Phone: (215) 590-4981
Dr. Mattei is an attending physician in the Division of General, Thoracic and Fetal Surgery at Children’s Hospital of Philadelphia (CHOP) and Associate Professor in Surgery at the Perelman School of Medicine at the University of Pennsylvania. In addition to being an experienced pediatric general surgeon and thoracic surgeon, he has developed a special interest and expertise in several areas including: Pediatric surgical oncology (neuroblastoma, Wilms tumor, hepatoblastoma, soft tissue sarcoma, tumors and cysts of the ovary), inflammatory bowel disease (Crohn’s disease, ulcerative colitis, familial adenomatous polyposis syndromes), and minimally invasive and robotic surgery (laparoscopy, thoracoscopy, daVinci surgery, single-site daVinci cholecystectomy).
Dr. Mattei is the CHOP Department of Surgery liaison with the Children’s Oncology Group and participates in national clinical trials of treatment options for children with cancer. He is an active and participating member of the CHOP Solid Tumor division, where he helps formulate therapeutic plans for children with solid tumors who need surgery in addition to chemotherapy and radiation therapy.
Dr. Mattei has active clinical research interests in Oncology and IBD and is the recipient of the Morgan Family Endowed Chair in Pediatric Surgery. As Vice-Chair for Quality, Safety and Outcomes for the Department of Surgery and Director of the Surgical Quality Improvement Program, he is active in designing, overseeing and conducting active and ongoing quality improvement projects at CHOP.
Dr. Mattei is also active in teaching and is invited to speak elsewhere for conferences and lectures at other institutions to discuss his expertise in surgical oncology, surgery for Crohn’s and colitis, and other aspects of pediatric surgery. He reviews cases and provides second opinions for children with tumors from all over the world. He has published extensively in the peer-review literature and is the editor of a major pediatric surgery textbook, Fundamentals of Pediatric Surgery.
MD - Harvard Medical School, Cambridge, MA
General Surgery - Johns Hopkins Hospital, Baltimore, MD
General Surgery - Johns Hopkins Hospital, Baltimore, MD
Research Fellow in Surgery - Johns Hopkins University School of Medicine, Baltimore, MD
Pediatric Surgery - Children’s Hospital Medical Center, Cincinnati, OH
Registrar in Surgery - Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, United Kingdom
General Surgery – American Board of SurgeryPediatric Surgery – American Board of Surgery
Attending Physician, Division of General, Thoracic and Fetal Surgery
Vice-Chair for Quality, Safety and Outcomes, Department of Surgery
Director, Surgical Quality Improvement Program
Medical Director, 4East-4South Surgical Nursing Unit
Morgan Family Endowed Chair in Pediatric Surgery
Director, General Surgery Robotics Program
Associate Professor of Surgery, Perelman School of Medicine at the University of Pennsylvania
Twist CJ, Naranjo A, Schmidt ML, Tenney SC, Cohn SL, Meany HJ, Mattei P, Adkins ES, Shimada H, London WB, Park JR, Matthay KK, Maris JM. Defining Risk Factors for Chemotherapeutic Intervention in Infants With Stage 4S Neuroblastoma: A Report From Children's Oncology Group Study ANBL0531. Journal of Clinical Oncology 37(2):115-124, 2019.
Elgarten CW, Levy EM, Mattei P, Fisher BT, Olson TS, Freedman JL. Successful treatment of pulmonary mucormycosis in two pediatric hematopoietic stem cell transplant patients. Pediatr Transplant 2018.
MacFarland SP, Duffy KA, Bhatti TR, Bagatell R, Balamuth NJ, Brodeur GM, Ganguly A, Mattei P, Surrey LF, Balis FM, Kalish JM. Diagnosis of Beckwith-Wiedemann syndrome in children presenting with Wilms tumor. Pediatr Blood Cancer 65(10) 2018.
Mattei P. Single-site robotic-assisted laparoscopic cholecystectomy in children and adolescents: a report of 20 cases. Surgical Endoscopy 32(5):2402-2408, 2018.
Nabavizadeh S, Zimmerman R, Mattei P, Liu G. Infantile Myofibroma of the Carotid Space Presenting as Horner Syndrome. Journal of Neuro-Ophthalmology 37(4):459-460, 2017.
Carlson CA, Kolon TF, Mattei P, Hobbie W, Gracia CR, Ogle S, Ginsberg JP. Developing a Hospital-Wide Fertility Preservation Service for Pediatric and Young Adult Patients. J Adolesc Health. 61(5):571-576, 2017.
Chu DI, Tan JM, Mattei P, Simpao AF, Costarino AT, Shukla AR, Rossano JW, Tasian GE. Outcomes of laparoscopic and open surgery in children with and without congenital heart disease. J Pediatr Surg 2017.
Hwang TJ, Servaes S, Mattei P, Anupindi SA Radiologist performance in the interpretation of contrast enemas performed for Hirschsprung's disease in children >1 year of age. Clinical Radiology 72(6):519, 2017.
Chu D, Mattei P, Tang J, Tasian G. Mortality and morbidity after laparoscopic surgery in children with and without congenital heart disease. J Pediatrics 185:88-93, 2017.
MacFarland SP, Mostoufi-Moab S, Zelley K, Mattei P, States LJ, Bhatti TR, Duffy KA, Brodeur GM, Kalish JM. Management of adrenal masses in patients with Beckwith-Wiedemann syndrome. Pediatr Blood Cancer 64(8) 2017.
Maxwell EC, Dawany N, Baldassano RN, Mamula P, Mattei P, Albenberg L, Kelsen JR. Diverting ileostomy for the treatment of severe, refractory pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr 65(3):299-305, 2017.
Wang KS, Tiao G, Bass LM, Hertel PM, Mogul D, Kerkar N, Clifton M, Azen C, Bull L, Rosenthal P, Stewart D, Superina R, Arnon R, Bozic M, Brandt ML, Dillon PA, Fecteau A, Iyer K, Kamath B, Karpen S, Karrer F, Loomes KM, Mack C, Mattei P, Miethke A, Soltys K, Turmelle YP, West K, Zagory J, Goodhue C, Shneider BL; the Childhood Liver Disease Research Network (ChiLDReN). Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis. Hepatology 65(5):1645-1654, 2016.
Boomer LA, Cooper JN, Anandalwar S, Fallon SC, Ostlie D, Leys CM, Rangel S, Mattei P, Sharp SW, St. Peter SD, Rodriguez JR, Kenney B, Besner GE, Deans KJ, Minneci PC: Delaying appendectomy does not lead to higher rates of surgical site infections: A multi-institutional analysis of children with appendicitis. Ann Surg 264(1):164-8, 2016.
Sulkowski JP, Cooper JN, Lopez JJ, Jadcherla Y, Cuenot A, Mattei P, Deans KJ, Minneci PC: Morbidity and mortality in patients with esophageal atresia. Surgery 156(2):483-91, 2014.
Vrecenak J, Mattei P: Fast-track management is safe and effective after bowel resection in children with Crohn's disease. J Pediatr Surg 49(1):99-102, 2014
De Zoeten EF, Pasternack BA, Mattei P, Kramerand RE, Kader HA: NASPGHAN clinical report and consensus statement: Diagnosis and Treatment of Perianal Crohns Disease. J Pediatr Gastroenterol Nutr 57(3):401-12, 2013.
Alcorn KM, Deans KJ, Congeni A, Sulkowski JP, Bagatell R, Mattei P, Minneci PC. Sentinel Lymph Node Biopsy in Pediatric Soft Tissue Sarcoma Patients: Utility and Concordance with Imaging. J Pediatr Surg 48(9):1903-6, 2013.
Tsai J, Sulkowski JP, Cooper JN, Mattei P, Deans KJ, Minneci PC. Sensitivity and Predictive Value of Ultrasound in Pediatric Cholecystitis. J Surg Res 184(1):378-82, 2013.
Sulkowski JP, Deans KJ, Asti L, Mattei P, Minneci PC. Using the Pediatric Health Information System to Study Rare Congenital Pediatric Surgical Diseases: Development of a Cohort of Esophageal Atresia Patients. J Pediatr Surg 48(9):1850-5, 2013.
Isaacoff E, Dimitriadi FF, Barrows F, Pawel BR, Mattei P, Mostoufi-Moab S: Malignant Acanthosis Nigricans Associated with an Adrenocortical Tumor in a Pediatric Patient. Case Reports in Endocrinology 2013:174593, 2013.
Mattei P: Surgery for Metastatic Disease. Curr Opin Pediatr 25(3):362-7, 2013.
McClelland C, Walsh RD, Chikwava KR, Johnson MP, Mattei P, Liu GT: Congenital mydriasis associated with megacystis microcolon intestinal hypoperistalsis syndrome. J Neuroophthalmol 33(3):271-5, 2013.
Kalish JM, Conlin LK, Mostoufi-Moab S, Wilkens AB, Mulchandani S, Zelley K, Kowalski M, Bhatti TR, Russo P, Mattei P, Mackenzie WG, Livolsi V, Nichols KE, Biegel JA, Spinner NB, Deardorff MA: Bilateral pheochromocytomas, hemihyperplasia, and subtle somatic mosaicism: the importance of detecting low-level uniparental disomy. Am J Med Genet A. 161(5):993-1001, 2013.
Mattei P: Double H-type tracheoesophageal fistulas identified and repaired in 1 operation. Journal of Pediatric Surgery 47(11):e11-3, 2012.
Tsai J, Mattei P: Median Sternotomy for Bilateral Pulmonary Metastasectomy in Children. Journal of Pediatric Surgery 47(7):1345-8, 2012.
Sulkowski J, Kolon T, Mattei P: Nephron-sparing partial nephrectomy for bilateral Wilms' tumor. Journal of Pediatric Surgery 47(6):1234-8, 2012.
Gollomp K, Rankin SC, White C, Mattei P, Harris MC, Kilpatrick LE, Sheffler-Collins S, McGowan KL, Shah SS. Broad-range bacterial polymerase chain reaction in the microbiologic diagnosis of complicated pneumonia. J Hosp Med. 7(1):8-13, 2012.
Gracia CR, Chang J, Kondapalli L, Prewitt M, Carlson CA, Mattei P, Jeffers S, Ginsberg JP: Ovarian tissue cryopreservation for fertility preservation in cancer patients: Successful establishment and feasibility of a multidisciplinary collaboration. Journal of Assistive Reproduction Genetics 29(6):495-502, 2012 .
Kotecha MK, Bellah RD, Pena AH, Mattei P: Multi-modality imaging manifestations of the Meckel’s diverticulum in pediatric patients, Pediatric Radiology 42(1):95-103, 2012 .
St Peter SD, Valusek PA, Hill S, Wulkan ML, Shah SS, Martinez Ferro M, Bignon H, Laje P, Mattei P, Graziano KD, Muensterer OJ, Pontarelli EM, Nguyen NX, Kane TD, Qureshi FG, Calkins CM, Leys CM, Baerg JE, Holcomb GW: Laparoscopic adrenalectomy in children: a multicenter experience. J Laparoendosc Adv Surg Tech A. 21(7):647-9, 2011.
Fitzgerald JC, Topjian AA, McInnes AD, Mattei P, McCloskey J, Friess SH, Kilbaugh TJ: Bi-caval dual lumen venovenous extracorporeal membrane oxygenation and high frequency percussive ventilatory support for postintubation tracheal injury and acute respiratory distress syndrome., Journal of Pediatric Surgery 46(12):e11-5, 2011.
Santore MT, Behar BJ, Blinman TA, Doolin EJ, Hedrick HL, Mattei P, Nance ML, Adzick NS, Flake AW: Hepaticoduodenostomy vs. hepaticojejunostomy for reconstruction after resection of choledochal cyst. Journal of Pediatric Surgery 46(1):209-213, 2011.
Mattei P: A simple suture-retrieval device for the placement of U-stitches during laparoscopic gastrostomy. Journal of Laparoendoscopic & Advanced Surgical Techniques 19(1):115-117, 2009.
Moore M, Anupindi S, Mattei P, Sengupta A, Darge K: Mesenchymal cystic hamartoma of the liver: MR imaging with pathologic correlation. Journal of Radiology Case Reports3(7):22-6, 2009.
Laje P, Mattei P: Laparoscopic adrenalectomy for adrenal tumors in children: a case series. Journal of Laparoendoscopic & Advanced Surgical Techniques 19(Suppl.1): S27-29, 2009.
Mattei P, Barnaby K: Rapid regression of duodenal inflammatory myofibroblastic tumor after intravenous ketorolac: Case report and review of the literature. Journal of Pediatric Surgery 43(6):1196-1199, 2008.
Kaye AJ, Slemp AE, Chang B, Mattei P, Fairman R, Velasquez OC: Complex vascular reconstruction of abdominal aorta and its branches in the pediatric population. Journal of Pediatric Surgery 43(6):1082-1088, 2008.
Kaye AJ, Jatlab M, Mattei P, Kelly J, Nance ML: Use of laparoscopic cholecystectomy for biliary dyskinesia in the child. Journal of Pediatric Surgery 43(6):1057-1059, 2008.
Jatla M, Bates NA, Mattei P: Fellow’s Corner: Meckel’s Diverticulum. Practical Gastroenterology 32(4): 67, 72, 2008.
Adibe O, Barnaby K, Dobies J, Comerford M, Drill A, Walker N, Mattei P: Postoperative antibiotic therapy for children with perforated appendicitis: Long course of intravenous antibiotics versus early conversion to an oral regimen. The American Journal of Surgery 195(2):141-143, 2008.
Dunning K, Mattei P: Burkitt’s Lymphoma Presenting as Colonic Ischemia and Overwhelming Sepsis. Journal of Pediatric Surgery 42(8):E15-7, 2007.
Adibe O, Nichol PF, Lim FY, Mattei P: Ad Libitum Feeds After Laparoscopic Pyloromyotomy: A Retrospective Comparison with a Standardized Feeding Regimen in 227 Patients. Journal of Laparoendoscopic & Advanced Surgical Techniques 17(2):235-237, 2007.
Mattei P: Urachal remnant perforation during umbilical vein catheterization in a newborn. Journal of Pediatric Surgery 42(4):722-724, 2007 .
Mattei P, Tyler DC: Carbon dioxide embolism during laparoscopic cholecystectomy due to a patent para-umbilical vein. Journal of Pediatric Surgery 42(3):570-2, 2007.
Adibe O, Nichol PF, Flake AW, Mattei P: Comparison of outcomes after laparoscopic and open pyloromyotomy at a high-volume pediatric teaching hospital. Journal of Pediatric Surgery 41(10):1676-1678, 2006.
Artz GJ, Reilly JS, Mattei P: Stridor in an infant. Clinical Pediatrics 45(6):578-581, 2006.
Ryan, M, Mattei P, Russo P, Flick J, Mamula P: A 2-year-old girl with chronic and recurrent emesis. Medscape General Medicine 8(1):10, 2006.
Mattei P, von Allmen D, Piccoli D, Rand E: Relief of intractable pruritis in Alagille syndrome by partial external biliary diversion. Journal of Pediatric Surgery 41(1):104-107, 2005.
Liu S, de Blacam C, Lim FY, Mattei P, Mamula P: Magnetic foreign body ingestions leading to duodenocolic fistula. Journal of Pediatric Gastroenterology and Nutrition 41(5):670-672, 2005.
Mattei P, Alonso M, Justinich C: Laparoscopic repair of colon perforation after colonoscopy in children: Report of two cases and review of the literature. Journal of Pediatric Surgery 40(10):1651-1653, 2005 .
Mattei P, Wolfson P: Prior gastrostomy does not preclude successful laparoscopic fundoplication. Pediatric Endosurgery & Innovative Techniques 5(3):277-280, 2001.
Mattei P, Wise B, Schwarz K, Klein A, Colombani PM: Orthotopic liver transplantation in patients with biliary atresia and situs inversus: Report of two cases and review of the literature. Pediatric Surgery International 14(1-2):104-110, Nov. 1998.
McKee M, P Mattei, K Schwarz, B Wise, P Colombani: Steroid withdrawal in Tacrolimus (FK506)-treated pediatric liver transplant recipients. Journal of Pediatric Surgery 32(7):973-975, July 1997.
Mattei P, Taylor GA, Colombani PM: Post-traumatic hepatic vein thrombosis (Budd-Chiari syndrome) in a child: Case report and review of the literature. Pediatric Surgery International 9(5-6):425-428, 1994.
Mattei P, Sola JE, Yeo CJ: Chronic and recurrent appendicitis: Unusual entities often misdiagnosed. Journal of the American College of Surgeons 178(4):385-389, Apr. 1994.
Sola JE, Mattei P, Pegoli W, Jr., Paidas CN: Rupture of the right diaphragm following blunt trauma in an infant. Journal of Trauma 36(3):417-420, Mar. 1994.
Mattei P, Wiebke E, Lipsett P: Tension pneumothorax as a presentation of traumatic diaphragmatic hernia. Southern Medical Journal 85(8):847-850, Aug. 1992.
Schultz RM, Endo Y, Mattei P, Kurasawa S, Kopf GS: Egg-induced modifications of the mouse zona pellucida. Progress in Clinical Biological Research 284:77-92, 1988.
Bornslaeger EA, Mattei P, Schultz RM: Protein phosphorylation in meiotically competent and incompetent mouse oocytes. Molecular Reproductive Development 1(1): 19-25, 1988.
Endo Y, Mattei P, Kopf GS, Schultz RM: Effects of phorbol esters on mouse eggs: dissociation of sperm receptor activity from acrosome reaction-inducing activity of the mouse zona pellucida protein, ZP3. Developmental Biology 123(2):574-577, Oct. 1987.
Bornslaeger EA, Poueymirou WT, Mattei P, Schultz RM: Effects of protein kinase C activators on germinal vesicle breakdown and polar body emission of mouse oocytes. Experimental Cell Research 165(2):507-517, Aug. 1986.
Bornslaeger EA, Mattei P, Schultz RM: Involvement of cAMP-dependent protein kinase and protein phosphorylation in regulation of mouse oocyte maturation. Developmental Biology 114(2):453-462, Aug. 1986.
Breton J, Mattei P, Rawley S, Baldassano R: Characterization of the fistula-associated microbiome in pediatric perianal Crohn's disease, Digestive Diseases Week, San Diego, California, 2019.
Rossidis AC, Brown EG, Payton KJ, Mattei P: Implementation of an Evidence-Based Protocol after Appendectomy Reduces Unnecessary Antibiotics, American Academy of Pediatrics Meeting, Orlando, Florida, November 2018.
Mattei P (ed. in chief), Nichol PF, Collins M, Muratore C: Fundamentals of Pediatric Surgery, 2e, Springer, New York, 2016.
Mattei P, editor. Fundamentals of pediatric surgery, 2nd Edition. New York: Springer; 2011.
Mattei P, editor. Surgical directives: Pediatric surgery. Philadelphia: Lippincott, Williams & Wilkins; 2003.
Brown E, Mattei P: ECMO. Shah S, 3ed. The Philadelphia Guide: Inpatient Pediatrics, McGraw-Hill Education/Medical, 2019.
Mattei P: Vagina. Mattei P, 2ed. Fundamentals of Pediatric Surgery, New York: Springer, 2016.
Mattei P: Crohn’s Disease. Mattei P, 2ed. Fundamentals of Pediatric Surgery, New York: Springer, 2016.
Mattei P: Meconium Ileus. Mattei P, 2ed. Fundamentals of Pediatric Surgery, New York: Springer, 2016.
Mattei P: Vascular Access. Mattei P, 2ed. Fundamentals of Pediatric Surgery, New York: Springer, 2016.
Mattei P: Enhanced Recovery Protocols. Mattei P, 2ed. Fundamentals of Pediatric Surgery, New York: Springer, 2016.
Mattei P: Surgical Treatment of Ulcerative Colitis. In Mamula P, Markowitz JE, Baldassano RN (eds): Pediatric Inflammatory Bowel Disease. New York: Springer, (2013).
Mattei P. Hirschsprung’s disease. In: Wyllie R, Hyams JS, Kay M, editors. Pediatric gastrointestinal and liver disease. 4th ed. Philadelphia: Elsevier Saunders; 2011, 576-82.
Mattei P. Fast-track protocols. In: Mattei P, editor. Fundamentals of pediatric surgery, 2nd Edition. New York: Springer, 2011, 37-40.
Mattei P. Crohn’s disease. In: Mattei P, editor. Fundamentals of pediatric surgery, 2nd Edition. New York: Springer, 2011, 437-442.
Mattei P. Congenital diaphragmatic hernia. In: Mattei P, editor. Fundamentals of pediatric surgery, 2nd Edition. New York: Springer, 2011, 535-542.
Mattei P. Surgical therapy of disorders if intrahepatic cholestasis. In: Mattei P, editor. Fundamentals of pediatric surgery, 2nd Edition. New York: Springer, 2011, 575-578.
Mattei P. Surgical site infections. In: Shah SS, editor. Infectious diseases. New York: McGraw-Hill Medical; 2009. p. 738-50.
Swami S, Mattei P, Shah SS. Complicated pneumonia. In: Shah SS, editor. Infectious diseases. New York: McGraw-Hill Medical; 2009. p. 310-20.
Mattei P. “Surgical Treatment of Inflammatory Bowel Disease in Children” GI-Surgery Morning Conference, Children’s National Medical Center, Washington, D.C. Jan 2019.
Mattei P. “How Cognitive Bias Contributes to Diagnostic Errors” Council of Chiefs Presentation, Children’s Hospital of Philadelphia, Philadelphia, Pa. Nov 2018.
Mattei P. “What’s New in Pediatric Surgery 2018” Surgical Grand Rounds, Fitzgeral Mercy Hospital, Darby, Pa. Jan 2018.
2018, 2022, Philadelphia Magazine's Top Doctors in Pediatric Surgery
2011, “Humanitarian of the Year” presented by the Columbus Forum, Lodge 1492 of The Sons of Italy, Philadelphia
2011, “Best Surgeons in America”
2008-2011, “Patients’ Choice Award”, American Registry
2004, Great Docs for Kids” Pediatric Surgery, Main Line Today
2004-2011, “Best Doctors in America”
2001, “Top Docs for Kids,” Philadelphia Magazine
2001, Physician of the Year, A.I. duPont Hospital for Children
1996, Alpha Omega Alpha
1996, Consultant of the Year, Dept. of Emergency Medicine
1994, George D. Zuidema Research Award Finalist
1985, Graduated Summa Cum Laude, University of Pennsylvania
1984, Phi Beta Kappa
1982-1985, Benjamin Franklin Scholar
1982, National Merit Scholar
Journal of Pediatric Surgery
Surgery
Pediatric Surgery International
Annals of Surgery
Pediatric Emergency Care
2017-present, Director, Surgical Quality Improvement Program, Department of Surgery
2016-present, Vice Chair for Quality, Safety and Outcomes, Department of Surgery
2015-present, Trauma Committee
2014-present, Unit-Leadership Partners Committee
2013-present, Perioperative Quality and Safety Committee
2013-present, Quality Improvement Committee
- 2015-present, Subcommittee: Ethics
2011-present, OR Steering Committee
2010–present, Clinical Care Committee
2009–present, Surgical CQI Committee
2008–present, Patient Safety Officer, Department of Surgery
2003-present, Cancer Committee
2003-present, Drug Use Evaluation Subcommittee
2001-present, American College of Surgeons
2001-present, American Pediatric Surgical Association
- 2018-present, Quality & Safety Committee
2000-present, American Academy of Pediatrics, Surgical Section