training

Medical School

MD - Duke University School of Medicine, Durham, NC

Internship

General Surgery - Brigham and Women's Hospital, Boston, MA

Residency

Pediatric Surgery - The Children's Hospital of Philadelphia, Philadelphia, PA (Chief Resident)
General Surgery - Brigham & Women's Hospital/Harvard Medical School, Boston, MA  (Chief Resident)

Fellowship

Pediatric Surgery - The Children's Hospital of Philadelphia, Philadelphia, PA
Research - Indiana University School of Medicine Biomedical Research Program, Krannert Institute of Cardiology, Bloomington, IN
Research - Duke University School of Medicine, Surgical Oncology Research Facility, Durham, NC

Board Certification

General Surgery – American Board of Surgery
Pediatric Surgery – American Board of Surgery

Titles and Academic Titles

Attending Surgeon

Surgical Director, ECMO Center

Co-director, Neonatal Surgical Team

Director, Pulmonary Hypoplasia Program

Louise Schnaufer Endowed Chair in Pediatric Surgery

Professor of Surgery, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Publications

Papers

2021

Soni S, Moldenhauer JS, Kallan MJ, Rintoul N, Adzick NS, Hedrick HL, Khalek N. Influence of Gestational Age and Mode of Delivery on Neonatal Outcomes in Prenatally Diagnosed Isolated Congenital Diaphragmatic Hernia. Fetal Diagn Ther. 2021 May 5:1-9. doi: 10.1159/000515252. Epub ahead of print. PMID: 33951652.

Pawlowski TW, Stoller JZ, Rintoul NE, Hedrick HL, Quartermain MD, Fraga MV. Point-of-care ultrasound for the evaluation of venous cannula position in neonatal extracorporeal membrane oxygenation. J Perinatol. 2021 Apr 1. doi: 10.1038/s41372-021-00936-8. Epub ahead of print. PMID: 33795791.

Wild KT, Bartholomew D, Edwards TM, Froh E, Spatz DL, Huber M, Hedrick HL, Nawab US. Achieving adequate growth in infants with congenital diaphragmatic hernia prior to discharge. J Pediatr Surg. 2021 Mar 26:S0022-3468(21)00282-7. doi: 10.1016/j.jpedsurg.2021.03.048. Epub ahead of print. PMID: 33888352.

Didier RA, Oliver ER, Rungsiprakarn P, DeBari SE, Adams SE, Hedrick HL, Scott Adzick N, Khalek N, Howell LJ, Coleman BG. Decreased morbidity of 'bowel-only' left congenital diaphragmatic hernia patients: implications of prenatal ultrasound diagnosis for prenatal counseling and postnatal management. Ultrasound Obstet Gynecol. 2021 Mar 16. doi: 10.1002/uog.23630. Epub ahead of print. PMID: 33724570.

Seabrook RB, Grover TR, Rintoul N, Weems M, Keene S, Brozanski B, DiGeronimo R, Haberman B, Hedrick H, Gien J, Ali N, Chapman R, Daniel J, Harrison HA, Johnson Y, Porta NFM, Uhing M, Zaniletti I, Murthy K; Children’s Hospitals Neonatal Consortium Congenital Diaphragmatic Hernia Focus Group. Treatment of pulmonary hypertension during initial hospitalization in a multicenter cohort of infants with congenital diaphragmatic hernia (CDH). J Perinatol. 2021 Mar 1. doi: 10.1038/s41372-021-00923-z. Epub ahead of print. PMID: 33649432.

Vergote S, De Bie F, Bosteels J, Hedrick H, Duffy J, Power B, Benachi A, De Coppi P, Fernandes C, Lally K, Reiss I, Deprest J. Study protocol: a core outcome set for perinatal interventions for congenital diaphragmatic hernia. Trials. 2021 Feb 23;22(1):158. doi: 10.1186/s13063-021-05120-z. PMID: 33622390.

Grover TR, Weems MF, Brozanski B, Daniel J, Haberman B, Rintoul N, Walden A, Hedrick H, Mahmood B, Seabrook R, Murthy K, Zaniletti I, Keene S; Children's Hospitals Neonatal Consortium (CHNC) Congenital Diaphragmatic Hernia Focus Group. Central Line Utilization and Complications in Infants with Congenital Diaphragmatic Hernia. Am J Perinatol. 2021 Feb 3. doi: 10.1055/s-0041-1722941. Epub ahead of print. PMID: 33535242.

2020

Moldenhauer JS, Soni S, Jatres J, Gebb J, Khalek N, Paidas Teefey C, Johnson MP, Flake AW, Hedrick HL, Peranteau WH, Heuer GG, Adzick NS. Open Fetal Surgical Outcomes for Myelomeningocele Closure Stratified by Maternal Body Mass Index in a Large Single-Center Cohort. Fetal Diagn Ther. 2020 Nov 9:1-5. doi: 10.1159/000511781. Epub ahead of print. PMID: 33166958.

Avitabile CM, Wang Y, Zhang X, Griffis H, Saavedra S, Adams S, Herkert L, Frank DB, Quartermain MD, Rintoul NE, Hedrick HL, Mercer-Rosa L. Right Ventricular Strain, Brain Natriuretic Peptide, and Mortality in Congenital Diaphragmatic Hernia. Ann Am Thorac Soc. 2020 Nov;17(11):1431-1439. doi: 10.1513/AnnalsATS.201910-767OC. PMID: 32730099; PMCID: PMC7640722.

De Bie FR, Allegaert K, Hedrick HL, Rintoul NE, Davidson A. Treprostinil Attains Clinically Therapeutic Concentrations in Neonates with Pulmonary Hypertension on Extracorporeal Membrane Oxygenation Support. Pharmacotherapy. 2020 Oct;40(10):1054-1060. doi: 10.1002/phar.2459. Epub 2020 Sep 16. PMID: 32866289.

Wild KT, Hedrick HL, Rintoul NE. Reconsidering ECMO in Premature Neonates [published online ahead of print, 2020 Sep 1]. Fetal Diagn Ther. 2020;1-6. doi:10.1159/000509243

Kim F, Bernbaum J, Connelly J, Gerdes M, Hedrick HL, Hoffman C, Rintoul NE, Ziolkowski K, DeMauro SB. Survival and Developmental Outcomes of Neonates Treated with Extracorporeal Membrane Oxygenation: A 10-Year Single-Center Experience. J Pediatr. 2021 Feb;229:134-140.e3. doi: 10.1016/j.jpeds.2020.10.011. Epub 2020 Oct 13. PMID: 33058857.

Chotzoglou E, Hedrick HL, Herkert LM, Goldshore MA, Rintoul NE, Panitch HB. Therapy at 30 days of life predicts lung function at 6 to 12 months in infants with congenital diaphragmatic hernia. Pediatr Pulmonol. 2020;55(6):1456-1467. doi:10.1002/ppul.24736

Soni S, Moldenhauer JS, Rintoul N, Adzick NS, Hedrick HL, Khalek N. Perinatal Outcomes in Fetuses Prenatally Diagnosed with Congenital Diaphragmatic Hernia and Concomitant Lung Lesions: A 10-Year Review. Fetal Diagn Ther. 2020;47(8):630-635. doi:10.1159/000507481

Franciscovich CD, Monk HM, Brodecki D, Rogers R, Rintoul NE, Hedrick HL, Ely E.. Sedation Practices of Neonates Receiving Extracorporeal Membrane Oxygenation. ASAIO J. 2020;66(5):559-564. doi:10.1097/MAT.0000000000001043

Lawrence KM, Monos S, Adams S, Herkert L, Peranteau WH, Munson DA, Hopper RK, Avitabile CM, Rintoul NE, Hedrick HL. Inhaled Nitric Oxide Is Associated with Improved Oxygenation in a Subpopulation of Infants with Congenital Diaphragmatic Hernia and Pulmonary Hypertension. J Pediatr. 2020;219:167-172. doi:10.1016/j.jpeds.2019.09.052

Victoria T, Johnson AM, Moldenhauer JS, Hedrick HL, Flake AW, Adzick NS. Imaging of fetal tumors and other dysplastic lesions: A review with emphasis on MR imaging. Prenat Diagn. 2020;40(1):84-99. doi:10.1002/pd.5630

Foglia EE, Ades A, Hedrick HL, et al. Initiating resuscitation before umbilical cord clamping in infants with congenital diaphragmatic hernia: a pilot feasibility trial. Arch Dis Child Fetal Neonatal Ed. 2020;105(3):322-326. doi:10.1136/archdischild-2019-317477

2019

Jaimes C, Delgado J, Cunnane MB, Hedrick HL, Adzick NS, Gee MS, Victoria T: Does 3T fetal MRI induce adverse acoustic effects in the neonate? A preliminary study comparing postnatal auditory test performance of fetuses scanned at 1.5 and 3T. Pediatric Radiology 49:37-45, 2019.

Oliver ER, DeBari SE, Adams SE, Didier RA, Horii SC, Victoria T, Hedrick HL, Adzick NS, Howell LJ, Moldenhauer JS, Coleman BG. Congenital diaphragmatic hernia sacs: prenatal imaging and associated postnatal outcomes. Pediatr Radiol. 2019 Jan 11. doi: 10.1007/s00247-018-04334-9. [Epub ahead of print]

Danzer E, Hoffman C, Miller JS, D'Agostino JA, Schindewolf EM, Gerdes M, Bernbaum J, Adams SE, Rintoul NE, Herkert LM, Taylor L, Schreiber J, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Autism spectrum disorder and neurodevelopmental delays in children with giant omphalocele. J Pediatr Surg. 2019;54(9):1771-1777.  doi:10.1016/j.jpedsurg.2019.05.017

2018

Fraga MV, Laje P, Peranteau WH, Hedrick HL, Khalek N, Gebb JS, Moldenhauer JS, Johnson MP, Flake AW, Adzick NS: The influence of gestational age, delivery mode, and abdominal wall closure method in neonates with uncomplicated gastroschisis.  Pediatr Surg Int 34:415-9, 2018.

Danzer E, Hoffman C, D'Agostino J, Ryan M, Gerdes M, Bernbaum J, Rintoul NE, Herkert LM, Peranteau WH, Flake AW, Adzick NS, Hedrick HL: Rate and risk factors associated with autism spectrum disorder in congenital diaphragmatic hernia.  Journal of Autism and Developmental Disorders48:2112-2121, 2018. 

Danzer E, Hoffman C, D’Agostino JA, Boelig MM, Gerdes M, Bernbaum J, Rosenthal H, Waqar LN, Rintoul NE, Herkert LM, Kallan MJ, Peranteau WH, Flake AW, Adzick NS, Hedrick HL: Short-term neurodevelopmental outcome in children born with high-risk congenital lung lesions. Annals of Thoracic Surgery 105:1827-1834, 2018.

Danzer E, Hoffman C, D'Agostino J, Connelly JT, Waqar LN, Gerdes M, Bernbaum J, Rintoul NE, Herkert LM, Peranteau WH, Flake AW, Adzick NS, Hedrick HL: Short-term neurodevelopmental outcome in congenital diaphragmatic hernia: The impact of extracorporeal membrane oxygenation and timing of repair. Pediatric Critical Care Medicine 19:64-74, 2018.

Victoria T, Johnson AM, Adzick NS, Hedrick HL, Shellock FG: Evaluation of MRI artifacts and safety issues associated with the occlusion balloon used for Fetoscopic Endoluminal Tracheal Occlusion (FETO). Fetal Diagnosis and Therapy 44:179-183, 2018. 

Riley JS, Urwin JW, Oliver ER, Coleman BG, Khalek N, Moldenhauer JS, Gebb J, Hedrick HL, Spinner SS, Adzick NS, Peranteau WH: Prenatal growth characteristics and pre/postnatal management of bronchopulmonary sequestrations. J Pediatr Surg 53:265-269, 2018.

Hopper RK, Rogers R, Lawrence KM, Hedrick HL. Reply. J Pediatr. 2018 Dec 14;. PMID: 30559025 

Lawrence KM, Berger K, Herkert L, Franciscovich C, O'Dea CLH, Waqar LN, Partridge E, Hanna BD, Peranteau WH, Avitabile CM, Hopper RK, Rintoul NE, Hedrick HL. Use of prostaglandin E1 to treat pulmonary hypertension in congenital diaphragmatic hernia. J Pediatr Surg. 2018 Oct 5;. PMID: 30442461 

Didier RA, DeBari SE, Oliver ER, Gebb JS, Howell LJ, Hedrick HL, Adzick NS, Coleman BG. Secondary Imaging Findings Aid in Prenatal Diagnosis and Characterization of Congenital Diaphragmatic Hernia: Role of an Abnormal Orientation of Vascular Structures and Gallbladder Position. J Ultrasound Med. 2018 Sep 23;. [Epub ahead of print] PMID: 30244484

Riley JS, Antiel RM, Rintoul NE, Ades AM, Waqar LN, Lin N, Herkert LM, D'Agostino JA, Hoffman C, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Reduced oxygen concentration for the resuscitation of infants with congenital diaphragmatic hernia. J Perinatol. 2018 Jun 11. [Epub ahead of print]

Lawrence KM, Hedrick HL, Monk HM, Herkert L, Waqar LN, Hanna BD, Peranteau WH, Rintoul NE, Hopper RK. Treprostinil Improves Persistent Pulmonary Hypertension Associated with Congenital Diaphragmatic Hernia. J Pediatr. 2018 May 18. [Epub ahead of print] PMID: 29784517 

Baumgarten HD, Gebb JS, Khalek N, Moldenhauer JS, Johnson MP, Peranteau WH, Hedrick HL, Adzick NS, Flake AW. Preemptive Delivery and Immediate Resection for Fetuses with High-Risk Sacrococcygeal Teratomas. Fetal Diagn Ther. 2018 May 7;:1-8. [Epub ahead of print] PMID: 29734172 

Partridge EA, Davey MG, Hornick M, Dysart KC, Olive A, Caskey R, Connelly JT, Hedrick HL, Peranteau WH, Flake AW. Pumpless arteriovenous extracorporeal membrane oxygenation: A novel mode of respiratory support in a lamb model of congenital diaphragmatic hernia. J Pediatr Surg. 2018 Mar 9;. [Epub ahead of print] PMID: 29605270

Laje P, Fraga MV, Peranteau WH, Hedrick HL, Khalek N, Gebb JS, Moldenhauer JS, Johnson MP, Flake AW, Adzick NS. Complex gastroschisis: Clinical spectrum and neonatal outcomes at a referral center. J Pediatr Surg. 2018 Mar 14;. [Epub ahead of print] PMID: 29628208 

Gebb JS, Khalek N, Qamar H, Ozcan T, Johnson MP, Oliver ER, Coleman BG, Peranteau WH, Hedrick HL, Flake AW, Adzick NS, Moldenhauer JS: High tumor volume to fetal weight ratio is associated with worse fetal outcomes and increased maternal risks in fetuses with sacrococcygeal teratoma. Fetal Diagn Ther. 2019;45(2):94-101. doi: 10.1159/000486782. Epub 2018 Mar 1.

Swarr DT, Peranteau WH, Pogoriler J, Frank DB, Adzick NS, Hedrick HL, Morley M, Zhou S, Morrisey EE. Novel Molecular and Phenotypic Insights into Congenital Lung Malformations. Am J Respir Crit Care Med. 2018 Jan 12. doi: 10.1164/rccm.201706-1243OC. [Epub ahead of print] PubMed PMID: 29328793.

Victoria T, Danzer E, Oliver ER, Edgar JC, Iyoob S, Partridge EA, Johnson AM, Peranteau WH, Coleman BG, Flake AW, Johnson MP, Hedrick HL, Adzick NS: Right congenital diaphragmatic hernias: Is there a correlation between prenatal lung volume and postnatal survival, as in isolated left diaphragmatic hernias? Fetal Diagnosis and Therapy 2018; 43: 12-18, January 2018.

2017

Kim AG, Danzer E, Moldenhauer JS, Khalek N, McClain LE, Waqar LN, Hedrick HL, Johnson MP, Adzick NS, Peranteau WH, Flake AW. Amniotic Fluid Concentrations of Glial Fibrillary Acidic Protein Do Not Correlate with Prenatal Metrics in Fetuses with Myelomeningocele. Fetal Diagn Ther. 2017 Jul 29. Doi: 10.1159/000478258. [Epub ahead of print].

Partridge EA, Davey MG, Hornick MA, McGovern PE,  Mejaddam AY, Vrecenak JD, Mesas-Burgos C, Olive A, Caskey RC, Weiland TR, Han J, Schupper AJ, Connelly JT, Dysart KC, Rychik J, Hedrick HL, Peranteau WH, Flake AW. Corrigendum: An extra-uterine system to physiologically support the extreme premature lamb. Nat Commun. 2017 May 23;8:15794. Doi: 10.1038/ncomms15794.

Emily A. Partridge, Marcus G. Davey, Matthew A. Hornick, Patrick E. McGovern, Ali Y. Mejaddam, Jesse D. Vrecenak, Carmen Mesas-Burgos, Aliza Olive, Robert C. Caskey, Theodore R. Weiland III, Jiancheng Han, James T. Connelly, Kevin C. Dysart, Alexander J. Schupper, Jack Rychik, Holly L. Hedrick, William H. Peranteau, and Alan W. Flake. “An extra-uterine physiologic support system for the extreme premature lamb.” Nature Communications. Published online April 25, 2017.

Danzer E, Hoffman C, D’Agostino JA, Gerdes M, Bernbaum J, Antiel RM, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcomes at 5 years of age in congenital diaphragmatic hernia. J Pediatr Surg. 2017 Mar;52(3):437-443.

Peranteau WH, Iyoob SD, Boelig MM, Khalek N, Moldenhauer JS, Johnson MP, Hedrick HL, Flake AW, Coleman BG, Adzick NS. Prenatal growth characteristics of lymphatic malformations. J Pediatr Surg. 2017 Jan;52(1):65-68.

2016

Rychik J, Khalek N, Gaynor JW, Johnson MP, Adzick NS, Flake AM, Hedrick HL. Fetal intrapericardial teratoma: natural history and management including successful in utero surgery. Am J Obstet Gynecol. 2016 Dec;215(6):780.e1-780.e7.

Bamat NA, Tharakan SJ, Connelly JT, Hedrick HL, Lorch SA, Rintoul NE, Williams SB, Dysart KC. Venoarterial extracorporeal life support for neonatal respiratory failure: indications and impact on mortality. ASAIO J. 2016 Dec 13. Doi:10.1097/MAT.0000000000000495 [Epub ahead of print]

Danzer E, Hoffman C, D'Agostino JA, Gerdes M, Bernbaum J, Antiel RM, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcomes at 5 years of age in congenital diaphragmatic hernia. J Pediatr Surg. 2016 Aug 30. pii: S0022-3468(16)30284-6. doi: 10.1016/j.jpedsurg.2016.08.008.

Rychik J, Khalek N, Gaynor JW, Johnson MP, Adzick NS, Flake AW, Hedrick HL. Fetal Intrapericardial Teratoma: Natural History and Management Including Successful In Utero Surgery. Am J Obstet Gynecol. 2016 Aug 13. pii: S0002-9378(16)30575-0. doi: 10.1016/j.ajog.2016.08.010.

Laje P, Tharakan SJ, Hedrick HL. Immediate operative management of the fetus with airway anomalies resulting from congenital malformations. Semin Fetal Neonatal Med. 2016 Aug;21(4):240-5.

Partridge EA, Peranteau WH, Herkert L, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Rate of increase of lung-to-head ratio over the course of gestation is predictive of survival in left-sided congenital diaphragmatic hernia. J Pediatr Surg. 2016 May;51(5):703-5.

Laje P, Hedrick HL, Flake AW, Adzick NS, Peranteau WH. Delayed abdominal closure after congenital diaphragmatic hernia repair. J Pediatr Surg. 2016 Feb;51(2):240-3.

Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Herkert LM, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Younger gestational age is associated with increased risk of adverse neurodevelopmental outcome during infancy in congenital diaphragmatic hernia. J Pediatr Surg. 2016 Jan 5.

Peranteau WH, Boelig MM, Khalek N, Moldenhauer JS, Martinez-Poyer J, Hedrick HL, Flake AW, Johnson MP, Adzick NS. Effect of single and multiple courses of maternal betamethasone on prenatal congenital lung lesion growth and fetal survival. J Pediatr Surg. 2016 Jan;51(1):28-32.

Antiel RM, Riley JS, Cahill PJ, Campbell RM, Waqar L, Herkert LM, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Management and outcomes of scoliosis in children with congenital diaphragmatic hernia. J Pediatr Surg. 2016;51(12):1921-1925.

2015

Laje P, Hedrick HL, Flake AW, Adzick NS, Peranteau WH. Delayed abdominal closure after congenital diaphragmatic hernia repair. J Pediatr Surg. 2015 Nov 11.

Partridge EA, Victoria T, Coleman BG, Martinez-Poyer J, Laje P, Hedrick HL, Flake AW, Adzick NS. Prenatal diagnosis of esophageal bronchus - first report of a rare foregut malformation in utero. J Pediatr Surg. 2015 Feb;50(2):306-10. Epub 2014 Nov 10.

Laje P, Pearson EG, Simpao AF, Rehman MA, Sinclair T, Hedrick HL, Adzick NS, Flake AW. The first 100 infant thoracoscopic lobectomies: Observations through the learning curve and comparison to open lobectomy. J Pediatr Surg. 2015 Nov;50(11):1811-6.

Peranteau WH, Boelig MM, Khalek N, Moldenhauer JS, Martinez-Poyer J, Hedrick HL, Flake AW, Johnson MP, Adzick NS. Effect of single and multiple courses of maternal betamethasone on prenatal congenital lung lesion growth and fetal survival. J Pediatr Surg. 2015 Oct 23.

Partridge EA, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Frequency and complications of inguinal hernia repair in giant omphalocele. J Pediatr Surg. 2015 Oct;50(10):1673-5.

Peranteau WH, Tharakan SJ, Partridge E, Herkert L, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Systemic hypertension in giant omphalocele: An underappreciated association. J Pediatr Surg. 2015 Sep;50(9):1477-80.

Moldenhauer JS, Soni S, Rintoul NE, Spinner SS, Khalek N, Martinez-Poyer J, Flake AW, Hedrick HL, Peranteau WH, Rendon N, Koh J, Howell LJ, Heuer GG, Sutton LN, Johnson MP, Adzick NS. Fetal Myelomeningocele Repair: The Post-MOMS Experience at the Children's Hospital of Philadelphia. Fetal Diagn Ther. 2015;37(3):235-40. Epub 2014 Aug 15.

Partridge EA, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Frequency and complications of inguinal hernia repair in giant omphalocele. J Pediatr Surg. 2015 Oct;50(10):1673-5. doi: 10.1016/j.jpedsurg.2015.05.001. Epub 2015 May 29.

Peranteau WH, Tharakan SJ, Partridge E, Herkert L, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Systemic hypertension in giant omphalocele: An underappreciated association. J Pediatr Surg. 2015 Sep;50(9):1477-80.

Panitch HB, Weiner DJ, Feng R, Perez MR, Healy F, McDonough JM, Rintoul N, Hedrick HL. Lung function over the first 3 years of life in children with congenital diaphragmatic hernia. Pediatr Pulmonol. 2015 Sep;50(9):896-907.

Healy F, Lin W, Feng R, Hanna BD, Hedrick H, Panitch HB. An association between pulmonary hypertension and impaired lung function in infants with congenital diaphragmatic hernia. Pediatr Pulmonol. 2015 Jul;50(7):672-82.

Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Herkert L, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcome at one year of age in congenital diaphragmatic hernia infants not treated with extracorporeal membrane oxygenation. J Pediatr Surg. 2015 Jun;50(6):898-903. doi: 10.1016.

Laje P, Pearson EG, Simpao AF, Rehman MA, Sinclair T, Hedrick HL, Adzick NS, Flake AW. The first 100 infant thoracoscopic lobectomies: Observations through the learning curve and comparison to open lobectomy. J Pediatr Surg. 2015 Jun 3. pii: S0022-3468(15)00369-3. pii: S0022-3468(15)00369-3. doi: 10.1016.

Danzer E, Gerdes M, D’Agostino JA, Bernbaum J, Hoffman C, Herkert L, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcome at one year of age in congenital diaphragmatic hernia infants not treated with extracorporeal membrane oxygenation. J Pediatr Surg. 2015 Jun;50(6):898-903.

Laje P, Peranteau WH, Hedrick HL, Flake AW, Johnson MP, Moldenhauer JS, Adzick NS. Ex utero intrapartum treatment (EXIT) in the management of cervical lymphatic malformation. J Pediatr Surg. 2015 Feb;50(2):311-4. doi: 10.1016/j.jpedsurg.2014.11.024. Epub 2014 Nov 10.

Partridge EA, Peranteau WH, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Timing of repair of congenital diaphragmatic hernia in patients supported by extracorporeal membrane oxygenation (ECMO). J Pediatr Surg. 2015 Feb;50(2):260-2.

Partridge EA, Hanna BD, Rintoul NE, Herkert L, Flake AW, Adzick NS, Hedrick HL, Peranteau WH. Brain-type natriuretic peptide levels correlate with pulmonary hypertension and requirement for extracorporeal membrane oxygenation in congenital diaphragmatic hernia. J Pediatr Surg. 2015 Feb;50(2):263-6.

Peranteau WH, Scott Adzick N, Boelig MM, Alan W F, Hedrick HL, Howell LJ, Moldenhauer JS, Khalek N, Martinez-Poyer J, Johnson MP. Thoracoamniotic shunts for the management of fetal lung lesions and pleural effusions: a single-institution review and predictors of survival in 75 cases. J Pediatr Surg. 2015 Feb;50(2):301-5.

Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Patient characteristics are important determinants of neurodevelopmental outcome during infancy in giant omphalocele. Early Hum Dev. 2015 Feb 9;91(3):187-193.

Partridge EA, Victoria T, Coleman BG, Martinez-Poyer J, Laje P, Hedrick HL, Flake AW, Adzick NS. Prenatal diagnosis of esophageal bronchus: first report of a rare foregut malformation in utero. J Pediatr Surg. 2015 Feb;50(2):306-10.

Laje P, Peranteau WH, Hedrick HL, Flake AW, Johnson MP, Moldenhauer JS, Adzick NS. Ex utero intrapartum treatment (EXIT) in the management of cervical lymphatic malformation. J Pediatr Surg. 2015 Feb;50(2):311-4.

Partridge EA, Hanna BD, Rintoul NE, Herkert L, Flake AW, Adzick NS, Hedrick HL, Peranteau WH. Brain-type natriuretic peptide levels correlate with pulmonary hypertension and requirement for extracorporeal membrane oxygenation in congenital diaphragmatic hernia. J Pediatr Surg. 2015 Feb;50(2):263-6.

Partridge EA, Peranteau WH, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Timing of repair of congenital diaphragmatic hernia in patients supported by extracorporeal membrane oxygenation (ECMO). J Pediatr Surg. 2015 Feb;50(2):260-2.

Rychik J, Cohen D, Tran KM, Szwast A, Natarajan SS, Johnson MP, Moldenhauer JS, Khalek N, Martinez-Poyer J, Flake AW, Hedrick HL, Adzick NS. The role of echocardiography in the intraoperative management of the fetus undergoing myelomeningocele repair. Fetal Diagn Ther. 2015;37(3):172-8.

Moldenhauer JS, Soni S, Rintoul NE, Spinner SS, Khalek N, Martinez-Poyer J, Flake AW, Hedrick HL, Peranteau WH, Rendon N, Koh J, Howell LJ, Heuer GG, Sutton LN, Johnson MP, Adzick NS. Fetal myelomeningocele repair: the post-MOMS experience at the Children’s Hospital of Philadelphia. Fetal Diagn Ther. 2015;37(3):235-40.

2014

Vrecenak JD, Howell LJ, Khalek N, Moldenhauer JS, Johnson MP, Coleman BG, Victoria T, Hedrick HL, Peranteau WH, Flake AW, Adzick NS. Outcomes of prenatally diagnosed lung lesions in multigestational pregnancies. Fetal Diagn Ther. 2014 Dec;36(4):312-9.

Partridge EA, Hanna BD, Panitch HB, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Pulmonary hypertension in giant omphalocele infants. J Pediatr Surg. 2014 Dec;49(12):1767-70.

Danzer E, Hedrick HL. Controversies in the management of severe congenital diaphragmatic hernia. Semin Fetal Neonatal Med. 2014 Dec;19(6):376-84.

Bebbington M, Victoria T, Danzer E, Moldenhauer J, Khalek N, Johnson M, Hedrick H, Adzick NS. Comparison of ultrasound and magnetic resonance imaging parameters in predicting survival in isolated left-sided congenital diaphragmatic hernia. Ultrasound Obstet Gynecol. 2014 Jun;43(6):670-4.

Partridge EA, Bridge C, Donaher JG, Herkert LM, Grill E, Danzer E, Gerdes M, Hoffman CH, D’Agostino JA, Bernbaum JC, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Incidence and factors associated with sensorineural and conductive hearing loss among survivors of congenital diaphragmatic hernia. J Pediatr Surg. 2014 Jun;49(6):890-4.

Tsai J, Blinman TA, Collins JL, Laje P, Hedrick HL, Adzick NS, Flake AW. The contribution of hiatal hernia to severe gastroesophageal reflux disease in patients with gastroschisis. J Pediatr Surg. 2014 Mar;49(3):395-8.

Simpao AF, Wong R, Ferrara TJ, Hedrick HL, Schwartz AJ, Snyder TL, Tharakan SJ, Bailey PD Jr. From simulation to separation surgery: a tale of two twins. Anesthesiology. 2014 Jan;120(1):110.

Partridge EA, Canning D, Long C, Peranteau WH, Hedrick HL, Adzick NS, Flake AW. Urologic and anorectal complications of sacrococcygeal teratomas: prenatal and postnatal predictors. J Pediatr Surg. 2014 Jan;49(1):139-43.

Peranteau WH, Moldenhauer JS, Khalek N, Martinez-Poyer JL, Howell LJ, Johnson MP, Flake AW, Adzick NS, Hedrick HL. Open fetal surgery for central bronchial atresia. Fetal Diagn Ther. 2014;35(2):141-7.

2013

Danzer E, Gerdes M, D’Agostino JA, Hoffman C, Bernbaum J, Bebbington MW, Siegle J, Sulkowski J, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Longitudinal neurodevelopmental and neuromotor outcome in congenital diaphragmatic hernia patients in the first 3 years of life. J Perinatol. 2013 Nov;33(11):893-8.

Laje P, Howell LJ, Johnson MP, Hedrick HL, Flake AW, Adzick NS. Perinatal management of congenital oropharyngeal tumors: the ex utero intrapartum treatment (EXIT) approach. J Pediatr Surg. 2013 Oct;48(10):2005-10.

2012

Danzer E, Zarnow D, Gerdes M, D'Agostino JA, Siegle J, Bebbington MW, et al. Abnormal brain development and maturation on magnetic resonance imaging in survivors of severe congenital diaphragmatic hernia. J Pediatr Surg. 2012 Mar;47(3):453-61. Cited in PubMed; PMID:22424337.

Laje P, Johnson MP, Howell LJ, Bebbington MW, Hedrick HL, Flake AW, et al. Ex utero intrapartum treatment in the management of giant cervical teratomas. J Pediatr Surg. 2012 Jun;47(6):1208-16. Cited in PubMed; PMID:22703795.

Abstracts

2020

Chotzoglou E, Hedrick H: Mode of Ventilation and Therapies Applied on Extracorporeal Membrane Oxygenation in Infants with Congenital Diaphragmatic Hernia  Pediatric Academic Societies 2020 Meeting, Philadelphia, PA April 2020.

Chotzoglou E, Goldshore M, Franciscovich C, Connelly J, Rintoul N, Hedrick H: "Mode of Ventilation and Therapied Applied on Extracorporal Membrane Oxygenation in Infants with Congenital Diaphragmatic Hernia" Pediatric Academic Societies (PAS)  May  2020.

Grover T, Weems M, Haberman B, Brozanski B, Daniel J, Rintoul N, Walden A, Hedrick H, Mahmood B, Seabrook R, Murthy K, Zaniletti I, Keene S: "Central line utilization and complications in infants with congenital diaphragmatic hernia (CDH)" Pediatric Academic Societies (PAS) 2020 Meeting  May  2020.

Goldshore M, Hedrick H, Herkert L, Harrington A, Hoffman-Craven C, Panitch H, Schreiber J, Miller J, Avitabile C, Stair E, Adams S: Growth, Cognition and Cardiopulmonary Health Among 8-13 year olds with Pulmonary Hypoplasia: A Prospective Cohort American Pediatric Surgical Association 2020 Annual Meeting, San Francisco, CA Sept 2020.

Hedrick H, Herkert L, Harrington A, Hoffman-Craven C, Panitch H, Schreiber J, Miller J, Avitabile C, Stair E, Adams, S: Implementation of a Multidisciplinary Care Team for Prenatally Diagnosed Oropharyngeal Masses  American Pediatric Surgical Society 2020 Annual Meeting, San Francisco, CA Sept 2020.

2019

Javia LR, Hedrick HL, Oliver ER, Rintoul NE, Tran KM, Lin EE, Isserman RS, Khalek N: PRESTO vs. EXIT for the Management of Prenatally Anticipated Difficult Airway: Techniques and Outcomes. Society for Obstetric Anesthesia 2019 Annual Meeting, Phoenix, AZ May 2019.

Coons B, Didier R, Sridharan A, Moon J, De Bie F, Hedrick H,Davey M, Flake A: The Carinal Index: A Novel Method of Quantifying Severity of Surgically-Created Diaphragmatic Hernia in the Ovine Model. IFMSS 38th annual meeting Switzerland  Oct 2019.

Coons B,Pang C, Moon J, Da Bie F, Senra J, Hwang G, Spina A, Reice C, Peterson H, Monos S, Butt Z, Hedrick H, Davey M, Flake A: Left Ventricular Cardiac Dysfunction is Seen in the Fetus in an Ovine Diaphragmatic Hernia Model in the Extrauterine Environment for Neonatal Development. IFMSS 38th Annual Meeting Switzerland Oct 2019.

Hedrick H, etc..: Barbara E Coons MD, Ryne Didier MD, Anush Sridharan MD, James Moon MD, Felix De Bie MD, Holly Hedrick MD, Marcus Davey PhD, Alan Flake MD. IFMSS 38th Annual Conference  Oct 2019.

Kennedy U, James J, Rintoul N, Herkert L, Adams S, Stair E, Gebb J, Daugherty M, Danzer E, Peranteau W, Flake A, Adzick NS, Hedrick H: The Role of Prematurity in neonates with Giant Omphalocele. 38th IFMSS Annual Meeting, Zurich, Switzerland  2019.

Books

Chapters

2015

Laje P, Hedrick HL. Operative Surgical Management of Fetuses with CHAOS: Management at Delivery. In: Sobol S, Lioy J, ed. Disorders of the Neonatal Airway. New York: Springer; 2015. p. 181-188.

Posters and Presentations

Invited Lectures

2021

Hedrick HL. "Extreme Thrombocytosis in Congenital Diaphragmatic Hernia Patients Suggests Underlying Splenic dysfunction During Critical Illness". Virtual Meeting. Mar 2021.

2019

Hedrick HL. "To Plug or Not to Plug, That is the Question: Debate on FETO", The Fetal Heart Program and Center for Fetal Diagnosis and Treatment at the Children's Hospital of Philadelphia, Philadelphia, PA. Nov 2019.

Hedrick HL. "The Carinal Index: A Novel Method for Standardizing Surgically Created Diaphragmatic Hernias in the Ovine Model", International Fetal Medicine and Surgical Society, Sils, Switzerland. Oct 2019.

Hedrick HL. "Left Ventricular Cardiac Dysfunction is Seen in the Fetus in an Ovine Diaphragmatic Hernia Model in the Extrauterine Environment for Neonatal Development", International Fetal Medicine and Surgical Society, Sils, Switzerland. Oct 2019.

Hedrick HL. "Use of the Extrauterine Environment for Neonatal Development (EXTEND) to treat Severe Diaphragmatic Hernia with Reversible Tracheal Occlusion (rTO) Results in Improved Pulmonary Growth and Function", International Fetal Medicine and Surgical Society, Sils, Switzerland. Oct 2019.

Hedrick HL. "Use of the Extrauterine Environment for Neonatal Development (EXTEND) to Support Severe Diaphragmatic Hernia via the Umbilical Artery and Umbilical Vein", Extracorporeal Life Support Organization Annual Conference, Austin, Texas. Sept 2019.

Hedrick HL. "Left Ventricular Cardiac Dysfunction is Seen in the Fetus in an Ovine Diaphragmatic Hernia Model in the Extrauterine Environment for Neonatal Development", Extracorporeal Life Support Organization, Austin, TX. Sept 2019.

Awards and Honors

2015-2022, Philadelphia Magazine's Top Doctors in Pediatric Surgery

Editorial and Academic Positions

Editorial Positions

2000-present, Periodic Reviewer, Journal of Pediatric Surgery
2000-present, Periodic Reviewer, American Journal of Obstetrics & Gynecology
2000-present, Periodic Reviewer, Surgical Laparoscopy, Endoscopy & Percutaneous Techniques

Academic and Institutional Committees

2018-present, Advisory Board Member, Clinical Trials Research Affinity Group, Penn Medicine
2004-present, Co-Chair, Neo-surgery Operations Steering Committee, Newborn Infant Intensive Care Unit
2004-present, Co-Chair, Neonatal Perioperative Committee, Newborn Infant Intensive Care Unit
2003-present, Chair, ECMO Operations Committee
1999-present, Operations Committee, Neonatal Intensive Care Unit

 

Leadership and Memberships

Memberships in Professional Organizations

2008-present, Friedreich's Ataxia Research Alliance, Board of Directors
2003-present, American Pediatric Surgical Association
1992-present, American College of Surgeons