Hypospadias Research

Researchers and clinicians at Children's Hospital of Philadelphia have written extensively about the management of hypospadias, and we continue this work to better understand and treat this disorder. Our hypospadias research efforts are focused on providing optimal care for these patients worldwide. This includes ongoing research focused on improving surgical outcomes, identifying and addressing risk factors, better understanding the psychological impact that hypospadias has on our patients so we can enhance psychosocial and follow-up support, and much more.

In 2016, CHOP urologists spearheaded a quality improvement project in hypospadias looking at the utilization of the 2 stage repair in proximal hypospadias and pre-operative testosterone administration in patients with a small glans with prior to surgical repair.

Several of our surgeons in the Division of Urology lead committees focused on coordinating national research efforts to improve hypospadias outcomes. Team members also frequently present at clinical conferences nationally and internationally, as well as participate in mission trips, with the goal of expanding access to high quality hypospadias care to children around the world.

Select Publications


Weiss DA, Long CJ. Editorial comment ‘Hyperbaric oxygen therapy improves oral graft take in hypospadias staged tubularized autograft reoperations’. Journal of Urology, 2019 Sep;202(3):621.

Long CJ, Weiss DA. Commentary to ‘Topical estradiol increases epidermal thickness and dermal collagen of foreskin prior to hypospadias surgery- randomized double blinded controlled trial’. Journal of Pediatric Urology, 2019 Aug;15(4): 353.

Zaontz MR, Long CJ. Reverse pedicle flap as a barrier layer for circumcised patients with megameatus hypospadias. Journal of Pediatric Urology 2019 May;15(3):286.


Long CJ. Hypospadias as a chronic illness. Journal of Urology, 2018 Dec;200(6):1172.

Weiss DA, Long CJ, Frazier JR, Shukla AR, Srinivasan AK, Kolon TF, DiCarlo H, Gearhart JP, Canning DA. Back to the future: The Cecil-Culp technique for salvage penile reconstructive procedures.  Journal Pediatric Urology, 2018 Aug;14(4):328.


Long CJ, Chu DI, Tenney RW, Morris AR, Weiss DA, Shukla AR, Srinivasan AK, Zderic SA, Kolon TF, Canning DA. Intermediate-term follow up of proximal hypospadias repair reveals high complication rate. Journal of Urology, 2017 Mar; 197:852-858.


Long CJ, Canning DA. Proximal hypospadias: we aren’t always keeping our promises. F1000Res, 2016 Sep;26:5.

Long CJ, Canning DA. Hypospadias: Are we as good as we think when we correct proximal hypospadias. Journal of Pediatric Urology, 2016 Aug; 12; 196.e1-196.e5.

Book Chapters


Long CJ, Zaontz MR, Canning DA. Hypospadias.  Campbell-Walsh Urology Review, 12th edition, 2020 (in press)

Long CJ, Zaontz MR, Canning DA. Hypospadias.  Campbell-Walsh Urology, 12th edition, 2020 (in press)


Long CJ, Zaontz MR. Two-stage repair of proximal hypospadias. Operative Manual of Pediatric and Adolescent Reconstruction, 2018 (in press)


Long CJ, Canning DA. Complications of hypospadias repair. Taneja’s Complications of Urologic Surgery, 5th edition. Elsevier, 2017.

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