Program for Integrated Immunodeficiency and Cellular Therapy (PIICT)
At Children's Hospital of Philadelphia (CHOP), we recognize learning your child has a complex immune disorder that will require life-long monitoring – even after treatment – is very challenging. Our Program for Integrated Immunodeficiency and Cellular Therapy (PIICT) provides comprehensive, patient-focused, long-term care to:
- Children with primary immune deficiencies who are treated with cellular therapies such as bone marrow transplant (hematopoietic stem cell transplant) and CAR-T therapy (chimeric antigen receptor T-cell therapy)
- Children who develop immune dysfunction after receiving cellular therapy for another disease, such as leukemia
Our collaborative program brings together experts from Immunology, Cell Therapy, and other specialties to support children and their families throughout their entire journey — from diagnosis through treatment and as they cope with the long-term effects of their disease.
How we serve you
We offer specialized programs and services to support patients with primary immune deficiencies, including those listed below.
Conditions we treat
Our program treats children with primary immune deficiencies and functional immune abnormalities, such as severe combined immunodeficiency (SCID), combined immunodeficiencies and others.
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Chronic granulomatous disease (CGD) -
Hemophagocytic lymphohistiocytosis (HLH) -
Hyper-IgM syndromes - Immune abnormalities following cellular therapy
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IPEX syndrome and related immune dysregulation disorders -
Severe combined immunodeficiency (SCID) and combined immunodeficiencies -
Very early onset inflammatory bowel disease (VEO-IBD) -
Wiskott-Aldrich syndrome (WAS)
Why choose us for cellular therapy
CHOP’s Immunology and Cellular Therapy teams are among the largest in North America caring for children with primary immune deficiency and cellular therapy recipients. Created in 2011, our program provides a long-term medical home for these children.
Meet your team
Our team includes specialists from Immunology and Cellular Therapy who have expertise in assessing and treating the long-term effects of primary immune deficiencies and related conditions.
Our locations
The PIICT clinic is available twice a month in the Buerger Center for Advanced Pediatric Care for patients before and after stem cell transplant.
Our research
Our program participates in several clinical trials investigating gene therapies. We are part of the Primary Immune Deficiency Treatment Consortium studying long-term outcomes after transplant and cellular therapy for children with rare primary immunodeficiencies.
Patient stories
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