Peter Mattei, MD, FACS, FAAP

Peter Mattei, MD, FACS, FAAP

Peter Mattei, MD, is an attending pediatric surgeon in the Division of General, Thoracic and Fetal Surgery at Children's Hospital of Philadelphia.

Areas of Expertise: Inflammatory bowel disease, Minimally Invasive and daVinci Robotic Surgery, Surgical Oncology, Thoracic Surgery
Locations: Main Campus; Specialty Care & Surgery Center, Brandywine Valley
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)


I am an attending physician in the Division of General, Thoracic and Fetal Surgery at Children’s Hospital of Philadelphia (CHOP) and assistant professor of surgery at the Perelman School of Medicine at the University of Pennsylvania. As the primary surgical liaison for pediatric surgical oncology, I am a member of CHOP’s Tumor Board and participate in clinical decision-making discussions for many children with pediatric solid tumors being treated or evaluated for a second opinion at CHOP. I have developed special expertise in the surgical treatment of neuroblastoma, Wilms’ tumor, hepatoblastoma, and abdominal and thoracic sarcomas, among other pediatric solid tumors.

One of the things I’m most proud of at CHOP is the partnership between surgeons, oncologists and other specialists through all stages of a child’s cancer treatment. Having a multidisciplinary team of experts in every specialty, working together to develop a complete care plan that takes into consideration all aspects of a child’s treatment and recovery, allows us to best serve the individual patient and ultimately produces better outcomes.

Children’s Hospital of Philadelphia has long been a pioneer in pediatric surgery and that continues today. We are at the forefront of many of the newest protocols, including the very exciting field of robotic surgery. I have a particular interest in daVinci robotic-assisted laparoscopy and thoracoscopy, which are minimally invasive and enable unprecedented surgical precision.

I also work very closely with the gastroenterologists at CHOP and perform many operations to help children and adolescents with Crohn’s disease, ulcerative colitis, familial adenomatous polyposis and GERD. These include: laparoscopic bowel resection and anastomosis; colectomy and proctectomy with J-pouch ileo-anal reconstruction; anorectal examination under anesthesia for incision and drainage of perirectal abscess or placement of a seton for anal fistula; operations for ileostomy or colostomy; laparoscopic placement of a gastrostomy button; laparoscopic Nissen fundoplication; laparoscopic esophageal myotomy for achalasia; and laparoscopic-assisted pull-through for Hirschsprung's disease.

Paralleling my excitement about the coming of new technologies and techniques is my commitment to helping kids get better. What gratifies me about this work continues to be the children I treat. They are simply amazing and inspirational — and they get it. They know they have something very serious going on, yet they have an inner calm and appreciation for everything we do for them that is awe-inspiring and very humbling.

Education and Training

Medical School

MD - Harvard Medical School, Cambridge, MA


General Surgery - Johns Hopkins Hospital, Baltimore, MD


General Surgery - Johns Hopkins Hospital, Baltimore, MD


Surgery - Johns Hopkins University School of Medicine, Baltimore, MD
Pediatric Surgery - Children’s Hospital Medical Center, Cincinnati, OH

Additional Training

Registrar in Surgery - Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, United Kingdom

Board Certification

General Surgery
Pediatric Surgery

Titles and Academic Titles

Attending Physician, Division of General, Thoracic and Fetal Surgery

Associate Professor of Surgery, The Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Research Interests

  • Study Committee Member: Treatment for intermediate risk neuroblastoma: A Phase III COG Study. (PI: Reaman G)
  • Co-Investigator: Impact of microbiological diagnosis of complicated pneumonia on clinical outcomes using a broad-range 16S rDNA PCR for pathogen detection. (PI: Shah S)




Sulkowski JP, Cooper JN, Lopez JJ, Jadcherla Y, Cuenot A, Mattei P, Deans KJ, Minneci PC: Morbidity and mortality in patients with esophageal atresia. Surgery 156(2):483-91, 2014

Vrecenak J, Mattei P: Fast-track management is safe and effective after bowel resection in children with Crohn's disease. J Pediatr Surg 49(1):99-102, 2014


De Zoeten EF, Pasternack BA, Mattei P, Kramerand RE, Kader HA: NASPGHAN clinical report and consensus statement: Diagnosis and Treatment of Perianal Crohns Disease. J Pediatr Gastroenterol Nutr 57(3):401-12, 2013

Alcorn KM, Deans KJ, Congeni A, Sulkowski JP, Bagatell R, Mattei P, Minneci PC. Sentinel Lymph Node Biopsy in Pediatric Soft Tissue Sarcoma Patients: Utility and Concordance with Imaging. J Pediatr Surg 48(9):1903-6, 2013

Tsai J, Sulkowski JP, Cooper JN, Mattei P, Deans KJ, Minneci PC. Sensitivity and Predictive Value of Ultrasound in Pediatric Cholecystitis. J Surg Res 184(1):378-82, 2013

Sulkowski JP, Deans KJ, Asti L, Mattei P, Minneci PC. Using the Pediatric Health Information System to Study Rare Congenital Pediatric Surgical Diseases: Development of a Cohort of Esophageal Atresia Patients. J Pediatr Surg 48(9):1850-5, 2013

Isaacoff E, Dimitriadi FF, Barrows F, Pawel BR, Mattei P, Mostoufi-Moab S: Malignant Acanthosis Nigricans Associated with an Adrenocortical Tumor in a Pediatric Patient. Case Reports in Endocrinology 2013:174593, 2013

Tsai J, Sulkowski JP, Cooper JN, Mattei P, Deans KJ, Minneci PC: Sensitivity and predictive value of ultrasound in pediatric cholecystitis. J Surg Res 184(1):378-82, 2013

Mattei P: Surgery for Metastatic Disease. Curr Opin Pediatr 25(3):362-7, 2013

McClelland C, Walsh RD, Chikwava KR, Johnson MP, Mattei P, Liu GT: Congenital mydriasis associated with megacystis microcolon intestinal hypoperistalsis syndrome. J Neuroophthalmol 33(3):271-5, 2013

Kalish JM, Conlin LK, Mostoufi-Moab S, Wilkens AB, Mulchandani S, Zelley K, Kowalski M, Bhatti TR, Russo P, Mattei P, Mackenzie WG, Livolsi V, Nichols KE, Biegel JA, Spinner NB, Deardorff MA: Bilateral pheochromocytomas, hemihyperplasia, and subtle somatic mosaicism: the importance of detecting low-level uniparental disomy. Am J Med Genet A. 161(5):993-1001, 2013




Pearson E, Bagatell R, Aplenc R, Mattei P: Fast-track Postoperative Management in Patients with High-Risk Neuroblastoma, American Academy of Pediatrics Meeting, Orlando, Florida, October 2013

Vrecenak J, Mattei P: Fast-track postoperative management in Crohn’s disease – A safe and effective strategy, American Pediatric surgical Association 44th Annual Meeting, Marco Island, Florida, May 2013



Mattei P, editor. Fundamentals of pediatric surgery, 2nd Edition. New York: Springer; 2011.


Mattei P, editor. Surgical directives: Pediatric surgery. Philadelphia: Lippincott, Williams & Wilkins; 2003.



Mattei P. Hirschsprung’s disease. In: Wyllie R, Hyams JS, Kay M, editors. Pediatric gastrointestinal and liver disease. 4th ed. Philadelphia: Elsevier Saunders; 2011, 576-82.

Mattei P. Fast-track protocols. In: Mattei P, editor. Fundamentals of pediatric surgery, 2nd Edition. New York: Springer, 2011, 37-40.

Mattei P. Crohn’s disease. In: Mattei P, editor. Fundamentals of pediatric surgery, 2nd Edition. New York: Springer, 2011, 437-442.

Mattei P. Congenital diaphragmatic hernia. In: Mattei P, editor. Fundamentals of pediatric surgery, 2nd Edition. New York: Springer, 2011, 535-542.

Mattei P. Surgical therapy of disorders if intrahepatic cholestasis. In: Mattei P, editor. Fundamentals of pediatric surgery, 2nd Edition. New York: Springer, 2011, 575-578.


Mattei P. Surgical site infections. In: Shah SS, editor. Infectious diseases. New York: McGraw-Hill Medical; 2009. p. 738-50.

Swami S, Mattei P, Shah SS. Complicated pneumonia. In: Shah SS, editor. Infectious diseases. New York: McGraw-Hill Medical; 2009. p. 310-20.

Posters and Presentations


Invited Lectures


Pediatric Surgical Oncology: Review of Current Therapy, Fellows’ Lecture, Children’s Hospital of Philadelphia, Philadelphia, Pa, June 2014.

Common Pediatric Surgery Diagnoses: Current Therapy, CHOP Outreach Program, Chester County Hospital, West Chester, Pa, March 2014.

“Ulcerative Colitis” Surgical Grand Rounds, The Children’s Hospital of Philadelphia, Philadelphia, Pa, January 2014.


“Neuroblastoma” Surgical Grand Rounds, The Children’s Hospital of Philadelphia, Philadelphia, Pa, March 2013.


Awards and Honors

2011, “Humanitarian of the Year” presented by the Columbus Forum, Lodge 1492, The Sons of Italy, Philadelphia

2011, “Best Surgeons in America”

2008-2011, “Patients’ Choice Award”, American Registry

2004, “Great Docs for Kids” Pediatric Surgery, Main Line Today

2004-2011, “Best Doctors in America”

2001, “Top Docs for Kids,” Philadelphia Magazine

2001, Physician of the Year, A.I. duPont Hospital for Children

1996, Alpha Omega Alpha

1996, Consultant of the Year, Dept. of Emergency Medicine

1994, George D. Zuidema Research Award Finalist

1985, Graduated Summa Cum Laude - University of Pennsylvania, Philadelphia, PA

1984, Phi Beta Kappa

1982-1985, Benjamin Franklin Scholar

1982, National Merit Scholar

Editorial and Academic Positions

Editorial Positions

Ad Hoc Editor

Journal of Pediatric Surgery
Annals of Surgery
Pediatric Emergency Care

Academic and Institutional Committees

2010–present, Clinical Care Committee, The Children’s Hospital of Philadelphia
2008–present, Patient Safety Officer, Department of Surgery,The Children’s Hospital of Philadelphia
2009–present, Surgical CQI Committee, Children’s Hospital of Philadelphia
2003-present, Cancer Committee

Leadership and Memberships

Memberships in Professional Organizations


2006-present, International Pediatric Endosurgery Group


2001-present, American College of Surgeons

2001-present, American Pediatric Surgical Association

 - 2011-present, Chairman

 - 2007-present, APSA Cancer Committee

2000-present, American Academy of Pediatrics, Surgical Section