Katherine J. Deans, MD, MHSc Areas of Expertise: Thoracic Surgery, Neonatal Surgery, Clinical outcomes research Locations: Main Campus Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467) Education and Training Medical SchoolMD, Dartmouth Medical School, Hanover, NHInternshipGeneral Surgery, Massachusetts General Hospital, Boston, MAResidencyGeneral Surgery, Massachusetts General Hospital, Boston, MAFellowshipCritical Care Fellow, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MDSenior Research Fellow, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MDResearch Fellow, Department of Surgery, MaBoard CertificationAmerican Board of SurgeryAmerican Board of Surgery/Pediatric SurgeryAmerican Board of Surgery/Surgical Critical CareUndergraduate DegreeBA, Political Science, Wellesley College, Wellesley, MAGraduate DegreeMHSc, Clinical Research, Duke University, Durham, NC Titles and Academic Titles Attending surgeonAssistant Professor of Surgery, Perelman School of Medicine at the University of Pennsylvania Research Interests Ongoing Research ProtocolsCo-Investigator; Children’s Hospital of Philadelphia Human Research Protocol IRB #2007-10-5512: Characterization of the levels and effects of intravascular hemolysis in patients undergoing cardiopulmonary bypass.Co-Investigator; Children’s Hospital of Philadelphia Human Research Protocol IRB #2007-8-5451: Characterization of the levels and effects of intravascular hemolysis in patients undergoing extracorporeal membrane oxygenation.Co-Investigator; University of Pennsylvania Human Research Protocol IRB #806867: Characterization of the levels and effects of intravascular hemolysis in patients undergoing cardiopulmonary bypass.Co-Investigator; National Institutes of Health Animal Protocol ASP#CCM04-XX: The effect of glucocorticoids in a sedated and ventilated model of canine sepsis. Publications Papers2010Deans KJ, Minneci PC, Klein HG, Natanson C. The relevance of practice misalignments to trials in transfusion medicine. Vox Sang. 2010 Jul 1;99(1):16-23. Epub 2010 Mar 21. Read abstractDeans KJ, Minneci PC. ACP Journal Club. Intensive insulin therapy did not reduce mortality more than conventional therapy in septic shock treated with corticosteroids. Ann Intern Med. 2010. See the abstract at Pub MedDeans KJ, Minneci PC, Klein HG, Natanson C. The relevance of practice misalignments to trials in transfusion medicine. Vox Sang. 2010.Deans KJ, Minneci PC, Danner RL, Eichacker PQ, Natanson C. Practice Misalignments in Randomized Controlled Trials: Identification, Impact and Potential Solutions. Anesth Anal. 2010. See the abstract at Pub Med2009Minneci PC, Deans KJ, Natanson C. Corticosteroid therapy for severe sepsis and septic shock. JAMA. 2009;302(15):643. See the abstract at Pub MedDeans KJ, Minneci PC, Chen H, Kern SJ, Logun C, Alsaaty S, Norsworthy KJ, Theel SM, Sennesh JD, Barb JJ, Munson PJ, Danner RL, Solomon MA. Impact of Animal Strain on Gene Expression in a Rat Model of Acute Cardiac Rejection. BMC Genomics 2009;10:280. See the article at Pub MedMinneci PC, Deans KJ, Eichacker PQ, Natanson C. The Effects of Steroids during Sepsis Depend on Dose and Severity of Illness: An Updated Meta-analysis. Clin Microbiol Infect.. 2009; 15(4):308-18.Solomon SB, Minneci PC, Deans KJ, et al. Effects of Intra-aortic Balloon Counterpulsation in a Model of Septic Shock. Crit Care Med 2009;37:7-18. See the article at Pub Med2008Deans KJ, Minneci PC, Shiva S, Zhi H, Banks SM, Kearns S, Natanson C, Solomon SB, Gladwin MT. Nitrite Reductase Activity of Hemoglobin: A systemic nitric oxide delivery mechanism to detoxify cell free plasma hemoglobin? Am J Physiol Heart Circ Physiol.2008;295:H743-754. See the abstract at Pub MedMinneci PC, Eichacker PQ, Danner RL, Banks SM, Natanson C, Deans KJ. The Importance of Usual Care Control Groups for Safety Monitoring and Validity during Critical Care Research. Intensive Care Med. 2008;34:942-947. See the abstract at Pub Med2007Deans KJ, Minneci PC, Suffredini AF, et al. Randomization in Clinical Trials of Titrated Therapies: Unintended Consequences of Using Fixed Treatment Protocols. Crit Care Med. 2007; 2007;35(6):1509-1516. See the abstract at Pub MedMinneci PC, Deans KJ, Banks SM, et al. A Canine Model of Septic Shock: Balancing Animal Welfare and Scientific Relevance. Am J Physiol Heart Circ Physiol. 2007;293(4):H2487-500. See the abstract at Pub Med2006Minneci PC, Deans KJ, Xizhong C, Banks SM, Natanson C, Eichacker PQ. Antithrombotic Therapies for Sepsis: A Need for More Studies. Crit Care Med. 2006;34(2)538-541. See the abstract at Pub MedDeans KJ, Minneci PC, Banks SM, Xizhong C, Natanson C, Eichacker PQ. Mechanical Ventilation in ARDS. Crit Care Med. 2006;34(1):263-267.AbstractsSantore M, Behar BJ, Flake AW, Deans KJ. Laparoscopic hepaticoduodenostomy for choledochal cyst excision and reconstruction. Accepted for oral presentation at American Pediatric Surgical Association National Meeting, Orlando, FL. May, 2010.Kilbaugh TJ, Topjian AA, Chandler HK, Hedrick HL, McCloskey JM, Deans KJ. Influenza A (H1N1) and MRSA acute respiratory distress syndrome and cardiogenic shock supported with Extracorporeal Membrane Oxygenation and Plasmapheresis. CNMC Symposium: ECMO & the Advanced Therapies for Respiratory Failure. 2010. A40.Behar B, Minneci PC, Kilbaugh TJ, Hedrick HL, Deans KJ. Variables associated with increased mortality on pediatric patients requiring Extracorporeal Life Support for a primary diagnosis of pneumonia. CNMC Symposium: ECMO & the Advanced Therapies for Respiratory Failure. 2010. A55.Minneci PC, Deans KJ, Yu EA, et al. Correlation of protein and gene expression in a rat heart transplant model of acute cellular rejection. Am J Transplant. 2005(4 Suppl):A Deans KJ, Minneci PC, Hergen AE, et al. Serum protein expression of acute cellular rejection in a rat heart transplant model. Am J Transplant. 2005(4 Suppl):A Deans KJ, Minneci PC, Banks SM, et al. The Development of a Ventilated Canine Model of Septic Shock. Crit Care Med. 2004;32(Suppl):A135 Minneci PC, Deans KJ, Zhi H, et al. Hemolysis-Endothelial Dysfunction Syndrome: A Novel Paradigm of Disease Mechanism. Blood. 2004;104:861A. Deans KJ, Minneci PC, Hergen AE, et al. Time-dependent changes in gene expression in a rat cardiac transplant model. Am J Transplant. 2004;4 (Suppl 8):308(A546). Deans KJ, Minneci PC, Hergen AE, et al. Gene expression profiles in a rat heart transplant model of acute cellular rejection. Am J Transplant. 2004;8 (Suppl 4):308(A545). Deans KJ, Minneci PC, Banks SM, et al. Coronary Artery Bypass Grafting without Cardiopulmonary Bypass Increases Survival Rate and Decreases Morbidity: A Meta-analysis. J Am Coll Cardiol. 2004;43:268A. Minneci PC, Deans KJ, Banks SM, et al. Effects of Epinephrine, Norepinephrine, and Vasopressin on Survival Rates in a Canine Model of Septic Shock. Crit Care Med. 2003;31:A47.Minneci PC, Deans KJ, Banks SM, Eichacker PQ, Natanson C. Dose Dependent Effects of Steroids on Survival Rates and Shock during Sepsis: A Meta-analysis. Crit Care Med. 2003;31:A20. BooksMinneci PC, Deans KJ, Natanson C. Applying the Results of Randomized Controlled Trials: Caveat Emptor. In: Chiche JD, Moreno R, Putensen C, Rhodes A, eds. Patient Safety and Quality of Care in Intensive Care Medicine. Berlin: MWV Medizinisch Wissenschaftliche. 2010.Deans, KJ. Gastrointestinal Bleeding. In: Mattei P, ed. Fundamentals of Pediatric Surgery. New York: Springer. 2010.Deans KJ, Minneci PC, Cui X, Banks SM, Natanson C, Eichacker PQ. The Need to Account for Existing Practice Patterns in Trials of Mechanical Ventilation. In: Tobin MJ, eds. Principles and Practice of Mechanical Ventilation,. 2nd edition. New York: McGraw Hill. 2006:1347-1354.Minneci PC, Deans KJ, Banks SM, Natanson C, Eichacker PQ. A Critical Review of Randomized Controlled Trials of Tidal Volume Reduction During ARDS. In: Dreyfuss D, Hubmayr RD, Saumon G, eds. Ventilator Induced Lung Injury. New York: Marcel Dekker, Inc.; 2006:519-536.Minneci PC, Deans KJ, Haley M, Xizhong C, Natanson C, Eichacker PQ. Factors Influencing the Efficacy of Mediator-Specific Anti-inflammatory, Glucocorticoid and Anti-Coagulant Therapies for Sepsis. In: Gad SC, ed. Drug Discovery Handbook. Vol 1. Hoboken: Wiley Interscience; 2005:937-960.Deans K, Minneci P, Eichacker PQ, Natanson C. Anti-Inflammatory Agents: A Double Edged Sword in Our Arsenal Against Septic Shock. In: Net A, ed. Shock and Multiorgan Failure. 2003 ed. 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