Maureen B. Josephson, DO

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Maureen B. Josephson, DO, is a pediatric pulmonologist and Medical Director of the Lung and Heart/Lung Transplant Programs at Children's Hospital of Philadelphia.

Locations: Main Hospital; Specialty Care, Virtua

Phone: 215-590-3749

Education and Training

Medical School

DO - University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford, NJ

Residency

Pediatrics - Schneider Children's Hospital at North Shore Long Island Jewish, New Hyde Park, NY

Fellowship

Pediatric Pulmonary and Sleep Medicine - Children's Hospital of Philadelphia, Philadelphia, PA

Additional Training

AmeriSpan SALUD Medical Spanish Program, Salamanca, Spain
BLS, PALS, NRP Certified

Board Certification

Pediatric Pulmonology
Pediatrics

Titles and Academic Titles

Attending Pulmonologist

Medical Director of the Lung and Heart/Lung Transplant Programs

Assistant Professor of Clinical Pediatrics, University of Pennsylvania School of Medicine

Conditions Treated

Departments and Services

Publications

Papers

2019

Dean T, McDonough JM, Josephson M, Ginsberg JP, Carlson CA, Fiorino EK, Goldfarb SB.: Thoracic growth deficiency in childhood cancer survivors may cause overestimation of lung disease. Pediatric Pulmonology 54(10): 1602-1609, October 2019.

2015

Hu A, Diener BL, Josephson MB, Grunstein MM: Constitutively active signaling by the G protein βγ-subunit mediates intrinsically increased phosphodiesterase-4 activity in human asthmatic airway smooth muscle cells. Plos One 10(3): e0118712, March 2015 Notes: http://dx.doi.org/ 10.1371/journal.pone.0118712

2013

Hu Aihua, Josephson Maureen B, Diener Barry L, Nino Gustavo, Xu Shuyun, Paranjape Chinmay, Orange Jordan S, Grunstein Michael M: Pro-asthmatic cytokines regulate unliganded and ligand-dependent glucocorticoid receptor signaling in airway smooth muscle. PloS one 8(4): e60452, 2013. PMCID: PMC3617099

2012

Josephson Maureen B, Jiao Junfang, Xu Shuyun, Hu Aihua, Paranjape Chinmay, Grunstein Judith S, Grumbach Yael, Nino Gustavo, Kreiger Portia A, McDonough Joseph, Grunstein Michael M: IL-13-induced changes in endogenous glucocorticoid metabolism in the lung regulate the proasthmatic response. American journal of physiology. Lung cellular and molecular physiology 303(5): L382-90, Sep 2012. PMCID: PMC3468426

Nino Gustavo, Hu Aihua, Grunstein Judith S, McDonough Joseph, Kreiger Portia A, Josephson Maureen B, Choi John K, Grunstein Michael M: G Protein βγ-subunit signaling mediates airway hyperresponsiveness and inflammation in allergic asthma. PloS one 7(2): e32078, 2012. PMCID: PMC3284547

Abstracts

2015

Dean T, Josephson M, Goldfarb S. Thoracic Growth Deficiency in Childhood Cancer Survivors: Are We Overestimating Restrictive Lung Disease? American Thoracic Society 2015.

2013

A. Hu, B.L. Diener, M.B. Josephson, M.M. Grunstein: Pro-Asthmatic Signaling via the G Protein beta gamma Subunit is Intrinsically Activated in Cultured Human Asthmatic Airway Smooth Muscle Cells. American Thoracic Society 2013 Notes: Poster Discussion Session at the American Thoracic Society, Philadelphia, May 2013.

B.L. Diener, A. Hu, M.B. Josephson, M.M. Grunstein: Differential Effects of IL-13 on Serine Site-Specific Glucocorticoid Receptor (GR) Phosphorylation in Human Airway Smooth Muscle (HASM) Cells. American Thoracic Society 2013 Notes: Poster Discussion Session at the American Thoracic Society, Philadelphia, May 2013.

M. B. Josephson, A. Hu, B. L. Diener, and M. M. Grunstein: Phosphodiesterase 4 (PDE4) Activity is Intrinsically Increased in Cultured Human Asthmatic Airway Smooth Muscle Cells Due to Upregulated G protein βγ-subunit Activation. American Thoracic Society 2013 Notes: Accepted as an oral presentation in a Mini-Symposium at the American Thoracic Society, Philadelphia, May 2013.

2012

 A. Hu, PhD, M.B. Josephson, D.O., S. Xu, M.D., G. Nino, MD, J.S. Grunstein, M.A., M.M. Grunstein, M.D. Ph.D. : Regulation Of Glucocorticoid Receptor (GR) Phosphorylation And Transcriptional Signaling By IL-13 In Human Airway Smooth Muscle (HASM) Cells. American Thoracic Society 2012.

G. Nino, MD, A. Hu, PhD, J.S. Grunstein, MA, M.B. Josephson, D.O., C.S. Paranjape, B.S., M.M. Grunstein, MD, PhD.: Glucocorticosteroids Prevent The Pro-Asthmatic Effects Of IgE On Airway Smooth Muscle (ASM) Function By Inhibiting Phosphodiesterase 4 (PDE4) Activity. American Thoracic Society 2012.

M. B. Josephson, S. Goldfarb: Plastic Bronchitis: An Unusual Cause For Atelectasis In A Patient With Prune Belly Syndrome. American Thoracic Society 2012.

M.B. Josephson, S. Xu, G. Nino, A. Hu, J.S. Grunstein, M.M. Grunstein: Expression And Activity Of The Endogenous Glucocorticoid (GC)-Activating Enzyme, 11β-Hydroxysteroid Dehydrogenase-1 (HSD-1), Are Suppressed In Asthmatic Airway Smooth Muscle Cells. American Thoracic Society 2012 Notes: Poster Discussion Session at the American Thoracic Society Meeting, San Francisco, May 2012.

Books

2020

Cassandra Aravelo and Maureen Banfe Josephson: Book Title: Diagnostic and Interventional Bronchoscopy in ChildrenChapter Title: Flexible Bronchoscopy and Children's Interstitial Lung Disease. Respiratory Medicine. Springer Nature Switzerland, 2020.

2019

Ambika G. Chidambaram Maureen Josephson: Clinical research study designs: The essentials. Pediatric Investigation 3(4): 245-252, December 2019.

2018

Shapiro AJ, Davis SD, Polineni D, Manion M, Rosenfeld M, Dell SD, Chilvers MA, Ferkol TW, Zariwala MA, Sagel SD, Josephson M, Morgan L, Yilmaz O, Olivier KN, Milla C, Pittman JE, Daniels MLA, Jones MH, Janahi IA, Ware SM, Daniel SJ, Cooper ML, Nogee LM, Anton B, Eastvold T, Ehrne L, Guadagno E, Knowles MR, Leigh MW, Lavergne V; American Thoracic Society Assembly on Pediatrics.: Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline. American Journal of Respiratory and Critical Care Medicine 197(1): e24- e39, June 2018.

Josephson M, Benden C, Hanna B: Solid Organ Transplantation in Infants and Children: Indications for lung transplantation. Organ and Tissue Transplantation Book Series Springer, 2018 Notes: Book chapter.

2017

Shapiro A, Josephson M, Rosenfeld M, Yilmaz O, Davis S, Polineni D, Guadagno E, Leigh M, Lavergne V: Accuracy of nasal nitric oxide as a diagnostic test for primary ciliary dyskinesia: A systematic review and metaanalysis. Annals of the American Thoracic Society 14(7): 1184-1196, July 2017.

2015

Goldfarb SB, Josephson M. Cystic Fibrosis. BMJ Best Practice 2015.

Goldfarb SB, Josephson M. Cystic Fibrosis. BMJ Point-of-Care 2015.

Posters and Presentations

Lectures by Invitation

2019

"Pulmonary Aspects of Cystic Fibrosis", The American Austrian Foundation, Salzburg, Austria

"Non-Pulmonary Aspects of Cystic Fibrosis", The American Austrian Foundation, Salzburg, Austria

"Clinical Trials- The Essentials", The American Austrian Foundation, Salzburg, Austria

2018

"Infants/child/Lung Transplant", lecture given at Neonatology Grand Rounds at Capital Health in Hopewell NJ

2015

Josephson MB. Community Acquired Pneumonia: When to Order What? Presented at: American Academy of Pediatrics; 2015 Oct; Washington DC.

Josephson MB. Cystic Fibrosis: An update on clinical and genetic aspects. Grandview Hospital; 2015 Oct; Sellersville PA.

Josephson MB. Interpreting genetic testing in PCD patients. PCD On the Move Clinical Conference; 2015 Aug; Minneapolis MN.

Awards and Honors

2011, American Thoracic Society Fellows Track Symposium, Travel Scholarship Recipient

2011, American College of Chest Physicians Pediatric Pulmonary and Critical Care Fellows Conference, Travel Scholarship Recipient

2011, Jacqueline E. Swartz Endowed Fellowship in Pediatric Pulmonology

Editorial and Academic Positions

2016-present, Reviewer, Pediatric Transplantation

Leadership and Memberships

International

2016-present, International Society of Heart and Lung Transplantation (ISHLT)

National

2020-Present, United Network for Organ Sharing (Lung Review Board Member

2009-Present, American Thoracic Society

2009-present, American College of Chest Physicians

2006-present, American Academy of Pediatrics (AAP)

2002-present, American Osteopathic Association