Constantine D. Mavroudis, MD, MSc, MTR

male silhouette icon
Constantine D. Mavroudis, MD, MSc, MTR, is an attending surgeon in the Division of Cardiothoracic Surgery at Children's Hospital of Philadelphia.

Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Loyola University of Chicago Stritch School of Medicine, Maywood, IL


Resident in Cardiothoracic Surgery, Hospital of the University of Pennsylvania


Postdoctoral Research Fellow, Department of Cardiothoracic Surgery, Children’s Hospital of Philadelphia

Fellow in Congenital Cardiothoracic Surgery, Children’s Hospital of Philadelphia

Titles and Academic Titles

Attending Surgeon

Assistant Professor of Surgery, Perelman School of Medicine at the University of Pennsylvania

Departments and Services




Morgan RW, Sutton RM, Himebauch AS, Roberts A, Landis WP, Lin Y, Starr J, Ranganathan A, Delso N, Mavroudis CD, Volk L, Slovis J, Marquez AM, Nadkarni VM, Hefti M, Berg RA, Kilbaugh TJ. A preclinical randomized and blinded trial of inhaled nitric oxide during pediatric cardiopulmonary resuscitation. Critical Care, 2021 (Submitted)

Mavroudis CD, Maeda K. Commentary: less is more. J Thorac Cardiovasc Surg 2021 (In review)

Padawer-Curry JA, Volk LE, Mavroudis CD, Ko TS, Morano VC, Busch DR, Rosenthal TM, Melchior RW, Shade BC, Schiavo KL, Boorady TW, Schmidt AL, Anderson KN, Breimann JS, Jahnavi J, Mensah-Brown KG, Yodh AG, Mascio CE, Gaynor JW, Kilbaugh TJ, Licht DJ, White BR, Baker WB. Differential effects of deep hypothermic circulatory arrest and cardiopulmonary bypass on cerebral autoregulation in neonatal swine. Pediatric Research 2021 (In Review)

Senthil K, Morgan RW, Hefti MM, Karlsson M, Lautz AJ, Mavroudis CD, Ko T, Nadkarni VM, Ehinger J, Berg RA, Sutton RM, McGowan FX, Kilbaugh TJ. Haemodynamic-guided cardiopulmonary resuscitation promotes mitochondrial fusion and preservation of mitochondrial mass after successful resuscitation in a pediatric porcine model. Resuscitation Plus 2021 (Submitted)


Goel NJ, Iyengar A, Kelly JJ, Mavroudis CD, Lancaster CW, Williams NN, Dempsey DT, Kucharczuk JC. Nationwide analysis of 30-day readmissions after esophagectomy: causes, costs and risk factors. Ann Thorac Surg. 2020 Jan;109(1):185-193

Busch DR, Baker WB, Mavroudis CD, Ko TS, Lynch JM, McCarthy AL, DuPont-Thibodeau G, Buckley EM, Jacobwitz M, Boorady TW, Mensah-Brown K, Connelly JT, Yodh AG, Kilbaugh TJ, Licht DJ. Noninvasive optical measurement of microvascular cerebral hemodynamics and autoregulation in the neonatal ECMO patient. Pediatr Res. 2020 Mar 14. doi: 10.1038/s41390-020-0841-6.

Mavroudis CD, Ko TS, Morgan RW, Volk LE, Landis WP, Smood BF, Xiao R, Hefti M, Boorady TW, Marquez A, Karlsson M, Licht DJ, Nadkarni VM, Berg RA, Sutton RM, Kilbaugh TJ. Epinephrine improves cardiovascular and systemic hemodynamics in a pre-clinical model of pediatric in-hospital cardiac arrest. Critical Care 2020 Sep 29;24(1):583

Slovis JC, Morgan RW, Landis WP, Riberts AL, Marquez AM, Mavroudis CD, Lin Y, Ko TS, Nadkarni VM, Berg RA, Sutton RM, Kilbaugh TJ. The physiologic response to rescue therapy with vasopressin versus epinephrine during experimental pediatric cardiac arrest. Resuscitation Plus. 2020 Nov 4.

Volk LE, Mavroudis CD, Ko T, Hallowell T, Delso N, Roberts AL, Starr J, Landis W, Lin Y, Hefti M, Morgan RW, Melchior RW, Rosenthal TM, Chappell A, Fisher D, Dreher M, Licht DJ, Chen JM, Gaynor JW, Mascio CE, Kilbaugh TJ. Increased cerebral mitochondrial dysfunction and reactive oxygen species with cardiopulmonary bypass. Eur J Cardiothorac Surg 2020 Dec 24

Mavroudis CD, Ko T, Volk LE, Smood BF, Morgan RW, Lynch JM, Licht DJ, Gaynor JW, Mascio CE, Kilbaugh TJ. Does supply meet demand? A comparison of perfusion strategies on maintaining cerebral metabolic demand while minimizing mitochondrial oxidative injury in a neonatal swine model. J Thorac Cardiovasc Surg 2020 (In Press)


Lautz AJ, Morgan RW, Karlsson M, Mavroudis CD, Ko TS, Licht DJ, Nadkarni VM, Berg RA, Sutton RM, Kilbaugh TJ. Hemodynamic-directed CPR Improves Neurologic Outcomes and Mitochondrial Function in Heart and Brain. Critical Care Medicine, 2019 Mar;47(3):e241-e249


Mavroudis CD, Mavroudis C, Jacobs JP, DeCampli W, Tweddell J. Simulation and Deliberate Practice in a Porcine Model for Congenital Heart Surgery Training. Ann Thor Surg. 2018 Feb;105(2):637-643

Mavroudis CD, Karlsson M, Ko T, Hefti M, Gentile JI, Morgan RW, Plyler R, Mensah-Brown KG, Boorady TW, Melchior RW, Rosenthal TM, Shade BC, Schiavo KL, Nicolson SC, Spray TL, Sutton RM, Berg RA, Licht DJ, Gaynor JW, Kilbaugh TJ. Cerebral mitochondrial dysfunction associated with deep hypothermic circulatory arrest. Eur J Cardiothorac Surg. 2018 Jan 15

Mavroudis CD, Mensah-Brown KG, Ko TS, Boorady TW, Massey SL, Abend NS, Nicolson SC, Morgan RW, Mascio CE, Gaynor JW, Kilbaugh TJ, Licht DJ. Electroencephalographic Response to Deep Hypothermic Circulatory Arrest in Neonatal Swine and Humans. Ann Thorac Surg. 2018 Jul 30

Ko TS, Mavroudis CD, Baker WB, Morano V, Mensah-Brown KG, Boorady T, Schmidt AL, Lynch JM, Busch DR, Gentile JI, Bratinov G, Lin Y, Jeong S, Melchior RW, Rosenthal TM, Shade BC, Schiavo KL, Xiao R, Gaynor JW, Yodh AG, Kilbaugh TJ, Licht DJ. Non-invasive optical neuromonitoring of the temperature –dependence of cerebral oxygen metabolism during deep hypothermic cardiopulmonary bypass in neonatal swine. J Cereb Blood Flow Metab. 2018 Oct 30:27



Mavroudis C, Cook JT, Mavroudis CD (eds) Bioethical Controversies in Pediatric Cardiology and Cardiac Surgery. Springer, 2020

Book Chapters


Mavroudis C, Mavroudis CD, Cook T, Golden A, Siegel A. Bioethics in Congenital Heart Surgery. Pediatric Cardiac Surgery, 5th Edition. Mavroudis C, Backer CL Eds. 2020. Submitted.

Mavroudis CD, Mavroudis C, Backer CL, Feins R. Education in Congenital Heart Surgery. Pediatric Cardiac Surgery, 5th Edition. Mavroudis C, Backer CL Eds. 2020. Submitted.

Mavroudis CD, Anderson RA, Backer CL, Mavroudis C. Divided left atrium, pulmonary vein stenosis, atresia of the common pulmonary vein and divided right atrium. Pediatric Cardiac Surgery, 5th Edition. Mavroudis C, Backer CL Eds. 2020. Submitted.

Awards and Honors

2020, Congenital Heart Disease Coalition Research Grant

2017, Research Grant, Swine Surgical Training Model

2017, Young Investigator Award, American Heart Association

2017, C. Walton Lillehei MD, PhD Young Investigator Award

2015, Outstanding Investigator Award: Cardiology 2015

2015, Children’s Hospital of Philadelphia Cardiac Center Research Grant 

2014, Institution for Translational Medicine and Therapeutics (ITMAT) Scholarship, University of Pennsylvania

Editorial and Academic Positions

2020-Present, Nature Scientific Reports, Guest reviewer

2020-present, Pediatric Research, Guest reviewer

2019-present, Cardiology in the Young, Editorial board member

2014-present, The Journal of Cardiovascular Surgery, Guest reviewer

2014-present, World Journal for Pediatric and Congenital Heart Surgery, Guest reviewer

Leadership and Memberships

2012-Present, Society of Thoracic Surgeons, Candidate Group

2012-Present, American Heart Association, Trainee Member

2013-Present, American College of Cardiology, Trainee Member