Constantine D. Mavroudis, MD, MSc, MTR

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Constantine D. Mavroudis, MD, MSc, MTR, is an attending surgeon in the Division of Cardiothoracic Surgery at Children's Hospital of Philadelphia.

Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Loyola University of Chicago Stritch School of Medicine, Maywood, IL


Cardiothoracic Surgery - Hospital of the University of Pennsylvania, Philadelphia, PA


Postdoctoral Research Fellow, Department of Cardiothoracic Surgery - Children’s Hospital of Philadelphia, Philadelphia, PA
Congenital Cardiothoracic Surgery - Children’s Hospital of Philadelphia, Philadelphia, PA

Titles and Academic Titles

Attending Surgeon

Assistant Professor of Surgery, Perelman School of Medicine at the University of Pennsylvania

Departments and Services




Slovis J, Volk LE, Mavroudis CD, Hefti M, Landis W, Roberts A, Delso N, Hallowell T, Graham K, Starr J, Lin Y, Melchior RW, Nadkarni VM, Sutton RA, Berg RA, Piel S, Morgan RW, Kilbaugh TJ. Pediatric extracorporeal cardiopulmonary resuscitation: development of a porcine model and the influence of CPR duration on brain injury. JAHA 2023. In Press.

Edelson JB, Wooster L, Huang J, Wang Z, Connelly J, Kilbaugh TJ, Rossano J, O’Connor M, Mavroudis CD, DeWitt A, Edwards J, Wittlieb-Weber C, Lin K, Lane-Fall M, Maeda K. Patients on veno-arterial extracorporeal membrane oxygenation undergoing cardiac rehabilitation have improved outcomes. J Heart Lung Transplant. 2023. In Review.

Aronowitz DI, Geoffrion TR, Piel S, Benson EJ, Morton SR, Starr J, Melchior RW, Gaudio HA, Degani RE, Widmann NJ, Weeks MK, Ko TS, Licht DJ, Hefti M, Gaynor JW, Kilbaugh TJ, Mavroudis CD. Early impairment of cerebral bioenergetics after cardiopulmonary bypass in neonatal swine. Ann Thorac Surg. 2023. In Review.

Widmann NJ, Weeks MK, Ranganathan A, Benson EJ, Ko TS, Licht DJ, Hefti M, Gaynor JW, Kilbaugh TJ, Mavroudis CD. Normoxemic cardiopulmonary bypass does not reduce cerebral mitochondrial dysfunction in neonatal swine. Ann Thorac Surg 2023, In Press

Aronowitz DI, Harris MA, Bhatti TR, Maeda K, Mavroudis CD. Epicardial involvement of constrictive pericarditis can be detected by magnetic resonance imaging Ann Thorac Surg Short Reports. 2023, In Press.


Ko T, Mavroudis CD, Benson EJ, Forti EM, Melchior RW, Boorady TW, Morano VC, Mensah-Brown K, Lin Y, Aronowitz D, Starr JP, Rosenthal TM, Shade BC, Schiavo KL, White BR, Lynch JM, Gaynor JW, Licht DJ, Yodh AG, Baker WB, Kilbaugh TJ. Correlation of cerebral microdialysis with non-invasive diffuse optical cerebral hemodynamic monitoring during deep hypothermic cardiopulmonary bypass. Metabolites. 2022. Aug 10;12(8):737.

Mavroudis CD, Edelson JB, Wittlieb-Weber CA, O’Connor MJ, Maeda K. The innominate artery-to-pulmonary artery shunt as ventricular assist device outflow in hybrid stage one procedure with aortic coarctation. JTCVS Tech 2022 Aug;14:204-206

Aronowitz D, Geoffrion TR, Burstein D, White RM, McHugh-Grant S, Mavroudis CD, Nuri MAK, Maeda K, Chen JM, Mascio CE, Gaynor JW, Fuller S. Reintervention for superior vena cava obstruction after heart transplant. Ann Thorac Surg. 2022 Aug 5:S0003-4975(22)01006-2

Senthil K, Hefti MM, Singh LN, Morgan RW, Mavroudis CD, Ko T, Gaudio H, Nadkarni VM, Ehinger J, Berg RA, Sutton RM, McGowan FX, Kilbaugh TJ. Transcriptome and metabolome after porcine hemodynamic-directed CPR compared with standard CPR and sham controls. Resuscitation Plus 2022 May 11;10:100243

Lewis AT, Forti RM, Alomaja O, Mesaros C, Piel S, Greenwood JC, Talebi FM, Mavroudis CD, Kelly M, Kao SH, Shofer FS, Ehinger JK, Kilbaugh TJ, Baker WB, Jang DH. Preliminary research: application of non-invasive measure of cytochrome c oxidase redox states and mitochondrial function in a porcine model of carbon monoxide poisoning. J Med Toxicol. 2022 Apr 28

Mejia E, O’Connor M, Samuelson-Jones BJ, Mavroudis CD, Giglia TM, Keashen R, Rossano JW, Naim M, Maeda K. Successful treatment of intracardiac thrombus in the presence of fulminant myocarditis with COVID-19. J Heart Lung Transplant. 2022 Mar 10:S1053-2498(22)01849-6

Mavroudis CD, Smood B, Grasty MA, Fuller S, Desai ND. A novel technique for safe redo sternotomy in patients with aortic proximity to the sternum. World J Pediatr Cong Heart Surg. 2022 Jan;13(1):89-91


Ko TS, Mavroudis CD, Morgan RW, Baker WB, Marquez AM, Boorady TW, Devarajan M, Lin Y, Roberts AL, Landis WP, Mensah-Brown K, Nadkarni VM, Berg RA, Sutton RM, Yodh AG, Licht DJ, Guo W, Kilbaugh TJ. Non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation. Sci Rep. 2021 Feb 15;11(1):3828.

Mavroudis CD, Maeda K. Commentary: Less is more. J Thorac Cardiovasc Surg. 2021 Jan 19:S0022-5223(21)00116-1.

Morgan RW, Sutton RM, Himebauch AS, Roberts A, Landis WP, Lin Y, Starr J, Ranganathan A, Delso N, Mavroudis CD, Volk L, Slovis J, Marquez AM, Nadkarni VM, Hefti M, Berg RA, Kilbaugh TJ. A randomized and blinded trial of inhaled nitric oxide in a piglet model of pediatric cardiopulmonary resuscitation. Resuscitation, 2021 Mar 22:S0300-9572(21)00108-8

Padawer-Curry JA, Volk LE, Mavroudis CD, Ko TS, Morano VC, Busch DR, Rosenthal TM, Melchior RW, Shade BC, Schiavo KL, Boorady TW, Schmidt AL, Anderson KN, Breimann JS, Jahnavi J, Mensah-Brown KG, Yodh AG, Mascio CE, Gaynor JW, Kilbaugh TJ, Licht DJ, White BR, Baker WB. Effects of circulatory arrest and cardiopulmonary bypass on cerebral autoregulation in neonatal swine. Pediatric Research 2021 May 4.

Senthil K, Morgan RW, Hefti MM, Karlsson M, Lautz AJ, Mavroudis CD, Ko T, Nadkarni VM, Ehinger J, Berg RA, Sutton RM, McGowan FX, Kilbaugh TJ. Haemodynamic-guided cardiopulmonary resuscitation promotes mitochondrial fusion and preservation of mitochondrial mass after successful resuscitation in a pediatric porcine model. Resusc Plus 2021 Apr 29;6:100124

Lynch JM, Mavroudis CD, Ko TS, Jacobwitz M, Busch DR, Xiao R, Nicolson SC, Montenegro LM, Gaynor JW, Yodh AG, Licht DJ. Association of ongoing cerebral oxygen extraction during deep hypothermic circulatory arrest with post-operative brain injury. Semin Thorac Cardiovasc Surg. 2021 Sep 8:S1043-0679(21)00405-6


Goel NJ, Iyengar A, Kelly JJ, Mavroudis CD, Lancaster CW, Williams NN, Dempsey DT, Kucharczuk JC. Nationwide analysis of 30-day readmissions after esophagectomy: causes, costs and risk factors. Ann Thorac Surg. 2020 Jan;109(1):185-193

Busch DR, Baker WB, Mavroudis CD, Ko TS, Lynch JM, McCarthy AL, DuPont-Thibodeau G, Buckley EM, Jacobwitz M, Boorady TW, Mensah-Brown K, Connelly JT, Yodh AG, Kilbaugh TJ, Licht DJ. Noninvasive optical measurement of microvascular cerebral hemodynamics and autoregulation in the neonatal ECMO patient. Pediatr Res. 2020 Mar 14. doi: 10.1038/s41390-020-0841-6.

Mavroudis CD, Ko TS, Morgan RW, Volk LE, Landis WP, Smood BF, Xiao R, Hefti M, Boorady TW, Marquez A, Karlsson M, Licht DJ, Nadkarni VM, Berg RA, Sutton RM, Kilbaugh TJ. Epinephrine improves cardiovascular and systemic hemodynamics in a pre-clinical model of pediatric in-hospital cardiac arrest. Critical Care 2020 Sep 29;24(1):583

Slovis JC, Morgan RW, Landis WP, Riberts AL, Marquez AM, Mavroudis CD, Lin Y, Ko TS, Nadkarni VM, Berg RA, Sutton RM, Kilbaugh TJ. The physiologic response to rescue therapy with vasopressin versus epinephrine during experimental pediatric cardiac arrest. Resuscitation Plus. 2020 Nov 4.

Volk LE, Mavroudis CD, Ko T, Hallowell T, Delso N, Roberts AL, Starr J, Landis W, Lin Y, Hefti M, Morgan RW, Melchior RW, Rosenthal TM, Chappell A, Fisher D, Dreher M, Licht DJ, Chen JM, Gaynor JW, Mascio CE, Kilbaugh TJ. Increased cerebral mitochondrial dysfunction and reactive oxygen species with cardiopulmonary bypass. Eur J Cardiothorac Surg 2020 Dec 24

Mavroudis CD, Ko T, Volk LE, Smood BF, Morgan RW, Lynch JM, Licht DJ, Gaynor JW, Mascio CE, Kilbaugh TJ. Does supply meet demand? A comparison of perfusion strategies on maintaining cerebral metabolic demand while minimizing mitochondrial oxidative injury in a neonatal swine model. J Thorac Cardiovasc Surg 2020 (In Press)


Lautz AJ, Morgan RW, Karlsson M, Mavroudis CD, Ko TS, Licht DJ, Nadkarni VM, Berg RA, Sutton RM, Kilbaugh TJ. Hemodynamic-directed CPR Improves Neurologic Outcomes and Mitochondrial Function in Heart and Brain. Critical Care Medicine, 2019 Mar;47(3):e241-e249


Mavroudis CD, Mavroudis C, Jacobs JP, DeCampli W, Tweddell J. Simulation and Deliberate Practice in a Porcine Model for Congenital Heart Surgery Training. Ann Thor Surg. 2018 Feb;105(2):637-643

Mavroudis CD, Karlsson M, Ko T, Hefti M, Gentile JI, Morgan RW, Plyler R, Mensah-Brown KG, Boorady TW, Melchior RW, Rosenthal TM, Shade BC, Schiavo KL, Nicolson SC, Spray TL, Sutton RM, Berg RA, Licht DJ, Gaynor JW, Kilbaugh TJ. Cerebral mitochondrial dysfunction associated with deep hypothermic circulatory arrest. Eur J Cardiothorac Surg. 2018 Jan 15

Mavroudis CD, Mensah-Brown KG, Ko TS, Boorady TW, Massey SL, Abend NS, Nicolson SC, Morgan RW, Mascio CE, Gaynor JW, Kilbaugh TJ, Licht DJ. Electroencephalographic Response to Deep Hypothermic Circulatory Arrest in Neonatal Swine and Humans. Ann Thorac Surg. 2018 Jul 30

Ko TS, Mavroudis CD, Baker WB, Morano V, Mensah-Brown KG, Boorady T, Schmidt AL, Lynch JM, Busch DR, Gentile JI, Bratinov G, Lin Y, Jeong S, Melchior RW, Rosenthal TM, Shade BC, Schiavo KL, Xiao R, Gaynor JW, Yodh AG, Kilbaugh TJ, Licht DJ. Non-invasive optical neuromonitoring of the temperature –dependence of cerebral oxygen metabolism during deep hypothermic cardiopulmonary bypass in neonatal swine. J Cereb Blood Flow Metab. 2018 Oct 30:27



Mavroudis C, Cook JT, Mavroudis CD (eds) Bioethical Controversies in Pediatric Cardiology and Cardiac Surgery. Springer, 2020.

Book Chapters


Mavroudis C, Mavroudis CD, Cook T, Golden A, Siegel A. Bioethics in Congenital Heart Surgery. Pediatric Cardiac Surgery, 5th Edition. Mavroudis C, Backer CL Eds. 2020. Submitted.

Mavroudis CD, Mavroudis C, Backer CL, Feins R. Education in Congenital Heart Surgery. Pediatric Cardiac Surgery, 5th Edition. Mavroudis C, Backer CL Eds. 2020. Submitted.

Mavroudis CD, Anderson RA, Backer CL, Mavroudis C. Divided left atrium, pulmonary vein stenosis, atresia of the common pulmonary vein and divided right atrium. Pediatric Cardiac Surgery, 5th Edition. Mavroudis C, Backer CL Eds. 2020. Submitted.

Awards and Honors

2023, Thoracic Surgical Foundation Research Grant
2022, Children’s Hospital of Philadelphia Cardiac Center Innovation Grant    
2022, Children’s Hospital of Philadelphia Academic Enrichment Grant
2021, McCabe Fund Award Research Grant
2020, Congenital Heart Disease Coalition Research Grant
2017, Research Grant, Swine Surgical Training Model
2017, Young Investigator Award, American Heart Association
2017, C. Walton Lillehei MD, PhD Young Investigator Award
2015, Outstanding Investigator Award: Cardiology 2015
2015, Children’s Hospital of Philadelphia Cardiac Center Research Grant
2014, Institution for Translational Medicine and Therapeutics (ITMAT) Scholarship, University of Pennsylvania

Editorial and Academic Positions

Editorial Positions

2022-Present, Journal of Surgical Research, Guest Reviewer
2021-Present, Annals of Thoracic Surgery, Guest Reviewer                
2021-Present, Journal of Cardiovascular and Thoracic Surgery, Guest Reviewer
2020-Present, Nature Scientific Reports, Guest reviewer
2020-Present, Pediatric Research, Guest reviewer
2019-Present, Cardiology in the Young, Editorial board member
2014-Present, The Journal of Cardiovascular Surgery, Guest reviewer
2014-Present, World Journal for Pediatric and Congenital Heart Surgery, Guest reviewer

Leadership and Memberships

Memberships in Professional Organizations

2023-present, Associate Program Director, Congenital Cardiac Surgery Fellowship
2022-present, Children’s Hospital of Philadelphia Wellness Workgroup            
2022-present, International Society for Nomenclature of Paediatric and Congenital Heart Disease, Member
2022-present, World Society for Pediatric and Congenital Heart Surgery, Member and Teaching Faculty
2013-present, American College of Cardiology, Associate Fellow
2012-present, American Heart Association, Early Career Member     
2010-present, Society of Thoracic Surgeons, Member