Pediatric Cardiology Fellowship Training Program
Program at a glance
- Six (6) first-year clinical fellowship positions (one (1) additional slot may be open for ROTC/military-sponsored applicants on a case-by-case basis, please contact program director)
- Advanced training possible in noninvasive, cath, electrophysiology, adult congenital heart disease, heart failure-transplant, pulmonary hypertension, path and research
- 66 patient beds (36 in CICU, 30 in CCU)
- 24,000 outpatient visits, 2,400 admissions, 1,000 surgeries, 1,200 catheterizations, 28,000 echocardiograms, 2,700 fetal echocardiograms per year
- Case volume (observation and participation, per fellow) = ~300 echocardiograms (TTE, TEE and fetal), 150 catheterization procedures and 10 electrophysiology procedures
- State-of-the-art operating room facilities and groundbreaking fetal diagnosis and treatment center, including the Garbose Family Special Delivery Unit
- 50+ core program faculty in every major cardiac subspecialty (~3:1 faculty to fellow ratio)
- Strong faculty mentoring program with emphasis on research and building academic clinicians
- Comprehensive didactic conference schedule and professional development opportunities
- Nightfloat coverage system and limited weekend calls (reduced by clinical year) to promote work/life balance, ACGME-mandated duty hours compliance and adequate time for research
Meryl S. Cohen, MD
Professor of Pediatrics
Director of Echocardiography
Associate program director
Chitra Ravishankar, MD
Associate Professor of Pediatrics
Core faculty representative and subspecialty liaison (Cardiology), General Pediatrics Residency Program
Clinical Competency Committee (CCC)
Meryl S. Cohen, MD — Echocardiography, Outpatient
Faculty members and areas of supervision/expertise
Jodi Chen, MD — Cardiac Critical Care
Andrew Glatz, MD — Interventional Cardiology
David Goldberg, MD — Echocardiography, Single Ventricle Program, Outpatient
Matthew O'Connor — Heart Failure/Transplant
Chitra Ravishankar, MD — Cardiac Care Unit
Susan Schachtner, MD — Cardiac Care Unit, Outpatient
Paul Weinberg, MD — Cardiac Pathology, Outpatient
Program Evaluation Committee (PEC)
Chitra Ravishankar, MD, associate program director
Current cardiac researchers
Dr. Alferiev's expertise is the synthesis of monomeric and polymeric compounds for biomedical investigations. One of the directions of his investigations is formulation and chemical modification of drugs and pro-drugs with the aim to improve their pharmaceutical efficacy. Another direction is development of chemical methods for modification of biomaterials to enhance their biocompatibility.
- Slee JB, Alferiev IS, Nagaswami C, Weisel JW, Levy RJ, Fishbein I, Stachelek SJ. Enhanced biocompatibility of CD47-functionalized vascular stents. Biomaterials. 2016 May; 87:82-92.
- I.S. Alferiev, R. Iyer, J.L. Croucher, R.F. Adamo, K. Zhang, J.L. Mangino, V. Kolla, I. Fishbein, G.M. Brodeur, R.J. Levy, M. Chorny: Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy. Biomaterials 51: 22-9, May 2015.
- Fishbein, S.P. Forbes, R.F. Adamo, M. Chorny, R.J. Levy, I.S. Alferiev: Vascular gene transfer from metallic stent surfaces using adenoviral vectors tethered through hydrolysable cross-linkers. J Vis Exp 90: e51653, Aug 2014.
- J.E. Tengood, I.S. Alferiev, K. Zhang, I. Fishbein, R.J. Levy, M. Chorny: Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media. Proc Natl Acad Sci U S A. 111(11): 4245–50, Mar 2014.
- Fishbein I, Forbes SP, Chorny M, Connolly JM, Adamo RF, Corrales RA, Alferiev IS, Levy RJ: Adenoviral vector tethering to metal surfaces via hydrolyzable cross-linkers for the modulation of vector release and transduction. Biomaterials 34(28): 6938-48, Sep 2013
Dr. Avitabile’s research endeavors focus on improving functional capacity in patients with Fontan physiology and pulmonary hypertension. She is particularly interested in the contribution of the peripheral musculature to exercise capacity in these groups and the design of exercise interventions. Finally, she is interested in the use of mobile technologies to assess physical activity and to provide positive feedback to patients. Dr. Avitabile is currently launching a dual-centered exercise training program for adolescent Fontan patients. She is also the site PI for a national pulmonary hypertension registry and a multicenter study using actigraphs and fitbits to measure physical activity and identify new study endpoints for clinical trials in PH patients.
- Avitabile CM, Goldberg DJ, Dodds K, Dori Y, Rychik J. A multifaceted approach to the management of plastic bronchitis after cavopulmonary palliation. Ann Thorac Surg. 2014;98:634-40.
- Avitabile CM, Leonard MB, Zemel BS, Brodsky JL, Lee D, Dodds K, Hayden-Rush C, Whitehead KK, Goldmuntz E, Paridon SM, Rychik J, Goldberg DJ. Lean mass deficits, vitamin D status, and exercise capacity in children and young adults after Fontan palliation. Heart. 2014;100:1702-7.
- Avitabile CM, Leonard MB, Brodsky JL, Whitehead KK, Ravishankar C, Cohen JW, Rychik J, Goldberg DJ. Usefulness of insulin-like growth factor-1 as a marker of heart failure in children and young adults after the Fontan palliation procedure. Am J Cardiol. 2015;115:816-20.
- Avitabile CM, Goldberg DJ, Zemel BS, Brodsky JL, Dodds K, Hayden-Rush C, Whitehead KK, Goldmuntz E, Rychik J, Leonard MB. Deficits in bone density and structure in children and young adults following Fontan palliation. Bone. 2015;77:12-16.
- Avitabile CM, Goldberg DJ, Leonard MB, Wei Z, Tang E, Paridon SM, Yoganathan AP, Fogel MA, Whitehead KK. Leg lean mass correlates with exercise systemic output in young Fontan patients. Heart. 2017 Oct 7. pii: heartjnl-2017-311661. doi: 10.1136/heartjnl-2017-311661. [Epub ahead of print]
Dr. Banerjee is an echocardiographer. His research interest is in cardiac mechanics. Left and right ventricular mechanics are studied using strain and strain-displacement relationship. His new interest is in the field of torsion. He has studied torsion in various cardiomyopathies like HCM, DCM and LVNC and in heart transplant recipients. For studying diastolic function he utilizes untwist rate measured by speckle tracking imaging. Left atrial mechanics and LA stiffness are two of his latest areas of research.
- Nawaytou HM, Yubbu P, Montero AE, Nandi D, O'Connor MJ, Shaddy RE, Banerjee A. Left Ventricular Rotational Mechanics in Children After Heart Transplantation. Circ Cardiovasc Imaging. 2016 Sep;9(9). pii: e004848. doi: 10.1161/CIRCIMAGING.116.004848. PMID: 27609818
- Montero A, Yubbu P, Miller KD, Lin KY, Rossano J, Banerjee A: Left Ventricular Rotational Indices in Children with Hypertrophic Cardiomyopathy: Unique Characteristics and Differences from Adults. Journal of the American Society of Echocardiography, Abstracts of Annual Scientific Session, Seattle,2016 2016.
- Banerjee MM, Ramesh Iyer V, Nandi D, Vetter VL, Banerjee A.: Reliability of Left Ventricular Hypertrophy by ECG Criteria in Children with Syncope: Do the Criteria Need to be Revised? Pediatr Cardiol. 2015 Dec 31. [Epub ahead of print]; PMID: 26717911 December 2015.
- Nawaytou H, O'Connor M, Banerjee A. : Left Ventricular Rotational Mechanics in Children after Heart Transplantation. Annual Scientific Session of American Society of Echocardiography, June, 2015, Boston, MA. June 2015.
- WangY, Hope K, Nawaytou H, Hanna BB, Banerjee A: Right Atrial Mechanics Provide Useful Insights in Idiopathic Pulmonary Hypertension in Children. Journal of the American Society of Echocardiography, Abstracts of Annual Scientific Session of American Society of Echocardiography, June, 2015, Boston, MA. June 2015.
Bird, Geoffrey L.
Geoffrey L. Bird’s academic interests are focused in the realms of quality improvement, patient safety, leadership, teamwork, and decision-making in pediatric cardiac ICU medicine. In addition to serving as the Departmental Patient Safety Officer for the Cardiac Center, he is CHOP CICU Physician Lead for the center’s membership in the Pediatric Cardiac Critical Care Consortium. He has mentored prior fellows in successful projects, matriculation in the University of Pennsylvania Masters of Science in Health Policy Program and Center for Healthcare Improvement and Patient Safety, and ongoing careers as national leaders in Quality Improvement.
- Sanders RC Jr, Nett ST, Davis KF, Parker MM, Bysani GK, Adu-Darko M, Bird GL, Cheifetz IM, Derbyshire AT, Emeriaud G, Giuliano JS Jr, Graciano AL, Hagiwara Y, Hefley G, Ikeyama T, Jarvis JD, Kamat P, Krishna AS, Lee A, Lee JH, Li S, Meyer K, Montgomery VL, Nagai Y, Pinto M, Rehder KJ, Saito O, Shenoi AN, Taekema HC, Tarquinio KM, Thompson AE, Turner DA, Nadkarni VM, Nishisaki A; National Emergency Airway Registry for Children NEAR4KIDS Investigators; Pediatric Acute Lung Injury and Sepsis Investigators Network. Family Presence During Pediatric Tracheal Intubations. JAMA Pediatr. 2016 Mar; 170(3):e154627. doi:10.1001/jamapediatrics.2015.4627. Epub 2016 Mar 7. PubMed PMID: 26954533.
- Gaies M, Tabbutt S, Schwartz SM, Bird GL, Alten JA, Shekerdemian LS, Klugman D, Thiagarajan RR, Gaynor JW, Jacobs JP, Nicolson SC, Donohue JE, Yu S, Pasquali SK, Cooper DS. Clinical Epidemiology of Extubation Failure in the Pediatric Cardiac ICU: A Report From the Pediatric Cardiac Critical Care Consortium. Pediatr Crit Care Med. 2015 Nov; 16(9):837-45 doi: 10.1097/PCC.0000000000000498. PubMed PMID: 26218260; PubMed Central PMCID: PMC4672991.
- Bates KE, Bird GL, Shea JA, Apkon M, Shaddy RE, Metlay JP. A tool to measure shared clinical understanding following handoffs to help evaluate handoff quality. J Hosp Med. 2014 Mar; 9 (3):142-7 doi: 10.1002/jhm.2147. Epub 2014 Jan 31. PubMed PMID: 24482325; PubMed Central PMCID: PMC4049065.
Dr. Blinder is interested in all aspects of cardiac critical care, with particular interest in cardio-renal syndromes in patients with critical congenital heart disease. He is also interested in blood product utilization in patients with cyanotic congenital heart disease.
- Alten JA, Rahman AF, Zaccagni HJ, Shin A, Cooper DS, Blinder JJ, Retzloff L, Aban IB, Graham EM, Zampi J, Domnina Y, Gaies MG. The Epidemiology of Health-Care Associated Infections in Pediatric Cardiac Intensive Care Units. Pediatr Infect Dis J. 2017 Dec 26. doi: 10.1097/INF.0000000000001884. [Epub ahead of print] PubMed PMID: 29280785.
- Kakajiwala A, Kim JY, Hughes JZ, Costarino A, Ferguson J, Gaynor JW, Furth SL, Blinder JJ. Lack of Furosemide Responsiveness Predicts Acute Kidney Injury in Infants After Cardiac Surgery. Ann Thorac Surg. 2017 Oct;104(4):1388-1394. doi: 10.1016/j.athoracsur.2017.03.015. Epub 2017 May 9. PubMed PMID: 28499652.
- Blinder JJ, Asaro LA, Wypij D, Selewski DT, Agus MSD, Gaies M, Ferguson MA. Acute Kidney Injury After Pediatric Cardiac Surgery: A Secondary Analysis of the Safe Pediatric Euglycemia After Cardiac Surgery Trial. Pediatr Crit Care Med. 2017 Jul;18(7):638-646. doi: 10.1097/PCC.0000000000001185. PubMed PMID: 28492399; PubMed Central PMCID: PMC5503840.
- Blinder JJ, Thiagarajan R, Williams K, Nathan M, Mayer J, Kulik TJ. Duration of Mechanical Ventilation and Perioperative Care Quality After Neonatal Cardiac Operations. Ann Thorac Surg. 2017 Jun;103(6):1956-1962. doi: 10.1016/j.athoracsur.2016.11.077. Epub 2017 Mar 3. PubMed PMID: 28262296.
- Blinder JJ, Martinez HR, Craigen WJ, Belmont J, Pignatelli RH, Jefferies JL. Noncompaction of the left ventricular myocardium in a boy with a novel chromosome 8p23.1 deletion. Am J Med Genet A. 2011 Sep;155A(9):2215-20. doi: 10.1002/ajmg.a.34129. Epub 2011 Aug 10. PubMed PMID: 21834050.
Dr. Brothers’s research interests are mainly in coronary anomalies, specifically anomalous aortic origin of a coronary artery (AAOCA). She has also serve as site PI on pharmaceutical drug trials in children with dyslipidemia.
- Brothers JA, McBride MG, Seliem MA, Marino BM, Tomlinson RS, Pampaloni MH, Gaynor JW, Spray TL, Paridon SM. Evaluation of myocardial ischemia following surgical repair of anomalous aortic origin of a coronary artery from the opposite sinus of Valsalva in a series of pediatric patients. J Am Coll Cardiol 50: 2078-82, Nov 2007.
- Poynter JA, Williams WG, McIntyre S, Brothers JA, Jacobs ML. Congenital Heart Surgeons Society AAOCA Working Group: Anomalous aortic origin of a coronary artery (AAOCA): A report from the Congenital Heart Surgeons Society registry. World J Pediatr Congen Heart Surg 5: 22-30, Jan 2014.
- Wittlieb-Weber CA, Paridon SM, Gaynor JW, Spray TL, Weber DR, Brothers JA. Medium-term outcome after anomalous aortic origin of a coronary artery repair in a pediatric cohort. J Thorac Cardiovasc Surg 147, May 2014.
- Wittlieb-Weber CA, Brothers JA. Coronary artery anomalies: current recognition and treatment strategies update on recent progress. Curr Cardiovasc Risk Rep 8: 395-98, July 2014.
- Brothers JA, Whitehead KK, Keller MS, Fogel MA, Paridon SM, Weinberg PM, Harris MA. Cardiac MR and CT virtual angioscopy demonstrate normal coronary ostial morphology in children with anomalous left coronary artery with intraseptal course. Am J Radiol 204: W104-9, Jan 2015.
Dr. Brunetti is a Cardiac Intensivist with the Division of Cardiac Critical Care Medicine at Children’s Hospital of Philadelphia and an Assistant Professor of Pediatrics in the Department of Anesthesiology & Critical Care Medicine at the Perelman School of Medicine at the University of Pennsylvania.
- Brunetti MA, Retzloff LB, Lehrich JL, Gaynor JW, Pasquali SK, Bailly DK, Klugman D, Koch J, Lasa JJ, Gaies M. Characteristics, Risk Factors and Outcomes of Extracorporeal Membrane Oxygenation Use in the Pediatric Cardiac Intensive Care Unit Oral Presentation. Congenital Heart Disease and The Year in Review Session, American College of Cardiology March 2017.
- Gardner MM, Dori Y, Mascio CE, Kozyak BW, Naim M, Rychik J, Brunetti MA. Management of Massive Pulmonary Artery Emboli in a Fontan Patient with Protein Losing Enteropathy. Oral Presentation. Pediatric Cardiac Intensive Care Society Meeting December 2016.
- Procaccini D, Woods-Hill C, Bisker P, Ascenzi J, Wieczorek B, McNamara L, Brunetti MA. Optimizing the Discharge Process for Pediatric Patients in the Pediatric Intensive Care Unit: Pilot Review of Discharge Prescriptions by Unit Pharmacists. Armstrong Safety Institute Research Day October 2015.
- Brunetti MA, Glatz AC, McCardle K, Mott AR, Ravishankar C, Gaynor JW. Risk factors for unplanned readmission of patients to the pediatric cardiac intensive care unit. World Journal for Pediatric and Congenital Heart Surgery 6: 597-603, 2015.
- Johnson JT, Sleeper LA, Chen S, Ohye RG, Gaies MG, Williams IA, Sachdeva, Pruetz JD, Tatum GH, Thacker D, Brunetti MA, Frommelt MA, Jacobs JP, Kirsh JA, Lambert LM, Newburger JW, Pemberton VL, Zyblewski SC, Divanovic AA, Pinto NM. for the Pediatric Heart Network Investigators: Associations Between Day of Admission and Day of Surgery on Outcome and Resource Utilization in Infants with Hypoplastic Left Heart Syndrome Undergoing Stage I Palliation From the Single Ventricle Reconstruction Trial. American Journal of Cardiology 116: 1263-1269, 2015.
- Johnson JT, Sleeper LA, Chen S, Williams IA, Sachdeva R, Pruetz J, Ohye RG, Gaies M, Thacker D, Tatum G, Brunetti M, Frommelt M, Jacobs J, Kirsh J, Lambert LM, Newburger J, Pemberton V, Zyblewski S, Pinto NM. Does weekend admission affect outcome and resource utilization in infants undergoing stage I palliation? A report from the single ventricle reconstruction trial. American Academy of Pediatrics National Conference October 2014.
- Peddy SB, Brunetti MA, Schwartz JM. Perioperative critical care of the pediatric cardiac surgical patient. Johns Hopkins Manual of Cardiothoracic Surgery. Yuh DD, Vricella LA Baumgartner WA (eds.). McGraw Hill, New York, NY, Page: 973-982, 2014.
- Schwartz JM, Brunetti MA. Cyanotic heart defects. Neonatal and Pediatric Respiratory Care: a Patient Case Method Perretta J (eds.). F.A. Davis, Philadelphia, PA, 1st Edition, 2014.
Dr. Chorny's research is focused on developing targeted, nanoparticle-based therapies to treat cardiovascular disease and pediatric malignancies. Different families of therapeutic agents are currently being evaluated in nano-carrier delivery systems as potential new treatments for restenosis and high-risk neuroblastomas. Future studies will continue to focus on refinement of nanoparticle formulations that can be used to deliver drugs and bio-therapeutics more effectively and safely than existing delivery approaches.
- Adamo RF, Fishbein I, Zhang K, Wen J, Levy RJ, Alferiev IS, Chorny M. Magnetically enhanced cell delivery for accelerating recovery of the endothelium in injured arteries. J Control Release. 222: 169-75, Jan 2016.
- Alferiev IS, Iyer R, Croucher JL, Adamo RF, Zhang K, Mangino JL, Kolla V, Fishbein I, Brodeur GM, Levy RJ, Chorny M. Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy. Biomaterials 51: 22-9, May 2015.
- Hood ED, Chorny M, Greineder CF, Alferiev IS, Levy RJ, Muzykantov VR. Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation. Biomaterials 35(11): 3708-15, Apr 2014.
- Tengood JE, Alferiev IS, Zhang K, Fishbein I, Levy RJ, Chorny M. Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media. Proc Natl Acad Sci U S A 111(11): 4245–50, Mar 2014.
- Chorny M, Fishbein I, Tengood JE, Adamo RF, Alferiev IS, Levy RJ. Site-specific gene delivery to stented arteries using magnetically guided zinc oleate-based nanoparticles loaded with adenoviral vectors. FASEB J 27: 2198-206, Jun 2013.
Dr. Cohen’s research interests are primarily growth and obesity in children with congenital and acquired heart disease, using imaging to help predict postoperative outcomes in patients with small left ventricle and other congenital heart disease and Hepatic disease in Fontan patients.
- Pasquali SK, Marino BS, Pudusseri A, Wernovsky G, Paridon SM, Walker SA, Cohen MS. Risk factors associated with obesity after congenital heart surgery. Amer Heart J 2009; 158: 473-9.
- Daymont C, Neal A, Prosnitz A, Cohen MS. Growth in children with congenital heart disease. Pediatrics, 2013; 131:e236-42.
- Schwartz MC, Sullivan L, Glatz AD, Rome JJ, Russo P, Rand EB, Cohen MS. Portal and sinusoidal fibrosis are common on liver biopsy after the Fontan operation. Pediatr Cardiol, 2013; 34:135-42.
- Cohen MS, Jegatheeswaran A, Baffa JM, Gremmels DB, Overman DM, Caldarone CA, McCrindle BW, Mertens L. Echocardiographic features defining right dominant unbalanced atrioventricular septal defect: A multi-institutional study of the Congenital Heart Surgeon’s Society. Circulation: Cardiovasc Imag, 2013; 6: 508-13.
- Wellen SL, Glatz AC, Gillespie MJ, Ravishakar C, Cohen MS. Usefulness of transthoracic echocardiography to accurately diagnose recoarctation of the aorta after the Norwood procedure. Amer J Cardiol, 2014; 114:117-21.
Dr. Degenhardt is interested in the molecular mechanisms of cardiovascular development. His work involves the use of mouse models of congenital heart defects, with specific targeted gene defects. This includes semaphorins and n-acetyl transferases.
Channing A, Szwast A, Natarajan S, Degenhardt K, Tian Z, Rychik J. Maternal Hyperoxygenation improves left heart filling in the fetus with atrial septal aneurysm causing impediment to left ventricular inflow. Ultrasound Obstet Gynecol 45(6): 630, Jun 2014.
- Liang D, Wang X, Mittal A, Dhiman S, Hou SY, Degenhardt K, Astrof S. Mesodermal expression of integrin α5β1 regulates neural crest development and cardiovascular morphogenesis. Dev Biol 395(2): 232-44, Nov 2014.
- Chen D, Wang X, Liang D, Gordon J, Mittal A, Manley N, Degenhardt K, Astrof S. Fibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific manner. Dev Biol 407(2): 195-210, Nov 2015.
- Saul D, Degenhardt K, Iyoob S, Johnson A, Surrey L, Johnson M, Rychik J, Victoria T. Hypoplastic Left Heart Syndrome and the Nutmeg Lung Pattern in Utero: A Cause and Effect Relationship or Prognostic Indicator?
Dr. DeWitt has a general interest in all aspects of cardiac critical care. In particular, he has interest in chronic & prolonged critical illness in pediatric patients with heart disease, palliative care and end-of-life in pediatric patients with heart disease, quality improvement in the CICU, and lymphatic flow disorders.
- DeWitt AG, Zampi JD, Donohue JE, Yu S, Lloyd TR. Fluoroscopy-guided Umbilical Venous Catheter Placement in Infants with Congenital Heart Disease. Congenit Heart Dis. 2015 Jul-Aug;10(4):317-25. doi: 10.1111/chd.12233. Epub 2014 Nov 17. PubMed PMID: 25399854.
- DeWitt AG, Charpie JR, Donohue JE, Yu S, Owens GE. Splanchnic near-infrared spectroscopy and risk of necrotizing enterocolitis after neonatal heart surgery. Pediatr Cardiol. 2014 Oct;35(7):1286-94. doi: 10.1007/s00246-014-0931-5. Epub 2014 Jun 4. PubMed PMID: 24894893; PubMed Central PMCID: PMC4368901.
- Wong JH, Selewski DT, Yu S, Leopold KE, Roberts KH, Donohue JE, Ohye RG, Charpie JR, Goldberg CS, DeWitt AG. Severe Acute Kidney Injury Following Stage 1 Norwood Palliation: Effect on Outcomes and Risk of Severe Acute Kidney Injury at Subsequent Surgical Stages. Pediatr Crit Care Med. 2016 Jul;17(7):615-23. doi:10.1097/PCC.0000000000000734. PubMed PMID: 27099973.
Dr. Dori’s main research focuses on abnormal lymphatic flow and the diseases that result. This has led to the development of novel MRI based imaging techniques as well as minimally invasive intervention techniques. Dr. Dori’s research is now investigating the lymphatic system’s role in certain complications related to heart failure and a possible treatment for these patients.
- Kirschen MP, Dori Y, Itkin M, Licht DJ, Ichord R, Vossough A. Cerebral Lipiodol Embolism after Lymphatic Embolization for Plastic Bronchitis, The Journal of Pediatrics, Available online 11 June 2016, ISSN 0022-3476, http://dx.doi.org/10.1016/j.jpeds.2016.05.036.
- Chick JF, Reddy SN, Nadolski GJ, Dori Y, Itkin M. Single-Session Endolymphatic Glue Embolization of Lymphocele after Heart Transplantation, Journal of Vascular and Interventional Radiology, Volume 27, Issue 6, June 2016, Pages 929-930, ISSN 1051-0443, http://dx.doi.org/10.1016/j.jvir.2016.02.023.
- Dori Y, Keller MS, Rome JJ, Gillespie MJ, Glatz AC, Dodds K, Goldberg DJ, Goldfarb S, Rychik J, Itkin M. Percutaneous Lymphatic Embolization of Abnormal Pulmonary Lymphatic Flow as Treatment of Plastic Bronchitis in Patients With Congenital Heart Disease, Circulation, Volume 133, Issue 12, March 2016, 1160-70. PMID: 26864093 http://dx.doi.org/10.1161/CIRCULATIONAHA.115.019710.
- Dori Y, Keller MS, Rychik J, Itkin M. Successful treatment of plastic bronchitis by selective lymphatic embolization in a Fontan patient. Pediatrics. 2014 Aug;134(2):e590-5. PubMed PMID: 25002668.
- Dori Y, Zviman MM, Itkin M. Dynamic contrast-enhanced MR lymphangiography: feasibility study in swine. Radiology. 2014 Nov; 273(2):410-6. PubMed PMID: 24988434.
Dr. Fishbein's research interests relate to the following: vascular pathology, imaging, atherosclerosis, restenosis, gene therapy, adenovirus, adeno-associated virus, NO, NO synthase, ROS, nanotechnology.
- Slee JB, Alferiev IS, Nagaswami C, Weisel JW, Levy RJ, Fishbein I, Stachelek SJ. Enhanced biocompatibility of CD47-functionalized vascular stents. Biomaterials. 2016 May; 87:82-92.
- Adamo RF, Fishbein I, Zhang K, Wen J, Levy RJ, Alferiev IS, Chorny M. Magnetically enhanced cell delivery for accelerating recovery of the endothelium in injured arteries. J Control Release. 2016 Jan 28; 222:169-75.
- Alferiev IS, Iyer R, Croucher JL, Adamo RF, Zhang K, Mangino JL, Kolla V, Fishbein I, Brodeur GM, Levy RJ, Chorny M. Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy. Biomaterials. 2015 May; 51:22-9.
- Fishbein I, Forbes SP, Adamo RF, Chorny M, Levy RJ, Alferiev IS. Vascular gene transfer from metallic stent surfaces using adenoviral vectors tethered through hydrolysable cross-linkers. J Vis Exp. 2014 Aug 12; (90):e51653.
- Tengood JE, Alferiev IS, Zhang K, Fishbein I, Levy RJ, Chorny M. Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):4245-50.
Dr. Fogel’s research focuses on the relationship between cerebral anatomy, hemodynamics and oxygen metabolism in single ventricle patients with neurodevelopment to ultimately positively affect patient care. Specifically this will be a renewal utilizing magnetic resonance imaging and neurodevelopmental testing, bringing back single ventricle patients studied by a recent NIH RO1 for which Dr. Fogel served as primary investigator.
- Fogel MA, Durning S, Wernovsky G, Pollock AN, Gaynor JW, Nicolson S. Brain versus lung: Hierarchy of feedback loops in single ventricle patients with superior cavopulmonary connection. Circulation. 2004; 110[suppl II]:II-147–II-152.
- Fogel MA, Pawlowski T, Schwab PJ, Nicolson SC, Montenegro LM, Diaz Berenstein L, Spray TL, Gaynor JW, Fuller S, Keller MS, Harris MA, Whitehead KK, Vossough A, Licht DJ. Brain Magnetic Resonance Immediately Prior To Surgery In Single Ventricles and Surgical Postponement. Annals Thoracic Surg. PMID: 25149046. PMCID: PMC4378907
- Fogel MA, Li C, Nicolson SC, Spray TL, Gaynor JW, Fuller S, Keller MS, Harris MA, Yoganathan AP, Whitehead KK. Comparison by Magnetic Resonance Phase Contrast of Pulse Wave Velocity in Patients with Single Ventricle and Reconstructed Aortas versus Those Without. American Journal of Cardiology. Am J Cardiol. NIHMS632877, Publ.ID: AJC20723
- Buckley EM, Hance D, Pawlowski T, Lynch JL, Wilson FB, Mesquita RC, Durduran T, Diaz LK, Putt ME, Licht DJ, Fogel MA, Yodh AG. Validation of Diffuse Correlation Spectroscopic Measurements of Cerebral Blood Flow Using Phase-Encoded Velocity Mapping MRI. Journal of Biomedical Optics. Journal of Biomedical Optics. 2012; 17(3):037007. PMCID PMC3380925
- Buckley EM, Naim MY, Lynch JL, Goff DA, Diaz LK, Nicolson SC, Montenegro LM, Lavin NA, Durduran T, Spray TL, Gaynor W, Putt AG, Yodh AG, Fogel MA, Licht DJ. Sodium bicarbonate causes dose-dependent increases in cerebral blood flow in infants and children with single ventricle physiology. Pediatric Research 2013;73(5):668-673 PMCID: PMC3724528
Dr. Frank is an attending physician in the Division of Cardiology at the Children’s Hospital of Philadelphia who specializes in Pulmonary Hypertension, pulmonary vascular remodeling in embryonic development, transitional pulmonary circulation, and transplant.
- Zacharias WJ, Frank DB, Zepp JA, Morley MP, Alkhaleel FA, Kong J, Zhou S, Cantu E, Morrisey EE. Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor. Nature. 2018 Mar 8;555(7695):251-255. doi: 10.1038/nature25786. Epub 2018 Feb 28.
- Swarr DT, Peranteau WH, Pogoriler J, Frank DB, Adzick NS, Hedrick HL, Morley M, Zhou S, Morrisey EE. Novel Molecular and Phenotypic Insights into Congenital Lung Malformations. Am J Respir Crit Care Med. 2018 Jan 12. doi: 10.1164/rccm.201706-1243OC. [Epub ahead of print] PubMed PMID: 29328793.
- Zepp JA, Zacharias WJ, Frank DB, Cavanaugh CA, Zhou S, Morley MP, Morrisey EE. Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung. Cell. 2017 Sep 7;170(6):1134-1148.e10. doi: 10.1016/j.cell.2017.07.034. PubMed PMID: 28886382; PubMed Central PMCID: PMC5718193.
- Frank DB, Peng T, Zepp JA, Snitow M, Vincent TL, Penkala IJ, Cui Z, Herriges MJ, Morley MP, Zhou S, Lu MM, Morrisey EE. Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation. Cell Rep. 2016 Nov 22;17(9):2312-2325. doi: 10.1016/j.celrep.2016.11.001. PubMed PMID: 27880906; PubMed Central PMCID: PMC5214982.
- Frank DB, Crystal MA, Morales DL, Gerald K, Hanna BD, Mallory GB Jr, Rossano JW. Trends in pediatric pulmonary hypertension-related hospitalizations in the United States from 2000-2009. Pulm Circ. 2015 Jun;5(2):339-48. doi: 10.1086/681226. PubMed PMID: 26064460; PubMed Central PMCID: PMC4449246.
- Dr. Fuller’s research includes two recent studies utilizing the Society of Thoracic Surgeons Congenital Heart Surgery Database. One study examined morbidity and mortality after adult congenital heart operations; the second reported on the use of mechanical circulatory support after pediatric cardiac surgery. Both studies resulted in national and peer-reviewed publications. She participates in the Society of Thoracic Surgeons Workforce on Adult Congenital Heart Disease.
- Fuller SM, He X, Jacobs JP, Pasquali SK, Gaynor JW, Mascio CE, Hill KD, Jacobs ML, Kim YY. Estimating Mortality Risk for Adult Congenital Heart Surgery: An Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database. Ann Thorac Surg. 2015 Sep 25. pii: S0003-4975(15)01189-3 doi: 10.1016/j.athoracsur.2015.07.002. [Epub ahead of print] PMID: 26411754
- Fuller S, Nord AS , Gerdes M, Wernovsky G, Jarvik GP, Bernbaum J, Zackai EH, Gaynor JW. Predictors of Impaired Neurodevelopmental Outcomes at One Year of Age after Infant Cardiac Surgery Eur J Cardiovasc Thorac Surg 2009; 36:40-48.
- Fuller S, Rajagopalan R, Jarvik GP, Gerdes M, Bernbaum J, Wernovsky G, Clancy RR, Solot C, Nicolson SC, Spray TL, and Gaynor JW. Deep hypothermic circulatory arrest does not impair neurodevelopmental outcome in school-age children. Ann Thorac Surg 2010; 90: 1985-1995. PMCID: PMC3297076
Dr. Gaynor has a long interest in long-term outcomes assessment in children with congenital heart defects. His research has focused on understanding neurodevelopmental outcomes and risk factors associated with adverse outcomes in this area. He currently serves as Director of the Long-term Follow-up Program in the Cardiac Center at CHOP, and is a member of the Pediatric Cardiac Critical Care Consortium (PC4) Executive Committee.
- Gaynor JW, Wernovsky G, Jarvik GP, Bernbaum J, Gerdes M, Zackai E, Nord AS, et al. Patient characteristics are important determinants of neurodevelopmental outcome at one year of age after neonatal and infant cardiac surgery J Thorac and Cardiovasc Surg 2007; 133: 1344 – 53. PMC: PMC2844117
- Tabbutt S, Nord AS, Jarvik GP, Bernbaum J, Wernovsky G, Gerdes M, Zackai E, Clancy RR, Nicolson SC, Spray TL, Gaynor JW. Neurodevelopmental outcomes after staged palliation for hypoplastic left heart syndrome. Pediatrics 2008; 121: 476-83.
- Fuller S, Nord AS, Gerdes M, Wernovsky G, Jarvik GP, Bernbaum J, Zackai EH, Gaynor JW. Predictors of Impaired Neurodevelopmental Outcomes at One Year of Age after Infant Cardiac Surgery Eur J Cardiovasc Thorac Surg 2009; 36:40-48.
- Pasquali SK, He X, Jacobs JP, Jacobs ML, O’Brien SM, Gaynor JW. Evaluation of failure to rescue as a quality metric in pediatric heart surgery. Ann Thorac Surg 2012; 94:573-579.
- Gaies MG, Cooper DS, Tabbutt S, Schwartz SM, Ghanayem N, Chanani NK, Costello JM, Thiagarajan RR, Laussen PC, Shekerdemian LS, Donohue JE, Willis GM, Gaynor JW, Jacobs JP, Ohye RG, Charpie JR, Pasquali SK, Scheurer MA. Collaborative quality improvement in the cardiac intensive care unit: Development of the Pediatric Cardiac Critical Care Consortium (PC4). Cardiol Young 2014; 28:1-7.
Dr. Giglia is an attending cardiologist and medical director of the Infant Single Ventricle Monitoring Program (ISVMP).
- Giglia TM, Dinardo J, Ghanayem NS, Ichord R, Niebler RA, Odegard KC, Massicotte MP, Yates AR, Laussen PC, Tweddell JS. Bleeding and thrombotic emergencies in pediatric cardiac intensive care: unchecked balances. World J Pediatr Congenit Heart Surg 3(4): 470-91, Oct 2012 Notes: PMID 23804911.
- Axelrod DM, Klugman D, Wright GE, Chang A, Bronicki R, Roth SJ. Board Members of the Pediatric Cardiac Intensive Care Society: One hundred useful references in pediatric cardiac intensive care: the 2012 update. Pediatr Crit Care Med 14(8): 770-85, Oct 2013 Notes: PMID 24088673.
- Giglia TM, Massicotte MP, Tweddell JS, Barst RJ, Bauman M, Erickson CC, Feltes TF, Foster E, Hinoki K, Ichord RN, Kreutzer J, McCrindle BW, Newburger JW, Tabbutt S, Todd JL, Webb CL. American Heart Association Congenital Heart Defects Committee of the Council on Cardiovascular Disease in the Young, Council on Cardiovascular and Stroke Nursing, Council on Epidemiology and Prevention, and Stroke Council. Prevention and treatment of thrombosis in pediatric and congenital heart disease: a scientific statement from the American Heart Association. Circulation 128(24): 2622-703, Dec 2013 Notes: This article is recognized as a landmark article in the field. PMID 24226806.
- Giglia TM, Witmer C, Procaccini DE, Brynes JW. Pediatric Cardiac Intensive Care Society 2014 consensus statement: Pharmacotherapies in cardiac critical care anticoagulation and thrombolysis. Pediatr Crit Care Med 17(3 Suppl 1): S77-88, Mar 2016 Notes: PMID 26945332.
- Giglia TM, Witmer C. Bleeding and thrombosis in pediatric cardiac intensive care. Pediatr Crit Care Med 17(8 Suppl 1): S287-95, Aug 2016 Notes: PMID 27490612.
Dr. Gillespie is an attending cardiologist In the Cardiac Center at Children's Hospital of Philadelphia with expertise in interventional cardiology and transcatheter treatment of heart disease.
- Qureshi AM, Bansal N, McElhinney DB, Boudjemline Y, Forbes TJ, Maschietto N, Shahanawaz S, Cheatham JP, Krasuski R, Lamers L, Chessa M, Morray BH, Goldstein BH, Wang CV, Gillespie MJ. Branch Pulmonary Artery Valve Implantation Reduces Pulmonary Regurgitation and Improves Right Ventricular Size/Function in Patients with Large Right Ventricular Outflow Tracts. JACC, Cardiovascular Interventions in press 2018.
- Wu SJ, Tacy Downing, Mascio C, Gillespie MJ, Dori Y, Rome JJ, Glatz AC. Reintervention Burden and Vessel Growth After Surgical Reimplantation of a Pulmonary Artery During Childhood. Pediatr Cardiol Nov 2017.
- Mozumdar NM, Burke E, Schweizer M, Gillespie MJ, Dori Y, Narayan HK, Rome JJ, Glatz AC. A Comparison of Anterograde Versus Retrograde Approaches for Neonatal Balloon Aortic Valvuloplasty. Pediatric cardiology Nov 2017.
- Whiteside W, Tretter JT, Aboulhosn J, Aldoss O, Armstrong AK, Bocks ML, Gillespie MJ, Jones TK, Martin MH, Meadows JJ, Metcalf CM, Turner ME, Zellers T, Goldstein BH. Acute and Midterm Outcomes of Transcatheter Pulmonary Valve Replacement for Treatment of Dysfunctional Left Ventricular Outflow Tract Conduits in Patients With Aortopulmonary Transposition and a Systemic Right Ventricle. Circulation. Cardiovascular interventions 10(9), Sep 2017.
- Downing TE, Allen KY, Goldberg DJ, Rogers LS, Ravishankar C, Rychik J, Fuller S, Montenegro LM, Steven JM, Gillespie MJ, Rome JJ, Spray TL, Nicolson SC, Gaynor JW, Glatz AC. Surgical and Catheter-Based Reinterventions Are Common in Long-Term Survivors of the Fontan Operation. Circulation. Cardiovascular interventions 10(9), Sep 2017.
- Bergersen L, Benson LN, Gillespie MJ, Cheatham SL, Crean AM, Hor KN, Horlick EM, Lung TH, McHenry BT, Osten MD, Powell AJ, Cheatham JP. Harmony Feasibility Trial: Acute and Short-Term Outcomes With a Self-Expanding Transcatheter Pulmonary Valve. JACC. Cardiovascular interventions 10(17): 1763-1773, Sep 2017.
- Gillespie MJ, Benson LN, Bergersen L, Bacha EA, Cheatham SL, Crean AM, Eicken A, Ewert P, Geva T, Hellenbrand WE, Hor KN, Horlick EM, Jones TK, Mayer J, McHenry BT, Osten MD, Powell AJ, Zahn EM, Cheatham JP. Patient Selection Process for the Harmony Transcatheter Pulmonary Valve Early Feasibility Study. The American journal of cardiology Jul 2017.
- Schoonbeek RC, Takebayashi S, Aoki C, Shimaoka T, Harris MA, Fu GL, Kim TS, Dori Y, McGarvey J, Litt H, Bouma W, Zsido G, Glatz AC, Rome JJ, Gorman RC, Gorman JH, Gillespie MJ. Implantation of the Medtronic Harmony Transcatheter Pulmonary Valve Improves Right Ventricular Size and Function in an Ovine Model of Postoperative Chronic Pulmonary Insufficiency. Circulation. Cardiovascular interventions 9(10), Oct 2016.
Dr. Glatz is a pediatric interventional cardiologist with a strong interest and focus on conducting rigorously designed clinical research. He has formal Masters-level training in study design, epidemiology, and biostatistics. His primary research focus relates to outcomes and quality of care for children with congenital heart disease, using both single-center data and larger multi-center administrative and registry datasets.
- O’Byrne ML, Gillespie MJ, Shinohara R, Dori Y, Rome JJ, Glatz AC. Cost-comparison of transcatheter and operative pulmonary valve replacement (from the Pediatric Health Information Systems Database). American Journal of Cardiology 2016;117(1):121-6. PMID 26552510.
- O’Byrne ML, Glatz AC, Hanna BD, Shinohara RT, Gillespie MJ, Dori Y, Rome JJ, Kawut S. Predictors of catastrophic adverse outcomes in children with pulmonary hypertension undergoing cardiac catheterization. Journal of the American College of Cardiology 2015;66:1261-9. PMID 26361158.
- O’Byrne ML, Glatz AC, Shinohara RT, Jayaram N, Gillespie MJ, Dori Y, Kawut S, Rome JJ. Effect of center catheterization volume on risk of catastrophic adverse event following cardiac catheterization in children. American Heart Journal 2015;169(6):823-832. PMID 26027620.
- O’Byrne ML, Gillespie MJ, Shinohara RT, Dori Y, Rome JJ, Glatz AC. Cost-comparison of trans-catheter and operative closure of ostium secundum atrial septal defects. American Heart Journal 2015;169(5):727-735. PMID 25965721.
- Glatz AC, Harrison N, Small AJ, Dori Y, Gillespie MJ, Harris MA, Fogel MA, Rome JJ, Whitehead KK. Factors associated with systemic to pulmonary arterial collateral flow in single ventricle patients with superior cavo-pulmonary connections. Heart 2015;101(22):1813-8. PMID 26385453.
Dr. Goldberg’s research interests are primarily focused on children and adolescents with single ventricle congenital heart disease who have undergone the Fontan operation. He is particularly interested in Fontan-associated complications and potential interventions to improve the efficacy of the total cavopulmonary connection. Currently, his primary focus is on a phase III clinical trial of udenafil as a potential medical intervention. In the future he hopes to focus on optimizing mechanical support for the failing single ventricle patient.
- Whitehead KK, Avitabile CM, Goldberg DJ, Leonard MB, Wei Z, Tang E, Paridon SM, Yoganathan AP, Fogel MA. Relationship between leg lean mass z-score and cardiac output at exercise as measured by exercise magnetic resonance imaging. Journal of Cardiovascular Magnetic Resonance 17(Suppl 1), 2015.
- Morsheimer MM, Rychik J, Forbes L, Dodds K, Goldberg DJ, Sullivan K, Heimall JR. Risk Factors and Clinical Significance of Lymphopenia in Survivors of the Fontan Procedure for Single-Ventricle Congenital Cardiac Disease. The journal of allergy and clinical immunology. In practice Feb 2016.
- Dori Y, Keller MS, Rome JJ, Gillespie MJ, Glatz AC, Dodds K, Goldberg DJ, Goldfarb S, Rychik J, Itkin M. Percutaneous Lymphatic Embolization of Abnormal Pulmonary Lymphatic Flow as Treatment of Plastic Bronchitis in Patients With Congenital Heart Disease. Circulation 133(12): 1160-70, Mar 2016.
- Misfeldt AM, Kirsch RE, Goldberg DJ, Mascio CE, Naim MY, Zhang X, Mott AR, Ravishankar C, Rossano JW. Outcomes of Single-Ventricle Patients Supported With Extracorporeal Membrane Oxygenation. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 17(3): 194-202, Mar 2016.
- Patel JK, Loomes KM, Goldberg DJ, Mercer-Rosa L, Dodds K, Rychik J. Early Impact of Fontan Operation on Enteric Protein Loss. The Annals of thoracic surgery 101(3): 1025-30, Mar 2016.
Dr. Goldmuntz’s research has focused on the genetic etiology of congenital heart disease as well as genetic modifiers of clinical outcomes. She has focused predominantly on the subgroup of patients with conotruncal defects. A translational program of research, it includes purely clinical to large-scale genomic endeavors. A new avenue of investigation will focus on health services research and health policy.
- Mercer-Rosa L, Pinto N, Yang W, Tanel R, Goldmuntz E. 22q11.2 deletion syndrome is associated with perioperative outcome in tetralogy of Fallot. J Thorac Cardiovasc Surg 146(4): 868-73, Oct 2013.
- O'Byrne ML, Yang W, Mercer-Rosa L, Parnell AS, Oster ME, Levenbrown Y, Tanel RE, Goldmuntz E. 22q11.2 deletion syndrome is associated with increased perioperative events and more complicated postoperative course in infants undergoing infant operative correction of truncus arteriosus communis or interrupted aortic arch. J Thorac Cardiovasc Surg 148(4): 1597-605, Oct 2014.
- Mercer-Rosa L, Paridon SM, Fogel MA, Rychik J, Tanel RE, Zhao H, Zhang X, Yang W, Shults J, Goldmuntz E. 22q11.2 deletion status and disease burden in children and adolescents with tetralogy of Fallot. Circ Cardiovasc Genet 8(1): 74-81, Feb 2015.
- Homsy J, Zaidi S, Shen Y, Ware JS, Samocha KE, Karczewski KJ, DePalma SR,McKean D, Wakimoto H, Gorham J, Jin SC, Deanfield J, Giardini A, Porter GA Jr, Kim R, Bilguvar K, López-Giráldez F, Tikhonova I, Mane S, Romano-Adesman A, Qi H, Vardarajan B, Ma L, Daly M, Roberts AE, Russell MW, Mital S, Newburger JW, Gaynor JW, Breitbart RE, Iossifov I, Ronemus M, Sanders SJ, Kaltman JR, Seidman JG, Brueckner M, Gelb BD, Goldmuntz E, Lifton RP, Seidman CE, Chung WK. De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies. Science 350(6265): 1262-6, Dec 2015
- Werner P, Latney B, Deardorff MA, Goldmuntz E. MESP1 mutations in patients with congenital heart defects. Hum Mutat 37(3): 308-14, Mar 2016
Dr. Harris’ current research includes using Cardiac MRI for assessment and quantification of ventricular function and pulmonary regurgitation in congenital heart disease animal models (swine and sheep). MRI studies are performed Pre and Post catheter intervention.
- Unterman TG, Fareeduddin A, Harris MA, Goswami RG, Porcella A, Costa RH, Lacson RG. Hepatocyte nuclear factor-3 (HNF-3) binds to the insulin response sequence in the IGF binding protein-1 (IGFBP-1) promoter and enhances promoter function. Biochem Biophys Res Commun 203: 1835-1841, September 1994 Notes: Biochemical and Biophysical Research Communications Volume 203, Issue 3, 30 September 1994, Pages 1835-1841 Erratum in:Biochem Biophys Res Commun 1994 Dec 15;205(2):1496.
- Harris MA, Weinberg PM, Whitehead KK, Fogel MA. Usefulness of branch pulmonary artery regurgitant fraction to estimate the relative right and left pulmonary vascular resistances in congenital heart disease. Am J Cardiol 95: 1514-1517, June 2005.
- Fogel MA, Weinberg PM, Harris M, Rhodes L. Usefulness of magnetic resonance imaging for the diagnosis of right ventricular dysplasia in children Am J Cardiol 97: 1232-1237, March 2006.
- Harris MA, Johnson TR, Weinberg PM, Fogel MA. Delayed-enhancement cardiovascular magnetic resonance identifies fibrous tissue in children after surgery for congenital heart disease. J Thorac and Cardiovasc Surg 133: 676-81, March 2007.
- Fogel MA, Weinberg PM, Parave E, Harris C, Montenegro L, Harris MA, Concepcion M. Deep Sedation For Cardiac Magnetic Resonance: A Comparison With Cardiac Anesthesia. J Pediatr 152(4): 534-9, April 2008.
Iyer, V. Ramesh
Dr. Iyer is an attending electrophysiologist in the Cardiac Center at Children’s Hospital of Philadelphia with a special interest in pacemakers and device therapy. His research expertise is in calcium signaling and electron microscopy in cardiac muscle ultrastructure in disease states such as hypertrophic cardiomyopathy and inherited ventricular tachycardias. He also has interest in calcium release unit ultrastructure and modeling for sinus node functioning.
- Vetter VL, Haley DM, Dugan NP, Iyer VR, Shults J. Innovative cardiopulmonary resuscitation and automated external defibrillator programs in schools: Results from the Student Program for Olympic Resuscitation Training in Schools (SPORTS) study. Resuscitation. 2016 Jul;104:46-52. doi: 10.1016/j.resuscitation.2016.04.010. Epub 2016 Apr 27. PubMed PMID: 27131845.
- Vetter VL, Covington TM, Dugan NP, Haley DM, Dykstra H, Overpeck M, Iyer VR, Shults J. Cardiovascular deaths in children: general overview from the National Center for the Review and Prevention of Child Deaths. Am Heart J. 2015 Mar;169(3):426-437.e23. doi: 10.1016/j.ahj.2014.11.014. Epub 2014 Dec 10. PubMed PMID: 25728734.
- Aziz PF, Wieand TS, Ganley J, Henderson J, Patel AR, Iyer VR, Vogel RL, McBride M, Vetter VL, Shah MJ. Genotype- and mutation site-specific QT adaptation during exercise, recovery, and postural changes in children with long-QT syndrome. Circ Arrhythm Electrophysiol. 2011 Dec;4(6):867-73. doi: 10.1161/CIRCEP.111.963330. Epub 2011 Sep 28. PubMed PMID: 21956039; PubMed Central PMCID: PMC3247652.
- Patel JK, Iyer VR. Managing arrhythmias before and after aortic valve surgery in children. Am J Cardiovasc Drugs. 2012 Feb 1;12(1):23-34. doi: 10.2165/11596350-000000000-00000. Review. PubMed PMID: 22185655.
- Iyer VR, Chin AJ. Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). Am J Med Genet C Semin Med Genet. 2013 Aug;163C(3):185-97. doi: 10.1002/ajmg.c.31368. Epub 2013 Jul 3. Review. PubMed PMID: 23824749.
Dr. Janson is an attending electrophysiologist in the Cardiac Center at Children's Hospital of Philadelphia.
- Janson CM, Shah MJ. Supraventricular Tachycardia in Adult Congenital Heart Disease - Mechanisms, Diagnosis and Clinical Aspects. Cardiac Electrophysiology Clinics 9(2): 189-211, June 2017.
- Janson CM, Ceresnak SR, Dubin AM, Motonaga KS, Mann GE, Kahana M, Fitz-James I, Wise-Faberowski L, Kamra K, Nappo L, Trela A, Choi JM, Pass RH. A Prospective Assessment of Optimal Mechanical Ventilation Parameters for Pediatric Catheter Ablation. Abstract Rapid Fire Oral at American Heart Association Scientific Sessions, New Orleans, LA November 2016.
- Pass RH, Liberman L, Silver ES, Janson CM, Blaufox AD, Nappo, L, SR Ceresnak. The "Hidden" Left Sided Accessory Pathway: An Uncommon Cause of SVT in Young People. Heart Rhythm Society Scientific Sessions, San Francisco, CA May 2016 Notes: POSTER.
- Ceresnak SR, Pass RH, Dubin AM, Motonaga KS, Avasarala K, Trela A, McElhinney DB, Hedlin H, Yang L, Janson CM, Nappo L, and GJ Gates. Ablation Made Ridiculously Simple: Validation of a novel automated signal analysis tool for the ablation of WPW in children. Heart Rhythm Society Scientific Sessions, San Francisco, CA May 2016 Notes: POSTER.
- Ceresnak SR, Pass RH, Dubin AM, Kim JJ, Valdes SO, Fishberger SM, Shetty I, Zimmerman F, Tanel RE, Epstein MR, Motonaga KS, Avasarala K, Capone CA, Nappo L, Gates GJ, Janson CM. Intermittent Pre-excitation ≠ “Low Risk”: Prevalence of “high risk” accessory pathways in children with intermittent pre-excitation undergoing EP study. Heart Rhythm Society Scientific Sessions, San Francisco, CA May 2016 Notes: POSTER.
- Hsu D, Janson CM. Pre-Sports Participation Screening: What You Need to Know. http://health.usnews.com/health-news/patient-advice/articles/2016-02-09/.... February 2016.
- Ceresnak SR, Nappo L, Janson CM, Pass RH. Tricking CARTO: Cryoablation of Supraventricular Tachycardia in Children with Minimal Radiation Exposure Using the CARTO3 System. Pacing and Clinical Electrophysiology 1(39): 36-41, 2016.
Dr. Kim is a board-certified cardiologist at CHOP and medical director of the Philadelphia Adult Congenital Heart Center. Her research interest includes congenital heart disease, echocardiography, and adult congenital heart disease
- Kim YY, He W, MacGillivray TE, Benavidez OJ. Readmissions after Adult Congenital Heart Surgery: Frequency and Risk Factors. Congenital Heart Disease 2016, in press.
- Kim YY, Rathod RH, Gauvreau K, Keenan EM, del Nido P, Geva T. Factors Associated with Severe Aortic Dilation in Patients with Fontan Palliation. Heart 2016; Aug 12. pii: heartjnl-2016-309615. doi: 10.1136/heartjnl-2016-309615. [Epub ahead of print].
- Londono-Obregon C, Goldmuntz E, Davey BT, Zhang X, Slap GB, Kim YY. Adult CHD: the Ongoing Need for Physician Counseling About Heredity and Contraceptive Options. Cardiol Young 2016; July7:1-6.
- D’Souza BA, Epstein AE, Garcia FC. Kim YY, Agarwal SC, Belott PH, Burke M, Leon AR, Morgan JM, Patton KK, Shah M. Outcomes in Patients with Congenital Heart Disease Receiving the Subcutaneous Implantable-Cardioverter Defibrillator: Results From a Pooled Analysis From the IDE Study and EFFORTLESS S-ICD Registry. JACC-Clinical Electrophysiology. Published online May 18, 2016. doi:10.1016/.jacep.2016.02.008
- Deng LX, Khan AM, Drajpuch D, Fuller S, Ludmir J, Mascio CE, Partington SL, Qadeer A, Tobin L, Kovacs AH, Kim YY. Prevalence and Correlates of Post-traumatic Stress Disorder in Adults with Congenital Heart Disease. Am J Cardiol 2016; 117:853-857.
Dr. Levy's research programs of interest concern the developmental basis for aortic valve disease, mechanistic studies of progression of calcific aortic stenosis, serotonin mechanisms in heart valve disease, and novel biomaterials for heart valve prostheses. Gene delivery stents are another area of major interest: plasmid or viral vectors configured in sustained release preparations onto vascular stents for site-specific vascular gene therapy. Magnetic delivery of nanoparticles for pharmaceutical and cell therapy to treat arterial disease and magnetic targeting for delivery of cells and pharmaceuticals using nanomedicine formulations are also areas of current research.
- Slee JB, Alferiev IS, Nagaswami C, Weisel JW, Levy RJ, Fishbein I, Stachelek SJ. Enhanced biocompatibility of CD47-functionalized vascular stents. Biomaterials. 2016 May; 87:82-92. Tengood JE, Levy RJ, Stachelek SJ. The use of CD47-modified biomaterials to mitigate the immune response. Exp Biol Med (Maywood). 2016 May; 241(10):1033-41.
- Christian AJ, Alferiev IS, Connolly JM, Ischiropoulos H, Levy RJ. The effects of the covalent attachment of 3-(4-hydroxy-3, 5-di-tert-butylphenyl) propyl amine to glutaraldehyde pretreated bovine pericardium on structural degeneration, oxidative modification, and calcification of rat subdermal implants. J Biomed Mater Res A. 2015 Jul; 103(7):2441-8.
- Alferiev IS, Iyer R, Croucher JL, Adamo RF, Zhang K, Mangino JL, Kolla V, Fishbein I, Brodeur GM, Levy RJ, Chorny M. Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy. Biomaterials.2015 May; 51:22-9.
Dr. Lin’s research focus is on cardiac biomarkers in Friedreich Ataxia, a disease marked by neuromuscular manifestations as well as cardiomyopathy. Her clinical work is primarily in the care of children and young adults with cardiomyopathy, heart failure, and heart transplantation. Relevant publications include:
- Isaacs CJ*, Shinnick JE*, Schadt K, Lynch DR, Lin KY. *co-first authors. Prospects of gene and cell therapy for managing cardiac complications in Friedreich ataxia. Expert Opinion on Orphan Drugs 3(10), August 2015.
- Friedman LS, Schadt KA, Regner SR, Mark GE, Lin KY, Sciascia T, St John Sutton M, Willi S, Lynch DR. Elevation of serum cardiac troponin I in asymptomatic subjects with Friedreich ataxia. International Journal of Cardiology 167(4): 1622-4, Aug 2013.
- Schadt KA, Friedman LS, Regner SR, Mark GE, Lynch DR, Lin KY. Cross-Sectional Analysis of Electrocardiograms in a Large Heterogeneous Cohort of Friedreich Ataxia Subjects. J Child Neurology 27(9): 1187-1192, Sep 2012.
- Savla J*, Lin KY*, Pradhan M, Ruebner RL, Rogers RS, Haskins SS, Owens AT, Abt P, Gaynor JW, Shaddy RE, Rossano JW. *co-first authors. Heart retransplant recipients have better survival with concurrent kidney transplant than with heart retransplant alone. J Am Heart Assoc 4(12), December 2015.
- Lin KY: Biomarkers in pediatric heart failure: is there value? Cardiol Young 25(8): 1469-72, December 2015.
Dr. Mascio is an Assistant Professor of Pediatric Cardiothoracic Surgery and his primary research interest has been clinically oriented. He has the surgical and research expertise, leadership, training and motivation necessary to successfully carry out a proposed research project involving 3D printing and surgical planning. He has a broad background in basic cardiac surgical research, however, recently the focus has become more clinical as evidenced by his current activities. His research includes two recent studies utilizing the Society of Thoracic Surgeons Congenital Heart Surgery Database. One study examined morbidity and mortality after adult congenital heart operations and the second reported on the use of mechanical circulatory support after pediatric cardiac surgery. Both studies resulted in presentations at the American Association for Thoracic Surgery and publication in the Journal of Thoracic and Cardiovascular Surgery.
- Van Natta TL, Ralphe JC, Mascio CE, Bedell KA, Scholz TD. Ontogeny of vascular growth factors in perinatal sheep myocardium. Journal of the Society of Gynecological Investigation 11(8):503-510, Dec. 2004.
- Ralphe JC, Nau PN, Mascio CE, Van Natta T, Segar JL, Scholz TO. Regulation of myocardial glucose transporters Glut1 and Glut4 in chronically anemic fetal lambs. Pediatric Research 58(4):713-718, Oct. 2005.
- Mascio CE, Olison AK, Ralphe JC, Tomanek RJ, Scholz TD, Segar JL. Myocardial vascular and metabolic adaptations in chronically anemic fetal sheep. American Journal of Physiologic Regulation & Integrative Comprehensive Physiology 289(6):R1736-1745, Dec. 2005 (Epub Aug. 25, 2005).
- Mascio CE, Pasquali SK. Jacobs JP, Jacobs ML, Austin EH. Outcomes in adult congenital heart surgery: Analysis of the Society of Thoracic Surgeons (STS) database. Journal of Thoracic & Cardiovascular Surgery 142(5):1090-1097, Nov. 2011 (Epub Sept. 10, 2011).
- Mascio CE, Austin EH 3rd, Jacobs JP, Jacobs ML, Wallace AS, He X, Pasquali SK. Perioperative mechanical circulatory support in children: An analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database. J Thorac Cardiovasc Surg. 2014 Feb; 147(2):658-64: discussion 664-5. doi: 10.1016/j.jtcvs.2013.09.075. Epub 2013 Nov 16.
- Fuller SM, He X, Jacobs JP, Pasquali SK, Gaynor JW, Mascio CE, Hill KD, Jacobs ML, Kim YY. Estimating Mortality Risk for Adult Congenital Heart Surgery: An Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database. Ann Thorac Surg. 2015 Sep 25. S0003-4975(15)01189-3. doi: 10.1016/j.athoracsur.2015.07.002. [Epub ahead of print] PMID: 26411754
Dr. Mercer-Rosa is a clinician scientist with a research interest in outcomes in tetralogy of Fallot. In addition, she investigates the factors that influence right ventricular remodeling in tetralogy of Fallot, single right ventricles and pulmonary hypertension using non-invasive imaging techniques.
- DiLorenzo MP, Bhatt SM, Mercer-Rosa L. How best to assess right ventricular function by echocardiography. Cardiol Young. 2015 Dec; 25(8):1473-81.
- DiLorenzo MP, Goldmuntz E, Nicolson SC, Fogel MA, Mercer-Rosa L. Early postoperative remodeling following repair of tetralogy of Fallot utilising unsedated cardiac magnetic resonance: a pilot study. Cardiol Young. 2018 Feb 15:1-5.
- Mercer-Rosa L, Paridon SM, Fogel MA, Rychik J, Tanel RE, Zhao H, Zhang X, Yang W, Shults J, Goldmuntz E. 22q11.2 deletion status and disease burden in children and adolescents with tetralogy of Fallot. Circ Cardiovasc Genet. 2015 Feb; 8(1):74-81.
- Mercer-Rosa L, Ingall E, Zhang X, McBride M, Kawut S, Fogel M, Paridon S, Goldmuntz E. The impact of pulmonary insufficiency on the right ventricle: a comparison of isolated valvar pulmonary stenosis and tetralogy of Fallot. Pediatr Cardiol. 2015 Apr; 36(4):796-801.
- Hopper RK, Wang Y, DeMatteo V, Santo A, Kawut SM, Elci OU, Hanna BD, Mercer-Rosa L. Right ventricular function mirrors clinical improvement with use of prostacyclin analogues in pediatric pulmonary hypertension. Pulm Circ. 2018 Apr-Jun;8(2)
- Mercer-Rosa L, Parnell A, Forfia PR, Yang W, Goldmuntz E, Kawut SM. Tricuspid annular plane systolic excursion in the assessment of right ventricular function in children and adolescents after repair of tetralogy of Fallot. J Am Soc Echocardiogr. 2013 Nov; 26(11):1322-9.
Dr. Naim is a Pediatric Cardiac Intensive Care Physician in the Division of Cardiac Critical Care Medicine at Children's Hospital of Philadelphia with an expertise in neuroprotection following traumatic brain injury and cardiopulmonary bypass as well as pediatric organ donation and transplantation.
- Yuerek M, Weiss SL, Naim MY. Chapter 33: The Failing Myocardium in Sepsis. Heart Failure in the Child and Young Adult: From Bench to Bedside. J.L. Jefferies, A.C. Chang, J.W. Rossano, R.E. Shaddy, J.A. Towbin (eds.). Academic Press, ELSEVIER, Philadelphia, PA 2018, pgs. 445-456, Page: 445-456, 2018.
- Naim MY, Rossano J. Decreasing Neurologic Injury in Children after Hypoxic Injury: Is Transcutaneous Doppler the Way to Go? Resuscitation 2018 Notes: In Press.
- Reeder RW, Girling A, Wolfe H, Holubkov R, Berg RA, Naim MY, Meert KL, Tilford B, Carcillo JA, Hamilton M, Bochkoris M, Hall M, Maa T, Yates A, Sapru A, Kelly R, Federman M, Dean JM, McQuillen PS, Franzon D, Pollack MM, Siems A, Diddle J, Wessel DL, Mourani P, Zebuhr C, Bishop R, Freiss S, Burns C, Viteri S, Hehir DA, Coleman RW, Jenkins TL, Notterman DA, Tamburro RF, Sutton RM. Improving outcomes from pediatric cardiac arrest - the ICU-RESUScitation project: study protocol for a randomized controlled trial. Trials 2018 Notes: In Press.
- Naim, MY Study Author: Conventional CPR education efforts should intensify for children. AHA News June 2017
- Lin J, Banwell BL, Berg RA, Dlugos DJ, Ichord RN, Kilbaugh TJ, Kirsch RE, Kirschen MP, Licht DJ, Massey SL, Naim MY, Rintoul NE, Topjian AA, Abend NS. Electrographic seizures in children and neonates undergoing extracorporeal membrane oxygenation. Pediatric Critical Care Medicine 18(3): 249-257, March 2017.
- Naim MY, Burke RV, McNally BF, Song L, Griffis HM, Berg RA, Vellano K, Markenson D, Bradley RN, Rossano JW for the CARES Surveillance Group: Association of bystander cardiopulmonary resuscitation with overall and neurologically favorable survival after pediatric out of hospital cardiac arrest in the United States. JAMA Pediatrics 171(2): 133-141, February 2017.
Dr. Natarajan is an attending cardiologist and Co-director of the Hypertension Clinic and the Medical Director of the Cardiac Center Quality Improvement Program at Children's Hospital of Philadelphia. Her expertise is in conducting non-invasive evaluation of ventricular and vascular function in congenital heart disease.
- Selamet Terney ES, Hollenbeck-Pringle D, Lee CK, Altmann K, Dunbar-Masterson C, Golding F, Lu M, Miller SG, Molina K, Natarajan S, Taylor CL, Trachtenberg F, Colan SD. Reproducibility of Left Ventricular Dimension Versus Area Versus Volume Measurements in Pediatric Patients With Dilated Cardiomyopathy. Circulation. Cardiovascular imaging 10(11), Nov 2017.
- Hatch-Stein J, Kelly A, Natarajan S, Dorfman A, Meyers KE. Arterial Stiffness Measured by Pulse Wave Analysis and EndoPAT Is Increased in Young Women with Turner Syndrome. Pediatric Academic Societies Meeting May 2016 Notes: Platform Presentation for session on Hypertension—Update on Research.
- Natarajan S, Cohen MS. Ventricular Septal Defects. Echocardiography in Pediatric and Congenital Heart Disease: From Fetus to Adult 2nd Edition. Lai WW, Mertens LL, Cohen MS and Geva T (eds.). Wiley-Blackwell, Page: 215-230, 2016.
- Patel JK, Glatz AC, Ghosh RM, Jones SM, Natarajan S, Ravishankar C, Mascio CE, Spray TL, Cohen MS. Intramural Ventricular Septal Defect Is a Distinct Clinical Entity Associated With Postoperative Morbidity in Children After Repair of Conotruncal Anomalies. Circulation 132(15): 1387-94, Oct 2015.
- Channing A, Szwast A, Natarajan S, Degenhardt K, Tian T, Rychik J. Maternal Hyperoxygenation Improves Left Heart Filling In The Fetus With Atrial Septal Aneurysm Causing Impediment To Left Ventricular Inflow. Ultrasound Obstet Gynecol 45(6): 664-9, Jun 2015.
Dr. O’Byrne is an interventional cardiologist. His research focuses on improving outcomes in patients with congenital and acquired heart disease. This combines use of large observational datasets to assess quality of care and practice variation between hospitals, comparative effectiveness research, and patient-centered outcomes (e.g. health related quality of life) of patients undergoing cardiac procedures and their families.
- O’Byrne ML, Glatz AC, Shinohara RT, Jayaram N, Gillespie MJ, Dori Y, Rome JJ, Kawut S. 2015. Effect of center catheterization volume on risk of catastrophic adverse event after cardiac catheterization in children. Am Heart J, 169(6): 823-832.
- O’Byrne ML, Glatz AC, Hanna BD, Shinohara RT, Gillespie MJ, Dori Y, Rome JJ, Kawut SM. 2015. Predictors of catastrophic adverse outcomes in children with pulmonary hypertension undergoing cardiac catheterization. J Am Coll Cardiol, 66(11): 1261-1269.3.
- O’Byrne ML, Gillespie MJ, Shinohara RT, Dori Y, Rome JJ, Glatz AC. 2016. Cost comparison of Transcatheter and Operative Pulmonary Valve Replacement (from the Pediatric Health Information Systems Database). Am J Cardiol, 117(1): 121-126.
- O’Byrne ML, Kim S, Hornik CP, Yerokun BA, Matsouaka RA, Jacobs JP, Jacobs ML, Jonas RA. 2017. Effect of Obesity and Underweight Status on Perioperative Outcomes of Congenital Heart Operations in Children, Adolescents, and Young Adults: An Analysis of Data from the Society of Thoracic Surgeons Database. Circulation, 136(8): 704-718.
- O’Byrne ML, Shinohara RT, Grant EK, Kanter JP, Gillespie MJ, Dori Y, Rome JJ, Glatz AC. 2017. Increasing Propensity to Pursue Operative Closure of Atrial Septal Defects Following Changes in the Instructions for Use of Amplatzer Septal Occluder Device: An Observational Study Using Data From the Pediatric Health Information Systems Database. Am Heart J, 192:85-97.
- O’Byrne ML, Kennedy KF, Berger JT, Kanter JP, Glatz AC. 2018. Risk factors for major early adverse events related to cardiac catheterization in children and young adults with pulmonary hypertension: An analysis of data from the Improving Adult and Congenital Treatment® (IMPACT®) Registry. J Am Heart Assoc, 7(5). pii: e008142.
- Glatz AC, Kennedy KF, Rome JJ, O’Byrne ML. 2018. Variations in practice patterns and consistency with published guidelines for balloon aortic and pulmonary valvuloplasty: An analysis of data from the IMPACT® Registry. JACC Cardiovasc Intervent, 1(6):529-538.
Dr. O’Connor is interested in immunology (PRAs) and healthcare utilization the heart failure and transplant patient population. Representative publications include the following:
- Wittlieb-Weber CA, Lin KY, Zaoutis TE, O'Connor MJ, Gerald K, Paridon SM, Shaddy RE, Rossano JW. Pediatric versus adult cardiomyopathy and heart failure-related hospitalizations: a value-based analysis. J Card Fail 21: 76-82, 2015.
- Nandi D, Lin KY, O'Connor MJ, Elci OU, Kim JJ, Decker JA, Price JF, Zafar F, Morales DL, Denfield SW, Dreyer WJ, Jefferies JL, Rossano JW. Hospital charges for pediatric heart failure-related hospitalizations from 2000 to 2009. Pediatr Cardiol December 2015 Notes: epub ahead of print.
- O'Connor MJ Keeshan BC, Lin KY, Monos D, Lind C, Paridon SM, Mascio CE, Shaddy RE, Rossano JW. Changes in the methodology of pre-heart transplant human leukocyte antibody assessment: an analysis of the United Network for Organ Sharing database. Clin Transplant 29(9): 842-50, Sept 2015
- O'Connor MJ, Harville TO, Rhodes-Clark B, Pye SE, Knecht KR, Imamura M, Frazier EA, Morrow WR. Quantification, identification, and relevance of anti-human leukocyte antibodies formed in association with the Berlin Heart ventricular assist device in children. Transplantation 95: 1542-1547, 2013
- O'Connor MJ, Lind C, Tang X, Gossett JC, Weber J, Monos D, Shaddy RE. Persistence of anti-human leukocyte antibodies in congenital heart disease late following surgery utilizing allografts and whole blood. J Heart Lung Transplant 4(32): 390-7, Apr 2013.
Dr. Paridon is medical director of the exercise physiology laboratory at the Children’s hospital of Philadelphia. In this capacity, he has directed clinical research in the laboratory for the past 20 years. The laboratory is the busiest clinical pediatric exercise laboratory in the nation and as such offers unique research opportunities due to its large volume. The lab is currently hosting multiple clinical research studies funded on local, regional, and national levels. Dr. Paridon is one of the co-primary investigators for the Pediatric Heart Network. This is a multi-center consortium funded by NHLBI through a 5-year U-23 grant for the purpose of promoting multi-center clinical trials for novel therapies in the treatment of congenital heart disease.
- Lacro RV, Dietz HC, Wruck LM, Bradley TJ, Colan SD, Devereux RB, Klein GL, Li JS, Minich LL, Paridon SM, Pearson GD, Printz BF, Pyeritz RE, Radojewski E, Roman MJ, Saul JP, Stylianou MP, Mahony L. Rationale and design of a randomized clinical trial of beta-blocker therapy (atenolol) versus angiotensin II receptor blocker therapy (losartan) in individuals with Marfan syndrome. American heart journal 154(4): 624-31, Oct 2007.
- Anderson PA, Sleeper LA, Mahony L, Colan SD, Atz AM, Breitbart RE, Gersony WM, MD Gallagher D, Geva T, MD Margossian R, McCrindle BW, MD, Paridon SM, Schwartz M, Stylianou M, Williams RV, Clar BJ. Contemporary Outcomes after the Fontan Procedure: A Pediatric Heart Network Multicenter Study. J of Amer Coll Card 8; 52(2): 85-98, July 2008.
- Paridon SM, Mitchell PD, Colan SD, Williams RV, Blaufox A, Li JS, Margossian R, Mital S, Russell J, Rhodes J. A cross-sectional study of exercise performance during the first 2 decades of life after the Fontan operation. Journal of the American College of Cardiology 52(2): 99-107, Jul 2008.
- McCrindle BW, Zak V, Sleeper LA, Paridon SM, Colan SD, Geva T, Mahony L, Li JS, Breitbart RE, Margossian R, Williams RV, Gersony WM, Atz AM. Laboratory measures of exercise capacity and ventricular characteristics and function are weakly associated with functional health status after Fontan procedure. Circulation 121(1): 34-42, Jan 2010.
- Goldberg DJ, French B, McBride MG, Marino BS, Mirarchi N, Hanna BD, Wernovsky G, Paridon SM, Rychik J. Impact of oral sildenafil on exercise performance in children and young adults after the Fontan operation: a randomized, double-blind, placebo-controlled, crossover trial. Circulation 123(11): 1185-93, Mar 2011.
Dr. Ravishankar’s research has focused on postoperative outcomes after pediatric cardiac surgery, especially for single ventricle heart defects. She has also maintained an interest in the role of mechanical circulatory support in children.
- Ohye RG, Sleeper LA, Mahony L, Newburger JW, Pearson GD, Lu M, Goldberg CS, Tabbutt S, Frommelt PC, Ghanayem NS, Laussen PC, Rhodes JF, Lewis AB, Mital S, Ravishankar C, Williams IA, Dunbar-Masterson C, Atz AM, Colan S, Minich LL, Pizarro C, Kanter KR, Jaggers J, Jacobs JP, Krawczeski CD, Pike N, McCrindle BW, Virzi L, Gaynor JW; Pediatric Heart Network Investigators. Comparison of shunt types in the Norwood procedure for single-ventricle lesions. N Engl J Med. 2010; 362(21):1980-92. PMID: 20505177.
- Ravishankar C, Gerstenberger E, Sleeper LA, Atz AM, Affolter JT, Bradley TJ, Gaynor JW, Goldstein BH, Henderson HT, Jacobs JP, Lewis AB, Dunbar-Masterson C, Menon SC, Pemberton VL, Petit CJ, Pike NA, Pizarro C, Schumacher KR, Williams IA, Newburger JW; Pediatric Heart Network Investigators. Factors affecting Fontan length of stay: Results from the Single Ventricle Reconstruction trial. J Thorac Cardiovasc Surg. 2015; 151(3): 669-75. PMID: 26519244.
- Burch PT, Gerstenberger E, Ravishankar C, Hehir DA, Davies RR, Colan SD, Sleeper LA, Newburger JW, Clabby ML, Williams IA, Li JS, Uzark K, Cooper DS, Lambert LM, Pemberton VL, Pike NA, Anderson JB, Dunbar-Masterson C, Khaikin S, Zyblewski SC, Minich LL; Pediatric Heart Network Investigators. Longitudinal assessment of growth in hypoplastic left heart syndrome: results from the single ventricle reconstruction trial. J Am Heart Assoc. 2014:23; 3(3):e000079.PMID: 24958780.
- Medoff-Cooper B, Irving SY, Hanlon AL, Golfenshtein N, Radcliffe J, Stallings VA, Marino BS, Ravishankar C. The Association among Feeding Mode, Growth, and Developmental Outcomes in Infants with Complex Congenital Heart Disease at 6 and 12 Months of Age. J Pediatr. 2016; 169:154-159. PMID: 26585995.
- Mansfield RT, Lin KY, Zaoutis T, Mott AR, Mohamad Z, Luan X, Kaufman BD, Ravishankar C, Gaynor JW, Shaddy RE, Rossano JW. The Use of Pediatric Ventricular Assist Devices in Children's Hospitals from 2000 to 2010: Morbidity, Mortality, and Hospital Charges. Pediatr Crit Care Med. 2015 Jul; 16(6):522-8. PMID: 25850863.
Dr. Rome’s research efforts have been on evaluating efficacy and applications of new devices and critical assessment of clinical impact and limitations of interventional techniques. He also focuses on integration of transcatheter therapy for patients with complex congenital defects and collaborates to develop methods and systems for allowing large scale assessment of outcomes after treatments with congenital heart disease.
- Schoonbeek RC, Takebayashi S, Aoki C, Shimaoka T, Harris MA, Fu GL, Kim TS, Dori Y, McGarvey J, Litt H, Bouma W, Zsido G 2nd, Glatz AC, Rome JJ, Gorman RC, Gorman JH 3rd, Gillespie MJ. Implantation of the Medtronic Harmony Transcatheter Pulmonary Valve Improves Right Ventricular Size and Function in an Ovine Model of Postoperative Chronic Pulmonary Insufficiency. Circ Cardiovasc Interv. 2016 Oct;9(10). pii: e003920. PMID: 27662847
- O'Byrne ML, Gillespie MJ, Kennedy KF, Dori Y, Rome JJ, Glatz AC. The influence of deficient retro-aortic rim on technical success and early adverse events following device closure of secundum atrial septal defects: An Analysis of the IMPACT Registry®. Catheter Cardiovasc Interv. 2016 May 18. doi: 10.1002/ccd.26585. [Epub ahead of print] PMID: 27189502
- O'Byrne ML, Rome JJ, Kawut SJ. Reply: The Need for Comprehensive Cardiac Catheterization in Children With Pulmonary Hypertension: To "Cath" or Not in Pediatric Pulmonary Hypertension? J Am Coll Cardiol. 2016 Mar 1;67(8):1011-2. doi: 10.1016/j.jacc.2015.12.021. PMID: 26916496
- Dori Y, Keller MS, Rome JJ, Gillespie MJ, Glatz AC, Dodds K, Goldberg DJ, Goldfarb S, Rychik J, Itkin M. Percutaneous Lymphatic Embolization of Abnormal Pulmonary Lymphatic Flow as Treatment of Plastic Bronchitis in Patients With Congenital Heart Disease. Circulation. 2016 Mar 22;133(12):1160-70. doi: 10.1161/CIRCULATIONAHA.115.019710. Epub 2016 Feb 10. PMID: 26864093
- Batlivala SP, Magill D, Felice MA, Jones V, Dori Y, Gillespie MJ, Rome JJ, Glatz AC. THE EFFECT OF RADIATION SHIELDS ON OPERATOR EXPOSURE DURING CONGENITAL CARDIAC CATHETERISATION. Radiat Prot Dosimetry. 2015 Nov 17. pii: ncv471. [Epub ahead of print] PMID: 26582175
Dr. Rossano is interested in evaluating the treatment and outcomes of pediatric cardiomyopathy, heart failure and transplantation.
- Naim MY, Rossano JW. Decreasing neurologic injury in children after hypoxic injury: Is transcutaneous doppler the way to go? Resuscitation. 2018 May;126:A9-A10. doi: 10.1016/j.resuscitation.2018.03.002. Epub 2018 Mar 7. PubMed PMID: 29524478.
- O'Connor MJ, Miller K, Shaddy RE, Lin KY, Hanna BD, Ravishankar C, Rossano JW. Disopyramide use in infants and children with hypertrophic cardiomyopathy. Cardiol Young. 2018 Apr;28(4):530-535. doi: 10.1017/S1047951117002384. PubMed PMID: 29513203.
- Broda CR, Cabrera AG, Rossano JW, Jefferies JL, Towbin JA, Chin C, Shamszad P. Cardiac transplantation in children with Down syndrome, Turner syndrome, and other chromosomal anomalies: A multi-institutional outcomes analysis. J Heart Lung Transplant. 2018 Jan 31. pii: S1053-2498(18)31297-X. doi: 10.1016/j.healun.2018.01.1296. [Epub ahead of print] PubMed PMID: 29449075.
- Castleberry CD, Jefferies JL, Shi L, Wilkinson JD, Towbin JA, Harrison RW, Rossano JW, Pahl E, Lee TM, Addonizio LJ, Everitt MD, Godown J, Mahgerefteh J, Rusconi P, Canter CE, Colan SD, Kantor PF, Razoky H, Lipshultz SE, Miller TL. No Obesity Paradox in Pediatric Patients With Dilated Cardiomyopathy. JACC Heart Fail. 2018 Mar;6(3):222-230. doi: 10.1016/j.jchf.2017.11.015. Epub 2018 Feb 7. PubMed PMID: 29428438; PubMed Central PMCID: PMC5834393.
- Shaddy RE, George AT, Jaecklin T, Lochlainn EN, Thakur L, Agrawal R, Solar-Yohay S, Chen F, Rossano JW, Severin T, Burch M. Systematic Literature Review on the Incidence and Prevalence of Heart Failure in Children and Adolescents. Pediatr Cardiol. 2018 Mar;39(3):415-436. doi: 10.1007/s00246-017-1787-2. Epub 2017 Dec 20. Review. PubMed PMID: 29260263; PubMed Central PMCID: PMC5829104.
- Mejia EJ, O'Connor MJ, Lin KY, Song L, Griffis H, Mascio CE, Shamszad P, Donoghue A, Ravishankar C, Shaddy RE, Rossano JW. Characteristics and Outcomes of Pediatric Heart Failure-Related Emergency Department Visits in the United States: A Population-Based Study. J Pediatr. 2018 Feb;193:114-118.e3. doi: 10.1016/j.jpeds.2017.10.009. Epub 2017 Dec 6. PubMed PMID: 29221691.
- Mansfield RT, Lin KY, Zaoutis T, Mott AR, Mohamad Z, Luan X, Kaufman BD, Ravishankar C, Gaynor JW, Shaddy RE, Rossano JW. The Use of Pediatric Ventricular Assist Devices in Children's Hospitals From 2000 to 2010: Morbidity, Mortality, and Hospital Charges. Pediatr Crit Care Med. 2015 Jul;16(6):522-8. doi: 10.1097/PCC.0000000000000401. PubMed PMID: 25850863.
As leader of the Single Ventricle Survivorship Clinic, Dr. Rychik is focused on studying the long-term effects of current management strategies for single ventricle conditions, in the interest of improving therapies.
- Sharma S, Ruebner RL, Furth SL, Dodds KM, Rychik J, Goldberg DJ. Assessment of Kidney Function in Survivors Following Fontan Palliation. Congenit Heart Dis. 2016 Apr 22. doi: 10.1111/chd.12358. [Epub ahead of print].
- Liu X, He Y, Tian Z, Rychik J. Persistent Left Superior Vena Cava Connected to the Coronary Sinus in the Fetus: Effects on Cardiac Structure and Flow Dynamics. Pediatr Cardiol. 2016 Apr 15. [Epub ahead of print]
- Dori Y, Keller MS, Rome JJ, Gillespie MJ, Glatz AC, Dodds K, Goldberg DJ, Goldfarb S, Rychik J, Itkin M. Percutaneous lymphatic embolization of abnormal pulmonary lymphatic flow as treatment of plastic bronchitis in patients with congenital heart disease. Circulation. 2016 Feb 10. pii: CIRCULATIONAHA.115.019710. [Epub ahead of print]
- Morsheimer MM, Rychik J, Forbes L, Dodds K, Goldberg DJ, Sullivan K, Heimall JR. Risk factors and clinical significance of lymphopenia in survivors of the Fontan procedure for single ventricle congenital cardiac disease. J Allergy Clin Immunol Pract 2016 Feb 18. pii: S2213-2198(16)00007-6. doi: 10.1016/j.jaip.2015.11.034. [Epub ahead of print]
- Saul D, Degenhardt K, Iyoob SD, Surrey LF, Johnson AM, Johnson MP, Rychik J, Victoria T. Hypoplastic left heart syndrome and the nutmeg lung pattern in utero: a cause and effect relationship pr prognostic indicator? Pediatr Radiol 2015 [Epub ahead of print]
Dr. Shah is an attending cardiologist in the Cardiac Center at Children's Hospital of Philadelphia with special interest in pacemakers, ICD implantation and cardiac therapy. Her research expertise includes catheter ablation, adult congenital heart disease, congenital heart disease, genotype-phenotype correlation, Cardiac Channelopathy, pacemakers, implantable cardioverter defibrillators, Wolff Parkinson White Syndrome, and Endovascular Lead Extraction.
- Dubin AM, Berul CI, Bevilacqua LM, Collins KK, Etheride SP, Feinrich AL, Friedman RA, Hamilton RM, Schaffer MS, Shah MJ, Silka MJ, VanHare GF, Kertesz NJ. The use of implantable cardioverter defibrillators in pediatric patients and patients with complex congenital heart disease awaiting heart transplantation. Journal of Cardiac Failure 9(5): 375-379, October 2003.
- Cengiz P, Shah MJ. Recognition of fascicular tachycardia in the emergency room. Pediatr Emergency Care 19(4), 2003.
- Rossano J, Bloemers B, Sreeram N, Balaji S, Shah MJ. Efficacy of implantable loop recorders in symptom rhythm correlation in young patients with syncope and palpitations. Pediatrics 112(3), 2003.
- Pinto N, Jones TK, Dyamenahalli U, Shah MJ*. Temporary transvenous pacing with an active fixation bipolar lead in children: A preliminary report. Paciing and Clinical Electrophysiology 26(7): 1519-1522, July 2003 Notes: *Senior author , responsible for study design, analysis and manuscript preparation.
- Aziz P, Shah MJ*. The Utility of a 15-Lead Electrocardiogram in Determining the Laterality of an Accessory Pathway in Pediatric Patients with Wolff-Parkinson-White Syndrome The Journal of Innovations in Cardiac Rhythm Management 3, September 2012 Notes: *senior author and research mentor.
Dr. Stachelek's research has been concerned with biocompatibility mechanisms and devising therapeutic solutions to polymeric biomaterials. In particular, his work examines the cellular and molecular response to CD47 modified surfaces such as those used as blood conduits for cardiovascular devices. He has published on the novel mechanistic roles that CD47 plays in mediating inflammatory cell interactions with polymeric biomaterials and cardiovascular devices which were the first to characterize the platelet response to CD47 modified surfaces. The overall goal is to characterize the anti-inflammatory properties of CD47 functionalized polyurethane and understanding the CD47 associated signaling mechanisms that mediate inflammatory cell activation.
- Slee JB, Alferiev IS, Nagaswami C, Weisel JW, Levy RJ, Fishbein I, Stachelek SJ. Enhanced biocompatibility of CD47-functionalized vascular stents. Biomaterials. 2016 May; 87:82-92.
- Tengood JE, Levy RJ, Stachelek SJ. The use of CD47-modified biomaterials to mitigate the immune response. Exp Biol Med (Maywood). 2016 May; 241(10):1033-41.
- Slee JB, Christian AJ, Levy RJ, Stachelek SJ. Addressing the Inflammatory Response to Clinically Relevant Polymers by Manipulating the Host Response Using ITIM Domain-Containing Receptors. Polymers (Basel). 2014 Sep 29; 6(10):2526-2551.
- Slee JB, Alferiev IS, Levy RJ, Stachelek SJ. The use of the ex vivo Chandler Loop Apparatus to assess the biocompatibility of modified polymeric blood conduits. J Vis Exp. 2014 Aug 20;(90).
- Finley MJ, Clark KA, Alferiev IS, Levy RJ, Stachelek SJ. Intracellular signaling mechanisms associated with CD47 modified surfaces. Biomaterials. 2013Nov; 34(34):8640-9.
Dr. Szwast is a board-certified attending cardiologist at CHOP with the Cardiac Center and Fetal Heart Program.
- Goldberg DJ, French B, Szwast A, MD, McBride MG, Paridon SM, Rychik J, Mercer-Rosa L. Tricuspid annular plane systolic excursion correlates with exercise capacity in a cohort of patients with hypoplastic left heart syndrome after Fontan operation. Echocardiography. Wiley Page: 1-6, 2016.
- Hahn, E, Szwast A, Cnota J 2nd, Levine JC, Fifer CH, Jaeggi E, Andrews H, Williams IA. Association of fetal growth, cerebral blood flow, and neurodevelopmental outcomes in single ventricle fetuses. Ultrasound Obstet Gynecol. 47(4): 460-5. April 2016.
- Rychik J, Cohen D, Tran KM, Szwast A, Natarajan SS, Johnson MP, Moldenhauser JS, Khalek N, Martinez-Poyer J, Flake AW, Hedrick HL, Adzick NS. The Role of Echocardiography in the Intraoperative Management of the Fetus Undergoing Myelomeningocele Repair. Fetal Diagn Ther. 37(3): 172-8, Jul 2015
- Channing A, Szwast A, Natarajan S, Degenhardt K, Tian Z, Rychik J. Maternal Hyperoxygenation Improves Left Heart Filling In The Fetus With Atrial Septal Aneurysm Causing Impediment To Left Ventricular Inflow Ultrasound Obstet Gynecol. 45(6): 664-9, Jun 2015.
- Margossian R, Chen S, Sleeper LA, Tani LY, Shirali G, Golding F, Selamet Tierney ES, Altmann K, Campell MJ, Szwast A, Sharkey A, Radojewski E, Colan SD; Pediatric Heart Network Investigators. The Reproducibility and Absolute Values of Echocardiographic Measurements of Left Ventricular Size and Function in Children Are Algorithm Dependent. J Am Soc Echocardiogr. 28(5): 549-558, May 2015
Dr. Vetter is a pediatric electrophysiologist whose research interests are related to the prevention of sudden cardiac death (SCD), both in the congenital heart population and in those with undiagnosed conditions leading to SCD. She is interested in studying both primary and secondary prevention to determine efficacy, best practices, and cost-effectiveness. She collaborates in SCD genetics research in a national consortium. She has access to local and national databases to evaluate outcomes of ECG screening, SCD genomic testing, child death reviews, and out of hospital cardiac arrest. With Masters-level training in public health and health policy, she is studying the impact of legislation on SCD and evaluating public health disparities and advocacy efforts at the state and national levels. She collaborates with the Department of Psychology at PCOM on quality of life studies in patients with long QT syndrome.
- Vetter VL, Haley DM, Dugan NP, Iyer VR, Shults J. Innovative cardiopulmonary resuscitation and automated external defibrillator programs in schools: Results from the Student Program for Olympic Resuscitation Training in Schools (SPORTS) study. Resuscitation. 2016 Jul;104:46-52
- Li MH, Abrudan JL, Dulik MC, Sasson A, Brunton J, Jayaraman V, Dugan N, Haley D, Rajagopalan R, Biswas S, Sarmady M, DeChene ET, Deardorff MA, Wilkens A, Noon SE, Scarano MI, Santani AB, White PS, Pennington J, Conlin LK, Spinner NB, Krantz ID, Vetter VL. Utility and limitations of exome sequencing as a genetic diagnostic tool for conditions associated with pediatric sudden cardiac arrest/sudden cardiac death. Hum Genomics. 2015 Jul 19;9:15.
- Vetter VL, Covington TM, Dugan NP, Haley DM, Dykstra H, Overpeck M, Iyer VR, Shults. Cardiovascular deaths in children: general overview from the National Center for the Review and Prevention of Child Deaths. Am Heart J. 2015 Mar;169(3):426-437.e23.
- Vetter VL. Electrocardiographic screening of all infants, children, and teenagers should be performed. Circulation. 2014 Aug 19;130(8):688-97;
- Sharma S, Drezner JA, Baggish A, Papadakis M, Wilson MG, Prutkin JM, La Gerche A, Ackerman MJ, Borjesson M, Salerno JC, Asif IM, Owens DS, Chung EH, Emery MS, Froelicher VF, Heidbuchel H, Adamuz C, Asplund CA, Cohen G, Harmon KG, Marek JC, Molossi S, Niebauer J, Pelto HF, Perez MV, Riding NR, Saarel T, Schmied CM, Shipon DM, Stein R, Vetter VL, Pelliccia A, Corrado D. International Recommendations for Electrocardiographic Interpretation in Athletes. J Am Coll Cardiol. 2017 Feb 28;69(8):1057-1075.
- Anderson BR, McElligott S, Polsky D, Vetter VL. Electrocardiographic screening for hypertrophic cardiomyopathy and long QT syndrome: the drivers of cost-effectiveness for the prevention of sudden cardiac death. Pediatr Cardiol. 2014 Feb;35(2):323-31.
- Sharma S, Estes NA 3rd, Vetter VL, Corrado D. Clinical decisions. Cardiac screening before participation in sports. N Engl J Med. 2013 Nov 21;369(21):2049-53.
The pediatric cardiology fellowship at Children’s Hospital of Philadelphia is one of the nation’s oldest, largest and most well-established pediatric subspecialty training programs, with continuous ACGME accreditation since May 8, 1965.
The goals of the program are:
- To produce well-rounded pediatric cardiologists who are competent clinicians in all subspecialty areas of practice
- To develop physician scientists whose published research and investigative activity will make significant contributions to the advancement of knowledge in the field
- To create innovators and leaders in academic medicine whose teaching and administrative skills will be an asset to the institutions they serve
The mission of the program is to prepare trainees for careers in academic pediatric cardiology. We accomplish this through a three (3)-year program that balances extensive clinical exposure to a broad spectrum of congenital and acquired heart defects and cardiac arrhythmias with time spent in active clinical or basic research. Fellows accept progressively more responsibility in each year of the training program. Fellows are encouraged to complete a fourth year of training in order to extend their research experience or develop specialized clinical expertise in areas such as interventional catheterization, electrophysiology, non-invasive imaging, cardiac intensive care, heart failure/transplant and pulmonary hypertension.
Fellows’ clinical and academic progress is monitored via monthly rotation evaluations as well as a semi-annual review process supervised by our Clinical Competency Committee (CCC), which measures Fellows’ professional growth and achievement of pediatric subspecialty training milestones in accordance with the following six (6) ACGME-defined core competency areas:
- Patient care
- Medical knowledge
- Practice-based learning
- Interpersonal skills and communication
- Systems-based practice
While the outcomes-based core curriculum is intentionally highly structured and rigorous, Fellows take an active role in shaping their own education through formal program evaluation and class representative participation on the Program Evaluation Committee (PEC). Fellows are also given the opportunity to provide informal feedback to the program director during Fellows’ meetings and to other teaching faculty, including medical directors, when they are on service or available to meet. Changes to the program or its stated goals are amply discussed and reviewed prior to implementation.
To further enhance our trainees’ opportunities for success and assist them with both navigating the transition from general to subspecialty practice and meeting their professional goals and academic requirements, each trainee is paired with a personal faculty mentor and a research faculty mentor. Mentors are selected for each mentee based on “model” career paths, goals and fields of interest. Additionally, program leadership is always available on an ad hoc basis for resources and support.
The first year of the program is 90 percent clinical in focus, with an emphasis on training fellows in the care of cardiac patients in the inpatient setting as well as in the use of various imaging modalities and other laboratory studies in the pediatric cardiologist’s repertoire.
Fellows will spend two months on the inpatient (CCU) service gaining exposure to a variety of congenital and acquired heart defects including rheumatic fever, Kawasaki disease, collagen vascular disease, bacterial endocarditis, and pre- and post-operative cardiac transplantation cases. Fellows will spend two months in the noninvasive imaging laboratories and two months in the cardiac catheterization laboratories, developing an understanding of major diagnostic tools and approaches to treatment.
Two (2) months in the cardiac intensive care unit (CICU) provide first-year fellows experience with critically ill patients of all ages, particularly those undergoing various forms and stages of heart surgery and palliation. Fellows assigned to the CICU will obtain and provide consultations with a diverse team of front line caregivers — cardiothoracic surgeons, cardiac anesthesiologists, critical care physicians, neurologists, geneticists, nutritionists and a highly specialized nursing team — to optimize patient-and-family-centered care.
Finally, in the first year of training, the program features a unique one (1)-month experience in cardiac pathology based on the morphologic method and segmental approach to the diagnosis of congenital heart disease. The outcomes-based curriculum provides trainees with a detailed knowledge of three-dimensional cardiac anatomy so that they will be able to utilize imaging tools, interpret studies and communicate precise diagnostic information effectively with colleagues and patients/families in their care.
The second year of fellowship incorporates additional time on the non-invasive and catheterization services (approximately one (1) month of each) with at least two (2) weeks’ exposure to the following subspecialty areas:
- Adult congenital heart disease
- Cardiac magnetic resonance imaging
- Exercise physiology
- Heart failure/transplant
- Pulmonary hypertension
These experiences help the fellow consider particular clinical interests and strengths and explore possibilities for advanced training.
In addition, as the second year fellow now has a foundation in the basics of clinical cardiology, five to six total months of research time will be set aside for research. Fellows working in a basic science laboratory may arrange their schedule for more contiguous blocks; fellows doing clinical research may opt to interrupt or alternate research blocks with some clinical rotations.
In the third year of fellowship, trainees will complete the formal research block (and the required scholarly work product for professional board exam eligibility) and resume clinical work in the CICU and various cardiology clinical laboratories. They will participate in the consult service, and in some cases, will participate on the CCU in a “pretending” role.
“Senior” fellows are expected to assume a greater degree of responsibility on these rotations, often taking on certain teaching responsibilities to junior fellows and residents that are commensurate with their experience, as determined and supervised by attending faculty.
Note: Many fellows opt to do additional “Consult” time in the second or third year, to continue skills-based learning in the inpatient setting that will enhance and further their progress toward the goal of becoming independent practitioners.
This rotation provides the opportunity to work closely in tandem with the cardiology attending to handle internal and external emergency department referrals, requests from other pediatric subspecialty inpatient units, and efficient management and use of hospital imaging and testing laboratory resources. The fellows’ skills in interpersonal communication, professionalism and systems-based practice are highlighted such that the service attendings can provide valuable, often real-time feedback regarding a fellow’s knowledge base and readiness for practice.
With a similar focus in mind, fellows are responsible for attending their weekly half-day continuity clinics throughout their three years of training with the exception of blocks of CCU, CICU, night float and vacation. In this manner, fellows learn effective time management from balancing patient care responsibilities with other aspects of their academic and clinical workload.
Adult congenital heart disease (ACHD)
Medical Director — Yuli Kim, MD
The Philadelphia Adult Congenital Heart Center is a joint venture between CHOP and the Hospital of the University of Pennsylvania. During the ACHD rotation, the fellow will gain the knowledge, skills and attitudes necessary to provide appropriate, effective and compassionate care to adults with congenital heart disease. Fellows are required to learn and review methods for taking an adult cardiac history and physical examination, and to competently make informed diagnostic and therapeutic decisions based on patient information, current scientific evidence and clinical judgment.
Under the supervision of the ACHD attending faculty, the fellow will outline management and treatment plans that incorporate understanding of the problems commonly seen in adults with congenital heart disease.
Fellows are expected to demonstrate knowledge of the natural and unnatural history of congenital heart disease and the established and evolving biomedical, clinical, epidemiological and social-behavioral science related to this population. They should be able to provide effective counseling with regard to medical issues such as pregnancy and contraception. Fellows should be aware of the unique psychosocial needs that must be met for these patients in transitioning from pediatric to adult care, and participate in care coordination that reflects understanding of the capacity and limitations of the healthcare system relevant to their clinical specialty.
Cardiac care unit (CCU)
Medical Director — Susan Schachtner, MD
The Cardiac Care Unit (CCU) rotation is designed for the fellow to develop expertise in the acute and chronic medical management of infants and children diagnosed with congenital and acquired heart disease. While on this rotation, fellows will learn how to interpret various imaging and other laboratory modalities for diagnosis and management, and when to refer patients for cardiac surgery.
Fellows participate in daily morning rounds with the pediatric residents and cardiology attending, reviewing physical findings, laboratory results and management plans for each patient. The fellow supervises the management of medical inpatients on the service (admissions and discharges), and teaches basic cardiology topics and focused histories to the residents.
Fellows spend two separate months in the CCU at different stages in the first year so they can build on the understanding acquired in their first rotation with additional skills and knowledge gleaned from other subspecialties later in the year. Service coverage rotates weekly; fellows may work with three to five different supervising faculty in a given four-week period, which provides ample opportunity for learning, mentoring, clinical skills development and feedback.
Cardiac intensive care unit (CICU)
Medical Director — Andrew Costarino, MD
Critically ill medical and surgical patients with cardiovascular disease are cared for in the Cardiac Intensive Care Unit (CICU) by a dedicated team of cardiologists and critical care specialists including cardiothoracic surgeons. During this rotation fellows become familiar with all aspects of care for critically ill cardiac patients including:
- Airway management and mechanical ventilation
- Preoperative stabilization
- Cardiopulmonary bypass and its sequelae
- Technical aspects of cardiac surgery and postoperative management
Cardiology fellows work closely with critical care, cardiac anesthesia and cardiac surgery fellows in the management of all patients in the CICU, including pre- and post-operative care and participation in invasive procedures. Responsibilities include:
- Participation in morning and evening rounds with the CICU team
- Participation in night call coverage
- Preparation of weekly pre-surgical conference and monthly CICU mortality and morbidity conference
- Coordination of all appropriate pre- and post-operative testing (e.g. electrocardiograms, 24-hour ambulatory monitoring, echocardiograms and cardiac catheterization
Medical Director —Joshua Blinder, MD
Faculty — Julie Brothers, MD, Aaron Dorfman, MD, Stanford Ewing, MD, Christine Falkensammer, MD, Paul Farrell, MD, Matthew Harris, MD, Alexa Hogarty, MD, Katharine Levinson, MD, Paul Stephens, MD, Kevin Whitehead, MD
The goal of the consult service rotation, undertaken in the fellow’s second and/or third year, is to ensure that the fellow fully develops the knowledge, skills and attitudes required to provide cardiology consultation service in the evaluation and treatment of infants, children, adolescents and adults with acquired and congenital cardiac disease.
The tasks of appropriately utilizing information technology to optimize patient care, providing sensitive counseling to families, and collaborating with other members of the allied health team to refer patients from other units and specialty disciplines for further cardiac screening create a focus on practice-based learning.
The fellow is challenged to perform honest self-assessment of strengths and limitations that will foster professional growth and further expand competency and understanding of systems-based practice. Viewed appropriately in its larger context, the consult service is a formative benchmark of the fellow’s maturity, fund of knowledge, and readiness to become an independent practitioner.
Medical Director — Maully Shah, MD
Approximately 200 procedures are performed annually in the Cardiac Electrophysiology Laboratory. Fellows rotate through this lab twice during their second or third year, learning how to use electrophysiologic information and technology to diagnose and treat various types of cardiac arrhythmia. Fellows gain experience with:
- Electrocardiographic interpretation of complex arrhythmias on standard electrocardiograms
- 24-hour ambulatory (Holter) monitors
- Transtelephonic monitors
- Acute and chronic management of arrhythmia patients
Trainees participate in daily arrhythmia rounds, all outpatient arrhythmia visits, pacemaker clinic, EP consult service, intracardiac electrophysiology studies and operative and catheter ablation procedures.
Interventional cardiology (cardiac catheterization)
Medical Director — Jonathan Rome, MD
Approximately 1,200 diagnostic and therapeutic procedures are performed each year in the Cardiac Catheterization Laboratory. Beginning in the first year of fellowship, trainees are assigned to catheterization laboratory procedures under the guidance of a staff physician. With each successive rotation through the lab, fellows assume more responsibility for performing procedures. At any given time, one or more attendings are available if help is needed or a complication develops. A comprehensive team including cardiac anesthesiologists and CT surgeons may lend assistance in cases of emergency.
Fellows participate in daily pre-catheterization conferences, present and discuss data at weekly post-catheterization conferences, and attend weekly angiogram review sessions. Fellows participate in approximately 150 catheterization procedures during their training.
By completion of fellowship, trainees are able to plan, perform and interpret a complete diagnostic study. For those with special interest in invasive cardiology, there is opportunity to develop skills in therapeutic catheterization during the latter portion of fellowship training.
Medical Director — Michael Quartermain, MD
Faculty — Anirban Banerjee, MD, Meryl S. Cohen, MD, Karl Degenhardt, MD, PhD, Aaron Dorfman, MD, Stanford Ewing, MD, Christine Falkensammer, MD, Mark Fogel, MD,Marie Gleason, MD, David Goldberg, MD, Betsy Goldmuntz, MD, Alexa Hogarty, MD, Matthew Jolley, MD, Laura Mercer-Rosa, MD, Sumekala Nadaraj, MD, Shobha Natarajan, MD, Matthew O’Connor, MD, Jack Rychik, MD, Mohamed Seliem, MD, Paul Stephens, MD, Anita Szwast, MD
During the echocardiography laboratory rotation, fellows acquire the knowledge and skills necessary to correctly perform and interpret transthoracic (TTE), transesophageal (TEE) and fetal echocardiograms. Fellows will participate in a minimum of 300 TTE studies and approximately 100 to 125 (total) TEE and fetal studies on patients ranging in age from neonates to adults.
Fellows will learn to differentiate various technical modalities including M-mode, 2D, Doppler and color flow imaging, conduct proper probe selection, and to correctly identify and describe the function of the echo machine knobs. They will be able to identify the indications for various types of studies and work collaboratively with laboratory staff to build efficiency, improve communications, create quality improvement initiatives and enhance procedural and process workflow.
A weekly didactic echocardiography laboratory conference and daily teaching sessions conducted by faculty and the senior noninvasive imaging fellow(s) provide multiple opportunities for trainees to develop and enhance their technical skills and fund of knowledge. Advanced imaging modalities are also introduced including 3D imaging and deformation imaging.
If the fellows’ proficiency and interest indicate and available funding for additional training can be secured, a fourth year of training is strongly encouraged.
Medical Director — Stephen Paridon, MD
Fellows will learn to competently monitor patients and collect, record and interpret data from exercise studies during their rotation in the Exercise Lab. At completion of the rotation, the fellow should be able to describe the conduct and protocols of a regular exercise and pharmacologic stress test, describe the equipment used, and develop a preliminary or independent interpretation of the study data depending upon the year of training (second and third year, respectively).
Fellows should know basic exercise physiology as it relates to the cardiovascular, pulmonary and musculoskeletal systems, and know the indications and contraindications for exercise testing.
Magnetic resonance imaging
Medical Director — Mark A. Fogel, MD
In the Cardiomagnetic Resonance Imaging Laboratory, fellows are required to observe at least 40 percent of the MRI studies conducted during the rotation. Fellows will:
- Learn to compare and contrast different types of MRIs (e.g. spin echo, cine, magnetic tagging) and be able to list the advantages and limitations of cardiac magnetic resonance as a diagnostic modality.
- Be able to correctly identify cardiac anatomy, interpret cardiac physiology and correctly synthesize diagnoses obtained from magnetic resonance studies. The fellow will be able to concisely and accurately convey pertinent data obtained from MRI at surgical conference.
Medical Director — Matthew O’Connor, MD
The goal of the Cardiomyopathy/Heart Failure/Transplant rotation is that at the end of the fellowship, the fellow has the required knowledge, skills and attitudes to effectively evaluate and initiate management of infants, children and adolescents with cardiomyopathy and heart failure, and patients who have undergone cardiac transplantation. The fellow will:
- Learn to competently obtain a complete history and physical examination for all subgroups within this population and to develop an initial management plan for heart failure and cardiac allograft rejection.
- Participate in new inpatient consults, transplant evaluations, consult follow-ups and inpatient rounds with a focus on compassionate, ethical care of patients, and sensitive, informed communication with families, including counseling regarding non-medical interventions and hospital and community services.
- Enhance his or her fund of knowledge by studying the natural history of cardiomyopathy, the role of genetic testing in cardiomyopathy evaluation, the pathology and pathophysiology of heart failure, post-transplant cardiac physiology, acute and chronic rejection, basic transplant immunology, and medications and interventions for patients with heart failure and post-transplant patients. Attend weekly multi-disciplinary Transplant Rounds, daily morning huddles in the Cardiac Intensive Care Unit and transplant surgical conference in addition to other didactic lectures and rounds in order to enhance understanding of patient advocacy and optimization of care.
Medical Director — Marie Gleason, MD
Each of our 18 categorical first- through third-year fellows is assigned to a half-day Fellows’ outpatient clinic held on a Tuesday, Wednesday or Thursday. These clinics are staffed by two (2) attendings. Each clinic has fellows from all years, and clinic assignments are distributed evenly by class year so that fellows may learn from and collaborate with peers as well as senior faculty and ancillary members of the healthcare team. The rationale is to create a “continuity of care” model wherein the fellow can see a wide range of patient referrals.
We encourage fellows to follow patients with acquired and congenital heart disease throughout their course of treatment — from inpatient unit, emergency department or primary caregiver referral to diagnosis and subsequent medical and/or surgical intervention and post-operative care.
Fellows will learn to perform a thorough cardiac-focused history and physical examination. They will learn to make informed diagnostic and therapeutic decisions, professionally counsel patients and families with cultural competence, awareness and sensitivity, and use information technology competently and efficiently to optimize patient care. Fellows must:
- Demonstrate the ability to investigate and evaluate the care of their patients.
- Locate, appraise and assimilate information from scientific studies.
- Incorporate formative evaluation feedback into their daily practice.
- Conduct constant self-evaluation regarding strengths, deficiencies and limits in their knowledge and expertise.
- Demonstrate a growing understanding of the larger context and system of healthcare and an ability to call effectively on other resources in the best interest of the patient.
Medical Director — Paul Weinberg, MD
Faculty — Meryl Cohen, MD
The ability of the cardiologist to provide precise anatomic diagnosis is essential to effective treatment including surgical intervention for the most complex congenital defects. During the one-month cardiac pathology rotation unique to our training program, the fellow will:
- Learn the segmental approach to cardiac diagnosis and the morphologic method of cardiac description and become acquainted with a wide variety of congenital heart defects.
- Learn the correlation of imaging (echocardiography, angiography, MRI) with a detailed knowledge of three-dimensional pathologic anatomy such that he or she will be able to use and teach others to use these powerful imaging tools effectively in the clinical setting.
- Perform a detailed examination of at least 30 postmortem specimens in the cardiac registry and review during independent study sessions with the director.
- Do a research project and case presentation and attend a weekly dissection conference and pathology conference in addition to all cardiac autopsies.
The Pulmonary Hypertension (PH) Program provides care to children with a wide variety of diagnoses that involve pulmonary vascular pathophysiology. The service averages approximately 20 inpatients on PH-specific therapies daily.
Fellows participating in the care of our patients have the opportunity to learn about the physiology of the failing cardiovascular and pulmonary vascular systems, hemodynamic evaluation, and medical management particular to the care of patients with end-stage heart and/or lung disease. This includes those children with idiopathic PH, congenital heart disease with associated pulmonary vascular disease, cardiomyopathy with severe restrictive physiology, “inoperable” pulmonary vein stenosis/occlusion and right heart failure from PH associated with chronic lung disease.
Fellows are involved in decisions around the evaluation and treatment of pulmonary hypertension with oral, intravenous and subcutaneous therapies and are welcomed in pulmonary hypertension clinic. This collaborative and comprehensive program involves the Divisions of Cardiology, Cardiothoracic Surgery, Cardiac Anesthesiology, Cardiac Critical Care Medicine and Pulmonary Medicine.
Fellows are encouraged to participate in and initiate research projects. The section is active in over two dozen hospital-based, multi-divisional and/or multi-centered research studies, and there is ample opportunity to present at national meetings and author manuscripts. A fourth year fellowship in pulmonary hypertension including advanced clinical and research objectives is offered.
Research opportunities and goals
In an increasingly competitive professional job market, the well-trained pediatric cardiologist should have solid bench research and academic investigative skills in addition to comprehensive clinical knowledge and expertise. The specialist should have detailed knowledge of industry standards for experimental design, data collection and analysis and laboratory techniques.
Our fellowship program’s research curriculum has a clearly outlined sequence of goals and objectives to ensure that each fellow meets the minimum requirements for scholarly activity and a scholarly work product per the American Board of Pediatrics criteria, but may also consider and incorporate graduate and post-graduate scholarship and funding opportunities for advanced specialization as part of training at CHOP (See research activity timeline).
Fellows are encouraged to begin thinking prospectively about their research work in cardiology as early as the fellowship interview/program selection. Fellows can follow up on this brainstorming process when they meet with a clinical faculty mentor early in the first year.
Fellows will receive a review of the research curriculum and expectations in the fall of their first year and work with their clinical faculty mentor to identify a research faculty mentor by the end of the first year.
In the second year, fellows work with the research director and coordinator (with input from their clinical mentor and research mentor) to form a Scholarship Oversight Committee (SOC) consisting of the following members:
- Chair – director of research
- A cardiology faculty member (can be the clinical faculty mentor but not the research faculty mentor)
- A non-cardiology faculty, including specialists from other area research facilities such as the University of Pennsylvania School of Medicine and The Wistar Institute.
The entire committee will meet with the fellow and research mentor two to three times in the second and third year of training to ensure project feasibility, timeliness and efforts toward completion. The SOC will review the fellow’s individual development plan, proposed project summary (aka “white paper”) and IRB submission protocols.
In addition to meeting with the SOC, fellows have an opportunity at least once per year in the second and third year to present research to division faculty and peers at Fellows’ Research Conference. Fellows are encouraged to submit posters and abstracts to major conferences such as the American College of Cardiology Scientific Sessions and CHOP’s own annual Cardiology Update.
The third and final year of training includes five to six months of largely uninterrupted research time, focused on project completion. Examples of scholarly activity work products per the American Board of Pediatrics may include:
- A first author or co-authored paper published in a peer-reviewed journal
- An in-depth manuscript describing a completed project
- A thesis or dissertation written in connection with pursuit of an advanced degree
- An extramural grant application that has been accepted or favorably reviewed
- A progress report for a project of exceptional complexity (e.g. a multi-year or multi-facility clinical trial)
In the fall of the second year, depending on personal academic and career goals, the fellow may wish to consider applying for the Master of Science in Clinical Epidemiology (MSCE) or Master of Science in Translational Research programs offered by the University of Pennsylvania and/or the Division-sponsored NIH T32 funding grant.
Applying for the T32 and other external funding sources is particularly encouraged for those trainees who wish to secure advanced clinical training (PGY-7 and PGY-8) positions. In the first year, fellows interested in these opportunities should arrange a meeting with the research director in the late fall and also collaborate with peers in the late spring to arrange their future block schedule so that clinical rotation requirements are completed as early as possible, in compliance with academic demands and grant protocols.
Fellows are required to attend an average of six (6) to eight (8) hours of didactic or lecture-based instruction per week that will enhance their clinical practice and fund of knowledge. Unless otherwise indicated, sessions are open to faculty and other members of the allied health professions from across disciplines and institutions.
9 a.m. — Echocardiography Teaching and Review Session
Echo Lab Conference Room, Third Floor, Main
8:15 a.m. — Echocardiography Conference
Echo Conference Room, Third Floor Main
4:00 p.m. — Rotating Conference: Pediatric Cardiology Research Lecture (PCRL)
Eighth Floor Conference Room, 8 NW 27
First and third Monday
7:30 a.m. — Clinical Case Conference
Large CICU Conference Room, 6S60
Second and fourth Monday
7:30 a.m. — Adult Congenital Heart Disease Conference
Second Monday — Radiology Conference Room, Level G, Perelman Center
Fourth Monday — Eighth Floor Conference Room, 8 NW 27, CHOP
Every other month (six times per year)
7:30 a.m. — Cardiac Center Morbidity and Mortality Conference
Stokes Auditorium, First Floor Main
7:30 a.m. — Pre-Surgical Conference
Hope Auditorium, Second Floor Main
3 p.m. — Cardiac Thrombosis Rounds
Large CICU Conference Room
First and third Tuesday
5 p.m. — MRI Conference
Radiology Conference Room, Third Floor Main
7:30 a.m. — Professor Rounds
CICU, Sixth Floor Main
Noon — ECG/Holter Reading Conference
Fellows Room, Eighth Floor, 8NW25 (confirm weekly with Cardiology Fellows)
4 p.m. — Fetal Heart Conference
Fetal Conference Room, Sixth Floor Main
1 p.m. — Pathology Dissection Conference
Autopsy Laboratory, Fifth Floor Main
4:30 p.m. — Pathology Conference
Eighth Floor Conference Room, 8NW27
Second and fourth Thursday
7:30 a.m. — Fellows’ Teaching Conference
Fellows’ Office, Eighth Floor Main, 8NW27
7:30 a.m. — Fellows’ Research Conference
Eighth Floor Conference Room, 8NW27
7:30 a.m. — Post-catheterization Conference
Cath/Angio Rm 6NE92, Sixth Floor Main
Noon — CICU Friday Conference
Week 1 – Case Conference
Week 2 – Respiratory Failure
Week 3 – Journal Club
Week 4 – Research
Large CICU Conference Room, 6S60
Annual and multi-year meetings (specialty-specific)
Fellows are encouraged to attend annual professional meetings in order to meet and learn from expert faculty in the field and to network with alumni and peers:
- February — Cardiology Update (“CHOP Conference”)
- March — American College of Cardiology (ACC)
- April — International Society for Heart & Lung Transplantation (ISHLT)
- June — American Society for Echocardiography (ASE)
- November — American Heart Association (AHA)
- December — Pediatric Cardiac Intensive Care Society (PCICS)
How to apply
To be eligible to apply for the Fellowship in Pediatric Cardiology, physicians:
- Must be a graduate of a U.S. or Canadian medical school or possess an ECFMG certificate and eligible J1 or H1B visa status.
- Must have completed pediatric residency training in an ACGME-accredited program.
- Must be eligible for board certification in pediatrics by the American Board of Pediatrics.
Pediatric Cardiology (three-year program)
All applications for standard three (3)-year categorical fellowships must be electronically through the Electronic Residency Application Service (ERAS), the online application service of the American Association of Medical Colleges (AAMC). The annual official deadline for a completed application is December 1. Although applications are considered on a rolling basis as they are completed, applicants who meet the deadline ensure consideration in the first round review by our fellowship selection committee. If selected to interview, requests for specific interview dates are more easily accommodated for applicants who are invited earlier in the season.
The following documents must be received by ERAS prior to consideration of your application:
- ERAS application form
- Curriculum vitae
- Personal statement
- Medical school transcript
- USMLE score reports
- Successful applicants must complete Steps 1, 2 and 3 prior to starting fellowship due to Pennsylvania licensure requirements
- Three (3) letters of recommendation (LORs)
- Three LORs is the minimum requirement — it is strongly recommended that one of these letters be from the applicant’s pediatric residency program director
- Educational Commission for Foreign Medical Graduates (ECFMG) certificate and visa information, if applicable
Our program participates in the National Residency Matching Program (NRMP) Pediatric Subspecialties Spring Match. Anticipated application and recruitment timeline (and notable deadlines) for the upcoming season are as follows (these dates are approximate and based on previous years):
- Applications due through ERAS: December 1, 2016
- Application reviews begin Dec. 2, 2016, and, continue through Feb. 15, 2017
- Interview invitations begin Dec. 19, 2016, and continue through Feb. 24, 2017
- Interviews begin Jan. 9, 2017, and continue through April 14, 2017
- NRMP Match Registration opens: Feb. 1, 2017
- NRMP Rank Order List system opens: April 5, 2017
- NRMP Program Quota Change Deadline (# of available positions/year) closes: April 26, 2017
- NRMP Rank Order List system closes: May 10, 2017
- NRMP Match Day/Results: May 24, 2017
Military (ROTC)-funded applicants and occasional non-traditional applicants may be program-eligible on a case-by-case basis. For consideration, please contact Meryl S. Cohen, MD, program director.
Fourth and fifth year fellowships (PGY-7 and PGY-8) are offered contingent on funding and availability.
In recent years, the noninvasive imaging (echo and MRI), interventional cardiology, electrophysiology and cardiac critical care practice groups have recruited trainees on a regular basis. There are also opportunities to pursue advanced training in adult congenital heart disease, heart failure/transplant, cardiac pathology, pulmonary hypertension, exercise physiology and research.
Training eligibility varies by subspecialty, though most applicants commonly will have completed a three-year fellowship in pediatric cardiology and/or pediatric critical care medicine. It is recommended that prospective advanced trainees contact the section director(s) with specific questions and concerns.
Application materials for advanced subspecialty fellowships are sent directly to the program, not through ERAS. Once completed, these files are sent to the director(s) for review. A completed fourth- and fifth-year training application will include:
- CHOP Common Graduate Medical Education (GME) Application Form (7 pp)
- 4th Year Pediatric Cardiology Fellowship Application (for all subspecialties except CICU)
- 4th Year Cardiac Critical Care Fellowship Application (1 pp)
- All supporting documents (CV, transcripts, LORs etc.) as listed above for three-year fellowship application process, with exception of ERAS form
Please send these materials directly via email to email@example.com or regular mail to:
Fellowship Administrative Coordinator
Division of Cardiology
3401 Civic Center Boulevard
Philadelphia, PA 19104
Children’s Hospital of Philadelphia is an equal opportunity employer, committed to creating an environment where all people feel valued and respected and can contribute to their fullest potential. A non-discrimination and harassment policy is strictly enforced. No applicant for employment shall be subjected to discrimination because of race, color, sex, national origin, religion, disability, age, sexual orientation or family status.
Tobacco-free hiring policy
To help preserve and improve the health of our patients, their families and our employees, Children’s Hospital of Philadelphia has a tobacco-free hiring policy. This policy applies to all candidates for employment (other than those with regularly scheduled hours in New Jersey) for all positions, including those covered by the Collective Bargaining Agreement. Job applicants who apply after July 1, 2014 will be expected to sign an attestation stating they’ve been free of nicotine or tobacco products in any form for the prior thirty (30) days. They will also undergo a cotinine test as a part of the Occupational Health pre-placement drug screen administered after the offer of employment has been accepted but before the first day of hire. Exemptions: Attending physicians (excluding CHOP physicians in the Care Network), psychologists, principal investigators and/or Penn-based faculty are exempt from this process to better align with our colleagues at the University of Pennsylvania Perelman School of Medicine.
For more information
If you are interested in fellowships at the Cardiac Center, please contact the individuals listed below.
Pediatric Cardiology (Core Program):
Adult Congenital Heart Disease
Cardiac Critical Care
Heart Failure – Heart Transplant
Interventional Cardiology (Cardiac Catheterization)
Non-Invasive Imaging (Pediatric Echocardiography)
Non-Invasive Imaging – (Pediatric Magnetic Resonance Imaging)
Dana Boucek, MD – Interventional Cardiology
Erin Bressler, MD – Cardiac Critical Care
Michelle Kaplinski, MD – Non-Invasive Imaging
Jill Savla, MD – Cardiac Morphology
Brian Snarr, MD, PhD – Non-Invasive Imaging
Reina Tan, MD - Electrophysiology
Celine Thibault, MD – Cardiac Critical Care
Past fellows and their current positions
(Graduates from previous five years)
- Jennifer Bailey, MD, Cardiac Critical Care Fellow, Children’s Hospital of Philadelphia
- Shivani Bhatt, MD, Non-invasive Imaging Fellow, Children’s Hospital of Philadelphia
- Edmund Burke, MD, Pediatric Intensive Care Fellow, UCSF Benioff Children’s Hospital (CA)
- Michael DiLorenzo, MD, Non-invasive Imaging Fellow, Children’s Hospital of Philadelphia
- Matthew Elias, MD, Assistant Professor of Pediatrics, Children’s Hospital of Philadelphia
- Alan Sing, MD, Pediatric Cardiologist, Pediatric Heart Specialists (TX)
- Alexandra Channing, MD, Assistant Professor of Pediatrics, New York Presbyterian - Weill Cornell College of Medicine (NY)
- Utkarsh Kohli, MD, Cardiac Electrophysiologist, St. John’s Hospital and Medical Center (MI)
- Andrew Misfeldt, MD, PhD, Pediatric Intensive Care Fellow, Washington University in St. Louis (MO)
- Shaun Mohan, MD, Assistant Professor of Pediatrics, University of Louisville (KY)
- Deipanjan Nandi, MD, Assistant Professor of Pediatrics, Nationwide Children’s Hospital (OH)
- Hari Narayan, MD, Assistant Professor of Pediatrics, UCSD – Rady Children’s Hospital (CA)
- Kiona Allen, MD, Assistant Professor of Pediatrics, University of Chicago – Lurie Children’s Hospital (IL)
- Misha Bhat, MD, Attending Faculty, Lund University Medical Center, Sweden
- Tacy Downing, MD, Assistant Professor of Pediatrics, Nicklaus - Miami Children’s Hospital
- David Frank, MD, PhD, Instructor in Pediatrics, Children’s Hospital of Philadelphia
- Kelvin Lau, MD, Assistant Professor of Pediatrics, University of Louisville (KY)
- Jyoti Patel, MD, Assistant Professor of Pediatrics, University of Indiana – Riley Children’s Hospital (IN)
2010 – 2013
- Anas Abu-Hazeem, MD, Clinical Faculty, Jordan University of Science and Technology, Jordan
- Catherine Avitabile, MD, Attending Cardiologist, St. Christopher’s Hospital for Children (PA)
- Benjamin Blevins, MD, Pediatric Cardiologist and Electrophysiologist, Naval Medical Center, San Diego (CA)
- Christopher Janson, MD, Assistant Professor of Pediatrics, Albert Einstein College of Medicine – Montefiore Medical Center (NY)
- Katharine Levinson, MD, Assistant Professor of Pediatrics, Children’s Hospital of Philadelphia
- Michael O’Byrne, MD, Assistant Professor of Pediatrics, Children’s National Medical Center (DC)
- Carol Wittlieb-Weber, MD, Assistant Professor of Pediatrics, University of Rochester (NY)
2009 – 2012
- Katherine Bates, MD, Assistant Professor of Pediatrics, University of Michigan (MI)
- Lisa D’Alessandro, MD, Assistant Professor of Pediatrics, Baylor College of Medicine – Texas Children’s Hospital (TX)
- Brooke Davey, MD, Assistant Professor of Pediatrics, Connecticut Children’s Medical Center (CT)
- Michael DiMaria, Assistant Professor of Pediatrics, Children’s Hospital of Colorado (CO)
- Camila Londono-Obregon, MD, Pediatric Cardiologist, Pediatric Cardiology Associates – San Antonio (TX)
- Shabnam Peyvandi, MD, Assistant Professor of Pediatrics, UCSF Benioff Children’s Hospital (CA)