Physicians at Children's Hospital of Philadelphia (CHOP) treat children with all types of pediatric liver disease – from the common to the most rare. While some liver disorders in children can cause minor disruptions in a child’s life, other disorders can be more serious – causing liver injury – and may become life-threatening without treatment.  

Pediatric liver disease can be caused by autoimmune conditions, infections, metabolic or genetic disorders, cardiovascular conditions, reactions to medications, anatomical issues, and others. Liver disorders can affect any part of the body, and in rare cases, pediatric liver disease can lead to liver failure in children. 

The Fred and Suzanne Biesecker Pediatric Liver Center – and its clinical care programs for Alagille syndrome, biliary atresia, and viral hepatitis – collaborate to provide the most comprehensive care for children’s liver disease and the best outcomes for young patients with liver disease. Our Liver Transplant Program supports children who require organ transplants to treat their disorders.  

The most common types of children’s liver disease include: 

• Acute Liver Failure
• Alagille Syndrome
• Alpha-1 Antitrypsin Deficiency
• Autoimmune Hepatitis
• Bile Acid Synthesis Defects
• Biliary Atresia
• Choledochal Cysts
• Congenital Hepatic Fibrosis
• Cystic Fibrosis Liver Disease
• Drug-Induced Liver Disease
• Gallbladder Disease
• Genetic/Metabolic Diseases of the Liver
• Hepatitis A
• Hepatitis B
• Hepatitis C
• Hepatitis E
• Liver Transplant
• Liver Tumors
• Mitochondrial Hepatopathies
• Neonatal Hepatitis
• Non-Alcoholic Fatty Liver Disease (NAFLD)
• Primary Sclerosing Cholangitis
• Progressive Familial Intrahepatic Cholestasis
• TPN-Associated Cholestasis

Providers who treat liver disorders in children:

Tamir Diamond, MD 

Alan W. Flake, MD, FACS, FAAP 

Kathleen M. Loomes, MD 

Michael L. Nance, MD, FACS, FAAP

Kim Olthoff, MD, FACS 

David A. Piccoli, MD 

Elizabeth B. Rand, MD 

Matthew J. Ryan, MD 

Abraham Shaked, MD, PhD 

Amit A. Shah, MD

Jessica W. Wen, MD